BR112014032316A2 - proteínas de repetição de anquirina projetadas que se ligam ao fator de crescimento derivado de plaqueta - Google Patents
proteínas de repetição de anquirina projetadas que se ligam ao fator de crescimento derivado de plaquetaInfo
- Publication number
- BR112014032316A2 BR112014032316A2 BR112014032316A BR112014032316A BR112014032316A2 BR 112014032316 A2 BR112014032316 A2 BR 112014032316A2 BR 112014032316 A BR112014032316 A BR 112014032316A BR 112014032316 A BR112014032316 A BR 112014032316A BR 112014032316 A2 BR112014032316 A2 BR 112014032316A2
- Authority
- BR
- Brazil
- Prior art keywords
- proteins
- platelet
- bind
- growth factor
- derived growth
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
Abstract
resumo patente de invenção: "proteínas de repetição de anquirina projetadas que se ligam a um fator de crescimento derivado de plaqueta". a presente invenção refere-se a novas proteínas de repetição de anquirina projetadas com especificidade de ligação para pdgf-bb que estão descritas, assim como ácidos nucleicos que codificam tais proteínas de ligação de pdgf, composições farmacêuticas que compreendem tais proteínas e o uso de tais proteínas no tratamento de doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12174020 | 2012-06-28 | ||
PCT/EP2013/063488 WO2014001442A1 (en) | 2012-06-28 | 2013-06-27 | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014032316A2 true BR112014032316A2 (pt) | 2017-06-27 |
Family
ID=48699826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014032316A BR112014032316A2 (pt) | 2012-06-28 | 2013-06-27 | proteínas de repetição de anquirina projetadas que se ligam ao fator de crescimento derivado de plaqueta |
Country Status (16)
Country | Link |
---|---|
US (2) | US9163070B2 (pt) |
EP (1) | EP2867360B1 (pt) |
JP (1) | JP2015522576A (pt) |
KR (1) | KR20150023957A (pt) |
CN (1) | CN104508129A (pt) |
AU (1) | AU2013283296A1 (pt) |
BR (1) | BR112014032316A2 (pt) |
CA (1) | CA2877584A1 (pt) |
HK (1) | HK1209156A1 (pt) |
IL (1) | IL236428A0 (pt) |
IN (1) | IN2014MN02522A (pt) |
MX (1) | MX2014015825A (pt) |
RU (1) | RU2014150224A (pt) |
SG (1) | SG11201408196RA (pt) |
WO (1) | WO2014001442A1 (pt) |
ZA (1) | ZA201408872B (pt) |
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AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
CN103459415B (zh) | 2010-11-26 | 2021-04-09 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
HUE046134T2 (hu) | 2012-05-07 | 2020-02-28 | Allergan Inc | Eljárás AMD kezelésére az anti-VEGF terápiára nem reagáló betegekben |
WO2020074469A1 (en) | 2018-10-08 | 2020-04-16 | Universität Zürich | Her2-binding tetrameric polypeptides |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
WO2014191574A1 (en) | 2013-05-31 | 2014-12-04 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
JP2017526053A (ja) | 2014-07-07 | 2017-09-07 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドYeda Research And Development Co.Ltd. | コンピュータ計算によるタンパク質設計方法 |
WO2016023898A2 (en) * | 2014-08-11 | 2016-02-18 | Medimmune Limited | Intracellular antigen binding |
JP6787888B2 (ja) | 2014-11-10 | 2020-11-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗il−1ベータ抗体及び使用方法 |
CA2963606A1 (en) | 2014-11-10 | 2016-05-19 | F.Hoffmann-La Roche Ag | Anti-ang2 antibodies and methods of use |
KR20170080584A (ko) * | 2014-11-10 | 2017-07-10 | 에프. 호프만-라 로슈 아게 | 이중특이적 항체 및 안과학에서 이의 사용 방법 |
JP6946184B2 (ja) | 2014-11-10 | 2021-10-06 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗pdgf−b抗体及び使用法 |
AU2016240220B2 (en) | 2015-04-02 | 2019-11-21 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
