|
CA1271477A
(en)
|
1983-11-18 |
1990-07-10 |
John F. Gerster |
1h-imidazo[4,5-c]quinolin-4-amines
|
|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
DE3346123A1
(de)
|
1983-12-21 |
1985-06-27 |
Janssen Pharmaceutica, N.V., Beerse |
Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
|
|
US4727064A
(en)
|
1984-04-25 |
1988-02-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Pharmaceutical preparations containing cyclodextrin derivatives
|
|
JPS61277612A
(ja)
*
|
1985-05-31 |
1986-12-08 |
Kiyoshi Morikawa |
接種用徐放性組成物
|
|
US6407079B1
(en)
|
1985-07-03 |
2002-06-18 |
Janssen Pharmaceutica N.V. |
Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
|
|
US4938949A
(en)
|
1988-09-12 |
1990-07-03 |
University Of New York |
Treatment of damaged bone marrow and dosage units therefor
|
|
US5736553A
(en)
|
1988-12-15 |
1998-04-07 |
Riker Laboratories, Inc. |
Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo 4,5-C!quinolin-4-amine
|
|
US5238944A
(en)
|
1988-12-15 |
1993-08-24 |
Riker Laboratories, Inc. |
Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
|
|
EP0386960A3
(en)
*
|
1989-03-07 |
1991-10-23 |
American Cyanamid Company |
Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
|
|
US5037986A
(en)
|
1989-03-23 |
1991-08-06 |
Minnesota Mining And Manufacturing Company |
Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
|
|
US4929624A
(en)
|
1989-03-23 |
1990-05-29 |
Minnesota Mining And Manufacturing Company |
Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
|
|
NZ232740A
(en)
*
|
1989-04-20 |
1992-06-25 |
Riker Laboratories Inc |
Solution for parenteral administration comprising a 1h-imidazo(4,5-c) quinolin-4-amine derivative, an acid and a tonicity adjuster
|
|
CA2044878C
(en)
*
|
1990-08-07 |
2000-12-26 |
Tacey X. Viegas |
Thermally reversible and irreversible gels
|
|
DK0553202T3
(da)
|
1990-10-05 |
1995-07-03 |
Minnesota Mining & Mfg |
Fremgangsmåde til fremstilling af imidazo(4,5-c)quinolin-4-aminer
|
|
US5175296A
(en)
|
1991-03-01 |
1992-12-29 |
Minnesota Mining And Manufacturing Company |
Imidazo[4,5-c]quinolin-4-amines and processes for their preparation
|
|
IL105325A
(en)
|
1992-04-16 |
1996-11-14 |
Minnesota Mining & Mfg |
Immunogen/vaccine adjuvant composition
|
|
US5395937A
(en)
|
1993-01-29 |
1995-03-07 |
Minnesota Mining And Manufacturing Company |
Process for preparing quinoline amines
|
|
US5352784A
(en)
|
1993-07-15 |
1994-10-04 |
Minnesota Mining And Manufacturing Company |
Fused cycloalkylimidazopyridines
|
|
US5648516A
(en)
|
1994-07-20 |
1997-07-15 |
Minnesota Mining And Manufacturing Company |
Fused cycloalkylimidazopyridines
|
|
US5525606A
(en)
|
1994-08-01 |
1996-06-11 |
The United States Of America As Represented By The Department Of Health And Human Services |
Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
|
|
US5624677A
(en)
|
1995-06-13 |
1997-04-29 |
Pentech Pharmaceuticals, Inc. |
Controlled release of drugs delivered by sublingual or buccal administration
|
|
US5741908A
(en)
|
1996-06-21 |
1998-04-21 |
Minnesota Mining And Manufacturing Company |
Process for reparing imidazoquinolinamines
|
|
US5693811A
(en)
|
1996-06-21 |
1997-12-02 |
Minnesota Mining And Manufacturing Company |
Process for preparing tetrahdroimidazoquinolinamines
|
|
DE19637209B4
(de)
|
1996-09-12 |
2006-12-14 |
Siemens Ag |
