|
US8227603B2
(en)
|
2006-08-01 |
2012-07-24 |
Cytokinetics, Inc. |
Modulating skeletal muscle
|
|
US8299248B2
(en)
|
2006-08-02 |
2012-10-30 |
Cytokinetics, Incorporated |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
|
|
DK2069352T5
(en)
|
2006-08-02 |
2017-04-03 |
Cytokinetics Inc |
SPECIFIC CHEMICAL UNITS, COMPOSITIONS AND PROCEDURES
|
|
US7981893B2
(en)
|
2006-10-19 |
2011-07-19 |
Signal Pharmaceuticals, Llc |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
|
|
US7998976B2
(en)
|
2008-02-04 |
2011-08-16 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
|
CN101983061A
(zh)
|
2008-02-04 |
2011-03-02 |
赛特凯恩蒂克公司 |
某种化学物质、组合物和方法
|
|
NZ590688A
(en)
|
2008-08-05 |
2012-09-28 |
Daiichi Sankyo Co Ltd |
imidazo[4,5-b]pyridin-2-one derivatives
|
|
JP5702293B2
(ja)
|
2008-11-10 |
2015-04-15 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用な化合物
|
|
AU2009324894B2
(en)
*
|
2008-11-25 |
2015-04-09 |
University Of Rochester |
MLK inhibitors and methods of use
|
|
BRPI0924084B1
(pt)
|
2008-12-19 |
2021-12-21 |
Vertex Pharmaceuticals Incorporated |
Derivados de pirazina e composição farmacêutica que os compreende
|
|
NZ618135A
(en)
|
2009-10-26 |
2015-05-29 |
Signal Pharm Llc |
Methods of synthesis and purification of heteroaryl compounds
|
|
US9062008B2
(en)
|
2010-05-12 |
2015-06-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
AU2011253025A1
(en)
|
2010-05-12 |
2012-11-29 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2569287B1
(en)
|
2010-05-12 |
2014-07-09 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
JP2013526538A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
WO2011143422A1
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
2 -aminopyridine derivatives useful as inhibitors of atr kinase
|
|
CA2800176C
(en)
*
|
2010-05-24 |
2018-08-28 |
University Of Rochester |
Bicyclic heteroaryl kinase inhibitors and methods of use
|
|
WO2011163527A1
(en)
*
|
2010-06-23 |
2011-12-29 |
Vertex Pharmaceuticals Incorporated |
Pyrrolo- pyrazine derivatives useful as inhibitors of atr kinase
|
|
DE102010049877A1
(de)
*
|
2010-11-01 |
2012-05-03 |
Merck Patent Gmbh |
7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate
|
|
EP2487159A1
(en)
|
2011-02-11 |
2012-08-15 |
MSD Oss B.V. |
RorgammaT inhibitors
|
|
WO2012138938A1
(en)
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
|
JP2014517079A
(ja)
|
2011-06-22 |
2014-07-17 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
EP2723745A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
US10272082B2
(en)
|
2011-07-13 |
2019-04-30 |
Cytokinetics, Inc. |
Combination ALS therapy
|
|
MX2014003796A
(es)
|
2011-09-30 |
2015-01-16 |
Vertex Pharma |
Compuestos utiles como inhibidores de la cinasa ataxia telangiectasia mutada y rad3 relacionados (atr).
