JP2012130342A5 - - Google Patents
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- Publication number
- JP2012130342A5 JP2012130342A5 JP2012009515A JP2012009515A JP2012130342A5 JP 2012130342 A5 JP2012130342 A5 JP 2012130342A5 JP 2012009515 A JP2012009515 A JP 2012009515A JP 2012009515 A JP2012009515 A JP 2012009515A JP 2012130342 A5 JP2012130342 A5 JP 2012130342A5
- Authority
- JP
- Japan
- Prior art keywords
- side region
- nucleic acid
- acid molecule
- stranded rna
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 39
- 230000014509 gene expression Effects 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 14
- 230000001629 suppression Effects 0.000 claims description 10
- 230000009368 gene silencing by RNA Effects 0.000 claims description 4
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 4
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000002585 base Substances 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 108091092195 Intron Proteins 0.000 description 1
- 108091030071 RNAI Proteins 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 230000030279 gene silencing Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012009515A JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010156122 | 2010-07-08 | ||
| JP2010156122 | 2010-07-08 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010174915 | 2010-08-03 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010230806 | 2010-10-13 | ||
| JP2010230808 | 2010-10-13 | ||
| JP2010230808 | 2010-10-13 | ||
| JP2010269824 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2010269824 | 2010-12-02 | ||
| JP2010269823 | 2010-12-02 | ||
| JP2012009515A JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Division JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015150156A Division JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012130342A JP2012130342A (ja) | 2012-07-12 |
| JP2012130342A5 true JP2012130342A5 (https=) | 2013-10-03 |
| JP5804642B2 JP5804642B2 (ja) | 2015-11-04 |
Family
ID=45441339
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Expired - Fee Related JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
| JP2012009515A Expired - Fee Related JP5804642B2 (ja) | 2010-07-08 | 2012-01-20 | 遺伝子発現制御のための一本鎖核酸分子 |
| JP2015150156A Expired - Fee Related JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537086A Expired - Fee Related JP4968811B2 (ja) | 2010-07-08 | 2011-07-08 | 遺伝子発現制御のための一本鎖核酸分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015150156A Expired - Fee Related JP6162182B2 (ja) | 2010-07-08 | 2015-07-29 | 遺伝子発現制御のための一本鎖核酸分子 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8785121B2 (https=) |
| EP (2) | EP2933333B1 (https=) |
| JP (3) | JP4968811B2 (https=) |
| KR (1) | KR101849798B1 (https=) |
| CN (2) | CN104818276B (https=) |
| AU (1) | AU2011274854B2 (https=) |
| BR (1) | BR112013000481A2 (https=) |
| CA (1) | CA2804511C (https=) |
| DK (2) | DK2933333T3 (https=) |
| ES (2) | ES2670017T3 (https=) |
| HU (2) | HUE026520T2 (https=) |
| MX (1) | MX352568B (https=) |
| NZ (2) | NZ606232A (https=) |
| PT (2) | PT2431466E (https=) |
| RU (1) | RU2628311C2 (https=) |
| SG (2) | SG186899A1 (https=) |
| TW (2) | TWI573870B (https=) |
| WO (1) | WO2012005368A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2933333B1 (en) * | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
