|
US8227603B2
(en)
|
2006-08-01 |
2012-07-24 |
Cytokinetics, Inc. |
Modulating skeletal muscle
|
|
EP2583970B1
(en)
|
2006-08-02 |
2015-10-14 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods comprising imidazopyrimidines
|
|
US8299248B2
(en)
|
2006-08-02 |
2012-10-30 |
Cytokinetics, Incorporated |
Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
|
|
ES2631003T3
(es)
|
2006-10-19 |
2017-08-25 |
Signal Pharmaceuticals, Llc |
Compuestos heteroarilo, sus composiciones y métodos de tratamiento con ellos
|
|
US7998976B2
(en)
|
2008-02-04 |
2011-08-16 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
|
CN101983061A
(zh)
|
2008-02-04 |
2011-03-02 |
赛特凯恩蒂克公司 |
某种化学物质、组合物和方法
|
|
AU2009278442B2
(en)
|
2008-08-05 |
2013-09-26 |
Daiichi Sankyo Company, Limited |
Imidazopyridin-2-one Derivatives
|
|
CN102264721B
(zh)
|
2008-11-10 |
2015-12-09 |
沃泰克斯药物股份有限公司 |
用作atr激酶抑制剂的化合物
|
|
AU2009324894B2
(en)
*
|
2008-11-25 |
2015-04-09 |
University Of Rochester |
MLK inhibitors and methods of use
|
|
CN106518856B
(zh)
|
2008-12-19 |
2020-04-28 |
沃泰克斯药物股份有限公司 |
用作atr激酶抑制剂的化合物
|
|
KR20120091240A
(ko)
|
2009-10-26 |
2012-08-17 |
시그날 파마소티칼 엘엘씨 |
헤테로아릴 화합물의 합성 및 정제 방법
|
|
US8962631B2
(en)
|
2010-05-12 |
2015-02-24 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
JP2013526540A
(ja)
|
2010-05-12 |
2013-06-24 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
US8969356B2
(en)
|
2010-05-12 |
2015-03-03 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
US9062008B2
(en)
|
2010-05-12 |
2015-06-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
MX2012013082A
(es)
|
2010-05-12 |
2013-05-09 |
Vertex Pharma |
Derivados de 2-aminopiridina utiles como iinhibidores de cinasa atr.
|
|
SG185524A1
(en)
|
2010-05-12 |
2012-12-28 |
Vertex Pharma |
Compounds useful as inhibitors of atr kinase
|
|
WO2011149950A2
(en)
*
|
2010-05-24 |
2011-12-01 |
University Of Rochester |
Bicyclic heteroaryl kinase inhibitors and methods of use
|
|
US8623869B2
(en)
|
2010-06-23 |
2014-01-07 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
DE102010049877A1
(de)
|
2010-11-01 |
2012-05-03 |
Merck Patent Gmbh |
7-((1,2,3)Triazol-4-yl)-pyrrolo(2,3) pyrazinderivate
|
|
EP2487159A1
(en)
|
2011-02-11 |
2012-08-15 |
MSD Oss B.V. |
RorgammaT inhibitors
|
|
CA2832100A1
(en)
|
2011-04-05 |
2012-10-11 |
Vertex Pharmaceuticals Incorporated |
Aminopyrazine compounds useful as inhibitors of tra kinase
|
|
JP2014520161A
(ja)
|
2011-06-22 |
2014-08-21 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Atrキナーゼ阻害剤として有用な化合物
|
|
US9309250B2
(en)
|
2011-06-22 |
2016-04-12 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors
|
|
US9096602B2
(en)
|
2011-06-22 |
2015-08-04 |
Vertex Pharmaceuticals Incorporated |
Substituted pyrrolo[2,3-B]pyrazines as ATR kinase inhibitors
|
|
EP2731611B1
(en)
|
2011-07-13 |
2019-09-18 |
Cytokinetics, Inc. |
Combination therapie for als
|
|
WO2013049720A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
CN103958507A
(zh)
|
2011-09-30 |
2014-07-30 |
沃泰克斯药物股份有限公司 |
可用作atr激酶抑制剂的化合物
|
|
CA2850566C
(en)
|
2011-09-30 |
2022-05-03 |
Vertex Pharmaceuticals Incorporated |
Process for making 4-[chloro-n-hydroxycarbonimidoyl]phenyl derivative
|
|
EP3733185B1
(en)
|
2011-09-30 |
2022-12-07 |
Vertex Pharmaceuticals Incorporated |
