CA2751220A1 - Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function - Google Patents
Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function Download PDFInfo
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- CA2751220A1 CA2751220A1 CA2751220A CA2751220A CA2751220A1 CA 2751220 A1 CA2751220 A1 CA 2751220A1 CA 2751220 A CA2751220 A CA 2751220A CA 2751220 A CA2751220 A CA 2751220A CA 2751220 A1 CA2751220 A1 CA 2751220A1
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Landscapes
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| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| GEP20105124B (en) * | 2005-07-25 | 2010-11-25 | Array Biopharma Inc | Novel macrocyclic inhibitors of hepatitis c virus replication |
| BRPI0617274A2 (pt) * | 2005-10-11 | 2011-07-19 | Intermune Inc | compostos e métodos para a inibição de replicação viral de hepatite c |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| CN102046622A (zh) * | 2008-04-15 | 2011-05-04 | 因特蒙公司 | 丙型肝炎病毒复制的新颖大环抑制剂 |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| JP5767643B2 (ja) | 2009-09-21 | 2015-08-19 | ギリード・サイエンシズ・インコーポレーテッド | １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体 |
| KR101995598B1 (ko) | 2010-07-19 | 2019-07-02 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
| PE20130400A1 (es) | 2010-07-22 | 2013-04-10 | Gilead Sciences Inc | Metodos y compuestos para tratar infecciones virales por paramyxoviridae |
| TW201300106A (zh) * | 2010-11-09 | 2013-01-01 | Hoffmann La Roche | 治療ｈｃｖ感染之醫藥組合物 |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
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| ES2572329B1 (es) | 2011-10-21 | 2017-08-24 | Abbvie Inc. | Combinación de al menos dos agentes antivirales de acción directa y ribavirina pero no interferón, para uso en el tratamientodel vhc |
| PT107924A (pt) | 2011-10-21 | 2014-12-03 | Abbvie Inc | Tratamento de combinação de daa (eg. com abt-072 ou abt-333) para utilização no tratamento de hcv |
| JP6038179B2 (ja) | 2012-01-11 | 2016-12-07 | アッヴィ・インコーポレイテッド | Ｈｃｖプロテアーゼ阻害剤の製造方法 |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| TW201402133A (zh) * | 2012-06-12 | 2014-01-16 | Hoffmann La Roche | 組合治療性組成物 |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| HRP20191939T1 (hr) * | 2012-09-18 | 2020-01-10 | Abbvie Inc. | Postupci za liječenje hepatitisa c |
| TWI698444B (zh) | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| HK1247829A1 (zh) | 2015-03-06 | 2018-10-05 | Atea Pharmaceuticals, Inc. | 用於治疗HCV的β-D-2'-脱氧-2'Α-氟-2'-β-C-取代-2-改性N6-取代的嘌呤核苷酸 |
| PT3349758T (pt) | 2015-09-16 | 2022-07-13 | Gilead Sciences Inc | Métodos para o tratamento de infeções pelo vírus arenaviridae |
| CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3512863B1 (en) | 2016-09-07 | 2021-12-08 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| CN106674224A (zh) * | 2016-12-20 | 2017-05-17 | 天津迈德新医药科技有限公司 | mPEG4‑阿巴卡韦及其制备方法和应用 |
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| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
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| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| CN105233249A (zh) | 2009-04-25 | 2016-01-13 | 弗·哈夫曼-拉罗切有限公司 | 改善药物动力学的方法 |
| WO2010151487A1 (en) | 2009-06-23 | 2010-12-29 | Gilead Sciences, Inc. | Combination of telaprevir with 5- ({6- [2,4-bis (trifluoromethyl) phenyl] pyridazin-3 -yl)methyl) -2- (2 -fluorophenyl) -5h- imidazo [4, 5-c]pyridine for the treatment of hcv |
