CA2717365A1 - Methods of treating inflammation - Google Patents
Methods of treating inflammation Download PDFInfo
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- CA2717365A1 CA2717365A1 CA2717365A CA2717365A CA2717365A1 CA 2717365 A1 CA2717365 A1 CA 2717365A1 CA 2717365 A CA2717365 A CA 2717365A CA 2717365 A CA2717365 A CA 2717365A CA 2717365 A1 CA2717365 A1 CA 2717365A1
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- mif
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Landscapes
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| US61/121,095 | 2008-12-09 | ||
| PCT/US2009/037887 WO2009117710A2 (en) | 2008-03-20 | 2009-03-20 | Methods of treating inflammation |
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| TWI407964B (zh) * | 2011-05-10 | 2013-09-11 | Univ Fu Jen Catholic | 干擾性核糖核酸用於治療或減緩疼痛之用途 |
| EP2723380B1 (en) | 2011-06-24 | 2019-08-21 | Stephen D. Gillies | Light chain immunoglobulin fusion proteins and methods of use thereof |
| US10596233B2 (en) | 2011-06-30 | 2020-03-24 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| WO2013003786A1 (en) * | 2011-06-30 | 2013-01-03 | Dignity Health | Use of pertussis toxin as a therapeutic agent |
| EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
| CN102357249A (zh) * | 2011-10-26 | 2012-02-22 | 广州赫尔氏药物开发有限公司 | 能够抑制耐药性结核杆菌的药物 |
| DK2844250T3 (en) | 2012-05-01 | 2018-01-08 | Translatum Medicus Inc | METHODS OF TREATMENT AND DIAGNOSTICATION OF EYE DISEASES CONCERNING BLINDNESS |
| US10561676B2 (en) * | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US10316075B2 (en) | 2013-10-03 | 2019-06-11 | Oregon Health & Science University | Recombinant polypeptides comprising MHC class II α1 domains |
| EP3242685B1 (en) | 2015-01-09 | 2022-05-04 | AdAlta Limited | Cxcr4 binding molecules |
| TW201718851A (zh) * | 2015-09-18 | 2017-06-01 | 通用醫院公司 | 具有抗化學排斥(anti-fugetactic)性質之經修飾自然殺手細胞及其用途 |
| CA3008279A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| CA3008272A1 (en) * | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| BR112018068393A2 (pt) | 2016-03-11 | 2019-01-15 | Ardea Biosciences Inc | inibidores de cxcr-2 para o tratamento de distúrbios de artropatia por cristais |
| KR102645432B1 (ko) * | 2016-03-28 | 2024-03-11 | (주)아모레퍼시픽 | 피부 세포 분화 촉진용 조성물 및 피부 세포 분화 촉진 물질의 스크리닝 방법 |
| JP2019510785A (ja) | 2016-04-08 | 2019-04-18 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 癌を処置する方法 |
| EP3445402A4 (en) * | 2016-04-21 | 2019-12-11 | The Board Of Regents Of The University Of Texas System | METHOD AND COMPOSITIONS FOR DETECTING ANEURYSMS |
| JP7461741B2 (ja) | 2016-06-20 | 2024-04-04 | カイマブ・リミテッド | 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン |
| CA3027498A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| CN109890364B (zh) | 2016-10-03 | 2023-10-17 | 儿童医疗中心公司 | 糖尿病肾病的预防和治疗 |
| CN108355133A (zh) * | 2017-01-26 | 2018-08-03 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| WO2019084313A1 (en) * | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | USE OF SDHA AS PROGNOSTIC MARKER AND THERAPEUTIC TARGET FOR UREAL MELANOMA |
| CN107964045B (zh) * | 2017-12-18 | 2021-04-23 | 南京医科大学 | 一种人鼠嵌合抗CXCR2全分子IgG及其应用 |