Treating non-small cell lung cancer with atr inhibitors
|
|
WO2013049719A1
(en)
|
2011-09-30 |
2013-04-04 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
KR101978537B1
(ko)
|
2011-10-19 |
2019-05-14 |
시그날 파마소티칼 엘엘씨 |
Tor 키나제 억제제를 사용한 암의 치료
|
|
WO2013071088A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
US8846918B2
(en)
|
2011-11-09 |
2014-09-30 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013071093A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Pyrazine compounds useful as inhibitors of atr kinase
|
|
US8841449B2
(en)
|
2011-11-09 |
2014-09-23 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
WO2013071090A1
(en)
|
2011-11-09 |
2013-05-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
SG10201604558SA
(en)
|
2011-12-02 |
2016-07-28 |
Signal Pharm Llc |
Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4 methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
JP6114317B2
(ja)
|
2012-02-24 |
2017-04-12 |
シグナル ファーマシューティカルズ,エルエルシー |
Torキナーゼ阻害剤の組合せ療法を用いて、非小細胞肺がんを処置する方法
|
|
CN102627646A
(zh)
*
|
2012-03-19 |
2012-08-08 |
苏州四同医药科技有限公司 |
一种3-碘-5-溴-4,7-二氮杂吲哚的制备方法
|
|
EP2833973B1
(en)
|
2012-04-05 |
2017-09-13 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase and combination therapies thereof
|
|
WO2014026327A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof
|
|
WO2014026330A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
WO2014026329A1
(en)
|
2012-08-15 |
2014-02-20 |
Merck Sharp & Dohme Corp. |
N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof
|
|
US8999632B2
(en)
|
2012-10-04 |
2015-04-07 |
Vertex Pharmaceuticals Incorporated |
Method for measuring ATR inhibition mediated increases in DNA damage
|
|
US8912198B2
(en)
|
2012-10-16 |
2014-12-16 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of ATR kinase
|
|
AU2013203714B2
(en)
|
2012-10-18 |
2015-12-03 |
Signal Pharmaceuticals, Llc |
Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
|
|
US9765039B2
(en)
|
2012-11-21 |
2017-09-19 |
Zenith Epigenetics Ltd. |
Biaryl derivatives as bromodomain inhibitors
|
|
US9073878B2
(en)
|
2012-11-21 |
2015-07-07 |
Zenith Epigenetics Corp. |
Cyclic amines as bromodomain inhibitors
|
|
EP2925319B1
(en)
*
|
2012-11-30 |
2019-01-09 |
University Of Rochester |
Mixed lineage kinase inhibitors for hiv/aids therapies
|
|
DK3418281T3
(da)
|
2012-12-07 |
2020-12-07 |
Vertex Pharma |
Pyrazolo[1,5-a]pyrimidiner, der er anvendelige som inhibitorer af atr-kinase til behandling af cancersygdomme
|
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
|
CN105073744B
(zh)
|
2012-12-21 |
2019-11-08 |
齐尼思表观遗传学有限公司 |
作为溴结构域抑制剂的新型杂环化合物
|
|
EA201591327A1
(ru)
|
2013-01-16 |
2015-12-30 |
СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи |
Замещенные пирролопиримидиновые соединения, их композиции и способы лечения с использованием таких соединений
|
|
CN105431148A
(zh)
*
|
2013-03-07 |
2016-03-23 |
加利菲亚生物公司 |
混合谱系激酶抑制剂及治疗方法
|
|
JP2016512815A
(ja)
|
2013-03-15 |
2016-05-09 |
バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated |
Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体
|
|
TWI631949B
(zh)
|
2013-04-17 |
2018-08-11 |
標誌製藥公司 |
使用tor激酶抑制劑組合療法以治療癌症之方法
|
|
MX377267B
(es)
|
2013-04-17 |
2025-03-07 |
Signal Pharm Llc |
Tratamiento de cáncer con dihidropirazino-pirazinas.
