JP2012518404A - Ｃｄ１９に結合するヒト化抗体及びその使用 - Google Patents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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Applications Claiming Priority (3)
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| US15452409P | 2009-02-23 | 2009-02-23 | |
| US61/154,524 | 2009-02-23 | ||
| PCT/IB2010/000353 WO2010095031A2 (en) | 2009-02-23 | 2010-02-23 | Humanized antibodies that bind to cd19 and their uses |
Publications (2)
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| JP2012518404A true JP2012518404A (ja) | 2012-08-16 |
| JP2012518404A5 JP2012518404A5 (cg-RX-API-DMAC7.html) | 2013-04-04 |
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| JP2011550666A Pending JP2012518404A (ja) | 2009-02-23 | 2010-02-23 | Ｃｄ１９に結合するヒト化抗体及びその使用 |
Country Status (17)
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013520194A (ja) * | 2010-02-23 | 2013-06-06 | サノフイ | 抗アルファ２インテグリン抗体及びそれらの使用 |
| JP2016514462A (ja) * | 2013-03-16 | 2016-05-23 | ノバルティス アーゲー | ヒト化抗ｃｄ１９キメラ抗原受容体を使用するがんの処置 |
| JP2017500009A (ja) * | 2013-10-31 | 2017-01-05 | フレッド ハッチンソン キャンサー リサーチ センター | 改変された造血幹／前駆細胞及び非エフェクターｔ細胞、そしてそれらの用途 |
| JP2018529733A (ja) * | 2015-10-01 | 2018-10-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ヒト化抗ヒトｃｄ１９抗体及び使用方法 |
| JP2018533929A (ja) * | 2015-10-02 | 2018-11-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗ｃｄ１９×ｃｄ３ｔ細胞活性化抗原結合分子 |
| JP2020517302A (ja) * | 2017-04-24 | 2020-06-18 | カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａｒｍａ， Ｉｎｃ | Ｃｄ１９に対するヒト化抗原結合ドメイン及び使用方法 |
| JP2020519285A (ja) * | 2017-05-10 | 2020-07-02 | ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー | 最適化された核酸抗体構築物 |
| JP2022028645A (ja) * | 2018-12-21 | 2022-02-16 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｃｄ３に結合する抗体 |
| US11780920B2 (en) | 2020-06-19 | 2023-10-10 | Hoffmann-La Roche Inc. | Antibodies binding to CD3 and CD19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI560199B (en) | 2010-08-31 | 2016-12-01 | Sanofi Sa | Peptide or peptide complex binding to α2 integrin and methods and uses involving the same |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012096975A2 (en) * | 2011-01-13 | 2012-07-19 | The Board Of Trustees Of The Leland Stanford Junior University | Method of predicting responsiveness of b cell lineage malignancies to active immunotherapy |
| AU2012235758B2 (en) | 2011-03-25 | 2015-05-07 | IGI Therapeutics SA | Hetero-dimeric immunoglobulins |
| CN107915775B (zh) | 2011-07-11 | 2022-07-12 | 伊克诺斯科学公司 | 结合ox40的抗体及其用途 |
| SI2744515T1 (sl) | 2011-08-16 | 2022-05-31 | Morphosys Ag | Kombinirana terapija s protitelesom proti CD19 in dušikovim iperitom |
| AU2012296905B2 (en) | 2011-08-16 | 2017-01-05 | Incyte Corporation | Combination therapy with an anti - CD19 antibody and a purine analog |
| AU2013322710A1 (en) | 2012-09-25 | 2015-04-16 | Glenmark Pharmaceuticals S.A. | Purification of hetero-dimeric immunoglobulins |
| EP2839860B1 (en) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| DK2906298T3 (en) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| JP2016503818A (ja) | 2013-01-02 | 2016-02-08 | グレンマーク ファーマシューティカルズ， エセ．アー． | Ｔｌ１ａと結合する抗体およびその使用 |
