JP2017522888A5 - - Google Patents

Download PDF

Info

Publication number
JP2017522888A5
JP2017522888A5 JP2017504773A JP2017504773A JP2017522888A5 JP 2017522888 A5 JP2017522888 A5 JP 2017522888A5 JP 2017504773 A JP2017504773 A JP 2017504773A JP 2017504773 A JP2017504773 A JP 2017504773A JP 2017522888 A5 JP2017522888 A5 JP 2017522888A5
Authority
JP
Japan
Prior art keywords
domain
heavy chain
amino acid
variable
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017504773A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017522888A (ja
JP6744292B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2015/067369 external-priority patent/WO2016016299A1/en
Publication of JP2017522888A publication Critical patent/JP2017522888A/ja
Publication of JP2017522888A5 publication Critical patent/JP2017522888A5/ja
Application granted granted Critical
Publication of JP6744292B2 publication Critical patent/JP6744292B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017504773A 2014-07-29 2015-07-29 多重特異性抗体 Active JP6744292B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14178908.1 2014-07-29
EP14178908 2014-07-29
PCT/EP2015/067369 WO2016016299A1 (en) 2014-07-29 2015-07-29 Multispecific antibodies

Publications (3)

Publication Number Publication Date
JP2017522888A JP2017522888A (ja) 2017-08-17
JP2017522888A5 true JP2017522888A5 (enExample) 2018-08-30
JP6744292B2 JP6744292B2 (ja) 2020-08-19

Family

ID=51225412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017504773A Active JP6744292B2 (ja) 2014-07-29 2015-07-29 多重特異性抗体

Country Status (5)