Verfahren zum Steuern des Antriebsstrangs eines Kraftfahrzeugs und integrierte Antriebsstrangsteuerung
|
|
IL129319A0
(en)
|
1996-10-25 |
2000-02-17 |
Minnesota Mining & Mfg |
Immune response modifier compounds for treatment of TH2 mediated and related diseases
|
|
JPH10298181A
(ja)
|
1997-04-25 |
1998-11-10 |
Sumitomo Pharmaceut Co Ltd |
タイプ２ヘルパーｔ細胞選択的免疫応答抑制剤
|
|
CN1130363C
(zh)
|
1997-11-12 |
2003-12-10 |
三菱化学株式会社 |
嘌呤衍生物以及含有其作为有效成分的药物
|
|
DE69817393T2
(de)
|
1997-11-28 |
2004-06-17 |
Sumitomo Pharmaceuticals Co., Ltd. |
Neue heterozyklische verbindungen
|
|
JP4189048B2
(ja)
|
1997-12-26 |
2008-12-03 |
大日本住友製薬株式会社 |
複素環化合物
|
|
US7001609B1
(en)
|
1998-10-02 |
2006-02-21 |
Regents Of The University Of Minnesota |
Mucosal originated drug delivery systems and animal applications
|
|
JP2000159767A
(ja)
|
1998-11-26 |
2000-06-13 |
Sumitomo Pharmaceut Co Ltd |
８−ヒドロキシアデニン誘導体の新規製造法
|
|
US6486168B1
(en)
|
1999-01-08 |
2002-11-26 |
3M Innovative Properties Company |
Formulations and methods for treatment of mucosal associated conditions with an immune response modifier
|
|
HU229441B1
(en)
|
1999-01-08 |
2013-12-30 |
3M Innovative Properties Co |
Formulations and methods for treating mucosal associated conditions with an immune response modifier
|
|
US20020058674A1
(en)
|
1999-01-08 |
2002-05-16 |
Hedenstrom John C. |
Systems and methods for treating a mucosal surface
|
|
CZ27399A3
(cs)
|
1999-01-26 |
2000-08-16 |
Ústav Experimentální Botaniky Av Čr |
Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv
|
|
IL131887A0
(en)
|
1999-09-14 |
2001-03-19 |
Dpharm Ltd |
Phospholipid prodrugs of anti-proliferative drugs
|
|
IL150594A0
(en)
|
2000-01-07 |
2003-02-12 |
Ustav Ex Botan Adademie Ved Ce |
Purine derivatives, process for their preparation and use
|
|
JP3675274B2
(ja)
|
2000-01-27 |
2005-07-27 |
ダイソー株式会社 |
９−（２−ヒドロキシアルキル）プリン誘導体および１−（２−ヒドロキシアルキル）ピリミジン誘導体の製造法
|
|
GB2359747B
(en)
*
|
2000-02-29 |
2002-04-24 |
Maelor Pharmaceuticals Ltd |
Anaesthetic formulations
|
|
US6733764B2
(en)
|
2000-06-14 |
2004-05-11 |
Alain Martin |
Immunostimulator anti-cancer compounds and methods for their use in the treatment of cancer
|
|
CA2352645A1
(en)
|
2000-07-28 |
2002-01-28 |
F. Hoffmann-La Roche Ag |
Compositions for dna transfection
|
|
AU1227302A
(en)
|
2000-09-15 |
2002-03-26 |
Virco Nv |
System and method for optimizing drug therapy for the treatment of diseases
|
|
GB0023008D0
(en)
|
2000-09-20 |
2000-11-01 |
Glaxo Group Ltd |
Improvements in vaccination
|
|
US20020127224A1
(en)
|
2001-03-02 |
2002-09-12 |
James Chen |
Use of photoluminescent nanoparticles for photodynamic therapy
|
|
ES2278016T3
(es)
|
2001-04-09 |
2007-08-01 |
Novartis Vaccines And Diagnostics, Inc. |
Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
|
|
US7157465B2
(en)
|
2001-04-17 |
2007-01-02 |
Dainippon Simitomo Pharma Co., Ltd. |
Adenine derivatives
|
|
WO2003037860A2
(en)
|
2001-10-30 |
2003-05-08 |
Conforma Therapeutics Corporation |
Purine analogs having hsp90-inhibiting activity
|
|
GB0206461D0
(en)
|
2002-03-19 |
2002-05-01 |
Glaxo Group Ltd |
Improvements in vaccination
|
|
DK1545597T3
(da)
|
2002-08-15 |
2011-01-31 |
3M Innovative Properties Co |
Immunstimulerende sammensætninger og fremgangsmåde til stimulering af en immunrespons
|
|
MXPA05003193A
(es)
|
2002-09-27 |
2005-06-08 |
Sumitomo Pharma |
Compuesto de adenina novedoso y uso del mismo.