| AU2014240083C1 (en) | 2013-03-15 | 2019-10-24 | Celgene Corporation | Modified T lymphocytes |
| US10150814B2 (en) | 2013-06-27 | 2018-12-11 | Abbvie Biotherapeutics Inc. | Fc variants with improved complement activation |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3176185A1 (en) | 2013-11-04 | 2017-06-07 | Glenmark Pharmaceuticals S.A. | Production of t cell retargeting hetero-dimeric immunoglobulins |
| RU2714902C2 (ru) | 2013-12-19 | 2020-02-20 | Новартис Аг | Химерные рецепторы антигена против мезотелина человека и их применение |
| ES2876263T3 (es) | 2014-04-07 | 2021-11-12 | Novartis Ag | Tratamiento del cáncer usando receptor de antígeno quimérico anti-cd19 |
| US11041021B2 (en) | 2014-05-23 | 2021-06-22 | University Of Florida Research Foundation, Incorporated | Car based immunotherapy |
| US10174095B2 (en) | 2014-07-21 | 2019-01-08 | Novartis Ag | Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor |
| TWI751102B (zh) * | 2014-08-28 | 2022-01-01 | 美商奇諾治療有限公司 | 對ｃｄ１９具專一性之抗體及嵌合抗原受體 |
| ES2688035T3 (es) | 2014-08-29 | 2018-10-30 | Gemoab Monoclonals Gmbh | Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| WO2016061368A1 (en) * | 2014-10-15 | 2016-04-21 | The Children's Hospital Of Philadelphia | Compositions and methods for treating b-lymphoid malignancies |
| MA41480A (fr) | 2014-10-17 | 2017-12-19 | Glenmark Pharmaceuticals Sa | Anticorps qui se lient au ccr6 et leurs utilisations |
| US11773166B2 (en) | 2014-11-04 | 2023-10-03 | Ichnos Sciences SA | CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production |
| WO2016090190A1 (en) | 2014-12-03 | 2016-06-09 | Juno Therapeutics, Inc. | Methods and compositions for adoptive cell therapy |
| US12428483B2 (en) * | 2014-12-22 | 2025-09-30 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of making and using thereof |
| US11248058B2 (en) * | 2015-02-19 | 2022-02-15 | University Of Florida Research Foundation, Inc. | Chimeric antigen receptors and uses thereof |
| GB201503742D0 (en) * | 2015-03-05 | 2015-04-22 | Ucl Business Plc | Chimeric antigen receptor |
| HUE059218T2 (hu) | 2015-04-08 | 2022-11-28 | Novartis Ag | CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel |
| WO2016168769A1 (en) * | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Chimeric receptor t cell switches for her2 |
| EP3288569A4 (en) * | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| CA2986175A1 (en) | 2015-05-26 | 2016-12-01 | Morphosys Ag | Combination of an anti-cd19 antibody and a bruton's tyrosine kinase inhibitor and uses thereof |
| US10493139B2 (en) | 2015-07-24 | 2019-12-03 | Innovative Cellular Therapeutics CO., LTD. | Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor |
| WO2017015783A1 (en) * | 2015-07-24 | 2017-02-02 | Shanghai Sidansai Biotechnology Co., Ltd | Humanized anti-cd19 antibody and use thereof |
| WO2018126369A1 (en) | 2017-01-05 | 2018-07-12 | Shanghai Sidansai Biotechnology Co., Ltd | Humanized anti-cd19 antibody and use thereof with chimeric antigen receptor |
| AU2016311136B2 (en) | 2015-08-21 | 2022-02-17 | Incyte Corporation | Combinations and uses thereof |
| MA44909A (fr) | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
