JP2011500858A5 - - Google Patents
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- Publication number
- JP2011500858A5 JP2011500858A5 JP2010531412A JP2010531412A JP2011500858A5 JP 2011500858 A5 JP2011500858 A5 JP 2011500858A5 JP 2010531412 A JP2010531412 A JP 2010531412A JP 2010531412 A JP2010531412 A JP 2010531412A JP 2011500858 A5 JP2011500858 A5 JP 2011500858A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mir
- cell
- antisense molecule
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 18
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 13
- 230000000692 anti-sense effect Effects 0.000 claims 12
- 201000001320 Atherosclerosis Diseases 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000033115 angiogenesis Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 208000034038 Pathologic Neovascularization Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 208000037921 secondary disease Diseases 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 230000005747 tumor angiogenesis Effects 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000004969 inflammatory cell Anatomy 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 210000005167 vascular cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007052114A DE102007052114B4 (de) | 2007-10-30 | 2007-10-30 | Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle |
| DE102007052114.8 | 2007-10-30 | ||
| PCT/DE2008/001759 WO2009056116A1 (de) | 2007-10-30 | 2008-10-30 | Verfahren zur förderung der angiogenese, vaskularisierung oder gefässreparatur oder zur hemmung der tumorangiogenese |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116545A Division JP2014196317A (ja) | 2007-10-30 | 2014-06-05 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500858A JP2011500858A (ja) | 2011-01-06 |
| JP2011500858A5 true JP2011500858A5 (https=) | 2012-12-13 |
| JP5898843B2 JP5898843B2 (ja) | 2016-04-06 |
Family
ID=40375407
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010531412A Expired - Fee Related JP5898843B2 (ja) | 2007-10-30 | 2008-10-30 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
| JP2014116545A Pending JP2014196317A (ja) | 2007-10-30 | 2014-06-05 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
| JP2016125260A Pending JP2016199565A (ja) | 2007-10-30 | 2016-06-24 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
| JP2017239230A Pending JP2018083817A (ja) | 2007-10-30 | 2017-12-14 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116545A Pending JP2014196317A (ja) | 2007-10-30 | 2014-06-05 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
| JP2016125260A Pending JP2016199565A (ja) | 2007-10-30 | 2016-06-24 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
| JP2017239230A Pending JP2018083817A (ja) | 2007-10-30 | 2017-12-14 | 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8258113B2 (https=) |
| EP (3) | EP2684955B1 (https=) |
| JP (4) | JP5898843B2 (https=) |
| CA (1) | CA2704290C (https=) |
| CY (2) | CY1120360T1 (https=) |
| DE (1) | DE102007052114B4 (https=) |
| DK (2) | DK2217704T3 (https=) |
| ES (2) | ES2618203T3 (https=) |
| HR (2) | HRP20170346T1 (https=) |
| HU (2) | HUE031559T2 (https=) |
| LT (2) | LT2684955T (https=) |
| NO (1) | NO2684955T3 (https=) |
| PL (2) | PL2217704T3 (https=) |
| PT (2) | PT2684955T (https=) |
| SI (2) | SI2217704T1 (https=) |
| WO (1) | WO2009056116A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| EP3342415B1 (en) | 2006-08-08 | 2022-01-26 | Rheinische Friedrich-Wilhelms-Universität Bonn | Structure and use of 5' phosphate oligonucleotides |
| DE102007052114B4 (de) | 2007-10-30 | 2011-01-05 | T2Cure Gmbh | Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle |
| EP2297323A1 (en) | 2008-05-21 | 2011-03-23 | Hartmann, Gunther | 5' triphosphate oligonucleotide with blunt end and uses thereof |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| EP2638158A4 (en) * | 2010-11-11 | 2015-07-15 | Univ Miami | COMPOSITIONS, CELLS, KITS AND METHODS FOR AUTOLOGOUS STEM CELL THERAPY |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| US9388408B2 (en) | 2012-06-21 | 2016-07-12 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| ES2606636T3 (es) * | 2013-01-24 | 2017-03-24 | Pierre Fabre Médicament S.A.S. | Composición que comprende un antagomir encapsulado |