|
|
JP2004137157A
(ja)
|
2002-10-16 |
2004-05-13 |
Sumitomo Pharmaceut Co Ltd |
新規アデニン誘導体を有効成分として含有する医薬
|
|
US20040202663A1
(en)
|
2003-01-28 |
2004-10-14 |
Shanghai Sunway Biotech Co., Ltd. |
Therapy for primary and metastatic cancers
|
|
US20040265351A1
(en)
|
2003-04-10 |
2004-12-30 |
Miller Richard L. |
Methods and compositions for enhancing immune response
|
|
US20050004144A1
(en)
|
2003-04-14 |
2005-01-06 |
Regents Of The University Of California |
Combined use of IMPDH inhibitors with toll-like receptor agonists
|
|
US20050059613A1
(en)
|
2003-07-08 |
2005-03-17 |
Bahram Memarzadeh |
Compositions and methods for the enhanced uptake of therapeutic agents through the bladder epithelium
|
|
CN1852721B
(zh)
|
2003-07-31 |
2013-03-27 |
得克萨斯大学体系董事会 |
用于治疗、预防和/或改善癌症、癌症发病或癌症症状的组合物和方法
|
|
US20070161582A1
(en)
|
2003-08-08 |
2007-07-12 |
Dusan Mijikovic |
Pharmaceutical compositions and methods for metabolic modulation
|
|
JP2007504232A
(ja)
|
2003-09-05 |
2007-03-01 |
アナディス ファーマシューティカルズ インク |
Ｃ型肝炎ウイルス感染治療用のｔｌｒ７リガンド及びそのプロドラッグの投与
|
|
JP2005089334A
(ja)
|
2003-09-12 |
2005-04-07 |
Sumitomo Pharmaceut Co Ltd |
８−ヒドロキシアデニン化合物
|
|
MXPA06002997A
(es)
|
2003-09-18 |
2007-02-08 |
Conforma Therapeutics Corp |
Novedosos compuestos heterociclicos como inhibidores- hsp90.
|
|
FR2863890B1
(fr)
|
2003-12-19 |
2006-03-24 |
Aventis Pasteur |
Composition immunostimulante
|
|
US20050266067A1
(en)
|
2004-03-02 |
2005-12-01 |
Shiladitya Sengupta |
Nanocell drug delivery system
|
|
WO2005092892A1
(ja)
|
2004-03-26 |
2005-10-06 |
Dainippon Sumitomo Pharma Co., Ltd. |
８−オキソアデニン化合物
|
|
EP2269638A3
(en)
|
2004-05-28 |
2012-06-13 |
GlaxoSmithKline Biologicals S.A. |
Vaccine compositions comprising virosomes and a saponin adjuvant
|
|
CA2587676A1
(en)
|
2004-11-19 |
2006-05-26 |
Institut Gustave Roussy |
Improved treatment of cancer by double-stranded rna
|
|
US8080560B2
(en)
*
|
2004-12-17 |
2011-12-20 |
3M Innovative Properties Company |
Immune response modifier formulations containing oleic acid and methods
|
|
JP2008526752A
(ja)
*
|
2004-12-30 |
2008-07-24 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答調節剤化合物の多経路投与
|
|
ES2347172T3
(es)
|
2005-02-16 |
2010-10-26 |
Astrazeneca Ab |
Compuestos quimicos.
|
|
PL1879893T3
(pl)
|
2005-03-21 |
2010-11-30 |
Ferrer Int |
Sposób otrzymywania podstawionych w pozycji 1, związków 1H-imidazo[4,5-c]chinolino-4-aminowych i związki pośrednie
|
|
US20070292418A1
(en)
|
2005-04-26 |
2007-12-20 |
Eisai Co., Ltd. |
Compositions and methods for immunotherapy
|
|
AU2006242920A1
(en)
|
2005-05-04 |
2006-11-09 |
Pfizer Limited |
2-amido-6-amino-8-oxopurine derivatives as Toll-Like receptor modulators for the treatment of cancer and viral infections, such as hepatitis C
|
|
WO2007015877A2
(en)
|
2005-07-20 |
2007-02-08 |
Kalypsys, Inc. |
Inhibitors of p38 kinase and methods of treating inflammatory disorders
|
|
CN101304748A
(zh)
|
2005-08-22 |
2008-11-12 |
加利福尼亚大学董事会 |
Tlr激动剂
|
|
US20090105212A1
(en)
|
2005-09-22 |
2009-04-23 |
Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan |
Novel adenine compound
|
|
JPWO2007034881A1
(ja)
|
2005-09-22 |
2009-03-26 |
大日本住友製薬株式会社 |
新規アデニン化合物
|
|
JPWO2007034882A1
(ja)
|
2005-09-22 |
2009-03-26 |
大日本住友製薬株式会社 |
新規アデニン化合物
|
|
JPWO2007034817A1
(ja)
|
2005-09-22 |
