JP2011526250A - ジグリシドエーテル誘導体治療剤およびその使用方法 - Google Patents

ジグリシドエーテル誘導体治療剤およびその使用方法 Download PDF

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JP2011526250A
JP2011526250A JP2011515039A JP2011515039A JP2011526250A JP 2011526250 A JP2011526250 A JP 2011526250A JP 2011515039 A JP2011515039 A JP 2011515039A JP 2011515039 A JP2011515039 A JP 2011515039A JP 2011526250 A JP2011526250 A JP 2011526250A
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JP2011526250A5 (https=
Inventor
サダル、マリアン、ディー．
マウジ、ナスリン、アール．
ワン、ジュン
アンダーソン、レイモンド、ジェイ．
ウィリアムズ、デイヴィッド、イー．
ルブラン、マイク
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ブリティッシュ コロンビア キャンサー エージェンシー ブランチ
ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア
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Application filed by ブリティッシュ コロンビア キャンサー エージェンシー ブランチ, ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア filed Critical ブリティッシュ コロンビア キャンサー エージェンシー ブランチ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
JP2011515039A 2008-07-02 2009-07-02 ジグリシドエーテル誘導体治療剤およびその使用方法 Pending JP2011526250A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12953708P 2008-07-02 2008-07-02
US61/129,537 2008-07-02
PCT/CA2009/000902 WO2010000066A1 (en) 2008-07-02 2009-07-02 Diglycidic ether derivative therapeutics and methods for their use

Related Child Applications (1)

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JP2015075887A Division JP6023250B2 (ja) 2008-07-02 2015-04-02 ジグリシドエーテル誘導体治療剤およびその使用方法

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JP2011526250A true JP2011526250A (ja) 2011-10-06
JP2011526250A5 JP2011526250A5 (https=) 2012-08-16

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JP2011515039A Pending JP2011526250A (ja) 2008-07-02 2009-07-02 ジグリシドエーテル誘導体治療剤およびその使用方法
JP2015075887A Active JP6023250B2 (ja) 2008-07-02 2015-04-02 ジグリシドエーテル誘導体治療剤およびその使用方法
JP2016198004A Active JP6190025B2 (ja) 2008-07-02 2016-10-06 ジグリシドエーテル誘導体治療剤およびその使用方法

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JP2015075887A Active JP6023250B2 (ja) 2008-07-02 2015-04-02 ジグリシドエーテル誘導体治療剤およびその使用方法
JP2016198004A Active JP6190025B2 (ja) 2008-07-02 2016-10-06 ジグリシドエーテル誘導体治療剤およびその使用方法

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US (3) US9862667B2 (https=)
EP (2) EP3252032A1 (https=)
JP (3) JP2011526250A (https=)
KR (3) KR20110044216A (https=)
CN (2) CN105012282A (https=)
AU (1) AU2009266379C1 (https=)
BR (1) BRPI0913673A2 (https=)
CA (1) CA2728219C (https=)
CL (1) CL2010001624A1 (https=)
CO (1) CO6351774A2 (https=)
DK (1) DK2307342T3 (https=)
ES (1) ES2640003T3 (https=)
HK (1) HK1216608A1 (https=)
HU (1) HUE034458T2 (https=)
IL (1) IL210120A (https=)
MX (1) MX2010014372A (https=)
NZ (1) NZ589759A (https=)
RU (2) RU2572596C2 (https=)
TR (1) TR201011157T1 (https=)
WO (1) WO2010000066A1 (https=)
ZA (1) ZA201100507B (https=)

Cited By (5)

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Publication number Priority date Publication date Assignee Title
JP2013516435A (ja) * 2010-01-06 2013-05-13 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲンレセプター活性調節因子としての、ビスフェノール誘導体およびその使用
WO2014069555A1 (ja) * 2012-11-02 2014-05-08 株式会社成和化成 プロピルフェニルエーテル誘導体、並びにそれを含むメラニン生成抑制剤、美白剤、抗菌剤及び化粧料
JP2016518394A (ja) * 2013-05-10 2016-06-23 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲン受容体調節薬のエステル誘導体およびそれらの使用のための方法
JP2017516866A (ja) * 2014-06-06 2017-06-22 ベイジン ズィボォ バイオメディカル テクノロジー カンパニー、リミテッド Ａβプラークと親和性を有するキラル側鎖の置換基を含む、フッ素置換２−アリールベンゾ複素環式化合物、その製法および応用
JP2019513795A (ja) * 2016-04-15 2019-05-30 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ ビスフェノール誘導体、及びアンドロゲン受容体活性調節因子としてのそれらの使用