| ES2928167T3 (es) * | 2015-12-03 | 2022-11-15 | Juno Therapeutics Inc | Composiciones y métodos para reducir las respuestas inmunitarias contra receptores de antígenos quiméricos |
| EP3383892B1 (en) | 2015-12-03 | 2022-12-21 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| MA45124B1 (fr) | 2016-05-30 | 2021-05-31 | Morphosys Ag | Procédés permettant de prédire un bénéfice thérapeutique d'une thérapie anti-cd19 chez des patients |
| CN115998859A (zh) | 2016-06-27 | 2023-04-25 | 莫佛塞斯公司 | 抗-cd19抗体制剂 |
| CA3039646A1 (en) | 2016-10-07 | 2018-04-12 | Novartis Ag | Chimeric antigen receptors for the treatment of cancer |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| JP7100028B2 (ja) | 2016-10-20 | 2022-07-12 | セルジーン コーポレイション | セレブロン系のヘテロ二量体化可能なキメラ抗原受容体 |
| IL266216B2 (en) | 2016-10-28 | 2023-09-01 | Morphosys Ag | Combination of anti-cd19 antibody with bcl-2 inhibitor and uses thereof |
| CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| IL266892B2 (en) | 2016-12-02 | 2025-10-01 | Univ Southern California | Artificial immune receptors and methods of using them |
| PL3544636T3 (pl) | 2017-02-08 | 2021-12-06 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| CN106967171B (zh) * | 2017-02-23 | 2021-04-27 | 郑州大学 | 一种全人源重组CD40L单抗Fab片段及其制备方法 |
| SMT202200490T1 (it) | 2017-04-18 | 2023-01-13 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| AU2018256436B2 (en) | 2017-04-19 | 2024-12-05 | Board Of Regents, The University Of Texas System | Immune cells expressing engineered antigen receptors |
| PL3630177T3 (pl) | 2017-05-31 | 2024-04-08 | Morphosys Ag | Paradygmat leczenia dla leczenia skojarzonego przeciwciałem anty-cd19 i wenetoklaksem |
| BR112019026564A2 (pt) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | regimes de dosagem para a administração de um adc anti-cd19 |
| WO2019011918A1 (en) | 2017-07-10 | 2019-01-17 | International - Drug - Development - Biotech | TREATMENT OF LYMPHOCYTE B MALIGNANCIES USING AFUCOSYLATED PRO-APOPTOTIC ANTI-CD19 ANTIBODIES IN COMBINATION WITH ANTI-CD20 ANTIBODIES OR CHEMOTHERAPEUTIC AGENTS |
| CA3099487A1 (en) * | 2017-07-20 | 2019-01-24 | Nbe-Therapeutics Ag | Human antibodies binding to ror2 |
| SMT202200225T1 (it) | 2017-08-18 | 2022-07-21 | Medimmune Ltd | Coniugati di pirrolobenzodiazepina |
| AU2018336520B2 (en) | 2017-09-21 | 2025-03-27 | WuXi Biologics Ireland Limited | Novel anti-CD19 antibodies |
| EP3703675A4 (en) | 2017-10-30 | 2021-06-16 | Neuropore Therapies, Inc. | SUBSTITUTED PHENYLSULFONYLPHÉNYLTRIAZOLETHIONES AND ASSOCIATED USES |
| CN111465616B (zh) * | 2017-12-06 | 2023-08-01 | 艾克隆株式会社 | 特异性识别恶性b细胞的抗体或其抗原结合片段、包含其的嵌合抗原受体及其用途 |
| CN111542541B (zh) * | 2017-12-22 | 2023-11-03 | 艾克隆株式会社 | 特异性识别恶性b细胞的抗体或其抗原结合片段、包含其的嵌合抗原受体及其用途 |
| CN109053899B (zh) * | 2017-12-22 | 2021-11-16 | 湖南远泰生物技术有限公司 | 一种含人转铁蛋白抗原表位序列的嵌合体抗原受体 |
| CN108047332B (zh) * | 2018-01-15 | 2021-08-24 | 阿思科力(苏州)生物科技有限公司 | 以cd19为靶点的特异性抗体、car-nk细胞及其制备和应用 |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| MY208825A (en) | 2018-06-13 | 2025-05-30 | Novartis Ag | Bcma chimeric antigen receptors and uses thereof |
| KR20200030337A (ko) | 2018-09-12 | 2020-03-20 | 주식회사 녹십자랩셀 | 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물 |