|
|
WO2013049719A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
SG10201606774UA
(en)
|
2011-09-30 |
2016-10-28 |
Vertex Pharma |
Processes for making compounds useful as inhibitors of atr kinase
|
|
IN2014CN02501A
(enExample)
|
2011-09-30 |
2015-06-26 |
Vertex Pharma |
|
|
WO2013049720A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
KR101978537B1
(ko)
*
|
2011-10-19 |
2019-05-14 |
시그날 파마소티칼 엘엘씨 |
Tor 키나제 억제제를 사용한 암의 치료
|
|
EP2776429A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
EP2776422A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8841449B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2776421A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013071093A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
US9403829B2
(en)
|
2011-12-02 |
2016-08-02 |
Signal Pharmaceuticals, Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use
|
|
JP6114317B2
(ja)
|
2012-02-24 |
2017-04-12 |
シグナル ファーマシューティカルズ,エルエルシー |
Torキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法
|
|
CN102627646A
(zh)
*
|
2012-03-19 |
2012-08-08 |
苏州四同医药科技有限公司 |
一种3-碘-5-溴-4,7-二氮杂吲哚的制备方法
|
|
US20140044802A1
(en)
|
2012-04-05 |
2014-02-13 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
and combination therapies thereof
|
|
WO2014026327A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
|
|
WO2014026330A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
WO2014026329A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
|
|
DK2904406T3
(en)
|
2012-10-04 |
2018-06-18 |
Vertex Pharma |
METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
|
|
US8912198B2
(en)
|
2012-10-16 |
2014-12-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
WO2014080291A2
(en)
|
2012-11-21 |
2014-05-30 |
Rvx Therapeutics Inc. |
Biaryl derivatives as bromodomain inhibitors
|
|
US9073878B2
(en)
|
2012-11-21 |
2015-07-07 |
Zenith Epigenetics Corp. |
Cyclic amines as bromodomain inhibitors
|
|
CN104884059B
(zh)
*
|
2012-11-30 |
2018-08-10 |
罗切斯特大学 |
用于hiv/aids治疗的混合谱系激酶抑制剂
|
|
SMT202000713T1
(it)
|
2012-12-07 |
2021-03-15 |
Vertex Pharma |
Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
US9271978B2
(en)
|
2012-12-21 |
2016-03-01 |
Zenith Epigenetics Corp. |
Heterocyclic compounds as bromodomain inhibitors
|
|
MX2015009209A
(es)
|
2013-01-16 |
2016-03-17 |
Signal Pharm Llc |
Compuestos sustituidos de pirrolopirimidina, composiciones de los mismos, y metodos de tratamiento con los mismos.
|
|
US9370515B2
(en)
|
2013-03-07 |
2016-06-21 |
Califia Bio, Inc. |
Mixed lineage kinase inhibitors and method of treatments
|
|
JP2016512815A
(ja)
|
2013-03-15 |
2016-05-09 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体
|
|
MX368286B
(es)
|
2013-04-17 |
2019-09-27 |
Signal Pharm Llc |
Terapia de combinacion que comprende un inhibidor de tor cinasa y un compuesto de quinazolinona 5-sustituida para tratar cancer.
|
|
CA2908957C
(en)
|
2013-04-17 |
2021-05-18 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
|
|
AU2014254059B2
(en)
|
2013-04-17 |
2019-06-06 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a TOR kinase inhibitor and a cytidine analog for treating cancer
|
|
US9505764B2
(en)
|
2013-04-17 |
2016-11-29 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
HK1221168A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
|
|
EA030726B1
(ru)
|
2013-04-17 |
2018-09-28 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ
|
|
CA2908353C
(en)
|
2013-04-17 |
2021-11-02 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
WO2014181813A1
(ja)
*
|
2013-05-10 |
2014-11-13 |
武田薬品工業株式会社 |
複素環化合物
|
|
HK1223286A1
(zh)
|
2013-05-29 |
2017-07-28 |
西格诺药品有限公司 |
7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3,4-二氢吡嗪并[2,3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法
|
|
SG11201510409QA
(en)
|
2013-06-21 |
2016-01-28 |
Zenith Epigenetics Corp |
Novel bicyclic bromodomain inhibitors
|
|
WO2015004533A2
(en)
|
2013-06-21 |
2015-01-15 |
Zenith Epigenetics Corp. |
Novel substituted bicyclic compounds as bromodomain inhibitors
|
|
AU2014298051B2
(en)
|
2013-07-31 |
2018-11-15 |
Zenith Epigenetics Ltd. |