| AR077139A1 (es) | 2009-06-23 | 2011-08-03 | Gilead Sciences Inc | Composiciones farmaceuticas utiles para tratar el vch |
| WO2010151472A1 (en) | 2009-06-23 | 2010-12-29 | Gilead Sciences, Inc. | Combination of a ns5b polymerase inhibitor and a hcv ns3 protease inhibitor for the treatment of hcv |
| US8232246B2 (en) | 2009-06-30 | 2012-07-31 | Abbott Laboratories | Anti-viral compounds |
| JP2013505951A (ja) | 2009-09-28 | 2013-02-21 | エフ．ホフマン−ラ ロシュ エルティーディー | Ｃ型肝炎ウイルス複製の新規の大環状インヒビター |
-
2010
- 2010-02-23 AR ARP100100517A patent/AR075584A1/es unknown
- 2010-02-26 JP JP2011552194A patent/JP2012519181A/ja active Pending
- 2010-02-26 WO PCT/US2010/025611 patent/WO2010099458A1/en not_active Ceased
- 2010-02-26 RU RU2011139180/15A patent/RU2011139180A/ru unknown
- 2010-02-26 TW TW99105744A patent/TWI473810B/zh not_active IP Right Cessation
- 2010-02-26 CN CN2010800099017A patent/CN102361641A/zh active Pending
- 2010-02-26 CA CA2751220A patent/CA2751220A1/en not_active Abandoned
- 2010-02-26 NZ NZ594524A patent/NZ594524A/xx not_active IP Right Cessation
- 2010-02-26 KR KR1020117021515A patent/KR20110135941A/ko not_active Ceased
- 2010-02-26 US US13/203,334 patent/US20120128628A1/en not_active Abandoned
- 2010-02-26 SG SG2011059904A patent/SG173774A1/en unknown
- 2010-02-26 EP EP10706121A patent/EP2400966A1/en not_active Withdrawn
- 2010-02-26 US US12/713,497 patent/US8735345B2/en not_active Expired - Fee Related
- 2010-02-26 MA MA34087A patent/MA33236B1/fr unknown
- 2010-02-26 AU AU2010217818A patent/AU2010217818A1/en not_active Abandoned
- 2010-02-26 PE PE2011001548A patent/PE20120777A1/es not_active Application Discontinuation
- 2010-02-26 MX MX2011008980A patent/MX2011008980A/es active IP Right Grant
- 2010-02-26 BR BRPI1009338A patent/BRPI1009338A2/pt not_active IP Right Cessation
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2011
- 2011-08-21 IL IL214760A patent/IL214760A0/en unknown
- 2011-08-23 CR CR20110453A patent/CR20110453A/es not_active Application Discontinuation
- 2011-08-25 CO CO11108893A patent/CO6410304A2/es not_active Application Discontinuation
- 2011-08-26 CL CL2011002082A patent/CL2011002082A1/es unknown
- 2011-08-26 EC EC2011011292A patent/ECSP11011292A/es unknown
-
2015
- 2015-03-03 JP JP2015041648A patent/JP2015098501A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CO6410304A2 (es) | 2012-03-30 |
| CR20110453A (es) | 2011-12-08 |
| US20100221217A1 (en) | 2010-09-02 |
| IL214760A0 (en) | 2011-11-30 |
| ECSP11011292A (es) | 2011-12-30 |
| JP2012519181A (ja) | 2012-08-23 |
| JP2015098501A (ja) | 2015-05-28 |
| KR20110135941A (ko) | 2011-12-20 |
| MX2011008980A (es) | 2011-11-18 |
| NZ594524A (en) | 2013-09-27 |
| PE20120777A1 (es) | 2012-06-27 |
| MA33236B1 (fr) | 2012-05-02 |
| AU2010217818A1 (en) | 2011-08-18 |
| TW201035099A (en) | 2010-10-01 |
| SG173774A1 (en) | 2011-09-29 |
| CL2011002082A1 (es) | 2012-04-13 |
| AR075584A1 (es) | 2011-04-20 |
| RU2011139180A (ru) | 2013-04-10 |
| TWI473810B (zh) | 2015-02-21 |
| EP2400966A1 (en) | 2012-01-04 |
| BRPI1009338A2 (pt) | 2016-11-01 |
| WO2010099458A1 (en) | 2010-09-02 |
| CN102361641A (zh) | 2012-02-22 |
| US8735345B2 (en) | 2014-05-27 |
| US20120128628A1 (en) | 2012-05-24 |
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