JP6068340B2 - Btk阻害剤のベシル酸塩 - Google Patents

Btk阻害剤のベシル酸塩 Download PDF

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JP6068340B2
JP6068340B2 JP2013524147A JP2013524147A JP6068340B2 JP 6068340 B2 JP6068340 B2 JP 6068340B2 JP 2013524147 A JP2013524147 A JP 2013524147A JP 2013524147 A JP2013524147 A JP 2013524147A JP 6068340 B2 JP6068340 B2 JP 6068340B2
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JP2013533314A (ja
JP2013533314A5 (enExample
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スティーブン リチャード ウィトウスキ,
スティーブン リチャード ウィトウスキ,
ウィリアム フレデリック ザ サード ウェストリン,
ウィリアム フレデリック ザ サード ウェストリン,
リッチランド ウェイン テスター,
リッチランド ウェイン テスター,
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セルジーン アヴィロミクス リサーチ, インコーポレイテッド
セルジーン アヴィロミクス リサーチ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P19/00Drugs for skeletal disorders
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    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
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    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
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  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013524147A 2010-08-10 2011-08-08 Btk阻害剤のベシル酸塩 Expired - Fee Related JP6068340B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37234910P 2010-08-10 2010-08-10
US61/372,349 2010-08-10
PCT/US2011/046926 WO2012021444A1 (en) 2010-08-10 2011-08-08 Besylate salt of a btk inhibitor

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JP2013533314A JP2013533314A (ja) 2013-08-22
JP2013533314A5 JP2013533314A5 (enExample) 2014-09-18
JP6068340B2 true JP6068340B2 (ja) 2017-01-25

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US (2) US8563568B2 (enExample)
EP (2) EP3144298A1 (enExample)
JP (1) JP6068340B2 (enExample)
KR (1) KR20130099040A (enExample)
CN (2) CN105566229A (enExample)
AR (1) AR082600A1 (enExample)
AU (1) AU2011289604C1 (enExample)
BR (1) BR112013003388A2 (enExample)
CA (1) CA2807051A1 (enExample)
DK (1) DK2603081T3 (enExample)
ES (1) ES2617763T3 (enExample)
IL (1) IL224271A (enExample)
MX (1) MX336875B (enExample)
MY (1) MY160734A (enExample)
NZ (1) NZ607845A (enExample)
PH (1) PH12013500246A1 (enExample)
PT (1) PT2603081T (enExample)
RU (1) RU2013109393A (enExample)
SG (1) SG187796A1 (enExample)
TW (1) TWI533872B (enExample)
WO (1) WO2012021444A1 (enExample)
ZA (1) ZA201301802B (enExample)

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