WO2008096870A1 - アザ架橋環化合物 - Google Patents
アザ架橋環化合物 Download PDFInfo
- Publication number
- WO2008096870A1 WO2008096870A1 PCT/JP2008/052189 JP2008052189W WO2008096870A1 WO 2008096870 A1 WO2008096870 A1 WO 2008096870A1 JP 2008052189 W JP2008052189 W JP 2008052189W WO 2008096870 A1 WO2008096870 A1 WO 2008096870A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aza
- bridged
- muscarinic
- receptor
- antagonistic activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020097018755A KR20090107567A (ko) | 2007-02-09 | 2008-02-08 | 아자 가교환 화합물 |
CA002678193A CA2678193A1 (en) | 2007-02-09 | 2008-02-08 | Aza-bridged-ring compound |
JP2008557177A JP5293192B2 (ja) | 2007-02-09 | 2008-02-08 | アザ架橋環化合物 |
EP08711068A EP2119716A4 (en) | 2007-02-09 | 2008-02-08 | AZA BRIDGE CYCLE COMPOUND |
US12/524,758 US8367696B2 (en) | 2007-02-09 | 2008-02-08 | Aza-bridged-ring compound |
AU2008212171A AU2008212171A1 (en) | 2007-02-09 | 2008-02-08 | Aza-bridged-ring compound |
MX2009008509A MX2009008509A (es) | 2007-02-09 | 2008-02-08 | Compuesto de anillo puenteado-aza. |
CN2008800044089A CN101605784B (zh) | 2007-02-09 | 2008-02-08 | 氮杂桥环化合物 |
BRPI0806972-7A2A BRPI0806972A2 (pt) | 2007-02-09 | 2008-02-08 | Composto cíclico contendo ponte azo |
IL200152A IL200152A0 (en) | 2007-02-09 | 2009-07-30 | Aza-bridged-ring compound |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-030963 | 2007-02-09 | ||
JP2007030963 | 2007-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008096870A1 true WO2008096870A1 (ja) | 2008-08-14 |
Family
ID=39681769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/052189 WO2008096870A1 (ja) | 2007-02-09 | 2008-02-08 | アザ架橋環化合物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8367696B2 (ja) |
EP (1) | EP2119716A4 (ja) |
JP (1) | JP5293192B2 (ja) |
KR (1) | KR20090107567A (ja) |
CN (1) | CN101605784B (ja) |
AU (1) | AU2008212171A1 (ja) |
BR (1) | BRPI0806972A2 (ja) |
CA (1) | CA2678193A1 (ja) |
IL (1) | IL200152A0 (ja) |
MX (1) | MX2009008509A (ja) |
RU (1) | RU2441868C2 (ja) |
WO (1) | WO2008096870A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
WO2014051055A1 (ja) * | 2012-09-28 | 2014-04-03 | 東レ株式会社 | キヌクリジンウレア誘導体及びその医薬用途 |
JP2015527406A (ja) * | 2012-09-11 | 2015-09-17 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤 |
JP2016525571A (ja) * | 2013-07-30 | 2016-08-25 | ドン−ア エスティ カンパニー リミテッド | 新規なビフェニル誘導体及びその製造方法 |
JP2016528199A (ja) * | 2013-07-13 | 2016-09-15 | ベイジン エフエスウェルカム テクノロジー ディベロップメント カンパニー リミテッド | キニン系化合物、その光学異性体及びその製造方法と医薬用途 |
US9464078B2 (en) | 2010-09-23 | 2016-10-11 | Abbvie Inc. | Monohydrate of azaadamantane derivatives |
WO2017114377A1 (zh) * | 2015-12-29 | 2017-07-06 | 四川海思科制药有限公司 | 一种苯基杂环衍生物及其在医药上的用途 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2679870A1 (en) * | 2007-03-23 | 2008-10-02 | Abbott Laboratories | Azaadamantane ester and carbamate derivatives and methods of use thereof |
SG11201901431PA (en) | 2016-08-26 | 2019-03-28 | Dong A St Co Ltd | Novel salt of (r)-(1-methylpyrrolidine-3-yl)methyl(3'-chloro-4'-fluoro-[1,1'-biphenyl]-2-yl)carbamate and a crystal form thereof |
KR102239776B1 (ko) * | 2016-08-26 | 2021-04-13 | 동아에스티 주식회사 | (r)-(1-메틸피롤리딘-3-일)메틸(3'-클로로-4'-플루오로-[1,1'-비페닐]-2-일)카바메이트의 신규염 및 이의 결정형 |
WO2019096226A1 (en) | 2017-11-16 | 2019-05-23 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Pasylated vegfr/pdgfr fusion proteins and their use in therapy |
