JP2012072152A5 - - Google Patents
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- JP2012072152A5 JP2012072152A5 JP2011236920A JP2011236920A JP2012072152A5 JP 2012072152 A5 JP2012072152 A5 JP 2012072152A5 JP 2011236920 A JP2011236920 A JP 2011236920A JP 2011236920 A JP2011236920 A JP 2011236920A JP 2012072152 A5 JP2012072152 A5 JP 2012072152A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- pdgf
- antibody
- vegf
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims description 11
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims description 11
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 5
- 208000002780 macular degeneration Diseases 0.000 claims description 5
- 206010055665 Corneal neovascularisation Diseases 0.000 claims description 4
- 201000000159 corneal neovascularization Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims 28
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 8
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 8
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 6
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 2
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 description 26
- WLCZTRVUXYALDD-IBGZPJMESA-N 7-[[(2s)-2,6-bis(2-methoxyethoxycarbonylamino)hexanoyl]amino]heptoxy-methylphosphinic acid Chemical compound COCCOC(=O)NCCCC[C@H](NC(=O)OCCOC)C(=O)NCCCCCCCOP(C)(O)=O WLCZTRVUXYALDD-IBGZPJMESA-N 0.000 description 9
- 238000002648 combination therapy Methods 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 229940005014 pegaptanib sodium Drugs 0.000 description 6
- 210000004087 cornea Anatomy 0.000 description 5
- 239000007928 intraperitoneal injection Substances 0.000 description 4
- UIYWFOZZIZEEKJ-XVFCMESISA-N 1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione Chemical group F[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 UIYWFOZZIZEEKJ-XVFCMESISA-N 0.000 description 3
- ZTCKUVQHKIMCLI-UHFFFAOYSA-N 3-[2-[2-[2-[2-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile Chemical compound C1=CC(OC)=CC=C1C(OCCOCCOCCOCCOCCOCCOP(OCCC#N)N(C(C)C)C(C)C)(C=1C=CC(OC)=CC=1)C1=CC=CC=C1 ZTCKUVQHKIMCLI-UHFFFAOYSA-N 0.000 description 3
- UPXRTVAIJMUAQR-UHFFFAOYSA-N 4-(9h-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid Chemical compound C1C(C(O)=O)N(C(=O)OC(C)(C)C)CC1NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21 UPXRTVAIJMUAQR-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 229960004184 ketamine hydrochloride Drugs 0.000 description 3
- 229940092110 macugen Drugs 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 2
- HLBRKRLKOQTVRY-UHFFFAOYSA-N 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxyphosphonamidous acid Chemical compound NP(O)OCCOCCOCCOCCOCCO HLBRKRLKOQTVRY-UHFFFAOYSA-N 0.000 description 2
- CKTSBUTUHBMZGZ-ULQXZJNLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-tritiopyrimidin-2-one Chemical compound O=C1N=C(N)C([3H])=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-ULQXZJNLSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 101150044441 PECAM1 gene Proteins 0.000 description 2
- 230000001772 anti-angiogenic effect Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000001775 bruch membrane Anatomy 0.000 description 2
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 229960001600 xylazine Drugs 0.000 description 2
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 2
- TYJOQICPGZGYDT-UHFFFAOYSA-N 4-methylsulfonylbenzenesulfonyl chloride Chemical compound CS(=O)(=O)C1=CC=C(S(Cl)(=O)=O)C=C1 TYJOQICPGZGYDT-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 108010062580 Concanavalin A Proteins 0.000 description 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 description 1
- BGDKAVGWHJFAGW-UHFFFAOYSA-N Tropicamide Chemical compound C=1C=CC=CC=1C(CO)C(=O)N(CC)CC1=CC=NC=C1 BGDKAVGWHJFAGW-UHFFFAOYSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000003161 choroid Anatomy 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000649 photocoagulation Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000004233 retinal vasculature Effects 0.000 description 1
