|
US8227603B2
(en)
|
2006-08-01 |
2012-07-24 |
Cytokinetics, Inc. |
Modulating skeletal muscle
|
|
BRPI0714725B1
(pt)
|
2006-08-02 |
2021-05-25 |
Cytokinetics, Inc |
Entidade química, composição farmaceuticamente aceitável, e, uso de uma entidade química
|
|
US8299248B2
(en)
|
2006-08-02 |
2012-10-30 |
Cytokinetics, Incorporated |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
|
|
ES2627352T3
(es)
|
2006-10-19 |
2017-07-27 |
Signal Pharmaceuticals, Llc |
Compuestos heteroarilo, sus composiciones y su uso como inhibidores de proteínas quinasas
|
|
CA2713864A1
(en)
|
2008-02-04 |
2009-08-13 |
Cytokinetics, Incorporated |
Certain chemical entities, compositions and methods
|
|
US7998976B2
(en)
|
2008-02-04 |
2011-08-16 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
|
DK2308877T3
(da)
|
2008-08-05 |
2014-04-22 |
Daiichi Sankyo Co Ltd |
Imidazopyridin-2-on-derivater
|
|
KR101712576B1
(ko)
|
2008-11-10 |
2017-03-06 |
버텍스 파마슈티칼스 인코포레이티드 |
Atr 키나제의 억제제로서 유용한 화합물
|
|
CN102264743B
(zh)
*
|
2008-11-25 |
2015-02-11 |
罗彻斯特大学 |
Mlk抑制剂及其使用方法
|
|
PL3354650T3
(pl)
|
2008-12-19 |
2022-06-13 |
Vertex Pharmaceuticals Incorporated |
Związki przydatne jako inhibitory kinazy atr
|
|
NZ599549A
(en)
|
2009-10-26 |
2013-11-29 |
Signal Pharm Llc |
Methods of synthesis and purification of heteroaryl compounds
|
|
JP2013526538A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
WO2011143423A2
(en)
|
2010-05-12 |
2011-11-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP5836367B2
(ja)
|
2010-05-12 |
2015-12-24 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼ阻害剤として有用な化合物
|
|
JP2013526540A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
US9096584B2
(en)
|
2010-05-12 |
2015-08-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
EP2576549A4
(en)
*
|
2010-05-24 |
2013-12-18 |
Univ Rochester |
Bicyclic Heteroarylkinase Inhibitors and Methods of Use
|
|
JP2013529643A
(ja)
*
|
2010-06-23 |
2013-07-22 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用なピロロピラジン誘導体
|
|
DE102010049877A1
(de)
|
2010-11-01 |
2012-05-03 |
Merck Patent Gmbh |
7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate
|
|
EP2487159A1
(en)
*
|
2011-02-11 |
2012-08-15 |
MSD Oss B.V. |
RorgammaT inhibitors
|
|
CA2832100A1
(en)
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
|
WO2012178123A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2012178125A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
JP2014522818A
(ja)
|
2011-06-22 |
2014-09-08 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
CN109316480A
(zh)
|
2011-07-13 |
2019-02-12 |
赛特凯恩蒂克公司 |
组合als疗法
|
|
IN2014KN00943A
(enExample)
|
2011-09-30 |
2015-08-21 |
Vertex Pharma |
|
|
US8853217B2
(en)
|
2011-09-30 |
2014-10-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
RU2018147217A
(ru)
|
2011-09-30 |
2019-01-18 |
Вертекс Фармасьютикалз Инкорпорейтед |
Способы получения соединений, которые можно использовать в качестве ингибиторов киназы atr
|
|
AU2012315384B2
(en)
|
2011-09-30 |
2017-08-10 |