JP2021505569A (ja) | 2017-12-04 | 2021-02-18 | フリードリヒ−アレクサンダー−ウニヴェルシテート エアランゲン−ニュルンベルク | M2よりもm3に対して選択性を有するフルオロフェニル置換ムスカリン受容体リガンド |
EP4185267A1 (en) | 2020-07-24 | 2023-05-31 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63290878A (ja) | 1987-04-15 | 1988-11-28 | ビーチャム・グループ・ピーエルシー | 新規化合物、その製法及びそれを含む医薬組成物 |
WO1995006635A1 (fr) | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de carbamate et medicament le contenant |
WO1995021820A1 (fr) | 1994-02-10 | 1995-08-17 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive du carbamate et composition correspondante |
JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
US5834499A (en) | 1994-03-11 | 1998-11-10 | Yamanouchi Pharmaceutical Co., Ltd. | 5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof |
JP2001521033A (ja) | 1997-10-29 | 2001-11-06 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 抗菌物質としてのプレウロムチリン誘導体 |
JP2003516391A (ja) * | 1999-12-07 | 2003-05-13 | セラヴァンス インコーポレーテッド | ムスカリン性レセプターアンタゴニスト活性を有するウレア化合物 |
JP2004530641A (ja) * | 2000-12-22 | 2004-10-07 | アルミラル・プロデスフアルマ・アクチエンゲゼルシヤフト | キヌクリジンカルバメート誘導体およびm3アンダゴニストとしてのそれらの使用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1140447A (zh) * | 1994-02-10 | 1997-01-15 | 山之内制药株式会社 | 新的氨基甲酸酯衍生物及其药物组合物 |
SE9600683D0 (sv) * | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
ATE260277T1 (de) | 2000-06-27 | 2004-03-15 | S A L V A T Lab Sa | Von arylalkylaminen abgeleitete carbamate |
AU2002238471B2 (en) | 2000-12-28 | 2007-06-28 | Almirall, S.A. | Quinuclidine derivatives and their use as M3 antagonists |
JP2003267977A (ja) * | 2002-03-14 | 2003-09-25 | Yamanouchi Pharmaceut Co Ltd | キヌクリジン誘導体 |
ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
AR040779A1 (es) | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Compuesto de tiazol anilina su uso para preparar una formulacion farmaceutica dicha formulacion recipiente que la contiene y dispositivo adaptado para la administracion intranasal de la formulacion |
DE10255040A1 (de) | 2002-11-26 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Carbaminsäureester mit anticholinerger Wirksamkeit |
TW200538095A (en) | 2004-03-11 | 2005-12-01 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
JP2008505118A (ja) | 2004-06-30 | 2008-02-21 | グラクソ グループ リミテッド | ムスカリン性アセチルコリン受容体アンタゴニスト |
EP1904446A2 (en) | 2005-07-11 | 2008-04-02 | Ranbaxy Laboratories Limited | Azabicyclo derivatives as muscarinic receptor antagonists |
WO2008041184A2 (en) | 2006-10-03 | 2008-04-10 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
-
2008
- 2008-02-08 US US12/524,758 patent/US8367696B2/en active Active
- 2008-02-08 CA CA002678193A patent/CA2678193A1/en not_active Abandoned
- 2008-02-08 EP EP08711068A patent/EP2119716A4/en not_active Withdrawn
- 2008-02-08 MX MX2009008509A patent/MX2009008509A/es not_active Application Discontinuation
- 2008-02-08 CN CN2008800044089A patent/CN101605784B/zh not_active Expired - Fee Related
- 2008-02-08 BR BRPI0806972-7A2A patent/BRPI0806972A2/pt not_active IP Right Cessation
- 2008-02-08 WO PCT/JP2008/052189 patent/WO2008096870A1/ja active Application Filing
- 2008-02-08 RU RU2009133781/04A patent/RU2441868C2/ru not_active IP Right Cessation
- 2008-02-08 AU AU2008212171A patent/AU2008212171A1/en not_active Abandoned
- 2008-02-08 KR KR1020097018755A patent/KR20090107567A/ko not_active Application Discontinuation
