JP2011526244A5 - - Google Patents
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- JP2011526244A5 JP2011526244A5 JP2011501003A JP2011501003A JP2011526244A5 JP 2011526244 A5 JP2011526244 A5 JP 2011526244A5 JP 2011501003 A JP2011501003 A JP 2011501003A JP 2011501003 A JP2011501003 A JP 2011501003A JP 2011526244 A5 JP2011526244 A5 JP 2011526244A5
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- Prior art keywords
- mif
- disease
- cancer
- domain
- peptide
- Prior art date
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- 102100030173 Muellerian-inhibiting factor Human genes 0.000 claims 47
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 239000000178 monomer Substances 0.000 claims 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 239000013638 trimer Substances 0.000 claims 12
- 229940044551 receptor antagonist Drugs 0.000 claims 9
- 239000002464 receptor antagonist Substances 0.000 claims 9
- 208000002223 abdominal aortic aneurysm Diseases 0.000 claims 8
- 208000007474 aortic aneurysm Diseases 0.000 claims 8
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 6
- 108090000288 Glycoproteins Proteins 0.000 claims 6
- 102000003886 Glycoproteins Human genes 0.000 claims 6
- 206010028851 Necrosis Diseases 0.000 claims 6
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- 239000003112 inhibitor Substances 0.000 claims 6
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- 239000000203 mixture Substances 0.000 claims 5
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims 4
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 4
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 4
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims 4
- 101100001347 Mus musculus Akt1s1 gene Proteins 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
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- 206010035664 Pneumonia Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
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- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
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- 208000002552 acute disseminated encephalomyelitis Diseases 0.000 claims 4
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- KEWSCDNULKOKTG-UHFFFAOYSA-N 4-cyano-4-ethylsulfanylcarbothioylsulfanylpentanoic acid Chemical compound CCSC(=S)SC(C)(C#N)CCC(O)=O KEWSCDNULKOKTG-UHFFFAOYSA-N 0.000 claims 3
- 102000005666 Apolipoprotein A-I Human genes 0.000 claims 3
- 108010059886 Apolipoprotein A-I Proteins 0.000 claims 3
- 102100037637 Cholesteryl ester transfer protein Human genes 0.000 claims 3
- 206010018691 Granuloma Diseases 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 3
- 101000880514 Homo sapiens Cholesteryl ester transfer protein Proteins 0.000 claims 3
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 claims 3
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 claims 3
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 3
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 3
- 201000009906 Meningitis Diseases 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 3
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- 206010001935 American trypanosomiasis Diseases 0.000 claims 2
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- 208000023328 Basedow disease Diseases 0.000 claims 2
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- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 2
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 2
- 208000020084 Bone disease Diseases 0.000 claims 2
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- 206010010741 Conjunctivitis Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 206010058838 Enterocolitis infectious Diseases 0.000 claims 2
- 208000001640 Fibromyalgia Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 206010018634 Gouty Arthritis Diseases 0.000 claims 2
- 208000015023 Graves' disease Diseases 0.000 claims 2
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 2
- 208000001204 Hashimoto Disease Diseases 0.000 claims 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 2
- 208000007514 Herpes zoster Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000005615 Interstitial Cystitis Diseases 0.000 claims 2
- 208000004852 Lung Injury Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 2
- 208000009433 Moyamoya Disease Diseases 0.000 claims 2
- 208000009525 Myocarditis Diseases 0.000 claims 2
- 208000000592 Nasal Polyps Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 208000035539 Ovarian infection Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034277 Pemphigoid Diseases 0.000 claims 2
- 201000011152 Pemphigus Diseases 0.000 claims 2
