CN102264743B - Mlk抑制剂及其使用方法 - Google Patents

Mlk抑制剂及其使用方法 Download PDF

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Publication number
CN102264743B
CN102264743B CN200980152665.1A CN200980152665A CN102264743B CN 102264743 B CN102264743 B CN 102264743B CN 200980152665 A CN200980152665 A CN 200980152665A CN 102264743 B CN102264743 B CN 102264743B
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compound
pyrrolo
pyridin
group
rudimentary
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CN102264743A (zh
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H·A·格尔巴德
S·杜赫斯特
V·S·古德费洛
T·维曼
C·劳维斯
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University of Rochester
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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CN200980152665.1A 2008-11-25 2009-11-25 Mlk抑制剂及其使用方法 Active CN102264743B (zh)

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US11795008P 2008-11-25 2008-11-25
US61/117,950 2008-11-25
US14877809P 2009-01-30 2009-01-30
US14875509P 2009-01-30 2009-01-30
US61/148,778 2009-01-30
US61/148,755 2009-01-30
PCT/US2009/065878 WO2010068483A2 (en) 2008-11-25 2009-11-25 Mlk inhibitors and methods of use

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AU (1) AU2009324894B2 (enExample)
CA (1) CA2744498C (enExample)
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US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
MX2009004077A (es) 2006-10-19 2009-05-05 Signal Pharm Llc Compuestos de heteroarilo, composiciones de los mismos, y su uso como inhibidores de proteina cinasas.
US7989469B2 (en) 2008-02-04 2011-08-02 Cytokinetics, Incorporated Certain chemical entities, compositions, and methods
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