LT2684955T - Angiogenezės, vaskuliarizacijos arba kraujagyslių atkūrimo skatinimo arba navikų angiogenezės inhibavimo būdas - Google Patents

Angiogenezės, vaskuliarizacijos arba kraujagyslių atkūrimo skatinimo arba navikų angiogenezės inhibavimo būdas

Info

Publication number
LT2684955T
LT2684955T LTEP13179144.4T LT13179144T LT2684955T LT 2684955 T LT2684955 T LT 2684955T LT 13179144 T LT13179144 T LT 13179144T LT 2684955 T LT2684955 T LT 2684955T
Authority
LT
Lithuania
Prior art keywords
angiogenesis
vascularisation
inhibiting tumour
vessel repair
promoting
Prior art date
Application number
LTEP13179144.4T
Other languages
English (en)
Inventor
Stefanie Dimmeler
Carmen Urbich
Andreas Zeiher
Angelika Bonauer
Original Assignee
T2Cure Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T2Cure Gmbh filed Critical T2Cure Gmbh
Publication of LT2684955T publication Critical patent/LT2684955T/lt

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/50Methods for regulating/modulating their activity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LTEP13179144.4T 2007-10-30 2008-10-30 Angiogenezės, vaskuliarizacijos arba kraujagyslių atkūrimo skatinimo arba navikų angiogenezės inhibavimo būdas LT2684955T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007052114A DE102007052114B4 (de) 2007-10-30 2007-10-30 Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle

Publications (1)

Publication Number Publication Date
LT2684955T true LT2684955T (lt) 2017-12-27

Family

ID=40375407

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP13179144.4T LT2684955T (lt) 2007-10-30 2008-10-30 Angiogenezės, vaskuliarizacijos arba kraujagyslių atkūrimo skatinimo arba navikų angiogenezės inhibavimo būdas
LTEP08844273.6T LT2217704T (lt) 2007-10-30 2008-10-30 Būdas, skirtas angiogenezės, vaskuliarizacijos arba kraujagyslių gijimo skatinimui arba naviko angiogenezės slopinimui

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP08844273.6T LT2217704T (lt) 2007-10-30 2008-10-30 Būdas, skirtas angiogenezės, vaskuliarizacijos arba kraujagyslių gijimo skatinimui arba naviko angiogenezės slopinimui

Country Status (16)

Country Link
US (4) US8258113B2 (lt)
EP (3) EP2684955B1 (lt)
JP (4) JP5898843B2 (lt)
CA (1) CA2704290C (lt)
CY (2) CY1120360T1 (lt)
DE (1) DE102007052114B4 (lt)
DK (2) DK2684955T3 (lt)
ES (2) ES2651287T3 (lt)
HR (2) HRP20170346T1 (lt)
HU (2) HUE037494T2 (lt)
LT (2) LT2684955T (lt)
NO (1) NO2684955T3 (lt)
PL (2) PL2217704T3 (lt)
PT (2) PT2217704T (lt)
SI (2) SI2217704T1 (lt)
WO (1) WO2009056116A1 (lt)