| CN109293774B (zh) * | 2018-10-16 | 2021-05-28 | 南京医科大学 | 特异性结合cd19的全人源化抗体及应用 |
| CN116726362A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| JP7386382B2 (ja) | 2018-12-12 | 2023-11-27 | カイト ファーマ インコーポレイテッド | キメラ抗原受容体及びｔ細胞受容体並びに使用方法 |
| US11672858B2 (en) | 2018-12-21 | 2023-06-13 | Hoffmann-La Roche Inc. | Bispecific antibody molecules binding to CD3 and TYRP-1 |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| AU2020242747B2 (en) | 2019-03-15 | 2025-09-18 | Medimmune Limited | Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer |
| CN114341176A (zh) * | 2019-04-08 | 2022-04-12 | 纪念斯隆凯特琳癌症中心 | Cd19抗体及其使用方法 |
| EA202192975A1 (ru) * | 2019-04-30 | 2022-02-01 | Криспр Терапьютикс Аг | Аллогенная клеточная терапия b-клеточных злокачественных новообразований с применением генетически сконструированных т-клеток, нацеливающихся на cd19 |
| MX2021013101A (es) | 2019-05-03 | 2022-01-04 | Morphosys Ag | Terapia anti-cd19 en pacientes que tienen una cantidad limitada de células nk. |
| KR20220026586A (ko) * | 2019-06-27 | 2022-03-04 | 크리스퍼 테라퓨틱스 아게 | 암 치료를 위한 키메라 항원 수용체 t세포 및 nk세포 억제제의 용도 |
| AU2020311511B2 (en) | 2019-07-09 | 2024-08-29 | Beijing Solobio Genetechnology Co., Ltd. | Antibodies specifically recognizing Pseudomonas PcrV and uses thereof |
| CN110396129B (zh) * | 2019-07-10 | 2020-11-24 | 武汉思安医疗技术有限公司 | 人源化cd19抗原结合单链抗体及其嵌合抗原受体、免疫细胞和应用 |
| JP2022550435A (ja) | 2019-10-04 | 2022-12-01 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 組換えａａｖの改善された治療的使用のための方法 |
| US20210130461A1 (en) | 2019-10-31 | 2021-05-06 | Morphosys Ag | Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells |
| IL317199A (en) | 2019-10-31 | 2025-01-01 | Morphosys Ag | Anti-CD19 therapy in combination with lenalidomide for the treatment of leukemia or lymphoma |
| PH12022551291A1 (en) | 2019-11-26 | 2023-11-20 | Novartis Ag | Chimeric antigen receptors binding bcma and cd19 and uses thereof |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN115279795A (zh) * | 2020-02-11 | 2022-11-01 | 克里斯珀医疗股份公司 | 靶向抗cd19嵌合抗原受体的抗独特型抗体 |
| US20210340524A1 (en) * | 2020-05-01 | 2021-11-04 | Massachusetts Institute Of Technology | Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof |
| CN115956088A (zh) | 2020-06-22 | 2023-04-11 | 莫佛塞斯公司 | 包括抗-CD19抗体和阻断SIRPα-CD47先天免疫检查点的多肽的抗肿瘤组合疗法 |
| IL301865A (en) | 2020-10-06 | 2023-06-01 | Xencor Inc | Biomarkers, methods, and compositions for treating autoimmune disease including systemic lupus erythematous (sle) |
| CN116848147A (zh) * | 2020-11-20 | 2023-10-03 | 先声再明医药有限公司 | Cd19人源化抗体及其应用 |
| US20220184208A1 (en) | 2020-12-04 | 2022-06-16 | Morphosys Ag | Anti-cd19 combination therapy |
| US20240425563A1 (en) * | 2021-01-13 | 2024-12-26 | Washington University | MHC-INDEPENDENT TCRs AND METHODS OF MAKING AND USING SAME |
| CN112679612B (zh) * | 2021-01-29 | 2022-07-01 | 武汉华美生物工程有限公司 | 抗cd19人源化抗体及其制备方法与应用 |
| US20240270842A1 (en) * | 2021-05-07 | 2024-08-15 | Viela Bio, Inc | Use of an anti-cd19 antibody to treat myasthenia gravis |
| WO2023073645A1 (en) | 2021-10-29 | 2023-05-04 | Takeda Pharmaceutical Company Limited | Therapy comprising anti-cd19 antibody and sumo-activating enzyme inhibitor |
| US20250084169A1 (en) | 2022-01-12 | 2025-03-13 | Biomolecular Holdings Llc | Nk/monocyte engagers |