Vertex Pharmaceuticals Incorporated |
Treating pancreatic cancer and non-small cell lung cancer with ATR inhibitors
|
|
US8765751B2
(en)
|
2011-09-30 |
2014-07-01 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
CN103998036B
(zh)
*
|
2011-10-19 |
2017-05-31 |
西格诺药品有限公司 |
利用tor激酶抑制剂治疗癌症
|
|
EP2776429A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
EP2776421A1
(en)
|
2011-11-09 |
2014-09-17 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8841449B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8841450B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
BR112014013332B1
(pt)
|
2011-12-02 |
2022-09-06 |
Signal Pharmaceuticals, Llc |
Composições farmacêuticas de 7-(6-(2-hidroxi-propan-2-il)piridin-3-il)-1-((trans)-4- metoxicicloexil)-3,4-diidropirazino [2,3-b]pirazin-2(1h)-ona, uma forma sólida dessa e métodos de seu uso
|
|
CN104271159B
(zh)
|
2012-02-24 |
2017-11-28 |
西格诺药品有限公司 |
利用tor激酶抑制剂联合治疗来治疗非小细胞肺癌的方法
|
|
CN102627646A
(zh)
*
|
2012-03-19 |
2012-08-08 |
苏州四同医药科技有限公司 |
一种3-碘-5-溴-4,7-二氮杂吲哚的制备方法
|
|
CN104582795B
(zh)
|
2012-04-05 |
2018-04-20 |
沃泰克斯药物股份有限公司 |
可用作atr激酶抑制剂的化合物及其组合疗法
|
|
WO2014026327A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
|
|
WO2014026329A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
|
|
WO2014026330A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
DK2904406T3
(en)
|
2012-10-04 |
2018-06-18 |
Vertex Pharma |
METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
|
|
US8912198B2
(en)
|
2012-10-16 |
2014-12-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
US9073878B2
(en)
|
2012-11-21 |
2015-07-07 |
Zenith Epigenetics Corp. |
Cyclic amines as bromodomain inhibitors
|
|
US9765039B2
(en)
|
2012-11-21 |
2017-09-19 |
Zenith Epigenetics Ltd. |
Biaryl derivatives as bromodomain inhibitors
|
|
US10485800B2
(en)
|
2012-11-30 |
2019-11-26 |
The University Of Rochester |
Mixed lineage kinase inhibitors for HIV/AIDS therapies
|
|
LT3418281T
(lt)
|
2012-12-07 |
2021-01-11 |
Vertex Pharmaceuticals Inc. |
Pirazolo[1,5-a]pirimidinai, naudotini kaip atr kinazės inhibitoriai, skirti vėžinių ligų gydymui
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
JP2016507496A
(ja)
|
2012-12-21 |
2016-03-10 |
ゼニス・エピジェネティクス・コーポレイションZenith Epigenetics Corp. |
ブロモドメイン阻害剤としての新規複素環式化合物
|
|
SG11201505446WA
(en)
|
2013-01-16 |
2015-08-28 |
Signal Pharm Llc |
Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
|
|
CN105431148A
(zh)
*
|
2013-03-07 |
2016-03-23 |
加利菲亚生物公司 |
混合谱系激酶抑制剂及治疗方法
|
|
WO2014143240A1
(en)
|
2013-03-15 |
2014-09-18 |
Vertex Pharmaceuticals Incorporated |
Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
|
|
HK1221168A1
(zh)
|
2013-04-17 |
2017-05-26 |
西格诺药品有限公司 |
用於治疗癌症的包括tor激酶抑制剂和n-(3-(5-氟-2-(4-(2-甲氧基乙氧基)苯基氨基)嘧啶-4-基氨基)苯基)丙烯醯胺的组合疗法
|
|
MY189663A
(en)
|
2013-04-17 |
2022-02-23 |
Signal Pharm Llc |
Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
|
|
WO2014172425A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Treatment of cancer with dihydropyrazino-pyrazines