2009-03-26 |
大日本住友製薬株式会社 |
新規アデニン化合物
|
|
WO2007038720A2
(en)
|
2005-09-27 |
2007-04-05 |
Coley Pharmaceutical Gmbh |
Modulation of tlr-mediated immune responses using adaptor oligonucleotides
|
|
CN1947717B
(zh)
|
2005-10-14 |
2012-09-26 |
卓敏 |
选择性抑制腺苷酸环化酶1的化合物在制备用于治疗神经性疼痛和炎性疼痛的药物中的应用
|
|
US20070100146A1
(en)
|
2005-11-03 |
2007-05-03 |
Trevor Dzwiniel |
Process for the preparation of imidazo[4,5-c]-quinolin-4-amines
|
|
US20070264317A1
(en)
*
|
2006-05-15 |
2007-11-15 |
Perrigo Israel Pharmaceuticals Ltd. |
Imiquimod cream formulation
|
|
EP2700638A1
(en)
|
2006-05-31 |
2014-02-26 |
The Regents Of the University of California |
Purine analogs
|
|
US20080008682A1
(en)
|
2006-07-07 |
2008-01-10 |
Chong Lee S |
Modulators of toll-like receptor 7
|
|
US20090181078A1
(en)
|
2006-09-26 |
2009-07-16 |
Infectious Disease Research Institute |
Vaccine composition containing synthetic adjuvant
|
|
US7902187B2
(en)
|
2006-10-04 |
2011-03-08 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
US7919490B2
(en)
|
2006-10-04 |
2011-04-05 |
Wyeth Llc |
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
|
|
WO2008045529A1
(en)
|
2006-10-12 |
2008-04-17 |
Serenex, Inc. |
Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases
|
|
CN101230064A
(zh)
|
2007-01-22 |
2008-07-30 |
靳广毅 |
9位亚甲基芳基上取代的嘌呤类衍生物
|
|
CN101790380B
(zh)
|
2007-02-07 |
2013-07-10 |
加利福尼亚大学董事会 |
合成tlr激动剂的缀合物及其应用
|
|
AR065372A1
(es)
|
2007-02-19 |
2009-06-03 |
Smithkline Beecham Corp |
Derivados de purina
|
|
ES2457316T3
(es)
|
2007-03-19 |
2014-04-25 |
Astrazeneca Ab |
Compuestos 8-oxo-adenina 9 sustituidos como moduladores del receptor similares a toll (TLR7)
|
|
AR065784A1
(es)
|
2007-03-20 |
2009-07-01 |
Dainippon Sumitomo Pharma Co |
Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.
|
|
WO2008118763A1
(en)
*
|
2007-03-23 |
2008-10-02 |
Graceway Pharmaceuticals, Llc. |
Methods and packages to enhance safety when using imiquimod to treat children diagnosed with skin disorders
|
|
CA2691444C
(en)
|
2007-06-29 |
2016-06-14 |
Gilead Sciences, Inc. |
Purine derivatives and their use as modulators of toll-like receptor 7
|
|
CN101129373B
(zh)
*
|
2007-08-16 |
2010-12-01 |
华中师范大学 |
一种制备咪喹莫特壳聚糖纳米粒的方法
|
|
CN102351880B
(zh)
|
2007-09-11 |
2014-11-12 |
杏林制药株式会社 |
作为gsk-3 抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
|
|
WO2009034386A1
(en)
|
2007-09-13 |
2009-03-19 |
Astrazeneca Ab |
Derivatives of adenine and 8-aza-adenine and uses thereof-796
|
|
MX2010007410A
(es)
|
2008-01-15 |
2011-02-25 |
Dow Pharmaceutical Sciences |
Formulacion de imiquimod.
|
|
EA201001264A1
(ru)
|
2008-02-07 |
2011-04-29 |
Дзе Регентс Оф Дзе Юниверсити Оф Калифорния |
Способ лечения заболеваний мочевого пузыря с помощью активатора tlr7
|
|
CN101239980B
(zh)
|
2008-02-18 |
2011-06-22 |
靳广毅 |
免疫受体调节剂偶联体前体和偶联体及其应用
|
|
WO2010088924A1
(en)
|
2009-02-06 |
2010-08-12 |
Telormedix Sa |
Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
|
|
KR20110117705A
(ko)
|
2009-02-11 |
2011-10-27 |
더 리전트 오브 더 유니버시티 오브 캘리포니아 |
톨-유사 수용체 조정제 및 질병의 치료
|
|
MX2012001524A
(es)
|
2009-08-07 |
2012-02-29 |
Glaxosmithkline Biolog Sa |
Derivados de oxoadenina lipidada.
|
|
JP2013525431A
(ja)
|
2010-04-30 |
2013-06-20 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
合成ｔｌｒ７アゴニストのリン脂質結合体の使用
|