JP2011526250A5 - - Google Patents
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- Publication number
- JP2011526250A5 JP2011526250A5 JP2011515039A JP2011515039A JP2011526250A5 JP 2011526250 A5 JP2011526250 A5 JP 2011526250A5 JP 2011515039 A JP2011515039 A JP 2011515039A JP 2011515039 A JP2011515039 A JP 2011515039A JP 2011526250 A5 JP2011526250 A5 JP 2011526250A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- gog
- ogog
- unsubstituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 102000001307 androgen receptors Human genes 0.000 claims 11
- 108010080146 androgen receptors Proteins 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 229920006395 saturated elastomer Polymers 0.000 claims 7
- 206010060862 Prostate cancer Diseases 0.000 claims 6
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 4
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 229920008712 Copo Polymers 0.000 claims 3
- 101100001675 Emericella variicolor andJ gene Proteins 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010020112 Hirsutism Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010036049 Polycystic ovaries Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 208000025661 ovarian cyst Diseases 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 208000006155 precocious puberty Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 0 CC(C)(CCNCC(C)=O)OCCC(C)(C)OCC* Chemical compound CC(C)(CCNCC(C)=O)OCCC(C)(C)OCC* 0.000 description 9
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12953708P | 2008-07-02 | 2008-07-02 | |
| US61/129,537 | 2008-07-02 | ||
| PCT/CA2009/000902 WO2010000066A1 (en) | 2008-07-02 | 2009-07-02 | Diglycidic ether derivative therapeutics and methods for their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075887A Division JP6023250B2 (ja) | 2008-07-02 | 2015-04-02 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526250A JP2011526250A (ja) | 2011-10-06 |
| JP2011526250A5 true JP2011526250A5 (https=) | 2012-08-16 |
Family
ID=41465435
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515039A Pending JP2011526250A (ja) | 2008-07-02 | 2009-07-02 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
| JP2015075887A Active JP6023250B2 (ja) | 2008-07-02 | 2015-04-02 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
| JP2016198004A Active JP6190025B2 (ja) | 2008-07-02 | 2016-10-06 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075887A Active JP6023250B2 (ja) | 2008-07-02 | 2015-04-02 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
| JP2016198004A Active JP6190025B2 (ja) | 2008-07-02 | 2016-10-06 | ジグリシドエーテル誘導体治療剤およびその使用方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9862667B2 (https=) |
| EP (2) | EP3252032A1 (https=) |
| JP (3) | JP2011526250A (https=) |
| KR (3) | KR20110044216A (https=) |
| CN (2) | CN105012282A (https=) |
| AU (1) | AU2009266379C1 (https=) |
| BR (1) | BRPI0913673A2 (https=) |
| CA (1) | CA2728219C (https=) |
| CL (1) | CL2010001624A1 (https=) |
| CO (1) | CO6351774A2 (https=) |
| DK (1) | DK2307342T3 (https=) |
| ES (1) | ES2640003T3 (https=) |
| HK (1) | HK1216608A1 (https=) |
| HU (1) | HUE034458T2 (https=) |
| IL (1) | IL210120A (https=) |
| MX (1) | MX2010014372A (https=) |
| NZ (1) | NZ589759A (https=) |
| RU (2) | RU2572596C2 (https=) |
| TR (1) | TR201011157T1 (https=) |
| WO (1) | WO2010000066A1 (https=) |
| ZA (1) | ZA201100507B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE034458T2 (en) | 2008-07-02 | 2018-02-28 | British Columbia Cancer Agency Branch | Diglycidyl ether derivatives, therapeutics and methods for their use |
| WO2011040421A1 (ja) | 2009-09-29 | 2011-04-07 | 武田薬品工業株式会社 | スクリーニング方法 |
| JP5375502B2 (ja) * | 2009-10-06 | 2013-12-25 | 信越化学工業株式会社 | アルコール性水酸基含有化合物及びその製造方法 |
| US20130109758A1 (en) * | 2010-01-06 | 2013-05-02 | The University Of British Columbia | Bisphenol derivative therapeutics and methods for their use |
| US9388112B2 (en) | 2010-01-06 | 2016-07-12 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| JP5892949B2 (ja) | 2010-02-10 | 2016-03-23 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | ビフェニル置換環状ケトエノール類 |