US10283384B2 (en) * | 2015-04-27 | 2019-05-07 | Taiwan Semiconductor Manufacturing Co., Ltd. | Method for etching etch layer and wafer etching apparatus |
NZ751689A (en) | 2016-09-22 | 2021-07-30 | Molecular Partners Ag | Recombinant binding proteins and their use |
US10037890B2 (en) * | 2016-10-11 | 2018-07-31 | Lam Research Corporation | Method for selectively etching with reduced aspect ratio dependence |
WO2018165046A1 (en) | 2017-03-07 | 2018-09-13 | Igc Bio, Inc. | A computational pipeline for antibody modeling and design |
US11655293B2 (en) | 2018-02-22 | 2023-05-23 | Universitat Zurich | Ligands to GM-CSF or GM-CSF-receptor for use in leukemia in a patient having undergone allo-HCT |
EP3623382A1 (en) | 2018-09-14 | 2020-03-18 | Universität Zürich | Ligands to gm-csf or gm-csf-receptor for use in leukemia in a patient having undergone allo-hct |
CN111886338A (zh) | 2018-03-22 | 2020-11-03 | 柏林夏瑞蒂医科大学 | Crispr相关蛋白反应性t细胞免疫 |
US20210253723A1 (en) | 2018-06-15 | 2021-08-19 | Universität Bern | LIGANDS TO LIGHT OR ITS RECEPTOR LTßR FOR USE IN HAEMATOLOGIC MALIGNANCIES |
EP3883919A1 (en) | 2018-11-21 | 2021-09-29 | Universität Zürich | Photochemically induced conjugation of radiometals to small molecules, peptides and nanoparticles in a simultaneous one-pot reaction |
EP3677911A3 (en) | 2019-01-03 | 2020-07-29 | Universität Basel | Use of non-agonist ligands for suppression of metastasis |
US20220088144A1 (en) | 2019-01-11 | 2022-03-24 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery |
EP3953712A1 (en) | 2019-04-10 | 2022-02-16 | Universität Zürich | A method for determining the likelihood of a patient being responsive to cancer immunotherapy |
WO2020245746A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Multispecific proteins |
AU2020286600A1 (en) * | 2019-06-04 | 2021-12-23 | Molecular Partners Ag | Recombinant FAP binding proteins and their use |
WO2021044050A1 (en) | 2019-09-05 | 2021-03-11 | Genome Biologics Ug | Inhibition of mthfd1l for use in hypertrophic heart disease and heart failure |
CA3161326A1 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Designed ankyrin repeat domains with altered surface residues |
WO2021122813A1 (en) | 2019-12-16 | 2021-06-24 | Universität Basel | Angiogenesis promoting agents for prevention of metastatic cancer |
WO2021176008A1 (en) | 2020-03-04 | 2021-09-10 | Cornell University | Agents targeting baf155 or brg1 for use in treatment of advanced prostate cancer |
WO2021204781A1 (en) | 2020-04-06 | 2021-10-14 | Universität Zürich | Artc1 ligands for cancer treatment |
IL297940A (en) * | 2020-05-06 | 2023-01-01 | Molecular Partners Ag | New ankyrin repeat binding proteins and their uses |
IL298168A (en) | 2020-05-14 | 2023-01-01 | Molecular Partners Ag | Multispecific proteins |
WO2021239844A1 (en) | 2020-05-27 | 2021-12-02 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia in prediabetes |
WO2021239999A1 (en) | 2020-05-28 | 2021-12-02 | Universität Zürich | Il-12 pd-l1 ligand fusion protein |
US20230303680A1 (en) | 2020-08-18 | 2023-09-28 | Universität Zürich | A cd25-biased anti-il-2 antibody |
WO2022130300A1 (en) | 2020-12-16 | 2022-06-23 | Molecular Partners Ag | Novel slow-release prodrugs |
EP4291901A1 (en) | 2021-02-11 | 2023-12-20 | Universität Zürich | Use of markers found on lymph node metastatic samples for the prognosis of breast cancer |
CA3211368A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based cd123 engagers |
AU2022231913A1 (en) | 2021-03-09 | 2023-09-28 | Molecular Partners Ag | Novel darpin based cd33 engagers |