| KR20210009315A (ko) | 2018-04-11 | 2021-01-26 | 오하이오 스테이트 이노베이션 파운데이션 | 안약 전달용 서방형 마이크로 입자를 이용한 방법 및 조성물 |
| US11679146B2 (en) | 2018-06-05 | 2023-06-20 | Anji Pharmaceuticals Inc. | Compositions and methods for treating pancreatitis |
| JP2021526820A (ja) * | 2018-06-07 | 2021-10-11 | オンコワン・リサーチ・アンド・ディベロップメント・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 癌治療のための抗ｏｘＭＩＦ／抗ＣＤ３抗体 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| EP3884277A1 (en) * | 2018-12-26 | 2021-09-29 | Colgate-Palmolive Company | Biomarkers of neutrophil deregulation as diagnostic for gingivitis |
| CN110133306B (zh) * | 2019-05-09 | 2023-04-07 | 北京勤邦生物技术有限公司 | 检测西马特罗的酶联免疫试剂盒及其应用 |
| EP4117662A4 (en) | 2020-03-10 | 2024-04-03 | X4 Pharmaceuticals, Inc. | METHODS OF TREATING NEUTROPENIA |
| MX2022011231A (es) * | 2020-03-11 | 2022-11-07 | Biolinerx Ltd | Inhibidor de cxcr4 para el tratamiento del sindrome de dificultad respiratoria aguda e infecciones virales. |
| WO2021219495A1 (en) * | 2020-04-28 | 2021-11-04 | Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch | Methods for treating or preventing a viral infection or inhibiting viral replication |
| CA3196362A1 (en) * | 2020-10-28 | 2022-05-05 | University Health Network (Uhn) | Methods of treating spondyloarthritis or symptoms thereof |
| KR102866709B1 (ko) * | 2021-03-22 | 2025-10-02 | 클립스비엔씨 주식회사 | 신규한 재조합 마이코박테리움 스메그마티스 균주 및 이의 용도 |
| EP4320445A1 (en) | 2021-04-08 | 2024-02-14 | Joslin Diabetes Center, Inc. | Methods of diagnosing and predicting renal decline |
| KR102561554B1 (ko) * | 2021-04-14 | 2023-07-28 | 부산대학교 산학협력단 | 치주질환 진단용 바이오마커 조성물, 치주질환 치료 효용성 평가용 바이오마커 조성물 및 이를 이용한 진단키트 |
| EP4472735A2 (en) * | 2022-02-04 | 2024-12-11 | University of Pittsburgh - of the Commonwealth System of Higher Education | Methods of detecting and treating cerebral aneurysms |
| WO2025171411A1 (en) * | 2024-02-09 | 2025-08-14 | Herophilus, Inc. | Compositions and methods related to modulating macrophage migration inhibitory factor (mif)-cd74 signaling and related treatments for neuroinflammatory conditions |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026307A1 (en) * | 1993-05-17 | 1994-11-24 | The Picower Institute For Medical Research | Inhibition of migration inhibitory factor in the treatment of diseases involving cytokine-mediated toxicity |
| US6030615A (en) * | 1993-05-17 | 2000-02-29 | The Picower Institute For Medical Research | Combination method for treating diseases caused by cytokine-mediated toxicity |
| US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
| CA2434671A1 (en) * | 2001-01-12 | 2002-09-06 | The Picower Institute For Medical Research | Methods and compositions for modulating regulation of the cytotoxic lymphocyte response by macrophage migration inhibitory factor |
| JP2003226653A (ja) * | 2001-11-30 | 2003-08-12 | Jun Nishihira | 多発性硬化症治療剤 |
| WO2003047622A1 (fr) * | 2001-11-30 | 2003-06-12 | Jun Nishihira | Remedes pour la sclerose en plaques |
| US6656168B2 (en) * | 2001-12-18 | 2003-12-02 | Kimberly-Clark Worldwide, Inc. | Feminine care product with discrete areas of a skin wellness additive |
