MX2013005508A - Compuestos de lipoilo y su uso para tratar lesion isquemica. - Google Patents

Compuestos de lipoilo y su uso para tratar lesion isquemica.

Info

Publication number
MX2013005508A
MX2013005508A MX2013005508A MX2013005508A MX2013005508A MX 2013005508 A MX2013005508 A MX 2013005508A MX 2013005508 A MX2013005508 A MX 2013005508A MX 2013005508 A MX2013005508 A MX 2013005508A MX 2013005508 A MX2013005508 A MX 2013005508A
Authority
MX
Mexico
Prior art keywords
compounds
ischemic injury
treating ischemic
prodrugs
pharmaceutically acceptable
Prior art date
Application number
MX2013005508A
Other languages
English (en)
Other versions
MX344933B (es
Inventor
Alexander B Baguisi
Reinier Beeuwkes
Ralph Casale
Steven A Kates
Original Assignee
Ischemix Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ischemix Llc filed Critical Ischemix Llc
Publication of MX2013005508A publication Critical patent/MX2013005508A/es
Publication of MX344933B publication Critical patent/MX344933B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere, en diversas realizaciones, a un compuesto representado por la Fórmula estructural (I), sales farmacéuticamente aceptables o profármacos del mismo, y a composiciones que comprenden dichos compuestos, o sales farmacéuticamente aceptables o profármacos de los mismos. También se divulgan procedimientos de uso de los compuestos de Fórmulas estructurales (I) y (Ia) o composiciones que comprenden compuestos de Fórmulas estructurales (I) y (la), o sales farmacéuticamente aceptables o profármacos de los mismos, para tratar isquemia o lesión por isquemia-reperfusión.
MX2013005508A 2010-11-18 2011-11-10 Compuestos de lipoílo y su uso para tratar lesión isquémica. MX344933B (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41524010P 2010-11-18 2010-11-18
US41524110P 2010-11-18 2010-11-18
US201161478310P 2011-04-22 2011-04-22
US201161500974P 2011-06-24 2011-06-24
PCT/US2011/060259 WO2012067947A1 (en) 2010-11-18 2011-11-10 Lipoyl compounds and their use for treating ischemic injury

Publications (2)

Publication Number Publication Date
MX2013005508A true MX2013005508A (es) 2013-07-17
MX344933B MX344933B (es) 2017-01-11

Family

ID=45217651

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005508A MX344933B (es) 2010-11-18 2011-11-10 Compuestos de lipoílo y su uso para tratar lesión isquémica.

Country Status (15)

Country Link
US (2) US8815937B2 (es)
EP (1) EP2640423B1 (es)
JP (3) JP2014502264A (es)
KR (1) KR20140020840A (es)
CN (1) CN103561770B (es)
AU (1) AU2011329215C1 (es)
BR (1) BR112013012057B1 (es)
CA (1) CA2817362C (es)
DK (1) DK2640423T3 (es)
ES (1) ES2640474T3 (es)
IL (1) IL226258A (es)
MX (1) MX344933B (es)
NZ (1) NZ610378A (es)
SG (1) SG190794A1 (es)
WO (1) WO2012067947A1 (es)

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US8541396B2 (en) 2009-04-24 2013-09-24 National University Of Singapore Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
SG190794A1 (en) 2010-11-18 2013-07-31 Ischemix Llc Lipoyl compounds and their use for treating ischemic injury
ITFI20120170A1 (it) * 2012-08-28 2014-03-01 Consorzio Interuniversitario Nazion Ale Per La Sci Nuovi composti ad azione anti-allodinica ed anti-iperalgesica.
WO2015128697A1 (en) 2014-02-27 2015-09-03 Consorzio Interuniversitario Nazionale Per La Scienza E Tecnologia Dei Materiali Novel compounds having anti-allodynic and antihyperalgesic activity
WO2015174948A1 (en) 2014-05-14 2015-11-19 Ischemix, LLC Formulations comprising lipoyl compounds
RU2737377C2 (ru) * 2016-03-14 2020-11-27 Неострата Компани, Инк. N-липоевая аминокислота или пептид, производные и их применение
RU2657820C1 (ru) * 2017-03-13 2018-06-15 Федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ФГБОУ ВО ВолгГМУ МЗ РФ 4-(4-Ацетоксибензоиламино)бутаноилглицин, обладающий церебропротекторным действием при ишемии головного мозга
US10744115B2 (en) 2017-04-25 2020-08-18 Ischemix Llc Compositions and methods for treating traumatic brain injury
US11306076B2 (en) * 2020-05-11 2022-04-19 Xi'an Taikomed Pharmaceutical Technology Co., Ltd. Silibinin lipoic acid ester with hepatoprotective activity and a method of preparing the same

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Also Published As

Publication number Publication date
NZ610378A (en) 2015-05-29
EP2640423A1 (en) 2013-09-25
JP2016033157A (ja) 2016-03-10
WO2012067947A1 (en) 2012-05-24
CN103561770B (zh) 2016-11-09
JP2018016652A (ja) 2018-02-01
BR112013012057B1 (pt) 2021-11-09
CN103561770A (zh) 2014-02-05
SG190794A1 (en) 2013-07-31
CA2817362C (en) 2018-10-23
US8815937B2 (en) 2014-08-26
US20150065564A1 (en) 2015-03-05
JP2014502264A (ja) 2014-01-30
AU2011329215A1 (en) 2013-05-30
BR112013012057A2 (pt) 2020-08-04
KR20140020840A (ko) 2014-02-19
IL226258A (en) 2017-02-28
EP2640423B1 (en) 2017-07-26
US20130237483A1 (en) 2013-09-12
MX344933B (es) 2017-01-11
AU2011329215B2 (en) 2016-04-28
ES2640474T3 (es) 2017-11-03
AU2011329215C1 (en) 2016-08-11
CA2817362A1 (en) 2012-05-24
US9359325B2 (en) 2016-06-07
DK2640423T3 (en) 2017-10-02
IL226258A0 (en) 2013-07-31
JP6280094B2 (ja) 2018-02-14

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