KR20230155464A (ko) | 2021-03-09 | 2023-11-10 | 몰리큘라 파트너스 아게 | 신규한 DARPin-기반 다중특이성 T-세포 인게이저 |
JP2024509890A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | プロテアーゼ切断可能なプロドラッグ |
IL310615A (en) | 2021-08-05 | 2024-04-01 | Immunos Therapeutics Ag | Pharmaceutical compositions comprising HLA fusion proteins |
WO2023012350A1 (en) | 2021-08-05 | 2023-02-09 | Immunos Therapeutics Ag | Combination medicaments comprising hla fusion proteins |
WO2023021006A1 (en) | 2021-08-16 | 2023-02-23 | Universität Zürich | Il-1 targeting agents for treatment of pitiyriasis rubra pilaris |
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EP4163380A1 (en) | 2021-10-08 | 2023-04-12 | ETH Zurich | Device and method for manipulation of extracellular vesicles |
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EP4260907A1 (en) | 2022-04-11 | 2023-10-18 | Universität Zürich | Agents for treatment of endometriosis and other benign gynecological neoplasms |
WO2024002914A1 (en) | 2022-06-27 | 2024-01-04 | Charité-Universitätsmedizin Berlin | Prediction of, and composition to improve, tendon healing |
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CN107011425B (zh) * | 2008-11-03 | 2021-01-01 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
TW201120210A (en) * | 2009-11-05 | 2011-06-16 | Hoffmann La Roche | Glycosylated repeat-motif-molecule conjugates |
AR081361A1 (es) * | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
CN103459415B (zh) | 2010-11-26 | 2021-04-09 | 分子组合公司 | 设计的与血清白蛋白结合的重复蛋白 |
CN104105704A (zh) * | 2011-04-29 | 2014-10-15 | 詹森生物科技公司 | Il4/il13结合重复蛋白及用途 |
-
2013
- 2013-06-27 JP JP2015519089A patent/JP2015522576A/ja active Pending
- 2013-06-27 EP EP13731809.3A patent/EP2867360B1/en active Active
- 2013-06-27 KR KR20157002327A patent/KR20150023957A/ko not_active Application Discontinuation
- 2013-06-27 RU RU2014150224A patent/RU2014150224A/ru not_active Application Discontinuation
- 2013-06-27 US US13/928,973 patent/US9163070B2/en active Active
- 2013-06-27 AU AU2013283296A patent/AU2013283296A1/en not_active Abandoned
- 2013-06-27 CN CN201380034192.1A patent/CN104508129A/zh active Pending
- 2013-06-27 WO PCT/EP2013/063488 patent/WO2014001442A1/en active Application Filing
- 2013-06-27 BR BR112014032316A patent/BR112014032316A2/pt not_active IP Right Cessation
- 2013-06-27 SG SG11201408196RA patent/SG11201408196RA/en unknown
- 2013-06-27 CA CA2877584A patent/CA2877584A1/en not_active Abandoned
- 2013-06-27 MX MX2014015825A patent/MX2014015825A/es unknown
-
2014
- 2014-12-03 ZA ZA2014/08872A patent/ZA201408872B/en unknown
- 2014-12-11 IN IN2522MUN2014 patent/IN2014MN02522A/en unknown
- 2014-12-24 IL IL236428A patent/IL236428A0/en unknown
-
2015
- 2015-09-08 US US14/847,403 patent/US20150368302A1/en not_active Abandoned
- 2015-10-07 HK HK15109777.3A patent/HK1209156A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US9163070B2 (en) | 2015-10-20 |
US20150368302A1 (en) | 2015-12-24 |
EP2867360B1 (en) | 2019-05-08 |
EP2867360A1 (en) | 2015-05-06 |
IL236428A0 (en) | 2015-02-26 |
KR20150023957A (ko) | 2015-03-05 |
IN2014MN02522A (pt) | 2015-07-17 |
CA2877584A1 (en) | 2014-01-03 |
JP2015522576A (ja) | 2015-08-06 |
RU2014150224A (ru) | 2016-08-20 |
US20140005125A1 (en) | 2014-01-02 |
MX2014015825A (es) | 2015-08-10 |
SG11201408196RA (en) | 2015-03-30 |
ZA201408872B (en) | 2016-05-25 |
AU2013283296A1 (en) | 2015-02-05 |
CN104508129A (zh) | 2015-04-08 |
HK1209156A1 (en) | 2016-03-24 |
WO2014001442A1 (en) | 2014-01-03 |
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Legal Events
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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