CN101454005B - 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 - Google Patents

用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 Download PDF

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CN101454005B
CN101454005B CN2007800177654A CN200780017765A CN101454005B CN 101454005 B CN101454005 B CN 101454005B CN 2007800177654 A CN2007800177654 A CN 2007800177654A CN 200780017765 A CN200780017765 A CN 200780017765A CN 101454005 B CN101454005 B CN 101454005B
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aliphatic
compound
alkyl
heteroaryl
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CN101454005A (zh
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杰拉尔德·R·科尔卡
罗尔夫·F·克莱齐恩
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Metabolic Solutions Development Co LLC
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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CN2007800177654A 2006-03-16 2007-03-14 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 Expired - Fee Related CN101454005B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78289406P 2006-03-16 2006-03-16
US60/782,894 2006-03-16
PCT/US2007/006321 WO2007109024A2 (en) 2006-03-16 2007-03-14 Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease

Publications (2)

Publication Number Publication Date
CN101454005A CN101454005A (zh) 2009-06-10
CN101454005B true CN101454005B (zh) 2013-01-02

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US (4) US20090143442A1 (enExample)
EP (3) EP2902026B1 (enExample)
JP (2) JP5269758B2 (enExample)
KR (1) KR101475955B1 (enExample)
CN (1) CN101454005B (enExample)
AU (1) AU2007227581B2 (enExample)
CA (1) CA2646207C (enExample)
ES (2) ES2654908T3 (enExample)
HU (1) HUE035314T2 (enExample)
MX (2) MX356584B (enExample)
NZ (1) NZ571871A (enExample)
PL (2) PL2001468T3 (enExample)
RU (1) RU2445957C2 (enExample)
UA (1) UA96441C2 (enExample)
WO (1) WO2007109024A2 (enExample)

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EP2902026B1 (en) 2006-03-16 2017-10-04 Metabolic Solutions Development Company LLC Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease
CN101454006B (zh) 2006-03-16 2012-12-26 新陈代谢解决方案开发公司 用于治疗高血压以及用于降低血脂的噻唑烷二酮类似物
CA2646170A1 (en) * 2006-03-16 2007-09-27 Metabolic Solutions Development Company Combination therapies of thiazolidinedione analogues and glucocorticoid agonists
CN101848901B (zh) 2007-09-14 2012-11-21 新陈代谢解决方案开发公司 用于治疗高血压的噻唑烷二酮类似物
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US8912335B2 (en) * 2009-12-15 2014-12-16 Metabolic Solutions Development Company, Llc PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
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KR101857307B1 (ko) 2010-08-10 2018-05-11 메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨 티아졸리딘디온 화합물의 합성법
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WO2012149083A1 (en) * 2011-04-28 2012-11-01 Metabolic Solutions Development Company, Llc Ppar-sparing thiazolidinediones for the treatment of kidney related diseases
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WO2014046474A2 (ko) * 2012-09-21 2014-03-27 가톨릭대학교 산학협력단 메트포민을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 조성물
KR101501375B1 (ko) 2012-09-21 2015-03-10 가톨릭대학교 산학협력단 메트포민을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 조성물
US20160051529A1 (en) * 2012-12-11 2016-02-25 Metabolic Solutions Development Company Llc Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative and other metabolic diseases
CA2941562C (en) 2013-03-14 2021-09-21 Deuterx, Llc Deuterium-enriched 2,4-thiazolidinediones and methods of treatment
MX2016000724A (es) 2013-07-22 2016-04-13 Metabolic Solutions Dev Co Llc Compuestos de reserva de los receptores activados del proliferador de peroxisoma (ppar) para el tratamiento de enfermedades metabolicas.
ES2831326T3 (es) 2014-01-15 2021-06-08 Poxel Sa Métodos para tratar trastornos neurológicos, metabólicos y otros mediante el uso de pioglitazona enantiopura enriquecida con deuterio
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MX379710B (es) 2016-12-01 2025-03-11 Minoryx Therapeutics S L 5-[[4-[2-[5-(1-hidroxietil)piridin-2-il]etoxi]fenil]metil]]-1,3-tiazolidin-2,4-diona para el tratamiento de enfermedad de higado graso no alcoholico.
US11767317B1 (en) 2020-06-30 2023-09-26 Poxel Sa Methods of synthesizing enantiopure deuterium-enriched pioglitazone
US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
GB202210503D0 (en) 2022-07-18 2022-08-31 Univ Court Univ Of Glasgow Materials and methods for treatment of chronic myeloid leukemia (CML)

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PL2902026T3 (pl) 2018-03-30
CN101454005A (zh) 2009-06-10
CA2646207C (en) 2016-01-19
WO2007109024A2 (en) 2007-09-27
MX2008011871A (es) 2009-02-10
RU2445957C2 (ru) 2012-03-27
EP2902026B1 (en) 2017-10-04
UA96441C2 (ru) 2011-11-10
PL2001468T3 (pl) 2013-03-29
US20150190385A1 (en) 2015-07-09
EP2902026A1 (en) 2015-08-05
NZ571871A (en) 2011-07-29
US8389556B2 (en) 2013-03-05
EP2486926A1 (en) 2012-08-15
EP2001468B1 (en) 2012-10-31
MX356584B (es) 2018-06-05
ES2397944T3 (es) 2013-03-12
US20120015982A1 (en) 2012-01-19
HUE035314T2 (en) 2018-05-02
CA2646207A1 (en) 2007-09-27
JP2009530283A (ja) 2009-08-27
KR20090037381A (ko) 2009-04-15
KR101475955B1 (ko) 2014-12-23
EP2001468A2 (en) 2008-12-17
JP2013100371A (ja) 2013-05-23
US20130203820A1 (en) 2013-08-08
US20090143442A1 (en) 2009-06-04
US9155729B2 (en) 2015-10-13
ES2654908T8 (es) 2018-04-11
AU2007227581A1 (en) 2007-09-27
AU2007227581B2 (en) 2012-11-08
JP5269758B2 (ja) 2013-08-21
WO2007109024A3 (en) 2007-11-15
ES2654908T3 (es) 2018-02-15
RU2008140943A (ru) 2010-04-27

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