Country Link
US (2) US20170349669A1 (enExample)
EP (1) EP3174897B1 (enExample)
JP (1) JP6744292B2 (enExample)
CN (1) CN106573986A (enExample)
WO (1) WO2016016299A1 (enExample)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
PT2417156E (pt) 2009-04-07 2015-04-29 Roche Glycart Ag Anticorpos trivalentes, biespecíficos
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
EP2681239B8 (en) 2011-02-28 2015-09-09 F. Hoffmann-La Roche AG Antigen binding proteins
AR085403A1 (es) 2011-02-28 2013-09-25 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos
RU2016115866A (ru) 2013-10-11 2017-11-16 Ф. Хоффманн-Ля Рош Аг Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
MA41375A (fr) 2015-01-22 2017-11-28 Lilly Co Eli Anticorps igg bispécifiques et leurs procédés de préparation
AR103477A1 (es) * 2015-01-28 2017-05-10 Lilly Co Eli Compuestos de vegfa / ang2
KR20250008141A (ko) 2015-08-07 2025-01-14 이미지냅 인코포레이티드 분자를 표적화하기 위한 항원 결합 구조체
EP3150636A1 (en) * 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Tetravalent multispecific antibodies
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
JP7082604B2 (ja) 2016-03-21 2022-06-08 マレンゴ・セラピューティクス,インコーポレーテッド 多重特異性および多機能性分子ならびにその使用
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
WO2018151820A1 (en) 2017-02-16 2018-08-23 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
RU2750721C2 (ru) * 2017-03-10 2021-07-01 Ф. Хоффманн-Ля Рош Аг Способ получения мультиспецифических антител
SG11201909218RA (en) 2017-04-03 2019-11-28 Hoffmann La Roche Antibodies binding to steap-1
KR102294136B1 (ko) 2017-04-05 2021-08-26 에프. 호프만-라 로슈 아게 항-lag3 항체
WO2018222901A1 (en) 2017-05-31 2018-12-06 Elstar Therapeutics, Inc. Multispecific molecules that bind to myeloproliferative leukemia (mpl) protein and uses thereof
JP7474193B2 (ja) * 2017-06-25 2024-04-24 システィミューン, インク. 多重特異性抗体とその作製及び使用方法
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
BR112020011469A2 (pt) 2017-12-21 2020-11-24 F. Hoffmann-La Roche Ag anticorpos, molécula de ligação ao antígeno biespecífica, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método para produzir um anticorpo, composição farmacêutica, uso do anticorpo, método de tratamento de uma doença e invenção
WO2019129679A1 (en) 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
EP3746470A1 (en) 2018-01-31 2020-12-09 F. Hoffmann-La Roche AG Stabilized immunoglobulin domains
CN111655730A (zh) 2018-01-31 2020-09-11 豪夫迈·罗氏有限公司 包含与lag3结合的抗原结合位点的双特异性抗体
TWI829667B (zh) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 結合gprc5d之抗體
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
EP3765516A2 (en) 2018-03-14 2021-01-20 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
JP2021519073A (ja) 2018-03-29 2021-08-10 ジェネンテック, インコーポレイテッド 哺乳動物細胞におけるラクトジェニック活性の制御
AR115052A1 (es) 2018-04-18 2020-11-25 Hoffmann La Roche Anticuerpos multiespecíficos y utilización de los mismos
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
WO2020010250A2 (en) 2018-07-03 2020-01-09 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
CN118271445A (zh) 2018-12-21 2024-07-02 豪夫迈·罗氏有限公司 与cd3结合的抗体
WO2020127873A1 (en) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Antibody that binds to vegf and il-1beta and methods of use
EP3902823A1 (en) * 2018-12-24 2021-11-03 Sanofi Multispecific binding proteins with mutant fab domains
US20220073630A1 (en) 2018-12-28 2022-03-10 Hoffmann-La Roche, Inc. A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response
EP3927745A1 (en) 2019-02-21 2021-12-29 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cells and uses thereof to treat autoimmune disorders
AU2020226893B2 (en) 2019-02-21 2025-02-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
AU2020226904B2 (en) 2019-02-21 2025-05-01 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
JP7706373B2 (ja) 2019-02-21 2025-07-11 マレンゴ・セラピューティクス,インコーポレーテッド カルレティキュリンに結合する多機能性分子およびその使用
GB2597851B (en) 2019-02-21 2024-05-29 Marengo Therapeutics Inc Antibody molecules that bind to NKP30 and uses thereof
CN114981286B (zh) 2019-05-03 2026-02-13 豪夫迈·罗氏有限公司 降低从纯化平台获得的组合物中酶水解活性速率的方法
MA55884A (fr) * 2019-05-09 2022-03-16 Merus Nv Domaines variants pour la multimérisation de protéines et leur séparation
KR20220005568A (ko) 2019-05-09 2022-01-13 제넨테크, 인크. 항체의 제조 방법
CA3138501A1 (en) 2019-06-13 2020-12-17 Thomas Charles PERTEL Anti-talen antibodies and uses thereof
