JP2011530535A5 - - Google Patents
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- JP2011530535A5 JP2011530535A5 JP2011522277A JP2011522277A JP2011530535A5 JP 2011530535 A5 JP2011530535 A5 JP 2011530535A5 JP 2011522277 A JP2011522277 A JP 2011522277A JP 2011522277 A JP2011522277 A JP 2011522277A JP 2011530535 A5 JP2011530535 A5 JP 2011530535A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- disease
- composition
- vasculitis
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 17
- 230000003463 hyperproliferative effect Effects 0.000 claims description 14
- 206010047115 Vasculitis Diseases 0.000 claims description 9
- 206010009944 Colon cancer Diseases 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 6
- 208000020816 lung neoplasm Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- 208000032514 Leukocytoclastic vasculitis Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 4
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims description 4
- 201000004681 Psoriasis Diseases 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 4
- 201000007455 central nervous system cancer Diseases 0.000 claims description 4
- 208000029742 colonic neoplasm Diseases 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 230000002757 inflammatory effect Effects 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 208000014018 liver neoplasm Diseases 0.000 claims description 4
- 201000006417 multiple sclerosis Diseases 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000000651 prodrug Substances 0.000 claims description 4
- 229940002612 prodrug Drugs 0.000 claims description 4
- 208000037803 restenosis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 208000000649 small cell carcinoma Diseases 0.000 claims description 4
- 239000012453 solvate Substances 0.000 claims description 4
- 208000037804 stenosis Diseases 0.000 claims description 4
- 230000036262 stenosis Effects 0.000 claims description 4
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims description 2
- 208000033116 Asbestos intoxication Diseases 0.000 claims description 2
- 208000004300 Atrophic Gastritis Diseases 0.000 claims description 2
- 206010051341 Bile duct stenosis Diseases 0.000 claims description 2
- 206010006458 Bronchitis chronic Diseases 0.000 claims description 2
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010009137 Chronic sinusitis Diseases 0.000 claims description 2
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims description 2
- 208000015943 Coeliac disease Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 208000032170 Congenital Abnormalities Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims description 2
- 208000036495 Gastritis atrophic Diseases 0.000 claims description 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000011200 Kawasaki disease Diseases 0.000 claims description 2
- 208000034624 Leukocytoclastic Cutaneous Vasculitis Diseases 0.000 claims description 2
- 208000009525 Myocarditis Diseases 0.000 claims description 2
- 201000002481 Myositis Diseases 0.000 claims description 2
- 208000000592 Nasal Polyps Diseases 0.000 claims description 2
- 206010068786 Overlap syndrome Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010034277 Pemphigoid Diseases 0.000 claims description 2
- 201000011152 Pemphigus Diseases 0.000 claims description 2
- 206010035664 Pneumonia Diseases 0.000 claims description 2
- 206010036774 Proctitis Diseases 0.000 claims description 2
- 206010036783 Proctitis ulcerative Diseases 0.000 claims description 2
- 206010037549 Purpura Diseases 0.000 claims description 2
- 241001672981 Purpura Species 0.000 claims description 2
- 206010039705 Scleritis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 201000010001 Silicosis Diseases 0.000 claims description 2
- 241000272534 Struthio camelus Species 0.000 claims description 2
- 208000031737 Tissue Adhesions Diseases 0.000 claims description 2
- 206010052779 Transplant rejections Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 206010003441 asbestosis Diseases 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 208000000594 bullous pemphigoid Diseases 0.000 claims description 2
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims description 2
- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims description 2
- 210000001072 colon Anatomy 0.000 claims description 2
- 230000004154 complement system Effects 0.000 claims description 2
- 208000018631 connective tissue disease Diseases 0.000 claims description 2
- 230000003210 demyelinating effect Effects 0.000 claims description 2
- 201000001981 dermatomyositis Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 210000001198 duodenum Anatomy 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 208000007475 hemolytic anemia Diseases 0.000 claims description 2
- 230000009610 hypersensitivity Effects 0.000 claims description 2
- 201000006362 hypersensitivity vasculitis Diseases 0.000 claims description 2
- 208000001875 irritant dermatitis Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims description 2
- 208000016366 nasal cavity polyp Diseases 0.000 claims description 2
- 208000012028 nasolacrimal duct disease Diseases 0.000 claims description 2
- 230000001613 neoplastic effect Effects 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 208000004235 neutropenia Diseases 0.000 claims description 2
- 201000001976 pemphigus vulgaris Diseases 0.000 claims description 2
- 208000028169 periodontal disease Diseases 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 206010035653 pneumoconiosis Diseases 0.000 claims description 2
- 201000006292 polyarteritis nodosa Diseases 0.000 claims description 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 2