|
|
CA2908742C
(en)
|
2013-04-17 |
2021-06-01 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer
|
|
EP3549940A1
(en)
|
2013-04-17 |
2019-10-09 |
Signal Pharmaceuticals, LLC |
Pharmaceutical formulations, of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
WO2014172436A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
|
|
JP6382946B2
(ja)
|
2013-04-17 |
2018-08-29 |
シグナル ファーマシューティカルズ,エルエルシー |
ジヒドロピラジノ−ピラジンによる癌治療
|
|
WO2014181813A1
(ja)
*
|
2013-05-10 |
2014-11-13 |
武田薬品工業株式会社 |
複素環化合物
|
|
CN107474051B
(zh)
|
2013-05-29 |
2020-10-30 |
西格诺药品有限公司 |
二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
|
|
CN105473581B
(zh)
|
2013-06-21 |
2019-04-23 |
齐尼思表观遗传学有限公司 |
作为溴结构域抑制剂的新取代的双环化合物
|
|
KR102307566B1
(ko)
|
2013-06-21 |
2021-10-05 |
제니쓰 에피제네틱스 리미티드 |
신규한 바이사이클릭 브로모도메인 억제제
|
|
CA2919948C
(en)
|
2013-07-31 |
2020-07-21 |
Zenith Epigenetics Corp. |
Novel quinazolinones as bromodomain inhibitors
|
|
HUE046727T2
(hu)
|
2013-12-06 |
2020-03-30 |
Vertex Pharma |
Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
WO2015160880A1
(en)
|
2014-04-16 |
2015-10-22 |
Signal Pharmaceuticals, Llc |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP3131552B1
(en)
|
2014-04-16 |
2020-07-15 |
Signal Pharmaceuticals, LLC |
Methods for treating cancer using tor kinase inhibitor combination therapy
|
|
US9718824B2
(en)
|
2014-04-16 |
2017-08-01 |
Signal Pharmaceuticals, Llc |
Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof
|
|
ES2777608T3
(es)
|
2014-06-05 |
2020-08-05 |
Vertex Pharma |
Derivados radiomarcados de un compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-carboxamida útiles como inhibidores de ATR cinasa, la preparación de dicho compuesto y diferentes formas sólidas del mismo
|
|
US11179394B2
(en)
|
2014-06-17 |
2021-11-23 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of Chk1 and ATR inhibitors
|
|
WO2016010886A1
(en)
|
2014-07-14 |
2016-01-21 |
Signal Pharmaceuticals, Llc |
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
EP3180329B1
(en)
|
2014-08-15 |
2020-03-18 |
Janssen Pharmaceuticals, Inc. |
Triazoles as nr2b receptor inhibitors
|
|
PT3180315T
(pt)
|
2014-08-15 |
2020-05-27 |
Janssen Pharmaceuticals Inc |
Pirazoles
|
|
HK1245246A1
(zh)
|
2014-12-01 |
2018-08-24 |
恒翼生物医药科技(上海)有限公司 |
作为溴域抑制剂的取代吡啶酮
|
|
US10179125B2
(en)
|
2014-12-01 |
2019-01-15 |
Zenith Epigenetics Ltd. |
Substituted pyridines as bromodomain inhibitors
|
|
WO2016092375A1
(en)
|
2014-12-11 |
2016-06-16 |
Zenith Epigenetics Corp. |
Substituted heterocycles as bromodomain inhibitors
|
|
CN107406438B
(zh)
|
2014-12-17 |
2021-05-14 |
恒翼生物医药科技(上海)有限公司 |
溴结构域的抑制剂
|
|
CA2975997A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
Substituted pyrazole compounds as rorgammat inhibitors and uses thereof
|
|
US10160755B2
(en)
*
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
MX2018000352A
(es)
|
2015-07-09 |
2018-08-15 |
Janssen Pharmaceutica Nv |
4-azaindoles sustituidos y su uso como moduladores del receptor glun2b.