HUE071032T2 (hu) 2019-06-26 2025-07-28 Hoffmann La Roche Emlõs sejtvonalak SIRT-1 gén kiiktatásával
AR119393A1 (es) 2019-07-15 2021-12-15 Hoffmann La Roche Anticuerpos que se unen a nkg2d
JP2022543551A (ja) 2019-07-31 2022-10-13 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Gprc5dに結合する抗体
CN119192386A (zh) 2019-07-31 2024-12-27 豪夫迈·罗氏有限公司 与gprc5d结合的抗体
US12312414B2 (en) 2019-09-18 2025-05-27 Genentech, Inc. Anti-KLK7 antibodies, anti-KLK5 antibodies, multispecific anti-KLK5/KLK7 antibodies, and methods of use
AU2020364071A1 (en) 2019-10-10 2022-05-26 Kodiak Sciences Inc. Methods of treating an eye disorder
EP4057980A1 (en) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Prevention of visible particle formation in aqueous protein solutions
JP7296467B2 (ja) 2019-12-18 2023-06-22 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Hla-a2/mage-a4に結合する抗体
WO2021122733A1 (en) 2019-12-18 2021-06-24 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
PE20221186A1 (es) 2019-12-23 2022-08-05 Genentech Inc Anticuerpos especificos de apolipoproteina l1 y metodos de uso
AU2020416273A1 (en) 2020-01-03 2022-07-28 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
WO2021138407A2 (en) 2020-01-03 2021-07-08 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
EP4090666A1 (en) 2020-01-15 2022-11-23 F. Hoffmann-La Roche AG Methods to decrease impurities from recombinant protein manufacturing processes
WO2021168274A1 (en) 2020-02-21 2021-08-26 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
JP2023518841A (ja) 2020-03-26 2023-05-08 ジェネンテック, インコーポレイテッド 宿主細胞タンパク質が減少した修飾哺乳動物細胞
EP4126940A1 (en) 2020-03-30 2023-02-08 F. Hoffmann-La Roche AG Antibody that binds to vegf and pdgf-b and methods of use
KR20230028242A (ko) 2020-04-24 2023-02-28 마렝고 테라퓨틱스, 인크. T 세포 관련 암 세포에 결합하는 다중기능성 분자 및 그것의 용도
JP2023520249A (ja) 2020-05-15 2023-05-16 エフ. ホフマン-ラ ロシュ アーゲー 非経口タンパク質溶液中の可視粒子形成の防止方法
CN115605185A (zh) 2020-05-19 2023-01-13 豪夫迈·罗氏有限公司(Ch) 螯合剂用于防止胃肠外蛋白质溶液中形成可见颗粒的用途
MX2022015206A (es) 2020-06-08 2023-01-05 Hoffmann La Roche Anticuerpos anti-hbv y metodos de uso.
AR122658A1 (es) 2020-06-19 2022-09-28 Hoffmann La Roche Anticuerpos que se unen a cd3
TWI852680B (zh) 2020-06-19 2024-08-11 瑞士商赫孚孟拉羅股份公司 與 cd3 及 cd19 結合之抗體
MX2022015887A (es) 2020-06-19 2023-01-24 Hoffmann La Roche Anticuerpos que se unen a cd3 y folr1.
WO2021255146A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cea
WO2021262783A1 (en) 2020-06-24 2021-12-30 Genentech, Inc. Apoptosis resistant cell lines
AU2021300362A1 (en) 2020-07-01 2023-02-23 ARS Pharmaceuticals, Inc. Anti-ASGR1 antibody conjugates and uses thereof
JP2023532764A (ja) 2020-07-07 2023-07-31 エフ. ホフマン-ラ ロシュ アーゲー 治療用タンパク質製剤の安定剤としての代替界面活性剤
CA3185122A1 (en) 2020-07-17 2022-01-20 Cecilia Pui Chi Chiu Anti-notch2 antibodies and methods of use
KR20230074144A (ko) 2020-08-26 2023-05-26 마렝고 테라퓨틱스, 인크. NKp30에 결합하는 항체 분자 및 이의 용도
GB2616354A (en) 2020-08-26 2023-09-06 Marengo Therapeutics Inc Methods of detecting TRBC1 or TRBC2
CN116249718A (zh) 2020-08-26 2023-06-09 马伦戈治疗公司 结合至钙网蛋白的多功能性分子及其用途
CA3192344A1 (en) 2020-08-28 2022-03-03 Genentech, Inc. Crispr/cas9 multiplex knockout of host cell proteins
PE20230986A1 (es) 2020-09-04 2023-06-21 Hoffmann La Roche Anticuerpo que se une a vegf-a y ang2, y metodos de uso
AU2021347580A1 (en) 2020-09-24 2023-04-06 F. Hoffmann-La Roche Ag Mammalian cell lines with gene knockout
TW202233671A (zh) 2020-10-20 2022-09-01 美商建南德克公司 Peg結合抗mertk抗體及其使用方法
CR20230263A (es) 2020-12-17 2023-08-21 Hoffmann La Roche Anticuerpos anti-hla-g y uso de estos
CN116670282A (zh) 2020-12-22 2023-08-29 豪夫迈·罗氏有限公司 靶向xbp1的寡核苷酸
WO2022169872A1 (en) 2021-02-03 2022-08-11 Genentech, Inc. Multispecific binding protein degrader platform and methods of use
CN117062839A (zh) 2021-03-12 2023-11-14 基因泰克公司 抗klk7抗体、抗klk5抗体、多特异性抗klk5/klk7抗体和使用方法
JP2024515591A (ja) 2021-04-08 2024-04-10 マレンゴ・セラピューティクス,インコーポレーテッド Tcrに結合する多機能性分子およびその使用
WO2022214565A1 (en) 2021-04-09 2022-10-13 F. Hoffmann-La Roche Ag Process for selecting cell clones expressing a heterologous polypeptide
JP2024514222A (ja) 2021-04-19 2024-03-28 ジェネンテック, インコーポレイテッド 改変された哺乳動物細胞
EP4341385A1 (en) 2021-05-21 2024-03-27 Genentech, Inc. Modified cells for the production of a recombinant product of interest
WO2022263501A1 (en) 2021-06-18 2022-12-22 F. Hoffmann-La Roche Ag Bispecific anti-ccl2 antibodies
US20230197278A1 (en) 2021-07-13 2023-06-22 Genentech, Inc. Multi-variate model for predicting cytokine release syndrome
