JP2013533314A5 - - Google Patents
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- JP2013533314A5 JP2013533314A5 JP2013524147A JP2013524147A JP2013533314A5 JP 2013533314 A5 JP2013533314 A5 JP 2013533314A5 JP 2013524147 A JP2013524147 A JP 2013524147A JP 2013524147 A JP2013524147 A JP 2013524147A JP 2013533314 A5 JP2013533314 A5 JP 2013533314A5
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- 150000001875 compounds Chemical class 0.000 claims description 28
- 239000007787 solid Substances 0.000 claims description 28
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 6
- 229940125782 compound 2 Drugs 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 150000003839 salts Chemical group 0.000 description 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- KXBDTLQSDKGAEB-UHFFFAOYSA-N COCCOc(cc1)ccc1Nc(nc1)nc(Nc2cccc(NC(C=C)=O)c2)c1F Chemical compound COCCOc(cc1)ccc1Nc(nc1)nc(Nc2cccc(NC(C=C)=O)c2)c1F KXBDTLQSDKGAEB-UHFFFAOYSA-N 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
- JEHKKBHWRAXMCH-UHFFFAOYSA-N OS(c1ccccc1)=O Chemical compound OS(c1ccccc1)=O JEHKKBHWRAXMCH-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000009277 hairy cell leukemia Diseases 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 230000009424 thromboembolic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37234910P | 2010-08-10 | 2010-08-10 | |
| US61/372,349 | 2010-08-10 | ||
| PCT/US2011/046926 WO2012021444A1 (en) | 2010-08-10 | 2011-08-08 | Besylate salt of a btk inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013533314A JP2013533314A (ja) | 2013-08-22 |
| JP2013533314A5 true JP2013533314A5 (enExample) | 2014-09-18 |
| JP6068340B2 JP6068340B2 (ja) | 2017-01-25 |
Family
ID=45567913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524147A Expired - Fee Related JP6068340B2 (ja) | 2010-08-10 | 2011-08-08 | Ｂｔｋ阻害剤のベシル酸塩 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8563568B2 (enExample) |
| EP (2) | EP2603081B1 (enExample) |
| JP (1) | JP6068340B2 (enExample) |
| KR (1) | KR20130099040A (enExample) |
| CN (2) | CN105566229A (enExample) |
| AR (1) | AR082600A1 (enExample) |
| AU (1) | AU2011289604C1 (enExample) |
| BR (1) | BR112013003388A2 (enExample) |
| CA (1) | CA2807051A1 (enExample) |
| DK (1) | DK2603081T3 (enExample) |
| ES (1) | ES2617763T3 (enExample) |
| IL (1) | IL224271A (enExample) |
| MX (1) | MX336875B (enExample) |
| MY (1) | MY160734A (enExample) |
| NZ (1) | NZ607845A (enExample) |
| PH (1) | PH12013500246A1 (enExample) |
| PT (1) | PT2603081T (enExample) |
| RU (1) | RU2013109393A (enExample) |
| SG (1) | SG187796A1 (enExample) |
| TW (1) | TWI533872B (enExample) |
| WO (1) | WO2012021444A1 (enExample) |
| ZA (1) | ZA201301802B (enExample) |
Families Citing this family (94)
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| EP2529621B1 (en) | 2006-09-22 | 2016-10-05 | Pharmacyclics LLC | Inhibitors of bruton's tyrosine kinase |
| US20120101114A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
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| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
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| EP3311818A3 (en) | 2008-07-16 | 2018-07-18 | Pharmacyclics, LLC | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
| NZ620174A (en) | 2009-09-16 | 2016-08-26 | Celgene Avilomics Res Inc | Protein kinase conjugates and inhibitors |
| EP2519664A4 (en) | 2009-12-30 | 2014-03-12 | Avila Therapeutics Inc | LIGAND-RELATED COVALENTS MODIFYING A PROTEIN |
| EA031737B1 (ru) | 2010-06-03 | 2019-02-28 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы |
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| JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ， インコーポレイテッド | 変異体選択的ｅｇｆｒ阻害剤およびその使用 |
| CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
| US9364476B2 (en) | 2011-10-28 | 2016-06-14 | Celgene Avilomics Research, Inc. | Methods of treating a Bruton's Tyrosine Kinase disease or disorder |
| ES2698298T3 (es) | 2012-03-15 | 2019-02-04 | Celgene Car Llc | Sales de un inhibidor de quinasa receptor de factor de crecimiento epidérmico |
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- 2011-08-08 PT PT118168749T patent/PT2603081T/pt unknown
- 2011-08-08 KR KR1020137006114A patent/KR20130099040A/ko not_active Ceased
- 2011-08-08 RU RU2013109393/04A patent/RU2013109393A/ru not_active Application Discontinuation
- 2011-08-08 EP EP11816874.9A patent/EP2603081B1/en active Active
- 2011-08-08 WO PCT/US2011/046926 patent/WO2012021444A1/en not_active Ceased
- 2011-08-08 ES ES11816874.9T patent/ES2617763T3/es active Active
- 2011-08-08 MX MX2013001126A patent/MX336875B/es active IP Right Grant
- 2011-08-08 CN CN201610071665.0A patent/CN105566229A/zh active Pending
- 2011-08-08 BR BR112013003388A patent/BR112013003388A2/pt not_active IP Right Cessation
- 2011-08-08 PH PH1/2013/500246A patent/PH12013500246A1/en unknown
- 2011-08-08 DK DK11816874.9T patent/DK2603081T3/en active
- 2011-08-08 US US13/205,062 patent/US8563568B2/en not_active Expired - Fee Related
- 2011-08-08 EP EP16192134.1A patent/EP3144298A1/en not_active Withdrawn
- 2011-08-08 AU AU2011289604A patent/AU2011289604C1/en not_active Ceased
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2013
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