| EP2639307B1 (en) | 2010-08-03 | 2015-03-04 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| WO2013077446A1 (ja) * | 2011-11-26 | 2013-05-30 | 株式会社ボナック | 遺伝子発現制御のための一本鎖核酸分子 |
| WO2013133393A1 (ja) * | 2012-03-07 | 2013-09-12 | 学校法人東京医科大学 | Ｖｅｇｆ遺伝子の発現抑制用一本鎖核酸分子 |
| CA2868716A1 (en) * | 2012-03-29 | 2013-10-03 | Kyushu University National University Corporation | Nucleic acid molecule capable of inhibiting expression of periostin gene, method for inhibiting expression of periostin gene, and use of said nucleic acid molecule |
| WO2013180038A1 (ja) | 2012-05-26 | 2013-12-05 | 株式会社ボナック | デリバリー機能を有する遺伝子発現制御用の一本鎖核酸分子 |
| WO2015099122A1 (ja) | 2013-12-26 | 2015-07-02 | 学校法人東京医科大学 | 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途 |
| CN106068324B (zh) | 2013-12-27 | 2020-12-29 | 株式会社博纳克 | 控制基因表达的人工匹配型miRNA及其用途 |
| EP3235906B1 (en) * | 2014-12-15 | 2021-06-23 | Bonac Corporation | Single-stranded nucleic acid molecule for inhibiting tgf- beta 1 expression |
| KR20170098914A (ko) | 2014-12-27 | 2017-08-30 | 가부시키가이샤 보낙 | 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도 |
| WO2016158809A1 (ja) | 2015-03-27 | 2016-10-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| SG11201803410RA (en) | 2015-10-30 | 2018-05-30 | Bonac Corp | COMPOSITION STABLY CONTAINING SINGLE-STRANDED NUCLEIC ACID MOLECULE THAT SUPPRESSES EXPRESSION OF TGF-ß1 GENE |
| MX2018008086A (es) * | 2015-12-29 | 2018-11-12 | Univ Hokkaido Nat Univ Corp | Molecula de acido nucleico monocatenario que inhibe la expresion del gen de prorrenina o el gen del receptor de prorrenina y uso de la misma. |
| WO2017131124A1 (ja) | 2016-01-26 | 2017-08-03 | 日産化学工業株式会社 | 一本鎖オリゴヌクレオチド |
| CN109072224B (zh) | 2016-01-30 | 2022-07-15 | 株式会社博纳克 | 人工单导rna及其用途 |
| CN108342386B (zh) * | 2017-01-22 | 2022-04-15 | 广州市锐博生物科技有限公司 | 一种多聚寡核酸分子及其在多靶标干扰中的应用 |
| AU2018215440B2 (en) | 2017-02-06 | 2024-10-24 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
| JPWO2018199338A1 (ja) * | 2017-04-27 | 2020-03-12 | 国立大学法人広島大学 | Ｂ型肝炎治療用核酸分子 |
| EP3659609B1 (en) | 2017-07-28 | 2024-05-08 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for fibrosis |
| US12428641B2 (en) * | 2017-09-15 | 2025-09-30 | Commonwealth Scientific And Industrial Research Organisation | RNA molecules |
| US11298371B2 (en) | 2017-10-11 | 2022-04-12 | Nitto Denko Corporation | Regulation of nucleic acid molecule expression |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| JP6817493B2 (ja) * | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖ｒｎａの製造方法 |
| US11920131B2 (en) | 2018-03-30 | 2024-03-05 | Toray Industries, Inc. | Method of producing hairpin single-stranded RNA molecule |
| KR20210069628A (ko) * | 2018-10-02 | 2021-06-11 | 도레이 카부시키가이샤 | 헤어핀형 단일쇄 rna 분자의 제조 방법 |
| WO2020152869A1 (ja) | 2019-01-25 | 2020-07-30 | 杏林製薬株式会社 | 線維症治療剤 |
| WO2020171092A1 (ja) | 2019-02-18 | 2020-08-27 | 味の素株式会社 | 相補部分を含む修飾オリゴヌクレオチドの製造方法 |
| JP7640461B2 (ja) | 2019-10-11 | 2025-03-05 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| JP7667788B2 (ja) | 2020-01-29 | 2025-04-23 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| EP4098655A4 (en) | 2020-01-29 | 2024-02-28 | Sumitomo Chemical Company, Limited | METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS |
| JP7613130B2 (ja) * | 2020-03-25 | 2025-01-15 | 味の素株式会社 | リガーゼ変異体 |