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ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
ES2647452T3 (es) 2006-08-08 2017-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Estructura y uso de oligonucleótidos 5' fosfato
DE102007052114B4 (de) 2007-10-30 2011-01-05 T2Cure Gmbh Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle
WO2009141146A1 (en) 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US20130302293A1 (en) * 2010-11-11 2013-11-14 Keith A. Webster Compositions, cells, kits and methods for autologous stem cell therapy
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
JP2015521054A (ja) 2012-06-05 2015-07-27 カプリコール,インコーポレイテッド 心臓組織から心臓幹細胞を作製するための最適化方法および心臓治療におけるそれらの使用
JP6208228B2 (ja) 2012-06-21 2017-10-04 ミラゲン セラピューティクス, インコーポレイテッド ロックド核酸モチーフを含むオリゴヌクレオチドベースの阻害剤
WO2014028493A2 (en) 2012-08-13 2014-02-20 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
ES2606636T3 (es) * 2013-01-24 2017-03-24 Pierre Fabre Médicament S.A.S. Composición que comprende un antagomir encapsulado
MX364814B (es) 2013-03-15 2019-05-08 Miragen Therapeutics Inc Nucleosidos biciclicos unidos en puente.
US11253549B2 (en) 2014-05-23 2022-02-22 JangoBio, LLC Methods to rebalance the hypothalamic-pituitary-gonadal axis
US11439668B2 (en) 2014-05-23 2022-09-13 JangoBio, LLC Methods to differentiate stem cells into hormone-producing cells
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
US20160122762A1 (en) * 2014-10-27 2016-05-05 University Of Iowa Research Foundation Methods of treating atherosclerosis
SG10201906716QA (en) * 2015-01-20 2019-08-27 Miragen Therapeutics Inc Mir-92 inhibitors and uses thereof
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
CN107586784B (zh) * 2016-07-08 2020-08-25 田小利 一种分离的rnasek基因及其在制备抗血管衰老药物中的应用
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191A4 (en) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MODIFIED EXTRACELLULAR VESICLES FOR IMPROVED TISSUE DELIVERY
EP3760209B1 (en) * 2018-02-28 2023-11-22 National University Corporation Tokyo Medical and Dental University Ischemic-lesion-site-specific gene therapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683036B2 (en) * 2003-07-31 2010-03-23 Regulus Therapeutics Inc. Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
AU2005250432B2 (en) * 2004-05-28 2011-09-15 Asuragen, Inc. Methods and compositions involving microRNA
EP1904111A4 (en) * 2005-06-03 2009-08-19 Univ Johns Hopkins COMPOSITIONS AND METHODS FOR DECREASING MICROARN EXPRESSION FOR THE TREATMENT OF NEOPLASIA
JP5230619B2 (ja) * 2006-07-13 2013-07-10 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 結腸癌関連疾患の診断及び治療のためのマイクロrnaに基づいた方法及び組成物
US8466117B2 (en) * 2006-07-28 2013-06-18 The Johns Hopkins University Compositions and methods for modulating angiogenesis
WO2008070082A2 (en) * 2006-12-04 2008-06-12 The Johns Hopkins University Stem-progenitor cell specific micro-ribonucleic acids and uses thereof
WO2009004632A2 (en) * 2007-07-05 2009-01-08 Yeda Research And Development Co. Ltd. Methods of identifying components of a biological pathway and use of said components in regulating diseases associated with altered cell proliferation
KR20100049079A (ko) * 2007-07-18 2010-05-11 더 리젠트스 오브 더 유니버시티 오브 콜로라도 인간의 정상 심장과 기능부진 심장에서 마이크로 rna의 차등 발현
DE102007052114B4 (de) 2007-10-30 2011-01-05 T2Cure Gmbh Verfahren zur Modulation der Funktion, des Wachstums oder der Differenzierung einer Zelle

Also Published As

Publication number Publication date
HRP20171874T1 (hr) 2018-01-12
JP2011500858A (ja) 2011-01-06
SI2217704T1 (sl) 2017-05-31
ES2651287T3 (es) 2018-01-25
DE102007052114A1 (de) 2009-05-07
EP2684956A1 (de) 2014-01-15
JP2018083817A (ja) 2018-05-31
NO2684955T3 (lt) 2018-02-03
PL2684955T3 (pl) 2018-05-30
DK2217704T3 (en) 2017-03-13
LT2217704T (lt) 2017-04-10
PT2217704T (pt) 2017-03-15
SI2684955T1 (en) 2018-01-31
JP5898843B2 (ja) 2016-04-06
HUE031559T2 (hu) 2017-07-28
PT2684955T (pt) 2017-12-13
DK2684955T3 (en) 2017-12-18
US20160237433A1 (en) 2016-08-18
US20120322856A1 (en) 2012-12-20
ES2618203T3 (es) 2017-06-21
DE102007052114B4 (de) 2011-01-05
US20100324118A1 (en) 2010-12-23
HUE037494T2 (hu) 2018-08-28
CY1120360T1 (el) 2019-07-10
US20150018407A1 (en) 2015-01-15
CA2704290A1 (en) 2009-05-07
HRP20170346T1 (hr) 2017-04-21
EP2684956B1 (de) 2017-08-23
JP2014196317A (ja) 2014-10-16
EP2217704B1 (de) 2016-12-07
US9862949B2 (en) 2018-01-09
JP2016199565A (ja) 2016-12-01
EP2684955B1 (de) 2017-09-06
US9279123B2 (en) 2016-03-08
US8258113B2 (en) 2012-09-04
EP2217704A1 (de) 2010-08-18
WO2009056116A1 (de) 2009-05-07
PL2217704T3 (pl) 2017-06-30
CY1120226T1 (el) 2018-12-12
CA2704290C (en) 2018-05-15
US8912158B2 (en) 2014-12-16
EP2684955A1 (de) 2014-01-15

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