| EP2693875A4 (en) | 2011-04-08 | 2014-10-22 | British Columbia Cancer Agency | BISPHENOL COMPOUNDS AND METHOD FOR THEIR USE |
| WO2012145330A1 (en) * | 2011-04-18 | 2012-10-26 | The University Of British Columbia | Fluorene-9-bisphenol compounds and methods for their use |
| WO2012145328A1 (en) * | 2011-04-18 | 2012-10-26 | The University Of British Columbia | Dibenzylphenyl compounds and methods for their use |
| US8533714B2 (en) | 2011-05-03 | 2013-09-10 | International Business Machines Corporation | Dynamic virtual machine domain configuration and virtual machine relocation management |
| US20130045204A1 (en) * | 2011-08-19 | 2013-02-21 | The University Of British Columbia | Fluorinated bisphenol ether compounds and methods for their use |
| WO2013028791A1 (en) * | 2011-08-22 | 2013-02-28 | British Columbia Cancer Agency Branch | 18f compounds for cancer imaging and methods for their use |
| US9365510B2 (en) * | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
| BR112015008936A2 (pt) * | 2012-11-02 | 2017-07-04 | Seiwa Kasei Co Ltd | derivado de éter de propilfenila, e um inibidor de produção de melanina, um agente de branqueamento, um agente antibacteriano e um cosmético contendo o mesmo |
| AU2014262333B2 (en) * | 2013-05-10 | 2016-06-16 | British Columbia Cancer Agency Branch | Ester derivatives of androgen receptor modulators and methods for their use |
| WO2015031984A1 (en) * | 2013-09-09 | 2015-03-12 | British Columbia Cancer Agency Branch | Halogenated compounds for cancer imaging and treatment and methods for their use |
| CN104059028B (zh) * | 2014-06-06 | 2020-10-16 | 北京智博高科生物技术有限公司 | 与Aβ斑块具有亲和力的含手性侧链取代的氟代2-芳基苯并杂环化合物、其制备方法及应用 |
| WO2016058080A1 (en) * | 2014-10-14 | 2016-04-21 | British Columbia Cancer Agency Branch | Fluoro-chloro bisphenol ether compounds and methods for their use |
| DK3988541T3 (da) | 2015-01-13 | 2024-09-16 | British Columbia Cancer Agency Branch | Heterocycliske forbindelser til billedscanning og behandling af cancer samt fremgangsmåder til anvendelse af disse |
| WO2016141458A1 (en) | 2015-03-12 | 2016-09-15 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
| US12415939B2 (en) * | 2015-09-30 | 2025-09-16 | The Regents Of The University Of California | Nano-adhesive and surface primer compound and use thereof |
| US20170298033A1 (en) | 2016-04-15 | 2017-10-19 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| US11485713B2 (en) | 2018-05-25 | 2022-11-01 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| WO2020081999A1 (en) | 2018-10-18 | 2020-04-23 | Essa Pharma, Inc. | Androgen receptor modulators and methods for their use |
| WO2020198712A1 (en) | 2019-03-28 | 2020-10-01 | Essa Pharma, Inc. | Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof |
| CN115916170A (zh) | 2020-04-17 | 2023-04-04 | 埃萨制药股份有限公司 | 固体形式的n-末端结构域雄激素受体抑制剂及其用途 |
| CN113666806A (zh) * | 2020-05-15 | 2021-11-19 | 上海安谱实验科技股份有限公司 | 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法 |
| WO2023046283A1 (en) | 2021-09-22 | 2023-03-30 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity |
| TWI874822B (zh) * | 2022-09-23 | 2025-03-01 | 上緯創新育成股份有限公司 | 降解酸酐環氧固化物的方法、其製備的多元醇以及熱固性樹脂 |
| CN121652089A (zh) * | 2024-09-11 | 2026-03-13 | 中国海洋大学 | 一种ntd抑制剂及其应用 |
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| HUE034458T2 (en) | 2008-07-02 | 2018-02-28 | British Columbia Cancer Agency Branch | Diglycidyl ether derivatives, therapeutics and methods for their use |
| US20130109758A1 (en) | 2010-01-06 | 2013-05-02 | The University Of British Columbia | Bisphenol derivative therapeutics and methods for their use |
| US9388112B2 (en) | 2010-01-06 | 2016-07-12 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
| EP2693875A4 (en) | 2011-04-08 | 2014-10-22 | British Columbia Cancer Agency | BISPHENOL COMPOUNDS AND METHOD FOR THEIR USE |
| WO2012145330A1 (en) | 2011-04-18 | 2012-10-26 | The University Of British Columbia | Fluorene-9-bisphenol compounds and methods for their use |
| WO2012145328A1 (en) | 2011-04-18 | 2012-10-26 | The University Of British Columbia | Dibenzylphenyl compounds and methods for their use |
| US20130045204A1 (en) | 2011-08-19 | 2013-02-21 | The University Of British Columbia | Fluorinated bisphenol ether compounds and methods for their use |