| EP4130018A4 (en) | 2020-03-27 | 2024-04-17 | Sumitomo Chemical Company, Limited | METHOD FOR PRODUCING A NUCLEIC ACID OLIGOMER |
| CN115867559A (zh) | 2020-07-09 | 2023-03-28 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| KR20230074205A (ko) | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| CN117980285A (zh) | 2021-09-28 | 2024-05-03 | 住友化学株式会社 | 纯化二氯乙酸的制造方法 |
| US12509485B2 (en) | 2022-03-23 | 2025-12-30 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7201190B1 (ja) | 2022-06-03 | 2023-01-10 | 株式会社セツロテック | 遺伝子改変動物由来の動物繊維 |
| WO2024089953A1 (ja) | 2022-10-27 | 2024-05-02 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5631148A (en) * | 1994-04-22 | 1997-05-20 | Chiron Corporation | Ribozymes with product ejection by strand displacement |
| GB9621367D0 (en) | 1996-10-14 | 1996-12-04 | Isis Innovation | Chiral peptide nucleic acids |
| US6509323B1 (en) | 1998-07-01 | 2003-01-21 | California Institute Of Technology | Linear cyclodextrin copolymers |
| FR2790757B1 (fr) * | 1999-03-09 | 2003-08-01 | Bioalliance Pharma | Oligonucleotides contenant une sequence antisens stabilises par une structure secondaire et compositions pharmaceutiques les contenant. |
| US6962906B2 (en) | 2000-03-14 | 2005-11-08 | Active Motif | Oligonucleotide analogues, methods of synthesis and methods of use |
| TWI321054B (en) | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| AU2004266311B2 (en) | 2001-05-18 | 2009-07-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| AU2003219900A1 (en) * | 2002-02-22 | 2003-09-09 | James R. Eshleman | Antigene locks and therapeutic uses thereof |
| AU2003224725A1 (en) | 2002-03-20 | 2003-10-08 | Brigham And Women's Hospital, Inc. | Hiv therapeutic |
| DE60310944T3 (de) * | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Weitere neue formen von interferierende rns moleküle |
| WO2004015075A2 (en) | 2002-08-08 | 2004-02-19 | Dharmacon, Inc. | Short interfering rnas having a hairpin structure containing a non-nucleotide loop |
| WO2004090108A2 (en) | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | Irna conjugates |
| CN1860228B (zh) | 2003-09-30 | 2010-04-28 | 安琪士摩奇株式会社 | 订书钉型寡核苷酸及包含该订书钉型寡核苷酸的药物 |
| EP1789553B1 (en) * | 2004-06-30 | 2014-03-26 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a non-phosphate backbone linkage |
| US20090005332A1 (en) | 2004-12-30 | 2009-01-01 | Hauser Todd M | Compositions and Methods for Modulating Gene Expression Using Self-Protected Oligonucleotides |
| KR100848666B1 (ko) * | 2006-03-17 | 2008-07-28 | (주)바이오니아 | NF-k B의 발현을 억제하는 s i RNA |
| EP2129680B1 (en) | 2007-03-21 | 2015-05-06 | Brookhaven Science Associates, LLC | Combined hairpin-antisense compositions and methods for modulating expression |
| JP5296328B2 (ja) | 2007-05-09 | 2013-09-25 | 独立行政法人理化学研究所 | １本鎖環状ｒｎａおよびその製造方法 |
| US20110212075A1 (en) | 2007-06-25 | 2011-09-01 | Siemens Aktiengesellschaft | Screening method for polymorphic markers in htra1 gene in neurodegenerative disorders |
| US20100317714A1 (en) | 2007-11-29 | 2010-12-16 | Suzhou Ribo Life Science Co., Ltd | Complex molecule interfering the expression of target genes and its preparing methods |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| US20110159586A1 (en) * | 2007-12-07 | 2011-06-30 | Halo-Bio Rnai Therapeutics, Inc. | Compositions and methods for modulating gene expression using asymmetrically-active precursor polynucleotides |