| JP2025528837A (ja) | 2022-08-17 | 2025-09-02 | インサイト・コーポレイション | 抗ｃｄ１９抗体及びｅｚｈ２モジュレーターを含む治療 |
| WO2024222859A1 (zh) * | 2023-04-28 | 2024-10-31 | 深圳深信生物科技有限公司 | 经修饰的递送载体及其应用 |
| WO2024251263A1 (en) | 2023-06-09 | 2024-12-12 | Jw Therapeutics R & D (Shanghai) Co., Ltd. | Fusion protein and medical use thereof |
| US20250197501A1 (en) * | 2023-12-19 | 2025-06-19 | Development Center For Biotechnology | Recombinant antibody, immunoconjugate comprising the same, and uses thereof in treating cancers |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004529636A (ja) * | 2000-11-07 | 2004-09-30 | シティ・オブ・ホープ | Ｃｄ１９特異的再指向免疫細胞 |
| JP2005532253A (ja) * | 2001-10-25 | 2005-10-27 | ジェネンテック・インコーポレーテッド | 糖タンパク質組成物 |
| JP2007528209A (ja) * | 2003-07-31 | 2007-10-11 | イミューノメディクス、インコーポレイテッド | 抗ｃｄ１９抗体 |
| JP2008530142A (ja) * | 2005-02-15 | 2008-08-07 | デューク ユニバーシティ | 抗ｃｄ１９抗体および腫瘍学における使用 |
| JP2008540447A (ja) * | 2005-05-05 | 2008-11-20 | デューク ユニバーシティ | 自己免疫疾患のための抗ｃｄ１９抗体治療 |
| JP2008543339A (ja) * | 2005-06-20 | 2008-12-04 | メダレックス インコーポレーティッド | Ｃｄ１９抗体およびその使用法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU600575B2 (en) * | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US5677425A (en) * | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5571894A (en) * | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| FI941572L (fi) * | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| WO1993022332A2 (en) * | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5869046A (en) * | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6121022A (en) * | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US6277375B1 (en) * | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
| CA2445611A1 (en) * | 2001-05-31 | 2002-12-05 | Chiron Corporation | P-cadherin as a target for anti-cancer therapy |
| US20040002587A1 (en) * | 2002-02-20 | 2004-01-01 | Watkins Jeffry D. | Fc region variants |
| MXPA05005558A (es) * | 2002-11-26 | 2005-07-26 | Protein Design Labs Inc | Anticuerpos quimericos y humanizados para integrina ( 5 ( 1 que modulan la angiogenesis. |
| PE20090046A1 (es) * | 2003-11-10 | 2009-01-26 | Schering Corp | Anticuerpo recombinante humanizado anti-interleuquina 10 |
| AR064464A1 (es) * | 2006-12-22 | 2009-04-01 | Genentech Inc | Anticuerpos anti - receptor del factor de crecimiento insulinico |
-
2010
- 2010-02-23 BR BRPI1005984A patent/BRPI1005984A2/pt not_active IP Right Cessation
- 2010-02-23 EP EP10706363A patent/EP2398829A2/en not_active Withdrawn
- 2010-02-23 CA CA2753158A patent/CA2753158A1/en not_active Abandoned
- 2010-02-23 JP JP2011550666A patent/JP2012518404A/ja active Pending
- 2010-02-23 EA EA201190132A patent/EA201190132A1/ru unknown
- 2010-02-23 AU AU2010215239A patent/AU2010215239A1/en not_active Abandoned
- 2010-02-23 CN CN2010800177548A patent/CN102421800A/zh active Pending
- 2010-02-23 AP AP2011005859A patent/AP2011005859A0/xx unknown
- 2010-02-23 MX MX2011008843A patent/MX2011008843A/es not_active Application Discontinuation
- 2010-02-23 SG SG2011058013A patent/SG173654A1/en unknown
- 2010-02-23 WO PCT/IB2010/000353 patent/WO2010095031A2/en not_active Ceased