- 229960004791 tropicamide Drugs 0.000 description 1
- 230000006459 vascular development Effects 0.000 description 1
- 229960004175 xylazine hydrochloride Drugs 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49840703P | 2003-08-27 | 2003-08-27 | |
| US60/498,407 | 2003-08-27 | ||
| US55683704P | 2004-03-26 | 2004-03-26 | |
| US60/556,837 | 2004-03-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524824A Division JP4951339B2 (ja) | 2003-08-27 | 2004-08-26 | 眼血管新生疾患の治療のための併用療法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014147781A Division JP2014237674A (ja) | 2003-08-27 | 2014-07-18 | 眼血管新生疾患の治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012072152A JP2012072152A (ja) | 2012-04-12 |
| JP2012072152A5 true JP2012072152A5 (OSRAM) | 2013-02-21 |
Family
ID=34278595
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524824A Expired - Fee Related JP4951339B2 (ja) | 2003-08-27 | 2004-08-26 | 眼血管新生疾患の治療のための併用療法 |
| JP2011236920A Pending JP2012072152A (ja) | 2003-08-27 | 2011-10-28 | 眼血管新生疾患の治療のための併用療法 |
| JP2014147781A Withdrawn JP2014237674A (ja) | 2003-08-27 | 2014-07-18 | 眼血管新生疾患の治療のための併用療法 |
| JP2016134790A Pending JP2017014215A (ja) | 2003-08-27 | 2016-07-07 | 眼血管新生疾患の治療のための併用療法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524824A Expired - Fee Related JP4951339B2 (ja) | 2003-08-27 | 2004-08-26 | 眼血管新生疾患の治療のための併用療法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014147781A Withdrawn JP2014237674A (ja) | 2003-08-27 | 2014-07-18 | 眼血管新生疾患の治療のための併用療法 |
| JP2016134790A Pending JP2017014215A (ja) | 2003-08-27 | 2016-07-07 | 眼血管新生疾患の治療のための併用療法 |
Country Status (18)
| Country | Link |
|---|---|
| US (9) | US7759472B2 (OSRAM) |
| EP (3) | EP1660057B1 (OSRAM) |
| JP (4) | JP4951339B2 (OSRAM) |
| KR (3) | KR101471732B1 (OSRAM) |
| CN (3) | CN1934255B (OSRAM) |
| AR (1) | AR046682A1 (OSRAM) |
| AU (2) | AU2004268614C1 (OSRAM) |
| BR (1) | BRPI0413977A (OSRAM) |
| CA (3) | CA2536912C (OSRAM) |
| CY (1) | CY1113058T1 (OSRAM) |
| DK (1) | DK1660057T3 (OSRAM) |
| ES (1) | ES2388138T3 (OSRAM) |
| NZ (4) | NZ546088A (OSRAM) |
| PL (1) | PL1660057T3 (OSRAM) |
| PT (1) | PT1660057E (OSRAM) |
| SI (1) | SI1660057T1 (OSRAM) |
| TW (3) | TWI414300B (OSRAM) |
| WO (1) | WO2005020972A2 (OSRAM) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853376B2 (en) | 2002-11-21 | 2014-10-07 | Archemix Llc | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| US20120183593A1 (en) * | 2003-04-09 | 2012-07-19 | Directcontact Llc | Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases |
| EP1620547B1 (en) * | 2003-04-21 | 2014-06-18 | Archemix LLC | Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics |
| SI1660057T1 (sl) | 2003-08-27 | 2012-10-30 | Ophthotech Corp | Kombinirana terapija za zdravljenje okularnih neovaskularnih nepravilnosti |
| US7803931B2 (en) | 2004-02-12 | 2010-09-28 | Archemix Corp. | Aptamer therapeutics useful in the treatment of complement-related disorders |
| PL1765362T3 (pl) * | 2004-06-04 | 2012-08-31 | Scripps Research Inst | Kompozycje i sposoby do leczenia chorób związanych z neowaskularyzacją |
| EP2324848A3 (en) * | 2004-10-21 | 2011-09-14 | Genentech, Inc. | Method for treating intraocular neovascular diseases |
| US20060257359A1 (en) * | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
| CN102614134B (zh) | 2005-03-25 | 2016-09-07 | 瑞泽恩制药公司 | Vegf拮抗剂制剂 |
| IL172297A (en) * | 2005-10-03 | 2016-03-31 | Compugen Ltd | Soluble vegfr-1 variants for the diagnosis of preeclampsia |
| JP5014143B2 (ja) * | 2005-10-14 | 2012-08-29 | 学校法人福岡大学 | 膵島移植における移植膵島障害抑制剤 |
| WO2007046489A1 (ja) * | 2005-10-21 | 2007-04-26 | Chugai Seiyaku Kabushiki Kaisha | 心疾患治療剤 |
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