DE102007052114B4 - Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle - Google Patents

Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle Download PDF

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DE102007052114B4
DE102007052114B4 DE102007052114A DE102007052114A DE102007052114B4 DE 102007052114 B4 DE102007052114 B4 DE 102007052114B4 DE 102007052114 A DE102007052114 A DE 102007052114A DE 102007052114 A DE102007052114 A DE 102007052114A DE 102007052114 B4 DE102007052114 B4 DE 102007052114B4
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cell
mir
expression
vascular
angiogenesis
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English (en)
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DE102007052114A1 (de
Inventor
Stefanie Prof. Dr. Dimmeler
Andreas M. Prof. Dr. Zeiher
Angelika Bonauer
Carmen Dr. Urbich
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Johann Wolfgang Goethe-Universitaet Frankfurt De
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T2cure GmbH
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Priority to DE102007052114A priority Critical patent/DE102007052114B4/de
Application filed by T2cure GmbH filed Critical T2cure GmbH
Priority to PL13179144T priority patent/PL2684955T3/pl
Priority to ES13179144.4T priority patent/ES2651287T3/es
Priority to SI200831894T priority patent/SI2684955T1/en
Priority to DK13179144.4T priority patent/DK2684955T3/en
Priority to US12/739,876 priority patent/US8258113B2/en
Priority to EP13179146.9A priority patent/EP2684956B1/de
Priority to PL08844273T priority patent/PL2217704T3/pl
Priority to JP2010531412A priority patent/JP5898843B2/ja
Priority to ES08844273.6T priority patent/ES2618203T3/es
Priority to PT131791444T priority patent/PT2684955T/pt
Priority to HRP20170346TT priority patent/HRP20170346T1/hr
Priority to DK08844273.6T priority patent/DK2217704T3/en
Priority to EP13179144.4A priority patent/EP2684955B1/de
Priority to HUE13179144A priority patent/HUE037494T2/hu
Priority to EP08844273.6A priority patent/EP2217704B1/de
Priority to NO13179144A priority patent/NO2684955T3/no
Priority to PT88442736T priority patent/PT2217704T/pt
Priority to CA2704290A priority patent/CA2704290C/en
Priority to LTEP13179144.4T priority patent/LT2684955T/lt
Priority to LTEP08844273.6T priority patent/LT2217704T/lt
Priority to HUE08844273A priority patent/HUE031559T2/hu
Priority to PCT/DE2008/001759 priority patent/WO2009056116A1/de
Priority to SI200831774A priority patent/SI2217704T1/sl
Publication of DE102007052114A1 publication Critical patent/DE102007052114A1/de
Application granted granted Critical
Publication of DE102007052114B4 publication Critical patent/DE102007052114B4/de
Priority to US13/569,786 priority patent/US8912158B2/en
Priority to JP2014116545A priority patent/JP2014196317A/ja
Priority to US14/448,119 priority patent/US9279123B2/en
Priority to US15/040,487 priority patent/US9862949B2/en
Priority to JP2016125260A priority patent/JP2016199565A/ja
Priority to CY20171100245T priority patent/CY1120360T1/el
Priority to HRP20171874TT priority patent/HRP20171874T1/hr
Priority to CY20171101283T priority patent/CY1120226T1/el
Priority to JP2017239230A priority patent/JP2018083817A/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity

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DE102007052114A 2007-10-30 2007-10-30 Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle Active DE102007052114B4 (de)

Priority Applications (33)