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HUE034458T2 (en) 2008-07-02 2018-02-28 British Columbia Cancer Agency Branch Diglycidyl ether derivatives, therapeutics and methods for their use
WO2011040421A1 (ja) 2009-09-29 2011-04-07 武田薬品工業株式会社 スクリーニング方法
JP5375502B2 (ja) * 2009-10-06 2013-12-25 信越化学工業株式会社 アルコール性水酸基含有化合物及びその製造方法
US20130109758A1 (en) * 2010-01-06 2013-05-02 The University Of British Columbia Bisphenol derivative therapeutics and methods for their use
JP5892949B2 (ja) 2010-02-10 2016-03-23 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ ビフェニル置換環状ケトエノール類
EP2693875A4 (en) 2011-04-08 2014-10-22 British Columbia Cancer Agency BISPHENOL COMPOUNDS AND METHOD FOR THEIR USE
WO2012145330A1 (en) * 2011-04-18 2012-10-26 The University Of British Columbia Fluorene-9-bisphenol compounds and methods for their use
WO2012145328A1 (en) * 2011-04-18 2012-10-26 The University Of British Columbia Dibenzylphenyl compounds and methods for their use
US8533714B2 (en) 2011-05-03 2013-09-10 International Business Machines Corporation Dynamic virtual machine domain configuration and virtual machine relocation management
US20130045204A1 (en) * 2011-08-19 2013-02-21 The University Of British Columbia Fluorinated bisphenol ether compounds and methods for their use
WO2013028791A1 (en) * 2011-08-22 2013-02-28 British Columbia Cancer Agency Branch 18f compounds for cancer imaging and methods for their use
US9365510B2 (en) * 2012-04-16 2016-06-14 British Columbia Cancer Agency Branch Aziridine bisphenol ethers and related compounds and methods for their use
WO2015031984A1 (en) * 2013-09-09 2015-03-12 British Columbia Cancer Agency Branch Halogenated compounds for cancer imaging and treatment and methods for their use
WO2016058080A1 (en) * 2014-10-14 2016-04-21 British Columbia Cancer Agency Branch Fluoro-chloro bisphenol ether compounds and methods for their use
DK3988541T3 (da) 2015-01-13 2024-09-16 British Columbia Cancer Agency Branch Heterocycliske forbindelser til billedscanning og behandling af cancer samt fremgangsmåder til anvendelse af disse
WO2016141458A1 (en) 2015-03-12 2016-09-15 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
US12415939B2 (en) * 2015-09-30 2025-09-16 The Regents Of The University Of California Nano-adhesive and surface primer compound and use thereof
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
WO2020081999A1 (en) 2018-10-18 2020-04-23 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
WO2020198712A1 (en) 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
CN115916170A (zh) 2020-04-17 2023-04-04 埃萨制药股份有限公司 固体形式的n-末端结构域雄激素受体抑制剂及其用途
CN113666806A (zh) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity
TWI874822B (zh) * 2022-09-23 2025-03-01 上緯創新育成股份有限公司 降解酸酐環氧固化物的方法、其製備的多元醇以及熱固性樹脂
CN121652089A (zh) * 2024-09-11 2026-03-13 中国海洋大学 一种ntd抑制剂及其应用

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JP2016518394A (ja) * 2013-05-10 2016-06-23 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲン受容体調節薬のエステル誘導体およびそれらの使用のための方法
JP2017125036A (ja) * 2013-05-10 2017-07-20 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ アンドロゲン受容体調節薬のエステル誘導体およびそれらの使用のための方法
JP2017516866A (ja) * 2014-06-06 2017-06-22 ベイジン ズィボォ バイオメディカル テクノロジー カンパニー、リミテッド Ａβプラークと親和性を有するキラル側鎖の置換基を含む、フッ素置換２−アリールベンゾ複素環式化合物、その製法および応用
JP2019513795A (ja) * 2016-04-15 2019-05-30 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ ビスフェノール誘導体、及びアンドロゲン受容体活性調節因子としてのそれらの使用
JP7142577B2 (ja) 2016-04-15 2022-09-27 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ ビスフェノール誘導体、及びアンドロゲン受容体活性調節因子としてのそれらの使用

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