| US20040009149A1 (en) * | 2002-02-27 | 2004-01-15 | Altman John D. | Multimeric binding complexes |
| JP4472351B2 (ja) * | 2002-03-01 | 2010-06-02 | イミューノメディクス、インコーポレイテッド | インターナライジング抗ｃｄ７４抗体およびその使用方法 |
| ES2364155T3 (es) * | 2002-11-25 | 2011-08-25 | Jallal Messadek | Composiciones de betaína y ácido acetilsalicílico. |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| US20050202010A1 (en) * | 2003-08-29 | 2005-09-15 | Giroir Brett P. | Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor |
| WO2005065328A2 (en) * | 2003-12-30 | 2005-07-21 | The United States Of America, As Represented By The Department Of Veterans Affairs | Macrophage migration inhibitory factor (mif) as marker for urological inflammatory disease |
| WO2006105666A1 (en) * | 2005-04-06 | 2006-10-12 | Queen's University At Kingston | Administration of macrophage targeted formulations of compounds which modulate cholesterol-metabolizing enzymes for treatment of atherosclerosis |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2007138961A1 (ja) * | 2006-05-29 | 2007-12-06 | Redox Bioscience Inc. | マクロファージ遊走阻止因子によって引き起こされる障害の予防乃至治療剤 |
| WO2009117706A2 (en) * | 2008-03-20 | 2009-09-24 | Carolus Therapeutics, Inc. | Methods of treatment using anti-mif antibodies |
| WO2009120186A1 (en) * | 2008-03-24 | 2009-10-01 | Carolus Therapeutics, Inc. | Methods and compositions for treating atherosclerosis and related conditions |
| US20100183598A1 (en) * | 2008-11-12 | 2010-07-22 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| WO2010065491A2 (en) * | 2008-12-01 | 2010-06-10 | Carolus Therapeutics, Inc. | Methods of treating inflammatory disorders |
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- 2009-03-20 CN CN200980109905XA patent/CN102046199A/zh active Pending
- 2009-03-20 EA EA201001529A patent/EA201001529A1/ru unknown
- 2009-03-20 AU AU2009225389A patent/AU2009225389A1/en not_active Abandoned
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- 2009-03-20 WO PCT/US2009/037887 patent/WO2009117710A2/en not_active Ceased
- 2009-03-20 KR KR1020107023480A patent/KR20110014141A/ko not_active Withdrawn
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- 2009-03-20 EP EP09721240A patent/EP2252318A4/en not_active Withdrawn
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| JP2011515416A (ja) | 2011-05-19 |
| US20110044988A1 (en) | 2011-02-24 |
| WO2009117706A3 (en) | 2010-01-21 |
| CO6300848A2 (es) | 2011-07-21 |
| AU2009225385A1 (en) | 2009-09-24 |
| EP2252318A2 (en) | 2010-11-24 |
| KR20110014141A (ko) | 2011-02-10 |
| WO2009117710A3 (en) | 2010-01-21 |
| CN102046199A (zh) | 2011-05-04 |
| WO2009117706A2 (en) | 2009-09-24 |
| WO2009117710A2 (en) | 2009-09-24 |
| EP2254597A2 (en) | 2010-12-01 |
| CA2717071A1 (en) | 2009-09-24 |
| EA201001529A1 (ru) | 2011-06-30 |
| EP2254597A4 (en) | 2012-04-18 |
| AU2009225389A1 (en) | 2009-09-24 |
| IL207752A0 (en) | 2010-12-30 |
| CN102088993A (zh) | 2011-06-08 |
| MX2010010198A (es) | 2010-12-21 |
| BRPI0910259A2 (pt) | 2015-12-01 |
| EP2252318A4 (en) | 2012-04-18 |
| JP2011526244A (ja) | 2011-10-06 |
| NZ588033A (en) | 2012-11-30 |
| US20110262386A1 (en) | 2011-10-27 |
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