Application Number Priority Date Filing Date Title
DE102007052114A DE102007052114B4 (de) 2007-10-30 2007-10-30 Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle
LTEP13179144.4T LT2684955T (lt) 2007-10-30 2008-10-30 Angiogenezės, vaskuliarizacijos arba kraujagyslių atkūrimo skatinimo arba navikų angiogenezės inhibavimo būdas
SI200831894T SI2684955T1 (en) 2007-10-30 2008-10-30 A method for promoting angiogenesis, vascular or repair of the vessels, or for inhibiting tumor angiogenesis
DK13179144.4T DK2684955T3 (en) 2007-10-30 2008-10-30 Method to promote angionesis, vascularization or vascular repair or to inhibit tumor angionesis
US12/739,876 US8258113B2 (en) 2007-10-30 2008-10-30 Method for promoting angiogenesis, vascularization or vessel repair
HUE08844273A HUE031559T2 (hu) 2007-10-30 2008-10-30 Eljárás angiogenezis, vaszkularizáció vagy érjavítás elõsegítésére vagy tumor-angiogenezis gátlására
PL08844273T PL2217704T3 (pl) 2007-10-30 2008-10-30 Sposób stymulowania angiogenezy, waskularyzacji lub naprawy naczyń lub hamowania angiogenezy nowotworowej
JP2010531412A JP5898843B2 (ja) 2007-10-30 2008-10-30 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法
ES08844273.6T ES2618203T3 (es) 2007-10-30 2008-10-30 Procedimiento para la estimulación de la angiogénesis, la vascularización o la reparación vascular o para la inhibición de la angiogénesis tumoral
PT131791444T PT2684955T (pt) 2007-10-30 2008-10-30 Método para promover a angiogénese, a vascularização ou reparação de vasos ou para inibir a angiogénese de tumor
HRP20170346TT HRP20170346T1 (hr) 2007-10-30 2008-10-30 Postupak za poticanje angiogeneze, prokrvljenosti, ili obnove krvnih žila ili za inhibiciju angiogeneze tumora
DK08844273.6T DK2217704T3 (en) 2007-10-30 2008-10-30 Method to promote angionesis, vascularization or vascular repair or to inhibit tumor angionesis
EP13179144.4A EP2684955B1 (de) 2007-10-30 2008-10-30 Verfahren zur Förderung der Angiogenese, Vaskularisierung oder Gefäßreparatur oder zur Hemmung der Tumorangiogenese
HUE13179144A HUE037494T2 (hu) 2007-10-30 2008-10-30 Eljárás angiogenezis, vaszkularizáció vagy érjavítás elõsegítésére, vagy tumor-angiogenezis gátlására
EP08844273.6A EP2217704B1 (de) 2007-10-30 2008-10-30 Verfahren zur förderung der angiogenese, vaskularisierung oder gefässreparatur oder zur hemmung der tumorangiogenese
NO13179144A NO2684955T3 (https=) 2007-10-30 2008-10-30
PL13179144T PL2684955T3 (pl) 2007-10-30 2008-10-30 Sposób stymulowania angiogenezy, waskularyzacji lub naprawy naczyń lub hamowania angiogenezy nowotworowej
CA2704290A CA2704290C (en) 2007-10-30 2008-10-30 Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis
LTEP08844273.6T LT2217704T (lt) 2007-10-30 2008-10-30 Būdas, skirtas angiogenezės, vaskuliarizacijos arba kraujagyslių gijimo skatinimui arba naviko angiogenezės slopinimui
ES13179144.4T ES2651287T3 (es) 2007-10-30 2008-10-30 Procedimiento para la estimulación de la angiogénesis, la vascularización o la reparación vascular o para la inhibición de la angiogénesis tumoral
EP13179146.9A EP2684956B1 (de) 2007-10-30 2008-10-30 Verfahren zur Förderung der Angiogenese, Vaskularisierung oder Gefäßreparatur oder zur Hemmung der Tumorangiogenese
PCT/DE2008/001759 WO2009056116A1 (de) 2007-10-30 2008-10-30 Verfahren zur förderung der angiogenese, vaskularisierung oder gefässreparatur oder zur hemmung der tumorangiogenese
SI200831774A SI2217704T1 (sl) 2007-10-30 2008-10-30 Postopek za pospeševanje angiogeneze, vaskularizacije ali popravilo žil ali za zaviranje tumorske angiogeneze
PT88442736T PT2217704T (pt) 2007-10-30 2008-10-30 Método para promover a angiogénese, a vascularização ou reparação de vasos ou para inibir a angiogénese de tumor
US13/569,786 US8912158B2 (en) 2007-10-30 2012-08-08 Method for treating myocardial infarct
JP2014116545A JP2014196317A (ja) 2007-10-30 2014-06-05 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法
US14/448,119 US9279123B2 (en) 2007-10-30 2014-07-31 Method for promoting angiogenesis, vascularization or vessel repair or for inhibiting tumor angiogenesis
US15/040,487 US9862949B2 (en) 2007-10-30 2016-02-10 Method for the inhibition of angiogenesis
JP2016125260A JP2016199565A (ja) 2007-10-30 2016-06-24 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法
CY20171100245T CY1120360T1 (el) 2007-10-30 2017-02-22 Μεθοδος για την προωθηση της αγγειογενεσης, της αγγειωσης ή της αποκαταστασης των αγγειων, ή για την αναστολη της αγγειογενεσης ογκων
HRP20171874TT HRP20171874T1 (hr) 2007-10-30 2017-12-04 Postupak za poticanje angiogeneze, vaskularizacije ili obnavljanje krvnih žila ili za inhibiciju angiogeneze tumora
CY20171101283T CY1120226T1 (el) 2007-10-30 2017-12-06 Μεθοδος για την προωθηση της αγγειογενεσης, της αγγειωσης ή της αποκαταστασης των αγγειων ή για την αναστολη της αγγειογενεσης ογκων
JP2017239230A JP2018083817A (ja) 2007-10-30 2017-12-14 血管新生、血管形成、若しくは血管修復を促進するか、又は腫瘍血管新生を阻害する方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007052114A DE102007052114B4 (de) 2007-10-30 2007-10-30 Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle

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DE102007052114A1 DE102007052114A1 (de) 2009-05-07
DE102007052114B4 true DE102007052114B4 (de) 2011-01-05

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US (4) US8258113B2 (https=)
EP (3) EP2217704B1 (https=)
JP (4) JP5898843B2 (https=)
CA (1) CA2704290C (https=)
CY (2) CY1120360T1 (https=)
DE (1) DE102007052114B4 (https=)
DK (2) DK2217704T3 (https=)
ES (2) ES2618203T3 (https=)
HR (2) HRP20170346T1 (https=)
HU (2) HUE031559T2 (https=)
LT (2) LT2684955T (https=)
NO (1) NO2684955T3 (https=)
PL (2) PL2217704T3 (https=)
PT (2) PT2684955T (https=)
SI (2) SI2684955T1 (https=)
WO (1) WO2009056116A1 (https=)

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DE102007052114B4 (de) 2007-10-30 2011-01-05 T2Cure Gmbh Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle
WO2009141146A1 (en) 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
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EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
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EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
ES2606636T3 (es) * 2013-01-24 2017-03-24 Pierre Fabre Médicament S.A.S. Composición que comprende un antagomir encapsulado
DK2970968T3 (en) 2013-03-15 2018-03-05 Miragen Therapeutics Inc CONNECTED BICYCLIC Nucleosides
US11253549B2 (en) 2014-05-23 2022-02-22 JangoBio, LLC Methods to rebalance the hypothalamic-pituitary-gonadal axis
US11439668B2 (en) 2014-05-23 2022-09-13 JangoBio, LLC Methods to differentiate stem cells into hormone-producing cells
EP4494699A3 (en) 2014-10-03 2025-04-30 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US20160122762A1 (en) * 2014-10-27 2016-05-05 University Of Iowa Research Foundation Methods of treating atherosclerosis
EP3247716A4 (en) 2015-01-20 2018-10-17 Miragen Therapeutics, Inc. Mir-92 inhibitors and uses thereof
WO2017123662A1 (en) 2016-01-11 2017-07-20 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
CN107586784B (zh) * 2016-07-08 2020-08-25 田小利 一种分离的rnasek基因及其在制备抗血管衰老药物中的应用
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
JP7336769B2 (ja) 2017-04-19 2023-09-01 シーダーズ―シナイ メディカル センター 骨格筋ジストロフィーを治療する方法及び組成物
WO2019126068A1 (en) 2017-12-20 2019-06-27 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
EP3749344A4 (en) 2018-02-05 2022-01-26 Cedars-Sinai Medical Center METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS
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Publication number Publication date
CA2704290C (en) 2018-05-15
DK2217704T3 (en) 2017-03-13
JP2011500858A (ja) 2011-01-06
CA2704290A1 (en) 2009-05-07
NO2684955T3 (https=) 2018-02-03
PL2217704T3 (pl) 2017-06-30
LT2217704T (lt) 2017-04-10
US20100324118A1 (en) 2010-12-23
JP2016199565A (ja) 2016-12-01
PL2684955T3 (pl) 2018-05-30
HUE037494T2 (hu) 2018-08-28
LT2684955T (lt) 2017-12-27
DK2684955T3 (en) 2017-12-18
US8258113B2 (en) 2012-09-04
US20120322856A1 (en) 2012-12-20
EP2684955A1 (de) 2014-01-15
JP2014196317A (ja) 2014-10-16
US20160237433A1 (en) 2016-08-18
EP2684955B1 (de) 2017-09-06
JP5898843B2 (ja) 2016-04-06
US8912158B2 (en) 2014-12-16
PT2217704T (pt) 2017-03-15
US9862949B2 (en) 2018-01-09
HUE031559T2 (hu) 2017-07-28
WO2009056116A1 (de) 2009-05-07
HRP20171874T1 (hr) 2018-01-12
CY1120360T1 (el) 2019-07-10
EP2684956B1 (de) 2017-08-23
ES2651287T3 (es) 2018-01-25
EP2217704B1 (de) 2016-12-07
HRP20170346T1 (hr) 2017-04-21
JP2018083817A (ja) 2018-05-31
US9279123B2 (en) 2016-03-08
EP2684956A1 (de) 2014-01-15
CY1120226T1 (el) 2018-12-12
US20150018407A1 (en) 2015-01-15
SI2217704T1 (sl) 2017-05-31
SI2684955T1 (en) 2018-01-31
EP2217704A1 (de) 2010-08-18
ES2618203T3 (es) 2017-06-21
DE102007052114A1 (de) 2009-05-07
PT2684955T (pt) 2017-12-13

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