|
|
SG10201708111YA
(en)
|
2013-04-17 |
2017-11-29 |
Signal Pharm Llc |
Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
|
|
CA2909629C
(en)
|
2013-04-17 |
2022-12-13 |
Signal Pharmaceuticals, Llc |
Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
|
|
TW201521725A
(zh)
|
2013-04-17 |
2015-06-16 |
Signal Pharm Llc |
使用tor激酶抑制劑組合療法以治療癌症之方法
|
|
JP6382946B2
(ja)
|
2013-04-17 |
2018-08-29 |
シグナル ファーマシューティカルズ,エルエルシー |
ジヒドロピラジノ−ピラジンによる癌治療
|
|
WO2014172436A1
(en)
|
2013-04-17 |
2014-10-23 |
Signal Pharmaceuticals, Llc |
Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
|
|
WO2014181813A1
(ja)
*
|
2013-05-10 |
2014-11-13 |
武田薬品工業株式会社 |
複素環化合物
|
|
CA3143529A1
(en)
|
2013-05-29 |
2014-12-04 |
Signal Pharmaceuticals, Llc |
Pharmaceutical compositions 0f 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
|
|
US9636328B2
(en)
|
2013-06-21 |
2017-05-02 |
Zenith Epigenetics Ltd. |
Substituted bicyclic compounds as bromodomain inhibitors
|
|
CA2915838C
(en)
|
2013-06-21 |
2023-04-18 |
Zenith Epigenetics Corp. |
Bicyclic bromodomain inhibitors
|
|
CN105593224B
(zh)
|
2013-07-31 |
2021-05-25 |
恒元生物医药科技(苏州)有限公司 |
作为溴结构域抑制剂的新型喹唑啉酮类化合物
|
|
PT3077397T
(pt)
|
2013-12-06 |
2020-01-22 |
Vertex Pharma |
Composto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inibidor da atr quinase, a sua preparação, diferentes formas sólidas e derivados radiomarcados do mesmo
|
|
EP3131551A4
(en)
|
2014-04-16 |
2017-09-20 |
Signal Pharmaceuticals, LLC |
SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
NZ714742A
(en)
|
2014-04-16 |
2017-04-28 |
Signal Pharm Llc |
Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
|
|
WO2015160882A1
(en)
|
2014-04-16 |
2015-10-22 |
Signal Pharmaceuticals, Llc |
SOLID FORMS COMPRISING 7-(6-(2-HYDROXYPROPAN-2YL) PYRIDIN-3-YL)-1-(TRANS)-4-METHOXYCYCLOHEXYL)-3, 4-DIHYDROPYRAZINO[2,3-b] PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
|
|
EP3131552B1
(en)
|
2014-04-16 |
2020-07-15 |
Signal Pharmaceuticals, LLC |
Methods for treating cancer using tor kinase inhibitor combination therapy
|
|
KR102575125B1
(ko)
|
2014-06-05 |
2023-09-07 |
버텍스 파마슈티칼스 인코포레이티드 |
Atr 키나제의 저해제로서 유용한 2-아미노-6-플루오로-n-[5-플루오로-피리딘-3-일]-피라졸로[1,5-a]피리미딘-3-카복스아미드 화합물의 방사성표지된 유도체, 상기 화합물의 제조 및 이의 다양한 고체 형태
|
|
DK3157566T3
(da)
|
2014-06-17 |
2019-07-22 |
Vertex Pharma |
Fremgangsmåde til behandling af cancer under anvendelse af en kombination chk1- og atr-inhibitorer
|
|
AU2015289929A1
(en)
|
2014-07-14 |
2017-03-02 |
Signal Pharmaceuticals, Llc |
Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
|
|
NZ629796A
(en)
|
2014-07-14 |
2015-12-24 |
Signal Pharm Llc |
Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
|
|
HUE049277T2
(hu)
|
2014-08-15 |
2020-09-28 |
Janssen Pharmaceuticals Inc |
Triazolok mint NR2B receptor inhibitorok
|
|
DK3180315T3
(da)
|
2014-08-15 |
2020-04-06 |
Janssen Pharmaceuticals Inc |
Pyrazoler
|
|
EP3227280B1
(en)
|
2014-12-01 |
2019-04-24 |
Zenith Epigenetics Ltd. |
Substituted pyridines as bromodomain inhibitors
|
|
EP3227281A4
(en)
|
2014-12-01 |
2018-05-30 |
Zenith Epigenetics Ltd. |
Substituted pyridinones as bromodomain inhibitors
|
|
US10292968B2
(en)
|
2014-12-11 |
2019-05-21 |
Zenith Epigenetics Ltd. |
Substituted heterocycles as bromodomain inhibitors
|
|
HK1245247A1
(zh)
|
2014-12-17 |
2018-08-24 |
恒翼生物医药科技(上海)有限公司 |
溴结构域的抑制剂
|
|
WO2016130818A1
(en)
|
2015-02-11 |
2016-08-18 |
Merck Sharp & Dohme Corp. |
SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
|
|
US10160755B2
(en)
*
|
2015-04-08 |
2018-12-25 |
Plexxikon Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
|
LT3319963T
(lt)
|
2015-07-09 |
2020-03-25 |
Janssen Pharmaceutica Nv |
Pakeistieji 4-azaindolai ir jų, kaip glun2b receptoriaus moduliatorių, panaudojimas
|
|
MX395066B
(es)
|
2015-09-30 |
2025-03-24 |
Vertex Pharma |
Método para tratar cáncer usando una combinación de agentes que dañan el adn e inhibidores de proteína relacionada con ataxia telangiectasia y rad3 (atr).