- 2010-02-23 KR KR1020117022435A patent/KR20110122859A/ko not_active Withdrawn
- 2010-02-23 US US12/710,442 patent/US8679492B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 IL IL214725A patent/IL214725A0/en unknown
- 2011-08-22 CL CL2011002039A patent/CL2011002039A1/es unknown
- 2011-08-31 ZA ZA2011/06369A patent/ZA201106369B/en unknown
- 2011-09-23 CO CO11124710A patent/CO6430469A2/es not_active Application Discontinuation
-
2014
- 2014-01-30 US US14/168,927 patent/US20140286934A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004529636A (ja) * | 2000-11-07 | 2004-09-30 | シティ・オブ・ホープ | Ｃｄ１９特異的再指向免疫細胞 |
| JP2005532253A (ja) * | 2001-10-25 | 2005-10-27 | ジェネンテック・インコーポレーテッド | 糖タンパク質組成物 |
| JP2007528209A (ja) * | 2003-07-31 | 2007-10-11 | イミューノメディクス、インコーポレイテッド | 抗ｃｄ１９抗体 |
| JP2008530142A (ja) * | 2005-02-15 | 2008-08-07 | デューク ユニバーシティ | 抗ｃｄ１９抗体および腫瘍学における使用 |
| JP2008540447A (ja) * | 2005-05-05 | 2008-11-20 | デューク ユニバーシティ | 自己免疫疾患のための抗ｃｄ１９抗体治療 |
| JP2008543339A (ja) * | 2005-06-20 | 2008-12-04 | メダレックス インコーポレーティッド | Ｃｄ１９抗体およびその使用法 |
Non-Patent Citations (8)
| Title |
|---|
| HWANG ET AL, METHODS, vol. 36, JPN6014027694, 2005, pages 35 - 42, ISSN: 0002845718 * |
| JOHNSON GEORGE ET AL: "KABAT DATABASE AND ITS APPLICATIONS: 30 YEARS AFTER THE FIRST VARIABILITY PLOT", NUCLEIC ACIDS RESEARCH, vol. 28, no. 1, JPN5012008541, 2000, pages 214 - 218, XP009132432, ISSN: 0002845725 * |
| NICHOLSON I C ET AL, MOLECULAR IMMUNOLOGY, vol. Vol. 34, No. 16-17, JPN5012008539, 1997, GB, pages 1157 - 1165, ISSN: 0002845723 * |
| ROGUSKA M A ET AL, PROTEIN ENGINEERING, vol. 9, no. 10, JPN5012008536, 1996, GB, pages 895 - 904, ISSN: 0002845720 * |
| TIWARI A ET AL, VACCINE, vol. 27, JPN5012008538, 13 February 2009 (2009-02-13), GB, pages 2356 - 2366, ISSN: 0002845722 * |
| WINTER G ET AL: "HUMANIZED ANTIBODIES", TRENDS IN PARMACOLOGICAL SCIENCES, vol. 14, JPN5012008537, May 1993 (1993-05-01), GB, pages 139 - 143, XP025809488, ISSN: 0002845721, DOI: 10.1016/0165-6147(93)90197-R * |
| ZOLA H ET AL: "PREPARATION AND CHARACTERIZATION OF A CHIMERIC CD19 MONOCLONAL ANTIBODY", IMMUNOLOGY AND CELL BIOLOGY, vol. 69, JPN5012008540, 1991, AU, pages 411 - 422, XP008115309, ISSN: 0002845724, DOI: 10.1038/icb.1991.58 * |
| 杉村和久: "＜概論＞ヒト抗体エンジニアリング", ＢＩＯベンチャー, vol. 2, no. 4, JPN6014025056, 1 July 2002 (2002-07-01), pages 30 - 33, ISSN: 0002845719 * |
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Also Published As
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|---|---|
| BRPI1005984A2 (pt) | 2016-10-04 |
| ZA201106369B (en) | 2012-05-30 |
| US8679492B2 (en) | 2014-03-25 |
| CA2753158A1 (en) | 2010-08-26 |
| MX2011008843A (es) | 2011-12-14 |
| CN102421800A (zh) | 2012-04-18 |
| AP2011005859A0 (en) | 2011-10-31 |
| US20100215651A1 (en) | 2010-08-26 |
| CO6430469A2 (es) | 2012-04-30 |
| WO2010095031A3 (en) | 2010-11-04 |
| SG173654A1 (en) | 2011-09-29 |
| US20140286934A1 (en) | 2014-09-25 |
| KR20110122859A (ko) | 2011-11-11 |
| EA201190132A1 (ru) | 2013-01-30 |
| AU2010215239A1 (en) | 2011-09-15 |
| WO2010095031A2 (en) | 2010-08-26 |
| EP2398829A2 (en) | 2011-12-28 |
| CL2011002039A1 (es) | 2012-03-30 |
| IL214725A0 (en) | 2011-11-30 |
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