JP2005519073A5 - - Google Patents

Info

Publication number

JP2005519073A5

JP2005519073A5 JP2003567333A JP2003567333A JP2005519073A5 JP 2005519073 A5 JP2005519073 A5 JP 2005519073A5 JP 2003567333 A JP2003567333 A JP 2003567333A JP 2003567333 A JP2003567333 A JP 2003567333A JP 2005519073 A5 JP2005519073 A5 JP 2005519073A5

Authority

JP

Japan

Prior art keywords

compound according

compound

group

metabolite

sleep

Prior art date

2003-01-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 150000001875 compounds Chemical class 0.000 claims 14
• 125000001424 substituent group Chemical group 0.000 claims 6
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
• 239000002207 metabolite Substances 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 125000006850 spacer group Chemical group 0.000 claims 4
• 230000005856 abnormality Effects 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 230000002060 circadian Effects 0.000 claims 2
• 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 125000004185 ester group Chemical group 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• -1 modified trazodone compound Chemical class 0.000 claims 2
• 229910052757 nitrogen Inorganic materials 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 208000019116 sleep disease Diseases 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• LKKWNBWRPDKMIB-UHFFFAOYSA-N 3-chloro-1-phenylpiperazine Chemical compound C1CNC(Cl)CN1C1=CC=CC=C1 LKKWNBWRPDKMIB-UHFFFAOYSA-N 0.000 claims 1
• 206010000117 Abnormal behaviour Diseases 0.000 claims 1
• 239000004215 Carbon black (E152) Substances 0.000 claims 1
• 208000019888 Circadian rhythm sleep disease Diseases 0.000 claims 1
• 206010010904 Convulsion Diseases 0.000 claims 1
• 208000007590 Disorders of Excessive Somnolence Diseases 0.000 claims 1
• 208000001456 Jet Lag Syndrome Diseases 0.000 claims 1
• 208000005793 Restless legs syndrome Diseases 0.000 claims 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
• 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 229930195733 hydrocarbon Natural products 0.000 claims 1
• 150000002430 hydrocarbons Chemical class 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 206010020765 hypersomnia Diseases 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 206010022437 insomnia Diseases 0.000 claims 1
• 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 208000033914 shift work type circadian rhythm sleep disease Diseases 0.000 claims 1
• 201000002859 sleep apnea Diseases 0.000 claims 1
• 208000020685 sleep-wake disease Diseases 0.000 claims 1
• 208000011580 syndromic disease Diseases 0.000 claims 1
• TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical group FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 claims 1
• 150000007970 thio esters Chemical group 0.000 claims 1
• PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical class ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1