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 2
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 206010038910 Retinitis Diseases 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 206010039710 Scleroderma Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 206010069363 Traumatic lung injury Diseases 0.000 claims 2
- 241000223109 Trypanosoma cruzi Species 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 206010047642 Vitiligo Diseases 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
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- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 2
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- 239000003972 antineoplastic antibiotic Substances 0.000 claims 2
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- 208000010668 atopic eczema Diseases 0.000 claims 2
- 230000001363 autoimmune Effects 0.000 claims 2
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- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 208000000594 bullous pemphigoid Diseases 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000003146 cystitis Diseases 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 206010014599 encephalitis Diseases 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 208000007565 gingivitis Diseases 0.000 claims 2
- 206010020718 hyperplasia Diseases 0.000 claims 2
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- 210000000265 leukocyte Anatomy 0.000 claims 2
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- 210000004698 lymphocyte Anatomy 0.000 claims 2
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- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
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- 208000016366 nasal cavity polyp Diseases 0.000 claims 2
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- 201000001976 pemphigus vulgaris Diseases 0.000 claims 2
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
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- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 230000036303 septic shock Effects 0.000 claims 2
- 208000000649 small cell carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000008827 tuberculosis Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 claims 1
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 claims 1
- 206010036774 Proctitis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3838108P | 2008-03-20 | 2008-03-20 | |
| US61/038,381 | 2008-03-20 | ||
| US3937108P | 2008-03-25 | 2008-03-25 | |
| US61/039,371 | 2008-03-25 | ||
| US4580708P | 2008-04-17 | 2008-04-17 | |
| US61/045,807 | 2008-04-17 | ||
| US12109508P | 2008-12-09 | 2008-12-09 | |
| US61/121,095 | 2008-12-09 | ||
| PCT/US2009/037887 WO2009117710A2 (en) | 2008-03-20 | 2009-03-20 | Methods of treating inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011526244A JP2011526244A (ja) | 2011-10-06 |
| JP2011526244A5 true JP2011526244A5 (enExample) | 2011-11-24 |
Family
ID=41091567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501003A Pending JP2011526244A (ja) | 2008-03-20 | 2009-03-20 | 炎症の処置方法 |
| JP2011501000A Pending JP2011515416A (ja) | 2008-03-20 | 2009-03-20 | 抗ｍｉｆ抗体を用いる処置方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501000A Pending JP2011515416A (ja) | 2008-03-20 | 2009-03-20 | 抗ｍｉｆ抗体を用いる処置方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20110044988A1 (enExample) |
| EP (2) | EP2252318A4 (enExample) |
| JP (2) | JP2011526244A (enExample) |
| KR (1) | KR20110014141A (enExample) |
| CN (2) | CN102046199A (enExample) |
| AU (2) | AU2009225385A1 (enExample) |
| BR (1) | BRPI0910259A2 (enExample) |
| CA (2) | CA2717365A1 (enExample) |
| CO (1) | CO6300848A2 (enExample) |
| EA (1) | EA201001529A1 (enExample) |
| IL (1) | IL207752A0 (enExample) |
| MX (1) | MX2010010198A (enExample) |
| NZ (1) | NZ588033A (enExample) |
| WO (2) | WO2009117706A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110044988A1 (en) * | 2008-03-20 | 2011-02-24 | Carolus Therpeutics, Inc. | Methods of treatment using anti-mif antibodies |
| US20110070184A1 (en) * | 2008-03-24 | 2011-03-24 | Carolus Therpeutics, Inc. | Methods and compositions for treating atherosclerosis and related condidtions |
| US20100183598A1 (en) * | 2008-11-12 | 2010-07-22 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| MX2012003514A (es) * | 2009-09-23 | 2012-04-19 | Carolus Therapeutics Inc | Metodos para tratamiento de inflamaciones. |
| EP2308484A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Inhibitors of cxcr1/2 as adjuvants in the transplant of pancreatic islets |
| EP2308485A1 (en) | 2009-10-06 | 2011-04-13 | Dompé S.p.a. | Sulfonamides for the prevention of diabetes |
| WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
| US9133164B2 (en) * | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| TWI407964B (zh) * | 2011-05-10 | 2013-09-11 | Univ Fu Jen Catholic | 干擾性核糖核酸用於治療或減緩疼痛之用途 |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| WO2013003786A1 (en) * | 2011-06-30 | 2013-01-03 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| US10596233B2 (en) | 2011-06-30 | 2020-03-24 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| JP2014526886A (ja) | 2011-07-15 | 2014-10-09 | モルフォシス・アー・ゲー | マクロファージ遊走阻止因子（ｍｉｆ）とｄ−ドーパクロームトートメラーゼ（ｄ−ｄｔ）に交差反応性がある抗体 |
| CN102357249A (zh) * | 2011-10-26 | 2012-02-22 | 广州赫尔氏药物开发有限公司 | 能够抑制耐药性结核杆菌的药物 |
| EP2844250B1 (en) | 2012-05-01 | 2017-11-08 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| WO2015051330A1 (en) | 2013-10-03 | 2015-04-09 | Oregon Health & Science University | RECOMBINANT POLYPEPTIDES COMPRISING MHC CLASS II α1 DOMAINS |
| SG10202111844VA (en) | 2015-01-09 | 2021-12-30 | Adalta Ltd | Cxcr4 binding molecules |
| TW201718851A (zh) * | 2015-09-18 | 2017-06-01 | 通用醫院公司 | 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途 |
| ES2907489T3 (es) | 2015-12-14 | 2022-04-25 | X4 Pharmaceuticals Inc | Métodos para el tratamiento del cáncer |
| US11357742B2 (en) | 2015-12-14 | 2022-06-14 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3426253A4 (en) | 2016-03-11 | 2019-11-06 | Ardea Biosciences, Inc. | CXCR-2 INHIBITORS FOR THE TREATMENT OF CRYSTALARTHROPATHIES |
| KR102645432B1 (ko) * | 2016-03-28 | 2024-03-11 | (주)아모레퍼시픽 | 피부 세포 분화 촉진용 조성물 및 피부 세포 분화 촉진 물질의 스크리닝 방법 |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3445402A4 (en) * | 2016-04-21 | 2019-12-11 | The Board Of Regents Of The University Of Texas System | METHOD AND COMPOSITIONS FOR DETECTING ANEURYSMS |
| TWI640536B (zh) | 2016-06-20 | 2018-11-11 | 克馬伯有限公司 | 抗體 |
| US11332470B2 (en) | 2016-06-21 | 2022-05-17 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| JP7054529B2 (ja) | 2016-06-21 | 2022-04-14 | エックス４ ファーマシューティカルズ， インコーポレイテッド | Ｃｘｃｒ４阻害剤およびその使用 |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| JP7252125B2 (ja) | 2016-10-03 | 2023-04-04 | ザ チルドレンズ メディカル センター コーポレーション | 糖尿病性腎症の予防および処置 |
| CN108355133A (zh) * | 2017-01-26 | 2018-08-03 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| WO2019084313A1 (en) * | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | USE OF SDHA AS PROGNOSTIC MARKER AND THERAPEUTIC TARGET FOR UREAL MELANOMA |
| CN107964045B (zh) * | 2017-12-18 | 2021-04-23 | 南京医科大学 | 一种人鼠嵌合抗CXCR2全分子IgG及其应用 |
| CA3096838A1 (en) | 2018-04-11 | 2019-10-17 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
| CA3102032A1 (en) * | 2018-06-05 | 2019-12-12 | Anji Pharma (Us) Llc | Compositions and methods for treating pancreatitis |
| JP2021526820A (ja) * | 2018-06-07 | 2021-10-11 | オンコワン・リサーチ・アンド・ディベロップメント・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 癌治療のための抗ｏｘＭＩＦ／抗ＣＤ３抗体 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| US11573228B2 (en) * | 2018-12-26 | 2023-02-07 | Colgate-Palmolive Company | Biomarkers of neutrophil deregulation as diagnostic for gingivitis |
| CN110133306B (zh) * | 2019-05-09 | 2023-04-07 | 北京勤邦生物技术有限公司 | 检测西马特罗的酶联免疫试剂盒及其应用 |
| WO2021183650A1 (en) | 2020-03-10 | 2021-09-16 | X4 Pharmaceuticals, Inc. | Methods for treating neutropenia |
| CN115996741A (zh) * | 2020-03-11 | 2023-04-21 | 百欧林纳克斯有限公司 | 用于治疗急性呼吸窘迫综合征及病毒感染的cxcr4抑制剂 |
| US20210338626A1 (en) * | 2020-04-28 | 2021-11-04 | Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch | Methods for treating or preventing a viral infection or inhibiting viral replication |
| EP4237002A4 (en) * | 2020-10-28 | 2025-02-12 | University Health Network | METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF |
| JP2024512499A (ja) * | 2021-03-22 | 2024-03-19 | クリップスビーエヌシー・カンパニー・リミテッド | 新規な組換えマイコバクテリウムスメグマチス菌株およびその用途 |
| WO2022217283A1 (en) | 2021-04-08 | 2022-10-13 | Joslin Diabetes Center, Inc. | Methods of diagnosing and predicting renal decline |
| KR102561554B1 (ko) * | 2021-04-14 | 2023-07-28 | 부산대학교 산학협력단 | 치주질환 진단용 바이오마커 조성물, 치주질환 치료 효용성 평가용 바이오마커 조성물 및 이를 이용한 진단키트 |
| EP4472735A2 (en) * | 2022-02-04 | 2024-12-11 | University of Pittsburgh - of the Commonwealth System of Higher Education | Methods of detecting and treating cerebral aneurysms |
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| WO2003047622A1 (fr) * | 2001-11-30 | 2003-06-12 | Jun Nishihira | Remedes pour la sclerose en plaques |
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| US20110256130A1 (en) * | 2008-12-01 | 2011-10-20 | Joshua Robert Schultz | Methods of treating inflammatory disorders |
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2010
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