JP2009530283A5 - - Google Patents

Info

Publication number

JP2009530283A5

JP2009530283A5 JP2009500436A JP2009500436A JP2009530283A5 JP 2009530283 A5 JP2009530283 A5 JP 2009530283A5 JP 2009500436 A JP2009500436 A JP 2009500436A JP 2009500436 A JP2009500436 A JP 2009500436A JP 2009530283 A5 JP2009530283 A5 JP 2009530283A5

Authority

JP

Japan

Prior art keywords

composition

optionally substituted

hydrogen

aliphatic

hydroxy

Prior art date

2007-03-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 229910052739 hydrogen Inorganic materials 0.000 claims 21
• 239000001257 hydrogen Substances 0.000 claims 21
• 125000001931 aliphatic group Chemical group 0.000 claims 20
• 150000001875 compounds Chemical class 0.000 claims 14
• 150000002431 hydrogen Chemical class 0.000 claims 13
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 13
• -1 furan-yl Chemical group 0.000 claims 12
• 125000005843 halogen group Chemical group 0.000 claims 10
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 8
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 206010061218 Inflammation Diseases 0.000 claims 6
• 230000004054 inflammatory process Effects 0.000 claims 6
• 230000001404 mediated effect Effects 0.000 claims 6
• 230000002503 metabolic effect Effects 0.000 claims 6
• 150000003839 salts Chemical class 0.000 claims 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
• 125000005842 heteroatom Chemical group 0.000 claims 4
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
• 125000004043 oxo group Chemical group O=* 0.000 claims 3
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000000304 alkynyl group Chemical group 0.000 claims 2
• 201000006417 multiple sclerosis Diseases 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
• 208000004611 Abdominal Obesity Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
• 206010065941 Central obesity Diseases 0.000 claims 1
• 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 208000027866 inflammatory disease Diseases 0.000 claims 1
• ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 1
• 206010025135 lupus erythematosus Diseases 0.000 claims 1
• 206010028417 myasthenia gravis Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 0 *Cc1cnc([C@@](*)COc2ccc(CC(*)(C([C@@](*)C3)=O)SC3=O)cc2)cc1 Chemical compound *Cc1cnc([C@@](*)COc2ccc(CC(*)(C([C@@](*)C3)=O)SC3=O)cc2)cc1 0.000 description 1