| CA2902571A1 (en) | 2013-03-15 | 2014-09-18 | MiRagen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| US11253549B2 (en) | 2014-05-23 | 2022-02-22 | JangoBio, LLC | Methods to rebalance the hypothalamic-pituitary-gonadal axis |
| US11439668B2 (en) | 2014-05-23 | 2022-09-13 | JangoBio, LLC | Methods to differentiate stem cells into hormone-producing cells |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| US20160122762A1 (en) * | 2014-10-27 | 2016-05-05 | University Of Iowa Research Foundation | Methods of treating atherosclerosis |
| US9885042B2 (en) | 2015-01-20 | 2018-02-06 | MiRagen Therapeutics, Inc. | miR-92 inhibitors and uses thereof |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| CN107586784B (zh) * | 2016-07-08 | 2020-08-25 | 田小利 | 一种分离的rnasek基因及其在制备抗血管衰老药物中的应用 |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| EP4699658A2 (en) | 2017-04-19 | 2026-02-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| JP7360170B2 (ja) * | 2018-02-28 | 2023-10-12 | 国立大学法人 東京医科歯科大学 | 虚血病変部位特異的な遺伝子治療法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7683036B2 (en) * | 2003-07-31 | 2010-03-23 | Regulus Therapeutics Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding RNAs |
| EP2290071B1 (en) * | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| WO2006133022A2 (en) * | 2005-06-03 | 2006-12-14 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
| CA2657030A1 (en) * | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| US8466117B2 (en) * | 2006-07-28 | 2013-06-18 | The Johns Hopkins University | Compositions and methods for modulating angiogenesis |
| WO2008070082A2 (en) * | 2006-12-04 | 2008-06-12 | The Johns Hopkins University | Stem-progenitor cell specific micro-ribonucleic acids and uses thereof |
| WO2009004632A2 (en) * | 2007-07-05 | 2009-01-08 | Yeda Research And Development Co. Ltd. | Methods of identifying components of a biological pathway and use of said components in regulating diseases associated with altered cell proliferation |
| CN101802227B (zh) * | 2007-07-18 | 2014-12-10 | 科罗拉多大学董事会法人团体 | 非衰竭与衰竭的人心脏中微小rna的差异表达 |
| DE102007052114B4 (de) | 2007-10-30 | 2011-01-05 | T2Cure Gmbh | Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle |
-
2007
- 2007-10-30 DE DE102007052114A patent/DE102007052114B4/de active Active
-
2008
- 2008-10-30 NO NO13179144A patent/NO2684955T3/no unknown
- 2008-10-30 SI SI200831774A patent/SI2217704T1/sl unknown
- 2008-10-30 DK DK08844273.6T patent/DK2217704T3/en active
- 2008-10-30 PL PL08844273T patent/PL2217704T3/pl unknown
- 2008-10-30 PT PT131791444T patent/PT2684955T/pt unknown
- 2008-10-30 DK DK13179144.4T patent/DK2684955T3/en active
- 2008-10-30 EP EP13179144.4A patent/EP2684955B1/de active Active
- 2008-10-30 HU HUE08844273A patent/HUE031559T2/hu unknown
- 2008-10-30 PL PL13179144T patent/PL2684955T3/pl unknown
- 2008-10-30 HU HUE13179144A patent/HUE037494T2/hu unknown
- 2008-10-30 US US12/739,876 patent/US8258113B2/en active Active
- 2008-10-30 CA CA2704290A patent/CA2704290C/en not_active Expired - Fee Related
- 2008-10-30 LT LTEP13179144.4T patent/LT2684955T/lt unknown
- 2008-10-30 ES ES08844273.6T patent/ES2618203T3/es active Active
- 2008-10-30 WO PCT/DE2008/001759 patent/WO2009056116A1/de not_active Ceased
- 2008-10-30 LT LTEP08844273.6T patent/LT2217704T/lt unknown
- 2008-10-30 EP EP08844273.6A patent/EP2217704B1/de active Active
- 2008-10-30 JP JP2010531412A patent/JP5898843B2/ja not_active Expired - Fee Related
- 2008-10-30 SI SI200831894T patent/SI2684955T1/en unknown
- 2008-10-30 EP EP13179146.9A patent/EP2684956B1/de active Active
- 2008-10-30 PT PT88442736T patent/PT2217704T/pt unknown
- 2008-10-30 HR HRP20170346TT patent/HRP20170346T1/hr unknown
- 2008-10-30 ES ES13179144.4T patent/ES2651287T3/es active Active
-
2012
- 2012-08-08 US US13/569,786 patent/US8912158B2/en active Active
-
2014
- 2014-06-05 JP JP2014116545A patent/JP2014196317A/ja active Pending
- 2014-07-31 US US14/448,119 patent/US9279123B2/en active Active
-
2016
- 2016-02-10 US US15/040,487 patent/US9862949B2/en active Active
- 2016-06-24 JP JP2016125260A patent/JP2016199565A/ja active Pending
-
2017
- 2017-02-22 CY CY20171100245T patent/CY1120360T1/el unknown
- 2017-12-04 HR HRP20171874TT patent/HRP20171874T1/hr unknown
- 2017-12-06 CY CY20171101283T patent/CY1120226T1/el unknown
- 2017-12-14 JP JP2017239230A patent/JP2018083817A/ja active Pending
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