|
US4666828A
(en)
|
1984-08-15 |
1987-05-19 |
The General Hospital Corporation |
Test for Huntington's disease
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4801531A
(en)
|
1985-04-17 |
1989-01-31 |
Biotechnology Research Partners, Ltd. |
Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
|
|
US5272057A
(en)
|
1988-10-14 |
1993-12-21 |
Georgetown University |
Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
|
|
US5270030A
(en)
|
1988-12-29 |
1993-12-14 |
Bio-Technology General Corp. |
Fibrin binding domain polypeptide and method of producing
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
US5192659A
(en)
|
1989-08-25 |
1993-03-09 |
Genetype Ag |
Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
|
|
US6153737A
(en)
*
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
EP0642589A4
(en)
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
US6235886B1
(en)
*
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
|
US5593972A
(en)
|
1993-01-26 |
1997-01-14 |
The Wistar Institute |
Genetic immunization
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US20050032067A1
(en)
|
2002-11-05 |
2005-02-10 |
Prakash Thazha P. |
Non-phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
*
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
US5929042A
(en)
*
|
1997-03-03 |
1999-07-27 |
The Trustees Of Columbia University In The City Of New York |
Antisense compounds which prevent cell death and uses thereof
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US6251666B1
(en)
*
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
|
US6395713B1
(en)
*
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
AU9063398A
(en)
|
1997-09-12 |
1999-04-05 |
Exiqon A/S |
Oligonucleotide analogues
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
DE19807426A1
(de)
|
1998-02-23 |
1999-10-14 |
Otogene Biotechnologische Fors |
Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs
|
|
EP2314700A1
(en)
|
1999-01-28 |
2011-04-27 |
Medical College of Georgia Research Institute, Inc |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
CZ296576B6
(cs)
|
1999-02-12 |
2006-04-12 |
Sankyo Company Limited |
Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
|
|
AU3369900A
(en)
|
1999-02-19 |
2000-09-04 |
General Hospital Corporation, The |
Gene silencing
|
|
WO2000063364A2
(en)
|
1999-04-21 |
2000-10-26 |
American Home Products Corporation |
Methods and compositions for inhibiting the function of polynucleotide sequences
|
|
CA2386270A1
(en)
|
1999-10-15 |
2001-04-26 |
University Of Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
|
GB9925459D0
(en)
*
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
|
JP4566494B2
(ja)
|
1999-11-02 |
2010-10-20 |
ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド |
CpGレセプター(CpG−R)およびCpG−Rに関する方法
|
|
GB9927444D0
(en)
*
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
DE10100586C1
(de)
*
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
WO2003070918A2
(en)
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Incorporated |
Rna interference by modified short interfering nucleic acid
|
|
US20050020525A1
(en)
*
|
2002-02-20 |
2005-01-27 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
EP1272630A2
(en)
|
2000-03-16 |
2003-01-08 |
Genetica, Inc. |
Methods and compositions for rna interference
|
|
PT1309726E
(pt)
*
|
2000-03-30 |
2010-03-08 |
Whitehead Biomedical Inst |
Mediadores de interferência por rna específicos de sequência de rna
|
|
AU2001289068A1
(en)
|
2000-09-20 |
2002-04-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of caspase 2 expression
|
|
US6693187B1
(en)
|
2000-10-17 |
2004-02-17 |
Lievre Cornu Llc |
Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge
|
|
US20040259247A1
(en)
*
|
2000-12-01 |
2004-12-23 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
US20050260620A1
(en)
*
|
2001-05-18 |
2005-11-24 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of retinolblastoma (RBI) gene expression using short interfering nucleic acid (siNA)
|
|
US20040019001A1
(en)
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
|
US20070032441A1
(en)
*
|
2001-05-18 |
2007-02-08 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
|
|
CN1608133A
(zh)
*
|
2001-10-26 |
2005-04-20 |
里伯药品公司 |
双链核糖核酸用于治疗正(+)链rna病毒感染的用途
|
|
DE10230997A1
(de)
*
|
2001-10-26 |
2003-07-17 |
Ribopharma Ag |
Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels
|
|
CN1612930A
(zh)
|
2001-11-21 |
2005-05-04 |
三菱化学株式会社 |
抑制基因表达的方法
|
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US7795422B2
(en)
*
|
2002-02-20 |
2010-09-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
|
BR0307913A
(pt)
*
|
2002-02-25 |
2005-01-11 |
Lyfjathroun Hf |
Uso de uma composição, composição farmacêutica para administração nasal, e, métodos para eliciar um efeito terapêutico, profilático e/ou diagnóstico em um mamìfero, para obter um inìcio rápido de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero e para melhorar a biodisponibilidade de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero
|
|
AU2003260370B2
(en)
*
|
2002-08-05 |
2008-05-22 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
|
WO2004014933A1
(en)
*
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
EP2305812A3
(en)
*
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
US20050233342A1
(en)
*
|
2003-03-07 |
2005-10-20 |
Muthiah Manoharan |
Methods of preventing off-target gene silencing
|
|
CA2519860C
(en)
|
2003-03-21 |
2018-01-16 |
Santaris Pharma A/S |
Short interfering rna (sirna) analogues
|
|
CA2526493A1
(en)
|
2003-05-22 |
2004-12-02 |
Theraptosis S.A. |
Means for preventing and treating cellular death and their biological applications
|
|
ES2357116T5
(es)
*
|
2003-06-02 |
2021-09-03 |
Univ Massachusetts |
Métodos y composiciones para mejorar la eficacia y especificad de FNAi
|
|
DK1633767T3
(en)
*
|
2003-06-02 |
2019-03-25 |
Univ Massachusetts |
METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING
|
|
US8673634B2
(en)
*
|
2003-11-13 |
2014-03-18 |
Massachusetts Eye & Ear Infirmary |
Method for the treatment of hearing loss
|
|
WO2005055921A2
(en)
|
2003-12-12 |
2005-06-23 |
Eran Eilat |
Compositions for treatment of ear disorders and methods of use thereof
|
|
US7293861B2
(en)
|
2004-01-21 |
2007-11-13 |
Silverbrook Research Pty Ltd |
Inkjet printer cartridge refill dispenser system with variably positioned outlets
|
|
US7842800B2
(en)
*
|
2004-04-02 |
2010-11-30 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory bacterial and bacterial associated oligonucleotides and uses thereof
|
|
US8173600B2
(en)
*
|
2004-04-30 |
2012-05-08 |
Chiesi Farmaceutici S.P.A. |
Caspase-2 inhibitors and their biological applications
|
|
EP1602926A1
(en)
|
2004-06-04 |
2005-12-07 |
University of Geneva |
Novel means and methods for the treatment of hearing loss and phantom hearing
|
|
JP4468989B2
(ja)
*
|
2004-08-16 |
2010-05-26 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
Rtp801阻害剤の治療への使用
|
|
JP3867091B2
(ja)
|
2004-09-16 |
2007-01-10 |
株式会社アドメテック |
交流磁場中で発熱する粉末材料およびその製造方法
|
|
AU2005288522B2
(en)
*
|
2004-09-28 |
2012-06-28 |
Quark Pharmaceuticals, Inc. |
Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
|
|
EP2230305A1
(en)
|
2005-07-21 |
2010-09-22 |
Alnylam Pharmaceuticals Inc. |
Rnai modulation of the rho-a gene and uses thereof
|
|
US7825099B2
(en)
*
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
|
NL2000439C2
(nl)
*
|
2006-01-20 |
2009-03-16 |
Quark Biotech |
Therapeutische toepassingen van inhibitoren van RTP801.
|
|
WO2007087451A2
(en)
|
2006-01-25 |
2007-08-02 |
University Of Massachusetts |
Compositions and methods for enhancing discriminatory rna interference
|
|
EP1989307B1
(en)
|
2006-02-08 |
2012-08-08 |
Quark Pharmaceuticals, Inc. |
NOVEL TANDEM siRNAS
|
|
US7910566B2
(en)
*
|
2006-03-09 |
2011-03-22 |
Quark Pharmaceuticals Inc. |
Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
|
|
US7741469B2
(en)
*
|
2006-04-05 |
2010-06-22 |
University Of Iowa Research Foundation |
Compositions for treating hearing loss and methods of use thereof
|
|
WO2007141796A2
(en)
|
2006-06-09 |
2007-12-13 |
Quark Pharmaceuticals, Inc. |
Therapeutic uses of inhibitors of rtp801l
|
|
TWI491953B
(zh)
|
2006-07-18 |
2015-07-11 |
希畢克斯幻像有限公司 |
電泳顯示器
|
|
JP2010507387A
(ja)
*
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
|
US20100292301A1
(en)
*
|
2007-02-28 |
2010-11-18 |
Elena Feinstein |
Novel sirna structures
|
|
AU2008306455C1
(en)
|
2007-10-03 |
2014-04-17 |
Quark Pharmaceuticals, Inc. |
Novel siRNA structures
|
|
JP5524189B2
(ja)
|
2008-06-06 |
2014-06-18 |
クォーク ファーマシューティカルズ インコーポレーティッド |
耳障害治療のための組成物および方法
|
|
ES2563984T3
(es)
*
|
2008-10-22 |
2016-03-17 |
Quark Pharmaceuticals, Inc. |
Métodos para el tratamiento de trastornos oculares
|