| US20110055965A1 (en) | 2008-02-15 | 2011-03-03 | Hiroshi Abe | Cycle single-stranded nucleic acid complex and method for producing the same |
| JP5187580B2 (ja) | 2008-12-26 | 2013-04-24 | 丸紅建材リース株式会社 | 掘削機の泥土飛散防止装置 |
| JP2010174915A (ja) | 2009-01-27 | 2010-08-12 | Toyota Motor Corp | 高圧ガスタンク |
| JP5233790B2 (ja) | 2009-03-26 | 2013-07-10 | 船井電機株式会社 | 液晶モジュール |
| JP5449815B2 (ja) | 2009-03-26 | 2014-03-19 | 住友化学株式会社 | 偏光板の製造方法 |
| JP4885255B2 (ja) | 2009-05-21 | 2012-02-29 | 株式会社エフピコ | 包装用容器 |
| JP2010269823A (ja) | 2009-05-21 | 2010-12-02 | British American Tobacco Japan Kk | 喫煙品用容器 |
| US20110052666A1 (en) | 2009-09-03 | 2011-03-03 | Medtronic, Inc. | Compositions, Methods, and Systems for SIRNA Delivery |
| EP2562257A4 (en) | 2010-04-19 | 2014-10-01 | Riken | PROCESS FOR STABILIZING FUNCTIONAL NUCLEIC ACIDS |
| EP2933333B1 (en) * | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
-
2011
- 2011-07-08 EP EP15169933.7A patent/EP2933333B1/en active Active
- 2011-07-08 PT PT117461475T patent/PT2431466E/pt unknown
- 2011-07-08 KR KR1020127033429A patent/KR101849798B1/ko not_active Expired - Fee Related
- 2011-07-08 DK DK15169933.7T patent/DK2933333T3/en active
- 2011-07-08 BR BR112013000481-9A patent/BR112013000481A2/pt not_active Application Discontinuation
- 2011-07-08 CN CN201510226685.6A patent/CN104818276B/zh not_active Expired - Fee Related
- 2011-07-08 SG SG2013000211A patent/SG186899A1/en unknown
- 2011-07-08 US US13/254,150 patent/US8785121B2/en active Active
- 2011-07-08 CN CN201180027223.1A patent/CN102918156B/zh not_active Expired - Fee Related
- 2011-07-08 JP JP2011537086A patent/JP4968811B2/ja not_active Expired - Fee Related
- 2011-07-08 WO PCT/JP2011/065737 patent/WO2012005368A1/ja not_active Ceased
- 2011-07-08 HU HUE11746147A patent/HUE026520T2/en unknown
- 2011-07-08 TW TW104143857A patent/TWI573870B/zh not_active IP Right Cessation
- 2011-07-08 SG SG2013097233A patent/SG196779A1/en unknown
- 2011-07-08 RU RU2013105329A patent/RU2628311C2/ru active
- 2011-07-08 HU HUE15169933A patent/HUE037500T2/hu unknown
- 2011-07-08 NZ NZ606232A patent/NZ606232A/en not_active IP Right Cessation
- 2011-07-08 PT PT151699337T patent/PT2933333T/pt unknown
- 2011-07-08 NZ NZ704812A patent/NZ704812A/en unknown
- 2011-07-08 EP EP11746147.5A patent/EP2431466B1/en active Active
- 2011-07-08 CA CA2804511A patent/CA2804511C/en active Active
- 2011-07-08 ES ES15169933.7T patent/ES2670017T3/es active Active
- 2011-07-08 DK DK11746147.5T patent/DK2431466T3/en active
- 2011-07-08 ES ES11746147.5T patent/ES2550487T3/es active Active
- 2011-07-08 TW TW100124393A patent/TWI527901B/zh not_active IP Right Cessation
- 2011-07-08 MX MX2013000315A patent/MX352568B/es active IP Right Grant
- 2011-07-08 AU AU2011274854A patent/AU2011274854B2/en not_active Ceased
-
2012
- 2012-01-20 JP JP2012009515A patent/JP5804642B2/ja not_active Expired - Fee Related
-
2014
- 2014-06-12 US US14/303,315 patent/US20150011605A1/en not_active Abandoned
-
2015
- 2015-07-29 JP JP2015150156A patent/JP6162182B2/ja not_active Expired - Fee Related
- 2015-10-29 US US14/927,270 patent/US20160108400A1/en not_active Abandoned
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