| WO2013028791A1 (en) | 2011-08-22 | 2013-02-28 | British Columbia Cancer Agency Branch | 18f compounds for cancer imaging and methods for their use |
| US9365510B2 (en) | 2012-04-16 | 2016-06-14 | British Columbia Cancer Agency Branch | Aziridine bisphenol ethers and related compounds and methods for their use |
| AU2014262333B2 (en) | 2013-05-10 | 2016-06-16 | British Columbia Cancer Agency Branch | Ester derivatives of androgen receptor modulators and methods for their use |
| CN103342892A (zh) | 2013-06-06 | 2013-10-09 | 西安交通大学 | 一种双马来酰亚胺树脂的增韧改性剂及其制备方法 |
| US20150010469A1 (en) | 2013-07-03 | 2015-01-08 | British Columbia Cancer Agency Branch | Bisphenol ether compounds with novel bridging groups and methods for their use |
| WO2015031984A1 (en) | 2013-09-09 | 2015-03-12 | British Columbia Cancer Agency Branch | Halogenated compounds for cancer imaging and treatment and methods for their use |
| WO2016058080A1 (en) | 2014-10-14 | 2016-04-21 | British Columbia Cancer Agency Branch | Fluoro-chloro bisphenol ether compounds and methods for their use |
| WO2016058082A1 (en) | 2014-10-14 | 2016-04-21 | British Columbia Cancer Agency Branch | 18f compounds for cancer imaging and methods for their use |
| DK3988541T3 (da) | 2015-01-13 | 2024-09-16 | British Columbia Cancer Agency Branch | Heterocycliske forbindelser til billedscanning og behandling af cancer samt fremgangsmåder til anvendelse af disse |
| WO2016141458A1 (en) | 2015-03-12 | 2016-09-15 | British Columbia Cancer Agency Branch | Bisphenol ether derivatives and methods for using the same |
-
2009
- 2009-07-02 HU HUE09771876A patent/HUE034458T2/en unknown
- 2009-07-02 EP EP17177010.0A patent/EP3252032A1/en not_active Withdrawn
- 2009-07-02 CA CA2728219A patent/CA2728219C/en active Active
- 2009-07-02 BR BRPI0913673A patent/BRPI0913673A2/pt not_active Application Discontinuation
- 2009-07-02 CN CN201510367512.6A patent/CN105012282A/zh active Pending
- 2009-07-02 EP EP09771876.1A patent/EP2307342B1/en active Active
- 2009-07-02 DK DK09771876.1T patent/DK2307342T3/en active
- 2009-07-02 ES ES09771876.1T patent/ES2640003T3/es active Active
- 2009-07-02 TR TR2010/11157T patent/TR201011157T1/xx unknown
- 2009-07-02 CN CN200980125734.XA patent/CN102083780B/zh active Active
- 2009-07-02 AU AU2009266379A patent/AU2009266379C1/en not_active Ceased
- 2009-07-02 NZ NZ589759A patent/NZ589759A/xx unknown
- 2009-07-02 WO PCT/CA2009/000902 patent/WO2010000066A1/en not_active Ceased
- 2009-07-02 KR KR1020117002474A patent/KR20110044216A/ko not_active Ceased
- 2009-07-02 RU RU2011103538/04A patent/RU2572596C2/ru not_active IP Right Cessation
- 2009-07-02 US US12/999,037 patent/US9862667B2/en not_active Expired - Fee Related
- 2009-07-02 KR KR1020167014006A patent/KR101717098B1/ko not_active Expired - Fee Related
- 2009-07-02 KR KR1020157004535A patent/KR101719550B1/ko not_active Expired - Fee Related
- 2009-07-02 RU RU2015107733/04A patent/RU2015107733A/ru not_active Application Discontinuation
- 2009-07-02 MX MX2010014372A patent/MX2010014372A/es active IP Right Grant
- 2009-07-02 JP JP2011515039A patent/JP2011526250A/ja active Pending
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2010
- 2010-12-20 IL IL210120A patent/IL210120A/en active IP Right Review Request
- 2010-12-30 CL CL2010001624A patent/CL2010001624A1/es unknown
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2011
- 2011-01-20 ZA ZA2011/00507A patent/ZA201100507B/en unknown
- 2011-02-02 CO CO11011677A patent/CO6351774A2/es active IP Right Grant
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2013
- 2013-04-19 US US13/866,933 patent/US8686050B2/en active Active
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2015
- 2015-04-02 JP JP2015075887A patent/JP6023250B2/ja active Active
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2016
- 2016-04-19 HK HK16104479.4A patent/HK1216608A1/zh unknown
- 2016-10-06 US US15/287,483 patent/US20170121261A1/en not_active Abandoned
- 2016-10-06 JP JP2016198004A patent/JP6190025B2/ja active Active
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