|
|
US11464774B2
(en)
|
2015-09-30 |
2022-10-11 |
Vertex Pharmaceuticals Incorporated |
Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
|
|
JP2018531958A
(ja)
|
2015-10-27 |
2018-11-01 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
RORγT阻害薬としてのヘテロアリール置換安息香酸及びその使用
|
|
EP3368516B1
(en)
|
2015-10-27 |
2020-07-15 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
US10287272B2
(en)
|
2015-10-27 |
2019-05-14 |
Merck Sharp & Dohme Corp. |
Substituted indazole compounds as RORgammaT inhibitors and uses thereof
|
|
KR20180108822A
(ko)
|
2016-02-10 |
2018-10-04 |
얀센 파마슈티카 엔.브이. |
Nr2b-선택적 nmda 조절제로서 치환된 1,2,3-트라이아졸
|
|
TW201819376A
(zh)
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
|
|
IL271491B2
(en)
|
2017-06-22 |
2023-09-01 |
Celgene Corp |
Treatment of carcinoma of the liver characterized by hepatitis b virus infection
|
|
CA3092828A1
(en)
|
2018-03-01 |
2019-09-06 |
The Trustees Of Columbia University In The City Of New York |
Compounds, compositions, and methods for suppressing toxic endoplasmic reticulum stress
|
|
EP3774732A4
(en)
|
2018-04-04 |
2022-02-09 |
Janssen Pharmaceutica NV |
PYRIDINE AND SUBSTITUTED PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
|
|
CN113015526A
(zh)
*
|
2018-09-19 |
2021-06-22 |
豪夫迈·罗氏有限公司 |
螺环2,3-二氢-7-氮杂吲哚化合物及其用途
|
|
EP3972606A4
(en)
*
|
2019-05-20 |
2022-09-21 |
Mayo Foundation for Medical Education and Research |
TREATMENT OF CHRONIC LIVER DISEASE
|
|
AU2020290772A1
(en)
|
2019-06-14 |
2022-01-06 |
Janssen Pharmaceutica Nv |
Pyrazine carbamates and their use as GluN2B receptor modulators
|
|
US20220324860A1
(en)
|
2019-06-14 |
2022-10-13 |
Janssen Pharmaceutica Nv |
SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
|
|
EP3983413A1
(en)
|
2019-06-14 |
2022-04-20 |
Janssen Pharmaceutica NV |
Substituted pyrazolo-pyrazines and their use as glun2b receptor modulators
|
|
SG11202112407PA
(en)
|
2019-06-14 |
2021-12-30 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
BR112021025132A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Carbamatos de piridina e seu uso como moduladores do receptor glun2b
|
|
AU2020291188A1
(en)
|
2019-06-14 |
2022-01-20 |
Janssen Pharmaceutica Nv |
Substituted heteroaromatic Pyrazolo-pyridines and their use as GluN2B receptor modulators
|
|
JP7667097B2
(ja)
|
2019-06-14 |
2025-04-22 |
ヤンセン ファーマシューティカ エヌ.ベー. |
置換ピラゾロ-ピリジンアミド及びglun2b受容体調節因子としてのその使用
|
|
JP7345220B2
(ja)
*
|
2019-08-30 |
2023-09-15 |
ティーエスディー ライフ サイエンス カンパニー リミテッド |
イミダゾピリジン誘導体及びこれを有効成分として含有する薬学的組成物
|
|
WO2021163683A1
(en)
|
2020-02-14 |
2021-08-19 |
President And Fellows Of Harvard College |
Inhibitors of nicotinamide n-methyltransferase, compositions and uses thereof
|
|
BR112022023559A2
(pt)
*
|
2020-05-21 |
2023-01-24 |
Stemsynergy Therapeutics Inc |
Inibidores de notch e seus usos
|
|
WO2023050323A1
(en)
*
|
2021-09-30 |
2023-04-06 |
Citrix Systems, Inc. |
Automated transfer of peripheral device operations
|
|
US11661409B1
(en)
*
|
2022-01-31 |
2023-05-30 |
Pioneura Corporation |
Acid addition salts, compositions, and methods of treating
|
|
US11479541B1
(en)
|
2022-01-31 |
2022-10-25 |
Pioneura Corporation |
Acid addition salts, compositions, and methods of treating thereof
|
|
WO2023207911A1
(zh)
*
|
2022-04-24 |
2023-11-02 |
上海医药集团股份有限公司 |
一种双环杂环化合物、药物组合物和应用
|
|
CN117050075B
(zh)
*
|
2022-05-05 |
2026-05-26 |
中国药科大学 |
一类联芳环类bet抑制剂及合成方法与用途
|
|
CN117447392B
(zh)
*
|
2023-09-13 |
2024-11-26 |
广州大学 |
一种荧光材料及其制备方法和应用
|
|
WO2026128614A1
(en)
*
|
2024-12-10 |
2026-06-18 |
Supercede Therapeutics, Inc. |
Activin receptor type ii inhibitors for preventing or treating obesity and related disorders
|