Novel quinazolinones as bromodomain inhibitors
|
|
HUE046727T2
(hu)
|
2013-12-06 |
2020-03-30 |
Vertex Pharma |
Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
|
|
US9718824B2
(en)
|
2014-04-16 |
2017-08-01 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
|
|
JP2017511367A
(ja)
|
2014-04-16 |
2017-04-20 |
シグナル ファーマシューティカルズ,エルエルシー |
1−エチル−7−(2−メチル−6−(1H−1,2,4−トリアゾール−3−イル)ピリジン−3−イル)−3,4−ジヒドロピラジノ[2,3−b]ピラジン−2(1H)−オン及び共形成物を含む固体形態、その組成物及び使用方法
|
|
EP3131552B1
(en)
|
2014-04-16 |
2020-07-15 |
Signal Pharmaceuticals, LLC |
Methods for treating cancer using tor kinase inhibitor combination therapy
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
CN107074863B
(zh)
|
2014-06-05 |
2019-12-03 |
沃泰克斯药物股份有限公司 |
Atr激酶抑制剂的制备方法及其不同的固体形式
|
|
PL3157566T3
(pl)
|
2014-06-17 |
2019-10-31 |
Vertex Pharma |
Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
EA201790189A1
(ru)
|
2014-07-14 |
2017-11-30 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе
|
|
US9981950B2
(en)
|
2014-08-15 |
2018-05-29 |
Janssen Pharmaceuticals, Inc. |
Triazoles as NR2B receptor inhibitors
|
|
WO2016025918A1
(en)
|
2014-08-15 |
2016-02-18 |
Janssen Pharmaceuticals, Inc. |
Pyrazoles
|
|
WO2016087936A1
(en)
|
2014-12-01 |
2016-06-09 |
Zenith Epigenetics Corp. |
Substituted pyridinones as bromodomain inhibitors
|
|
WO2016087942A1
(en)
|
2014-12-01 |
2016-06-09 |
Zenith Epigenetics Corp. |
Substituted pyridines as bromodomain inhibitors
|
|
CN107207474B
(zh)
|
2014-12-11 |
2021-05-07 |
恒翼生物医药科技(上海)有限公司 |
被取代的杂环作为溴结构域抑制剂
|
|
CA2966450A1
(en)
|
2014-12-17 |
2016-06-23 |
Olesya KHARENKO |
Inhibitors of bromodomains
|
|
WO2016130818A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
US10160755B2
(en)
*
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
BR112018000468A2
(pt)
|
2015-07-09 |
2018-09-18 |
Janssen Pharmaceutica Nv |
4-azaindóis substituídos e seu uso como moduladores do receptor de glun2b
|
|
KR102678021B1
(ko)
|
2015-09-30 |
2024-06-26 |
버텍스 파마슈티칼스 인코포레이티드 |
Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물
|
|
US10344000B2
(en)
|
2015-10-27 |
2019-07-09 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof
|
|
WO2017075182A1
(en)
|
2015-10-27 |
2017-05-04 |
Merck Sharp & Dohme Corp. |
Substituted indazole compounds as rorgammat inhibitors and uses thereof
|
|
WO2017075185A1
(en)
|
2015-10-27 |
2017-05-04 |
Merck Sharp & Dohme Corp. |
Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
|
|
MA44008A
(fr)
|
2016-02-10 |
2018-12-19 |
Janssen Pharmaceutica Nv |
1,2,3-triazoles substitués utilisés comme modulateurs de nmda sélectifs de nr2b
|
|
TW201819376A
(zh)
*
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
|
|
ES2959860T3
(es)
|
2017-06-22 |
2024-02-28 |
Celgene Corp |
Tratamiento del carcinoma hepatocelular caracterizado por la infección por el virus de la hepatitis B
|
|
JP7487170B2
(ja)
*
|
2018-03-01 |
2024-05-20 |
ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク |
毒性小胞体ストレスを抑制するための化合物、組成物および方法
|
|
EP3774732A4
(en)
|
2018-04-04 |
2022-02-09 |
Janssen Pharmaceutica NV |
PYRIDINE AND SUBSTITUTED PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
|
|
WO2020061377A1
(en)
*
|
2018-09-19 |
2020-03-26 |
Genentech, Inc. |
Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof
|
|
EP3972606A4
(en)
*
|
2019-05-20 |
2022-09-21 |
Mayo Foundation for Medical Education and Research |
TREATMENT OF CHRONIC LIVER DISEASE
|
|
BR112021025132A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Carbamatos de piridina e seu uso como moduladores do receptor glun2b
|
|
PH12021552839A1
(en)
|
2019-06-14 |
2022-10-03 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
CR20210580A
(es)
|
2019-06-14 |
2022-01-31 |
Janssen Pharmaceutica Nv |
Amidas depirazol-piridina sustituidos y su uso como moduladores del receptor glun2b
|
|
CN113993583A
(zh)
|
2019-06-14 |
2022-01-28 |
詹森药业有限公司 |
取代的吡唑并[4,3-b]吡啶及其作为GLUN2B受体调节剂的用途
|
|
EP3982958A1
(en)
|
2019-06-14 |
2022-04-20 |
Janssen Pharmaceutica NV |
Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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