- 2008-02-08 JP JP2008557177A patent/JP5293192B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-30 IL IL200152A patent/IL200152A0/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63290878A (ja) | 1987-04-15 | 1988-11-28 | ビーチャム・グループ・ピーエルシー | 新規化合物、その製法及びそれを含む医薬組成物 |
WO1995006635A1 (fr) | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de carbamate et medicament le contenant |
WO1995021820A1 (fr) | 1994-02-10 | 1995-08-17 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveau derive du carbamate et composition correspondante |
US5834499A (en) | 1994-03-11 | 1998-11-10 | Yamanouchi Pharmaceutical Co., Ltd. | 5-HT3 receptor agonist, novel thiazole derivative and intermediate thereof |
JPH08198751A (ja) * | 1995-01-19 | 1996-08-06 | Yamanouchi Pharmaceut Co Ltd | カルバメート誘導体 |
JP2001521033A (ja) | 1997-10-29 | 2001-11-06 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 抗菌物質としてのプレウロムチリン誘導体 |
JP2003516391A (ja) * | 1999-12-07 | 2003-05-13 | セラヴァンス インコーポレーテッド | ムスカリン性レセプターアンタゴニスト活性を有するウレア化合物 |
JP2004530641A (ja) * | 2000-12-22 | 2004-10-07 | アルミラル・プロデスフアルマ・アクチエンゲゼルシヤフト | キヌクリジンカルバメート誘導体およびm3アンダゴニストとしてのそれらの使用 |
Non-Patent Citations (12)
Title |
---|
"Greene's Protective Groups in Organic Synthesis", 2006 |
AMERICAN JOURNAL RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 158, 1998, pages 154S - 160S |
AMERICAN JOURNAL RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 163, 2001, pages 1256 - 1276 |
JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1990, pages 2690 - 2697 |
JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, 1993, pages 683 - 689 |
KIM ET AL., SYNLETT., 1999, pages 1239 |
LIFE SCIENCE, vol. 64, no. 6-7, 1999, pages 449 - 455 |
LYAKUHIN NO KAIHATSU (DEVELOPMENT OF MEDICINES), vol. 7, 1990, pages 163 - 198 |
PHARMACOLOGY AND THERAPEUTICS, vol. 58, 1993, pages 319 - 379 |
PROG. MED., vol. 5, 1985, pages 2157 - 2161 |
See also references of EP2119716A4 |
TSUBOI ET AL., BULLETIN OF CHEMICAL SOCIETY OF JAPAN, vol. 60, 1987, pages 2475 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US8987453B2 (en) | 2006-11-06 | 2015-03-24 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US9464078B2 (en) | 2010-09-23 | 2016-10-11 | Abbvie Inc. | Monohydrate of azaadamantane derivatives |
JP2015527406A (ja) * | 2012-09-11 | 2015-09-17 | ジェンザイム・コーポレーション | グルコシルセラミド合成酵素阻害剤 |
WO2014051055A1 (ja) * | 2012-09-28 | 2014-04-03 | 東レ株式会社 | キヌクリジンウレア誘導体及びその医薬用途 |
JP2016528199A (ja) * | 2013-07-13 | 2016-09-15 | ベイジン エフエスウェルカム テクノロジー ディベロップメント カンパニー リミテッド | キニン系化合物、その光学異性体及びその製造方法と医薬用途 |
JP2016525571A (ja) * | 2013-07-30 | 2016-08-25 | ドン−ア エスティ カンパニー リミテッド | 新規なビフェニル誘導体及びその製造方法 |
WO2017114377A1 (zh) * | 2015-12-29 | 2017-07-06 | 四川海思科制药有限公司 | 一种苯基杂环衍生物及其在医药上的用途 |
Also Published As
Publication number | Publication date |
---|---|
KR20090107567A (ko) | 2009-10-13 |
RU2009133781A (ru) | 2011-03-20 |
CA2678193A1 (en) | 2008-08-14 |
AU2008212171A1 (en) | 2008-08-14 |
EP2119716A1 (en) | 2009-11-18 |
CN101605784B (zh) | 2013-04-10 |
MX2009008509A (es) | 2009-08-20 |
US20100105658A1 (en) | 2010-04-29 |
RU2441868C2 (ru) | 2012-02-10 |
JPWO2008096870A1 (ja) | 2010-05-27 |
CN101605784A (zh) | 2009-12-16 |
BRPI0806972A2 (pt) | 2014-04-08 |
JP5293192B2 (ja) | 2013-09-18 |
IL200152A0 (en) | 2010-04-15 |
US8367696B2 (en) | 2013-02-05 |
EP2119716A4 (en) | 2011-06-01 |
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