|
|
CA3002846A1
(en)
|
2015-10-27 |
2017-05-04 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic pyrazole compounds as rorgammat inhibitors and uses thereof
|
|
AU2016344118A1
(en)
|
2015-10-27 |
2018-05-10 |
Merck Sharp & Dohme Corp. |
Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof
|
|
KR20180070697A
(ko)
|
2015-10-27 |
2018-06-26 |
머크 샤프 앤드 돔 코포레이션 |
Ror감마t 저해제로서의 치환된 인다졸 화합물 및 이의 용도
|
|
JP6923543B2
(ja)
|
2016-02-10 |
2021-08-18 |
ヤンセン ファーマシューティカ エヌ.ベー. |
Nr2b選択的nmda調節因子としての置換1,2,3−トリアゾール
|
|
TW201819376A
(zh)
|
2016-10-06 |
2018-06-01 |
比利時商健生藥品公司 |
經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途
|
|
BR112019027402A2
(pt)
|
2017-06-22 |
2020-07-07 |
Celgene Corporation |
tratamento de carcinoma hepatocelular caracterizado por infecção pelo vírus da hepatite b
|
|
WO2019169306A1
(en)
|
2018-03-01 |
2019-09-06 |
The Trustees Of Columbia University In The City Of New York |
Compounds, compositions, and methods for suppressing toxic endoplasmic reticulum stress
|
|
US11008302B2
(en)
|
2018-04-04 |
2021-05-18 |
Janssen Pharmaceutica Nv |
Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators
|
|
WO2020061377A1
(en)
*
|
2018-09-19 |
2020-03-26 |
Genentech, Inc. |
Spirocyclic 2,3-dihydro-7-azaindole compounds and uses thereof
|
|
US20220220206A1
(en)
*
|
2019-05-20 |
2022-07-14 |
Mayo Foundation For Medical Education And Research |
Treating chronic liver disease
|
|
PH12021552839A1
(en)
|
2019-06-14 |
2022-10-03 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyridine amides and their use as glun2b receptor modulators
|
|
WO2020249791A1
(en)
|
2019-06-14 |
2020-12-17 |
Janssen Pharmaceutica Nv |
SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
|
|
PE20220386A1
(es)
|
2019-06-14 |
2022-03-18 |
Janssen Pharmaceutica Nv |
Amidas de pirazolo-piridina sustituidas y su uso como moduladores del receptor glun2b
|
|
AU2020293584A1
(en)
|
2019-06-14 |
2022-01-20 |
Janssen Pharmaceutica Nv |
Pyridine carbamates and their use as GluN2B receptor modulators
|
|
US11993587B2
(en)
|
2019-06-14 |
2024-05-28 |
Janssen Pharmaceutica Nv |
Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
|
|
BR112021025141A2
(pt)
|
2019-06-14 |
2022-01-25 |
Janssen Pharmaceutica Nv |
Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b
|
|
MX2021015511A
(es)
|
2019-06-14 |
2022-01-31 |
Janssen Pharmaceutica Nv |
Carbamatos de pirazina y sus usos como moduladores del receptor glun2b.
|
|
US20220396575A1
(en)
*
|
2019-08-30 |
2022-12-15 |
Tsd Life Sciences Co., Ltd. |
Imidazopyridine derivative and pharmaceutical composition comprising same as active ingredient
|
|
US12509430B2
(en)
|
2020-02-14 |
2025-12-30 |
President And Fellows Of Harvard College |
Inhibitors of nicotinamide N-methyltransferase, compositions and uses thereof
|
|
WO2021237111A1
(en)
*
|
2020-05-21 |
2021-11-25 |
Stemsynergy Therapeutics, Inc. |
Notch inhibitors and uses thereof
|
|
WO2023050323A1
(en)
*
|
2021-09-30 |
2023-04-06 |
Citrix Systems, Inc. |
Automated transfer of peripheral device operations
|
|
US11661409B1
(en)
|
2022-01-31 |
2023-05-30 |
Pioneura Corporation |
Acid addition salts, compositions, and methods of treating
|
|
US11479541B1
(en)
|
2022-01-31 |
2022-10-25 |
Pioneura Corporation |
Acid addition salts, compositions, and methods of treating thereof
|
|
WO2023207911A1
(zh)
*
|
2022-04-24 |
2023-11-02 |
上海医药集团股份有限公司 |
一种双环杂环化合物、药物组合物和应用
|
|
CN117050075A
(zh)
*
|
2022-05-05 |
2023-11-14 |
中国药科大学 |
一类联芳环类bet抑制剂及合成方法与用途
|
|
CN117447392B
(zh)
*
|
2023-09-13 |
2024-11-26 |
广州大学 |
一种荧光材料及其制备方法和应用
|