CN101454005B - 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 - Google Patents

用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 Download PDF

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CN101454005B
CN101454005B CN2007800177654A CN200780017765A CN101454005B CN 101454005 B CN101454005 B CN 101454005B CN 2007800177654 A CN2007800177654 A CN 2007800177654A CN 200780017765 A CN200780017765 A CN 200780017765A CN 101454005 B CN101454005 B CN 101454005B
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aliphatic
compound
alkyl
heteroaryl
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CN101454005A (zh
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杰拉尔德·R·科尔卡
罗尔夫·F·克莱齐恩
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Metabolic Solutions Development Co LLC
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Transplantation (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2007800177654A 2006-03-16 2007-03-14 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 Expired - Fee Related CN101454005B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78289406P 2006-03-16 2006-03-16
US60/782,894 2006-03-16
PCT/US2007/006321 WO2007109024A2 (en) 2006-03-16 2007-03-14 Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease

Publications (2)

Publication Number Publication Date
CN101454005A CN101454005A (zh) 2009-06-10
CN101454005B true CN101454005B (zh) 2013-01-02

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CN2007800177654A Expired - Fee Related CN101454005B (zh) 2006-03-16 2007-03-14 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物

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US (4) US20090143442A1 (enExample)
EP (3) EP2902026B1 (enExample)
JP (2) JP5269758B2 (enExample)
KR (1) KR101475955B1 (enExample)
CN (1) CN101454005B (enExample)
AU (1) AU2007227581B2 (enExample)
CA (1) CA2646207C (enExample)
ES (2) ES2397944T3 (enExample)
HU (1) HUE035314T2 (enExample)
MX (2) MX356584B (enExample)
NZ (1) NZ571871A (enExample)
PL (2) PL2902026T3 (enExample)
RU (1) RU2445957C2 (enExample)
UA (1) UA96441C2 (enExample)
WO (1) WO2007109024A2 (enExample)

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NZ597381A (en) 2007-09-14 2013-03-28 Metabolic Solutions Dev Co Llc Thiazolidinedione analogues for the treatment of diabetes and inflammatory diseases
US8304441B2 (en) 2007-09-14 2012-11-06 Metabolic Solutions Development Company, Llc Thiazolidinedione analogues for the treatment of metabolic diseases
US8722710B2 (en) 2007-09-26 2014-05-13 Deuterx, Llc Deuterium-enriched pioglitazone
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CA2783556C (en) * 2009-12-15 2017-12-12 Metabolic Solutions Development Company, Llc Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases
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EP2560956B1 (en) 2010-04-19 2016-10-26 Octeta Therapeutics, LLC Novel synthesis for thiazolidinedione compounds
HUE031424T2 (en) 2010-08-10 2017-07-28 Octeta Therapeutics Llc New synthesis of thiazolidinedione compounds
PL2603507T3 (pl) * 2010-08-10 2016-12-30 Synteza związków tiazolidynodionu
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
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KR20130015932A (ko) * 2011-08-05 2013-02-14 연세대학교 산학협력단 저용량의 치아졸리딘다이온을 포함하는 알츠하이머 병 치료용 약학조성물
KR101501375B1 (ko) 2012-09-21 2015-03-10 가톨릭대학교 산학협력단 메트포민을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 조성물
WO2014046474A2 (ko) * 2012-09-21 2014-03-27 가톨릭대학교 산학협력단 메트포민을 유효성분으로 함유하는 염증성 장질환의 예방 또는 치료용 조성물
EP2931274A1 (en) * 2012-12-11 2015-10-21 Metabolic Solutions Development Company LLC Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases
JP6800013B2 (ja) * 2013-03-14 2020-12-16 ポクセル・ソシエテ・アノニムＰｏｘｅｌ ＳＡ 重水素化２，４−チアゾリジンジオン及び治療方法
JP6498195B2 (ja) 2013-07-22 2019-04-10 メタボリック ソリューションズ ディベロップメント カンパニー， エルエルシー 代謝疾患を処置するためのｐｐａｒ節約化合物
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US11319313B2 (en) 2020-06-30 2022-05-03 Poxel Sa Crystalline forms of deuterium-enriched pioglitazone
GB202210503D0 (en) 2022-07-18 2022-08-31 Univ Court Univ Of Glasgow Materials and methods for treatment of chronic myeloid leukemia (CML)

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US9155729B2 (en) 2015-10-13
RU2445957C2 (ru) 2012-03-27
EP2902026A1 (en) 2015-08-05
MX356584B (es) 2018-06-05
HUE035314T2 (en) 2018-05-02
NZ571871A (en) 2011-07-29
US8389556B2 (en) 2013-03-05
JP2013100371A (ja) 2013-05-23
WO2007109024A3 (en) 2007-11-15
ES2654908T3 (es) 2018-02-15
US20090143442A1 (en) 2009-06-04
UA96441C2 (ru) 2011-11-10
US20150190385A1 (en) 2015-07-09
CA2646207C (en) 2016-01-19
PL2001468T3 (pl) 2013-03-29
CA2646207A1 (en) 2007-09-27
US20130203820A1 (en) 2013-08-08
CN101454005A (zh) 2009-06-10
EP2001468B1 (en) 2012-10-31
ES2654908T8 (es) 2018-04-11
EP2902026B1 (en) 2017-10-04
AU2007227581A1 (en) 2007-09-27
RU2008140943A (ru) 2010-04-27
MX2008011871A (es) 2009-02-10
WO2007109024A2 (en) 2007-09-27
EP2486926A1 (en) 2012-08-15
JP2009530283A (ja) 2009-08-27
KR101475955B1 (ko) 2014-12-23
US20120015982A1 (en) 2012-01-19
JP5269758B2 (ja) 2013-08-21
PL2902026T3 (pl) 2018-03-30
EP2001468A2 (en) 2008-12-17
KR20090037381A (ko) 2009-04-15
AU2007227581B2 (en) 2012-11-08
ES2397944T3 (es) 2013-03-12

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