- 201000000742 primary sclerosing cholangitis Diseases 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 2
- 208000010157 sclerosing cholangitis Diseases 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 210000000813 small intestine Anatomy 0.000 claims description 2
- 206010043207 temporal arteritis Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 210000000653 nervous system Anatomy 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 7
- 208000035475 disorder Diseases 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- ABGCNXRYIJEOAK-UHFFFAOYSA-N CC1=CC2OC2OC1 Chemical compound CC1=CC2OC2OC1 ABGCNXRYIJEOAK-UHFFFAOYSA-N 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 210000000613 ear canal Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8701008P | 2008-08-07 | 2008-08-07 | |
| US61/087,010 | 2008-08-07 | ||
| PCT/US2009/053159 WO2010017480A1 (en) | 2008-08-07 | 2009-08-07 | Glycoside compounds and pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011530535A JP2011530535A (ja) | 2011-12-22 |
| JP2011530535A5 true JP2011530535A5 (enExample) | 2013-05-02 |
Family
ID=41663995
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522277A Pending JP2011530535A (ja) | 2008-08-07 | 2009-08-07 | グリコシド化合物およびその医薬組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US8361973B2 (enExample) |
| EP (1) | EP2320729B1 (enExample) |
| JP (1) | JP2011530535A (enExample) |
| WO (1) | WO2010017480A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011530535A (ja) | 2008-08-07 | 2011-12-22 | セントローズ， エルエルシー | グリコシド化合物およびその医薬組成物 |
| CA2809819A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| CN103980338B (zh) | 2010-01-15 | 2017-04-26 | 苏州润新生物科技有限公司 | 蟾蜍灵衍生物、其药物组合物及用途 |
| EP3453714B1 (en) | 2011-02-02 | 2020-11-04 | Suzhou Neupharma Co., Ltd | Cardenolide and bufadienolide 3-carbonate and 3-carbamate derivatives for the treatment of cancer and compositions thereof |
| WO2012122514A1 (en) * | 2011-03-09 | 2012-09-13 | Centrose, Llc | Extracellular targeted drug conjugates |
| EP2852285B1 (en) * | 2012-04-29 | 2018-08-08 | Neupharma, Inc. | Bufadienolide compounds substituted in position 3 by a heterocyclic amine for use in the treatment of cancer |
| RU2681730C2 (ru) | 2012-07-25 | 2019-03-12 | Селлдекс Терапьютикс Инк. | Антитела против kit и их применения |
| WO2017023760A1 (en) | 2015-07-31 | 2017-02-09 | Prudent James R | Extracellular drug conjugates targeting cd20 |
| JP6603551B2 (ja) * | 2015-11-11 | 2019-11-06 | 花王株式会社 | 毛成長抑制剤 |
| GB2586516B (en) | 2019-08-23 | 2022-07-06 | Imagination Tech Ltd | Random accessible image data compression |
| WO2021054978A1 (en) * | 2019-09-20 | 2021-03-25 | Pollard Bette Silver | Cardiac cardenolides to reduce fibrosis and enhance epithelial differentiation |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3987031A (en) * | 1970-12-23 | 1976-10-19 | Boehringer Ingelheim Gmbh | Acyl derivatives of proscillaridin a |
| DE2254060A1 (de) * | 1972-11-04 | 1974-05-16 | Hoechst Ag | Cardenolid-3-eckige klammer auf 4'-amino-2',3',4'-tridesoxy-glykoside eckige klammer zu und verfahren zu ihrer herstellung |
| DE2319874C2 (de) * | 1973-04-19 | 1983-06-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Derivate des Digitoxigenin-α-L-arabinosids, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| IT1147806B (it) * | 1981-01-23 | 1986-11-26 | Wellcome Found | Complessi di ciclodestrine e glicosidi cardiaci per uso terapeutico e procedimento di preparazione |
| GB8600491D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid derivatives |
| US5280113A (en) * | 1989-08-16 | 1994-01-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| JP3826235B2 (ja) * | 1994-06-10 | 2006-09-27 | 松森 昭 | 炎症性サイトカイン分泌抑制剤 |
| US5668272A (en) * | 1995-06-30 | 1997-09-16 | National Research Council Of Canada | Method for producing synthetic N-linked glycoconjugates |
| US6180612B1 (en) * | 1997-10-31 | 2001-01-30 | The University Of Virginia Patent Foundation | Methods and compositions for targeting DNA metabolic processes using aminoglycoside derivatives |
| CA2362917C (en) * | 1999-02-12 | 2003-08-05 | Compass Pharmaceuticals, Llc | Methods for anti-tumor therapy |
| AU2001282088A1 (en) * | 2000-08-17 | 2002-02-25 | Terness, Peter | Immunosuppressive, antiinflammatory and analgetic compounds |
| WO2003000201A2 (en) | 2001-06-25 | 2003-01-03 | Drug Innovation & Design, Incorporated | Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| WO2004087121A2 (en) * | 2003-03-28 | 2004-10-14 | Azaya Therapeutics, Inc. | Water soluble formulations of digitalis glycosides for treating cell-proliferative and other diseases |
| WO2006002381A1 (en) * | 2004-06-24 | 2006-01-05 | Wisconsin Alumni Research Foundation | Neoglycorandomization and digitoxin analogs |
| JP2007008879A (ja) * | 2005-06-30 | 2007-01-18 | Yanbaru Green Health:Kk | 抗腫瘍剤及びこれを含有する食品 |
| US7402325B2 (en) * | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| CA2635370A1 (en) * | 2006-01-09 | 2007-07-09 | Btg International Limited | Modulators of hypoxia inducible factor-1 and related uses |
| CN101505795B (zh) | 2006-07-03 | 2013-02-13 | 查尔斯·戴维·阿代尔 | 用于调节细胞粘附分子表达的组合物 |
| EP2129399A1 (en) | 2007-03-28 | 2009-12-09 | Novartis Ag | Fxdy5 modulators for treating, diagnosing, and detecting cancer |
| JP2011530535A (ja) | 2008-08-07 | 2011-12-22 | セントローズ， エルエルシー | グリコシド化合物およびその医薬組成物 |
-
2009
- 2009-08-07 JP JP2011522277A patent/JP2011530535A/ja active Pending
- 2009-08-07 WO PCT/US2009/053159 patent/WO2010017480A1/en not_active Ceased
- 2009-08-07 EP EP20090805612 patent/EP2320729B1/en active Active
- 2009-08-07 US US13/057,961 patent/US8361973B2/en active Active
-
2012
- 2012-12-27 US US13/728,639 patent/US8703723B2/en active Active
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