EP4373859A1 (en) 2021-07-22 2024-05-29 F. Hoffmann-La Roche AG Heterodimeric fc domain antibodies
US20250215103A1 (en) 2021-08-03 2025-07-03 Hoffmann-La Roche Inc. Bispecific antibodies and methods of use
AR127887A1 (es) 2021-12-10 2024-03-06 Hoffmann La Roche Anticuerpos que se unen a cd3 y plap
CN118401674A (zh) 2021-12-21 2024-07-26 豪夫迈·罗氏有限公司 用于确定水解活性的方法
WO2023141445A1 (en) 2022-01-19 2023-07-27 Genentech, Inc. Anti-notch2 antibodies and conjugates and methods of use
WO2023202967A1 (en) 2022-04-19 2023-10-26 F. Hoffmann-La Roche Ag Improved production cells
AR129268A1 (es) 2022-05-11 2024-08-07 Hoffmann La Roche Anticuerpo que se une a vegf-a e il6 y métodos de uso
CN119630690A (zh) 2022-06-03 2025-03-14 豪夫迈·罗氏有限公司 改进的生产细胞
KR20250041021A (ko) 2022-07-22 2025-03-25 제넨테크, 인크. 항-steap1 항원 결합 분자 및 이의 용도
TW202423969A (zh) 2022-10-10 2024-06-16 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及蛋白酶體抑制劑之組合療法
TW202423970A (zh) 2022-10-10 2024-06-16 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及cd38抗體之組合療法
TW202430211A (zh) 2022-10-10 2024-08-01 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及imid之組合療法
EP4602371A1 (en) 2022-10-12 2025-08-20 F. Hoffmann-La Roche AG Method for classifying cells
KR20250110226A (ko) 2022-11-23 2025-07-18 에프. 호프만-라 로슈 아게 재조합 단백질 발현을 증가시키는 방법
CN119546630A (zh) 2022-12-08 2025-02-28 南京诺唯赞生物科技股份有限公司 特异性结合rsv的抗体
EP4634397A1 (en) 2022-12-12 2025-10-22 Genentech Inc. Optimizing polypeptide sialic acid content
CN120569410A (zh) 2023-01-25 2025-08-29 豪夫迈·罗氏有限公司 与csf1r和cd3结合的抗体
JP2026510318A (ja) 2023-03-06 2026-04-02 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 抗EGFRvIII/抗CD3抗体と腫瘍標的化4-1BBアゴニストの併用療法
EP4676951A1 (en) 2023-03-10 2026-01-14 Genentech Inc. Fusions with proteases and uses thereof
CN120936626A (zh) 2023-03-31 2025-11-11 基因泰克公司 抗αvβ8整合素抗体及使用方法
WO2024231320A1 (en) 2023-05-08 2024-11-14 F. Hoffmann-La Roche Ag Targeted interferon alpha fusion proteins and methods of use
TW202502809A (zh) 2023-06-22 2025-01-16 美商建南德克公司 抗體及其用途
CN121712799A (zh) 2023-07-26 2026-03-20 豪夫迈·罗氏有限公司 与cd3结合的抗体
CN121693516A (zh) 2023-08-09 2026-03-17 豪夫迈·罗氏有限公司 单特异性和多特异性抗trem2抗体、其方法及用途
CN121666400A (zh) 2023-08-09 2026-03-13 豪夫迈·罗氏有限公司 单特异性和多特异性抗trem2抗体、其方法和用途
WO2025040567A1 (en) 2023-08-18 2025-02-27 F. Hoffmann-La Roche Ag Protease activatable fc domain binding molecules
AR133909A1 (es) 2023-09-25 2025-11-12 Hoffmann La Roche ANTICUERPO QUE SE UNE A C3bBb
WO2025125386A1 (en) 2023-12-14 2025-06-19 F. Hoffmann-La Roche Ag Antibodies that bind to folr1 and methods of use
US20260071002A1 (en) 2023-12-20 2026-03-12 Hoffmann-La Roche Inc. Antibodies binding to ceacam5
WO2025137086A1 (en) 2023-12-20 2025-06-26 Genentech, Inc. Reducing alpha-gal
WO2025133042A2 (en) 2023-12-22 2025-06-26 F. Hoffmann-La Roche Ag Activatable fusion proteins and methods of use
WO2025181189A1 (en) 2024-03-01 2025-09-04 F. Hoffmann-La Roche Ag Antibodies binding to cd3
WO2025215060A1 (en) 2024-04-11 2025-10-16 F. Hoffmann-La Roche Ag Antibodies that specifically bind modified oligonucleotides
WO2025240670A2 (en) 2024-05-15 2025-11-20 Abalytics Oncology, Inc. Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
WO2026006162A2 (en) 2024-06-24 2026-01-02 Genentech, Inc. B vitamin modulation
WO2026011013A1 (en) 2024-07-02 2026-01-08 Epibiologics, Inc. Binding agents and uses thereof
WO2026037841A1 (en) 2024-08-12 2026-02-19 ONA Therapeutics S.L. Anti-fgfr4 molecules and uses thereof
WO2026041568A1 (en) 2024-08-20 2026-02-26 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and dotam
WO2026050572A2 (en) 2024-08-29 2026-03-05 Marengo Therapeutics, Inc. Multifunctional molecules binding to tcr and uses thereof
WO2026073840A1 (en) 2024-10-01 2026-04-09 F. Hoffmann-La Roche Ag Antibodies that bind to cd3 and uses therefor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266967B2 (en) * 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
EP3663318A1 (en) * 2008-01-07 2020-06-10 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
MX2010014574A (es) * 2008-07-08 2011-04-27 Abbott Lab Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
US8703132B2 (en) * 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
KR101584416B1 (ko) * 2010-10-05 2016-01-13 에프. 호프만-라 로슈 아게 인간 tweak에 대한 항체 및 그의 용도
TWI638833B (zh) * 2010-11-30 2018-10-21 中外製藥股份有限公司 細胞傷害誘導治療劑
CA2868404A1 (en) * 2012-04-05 2013-10-10 F. Hoffmann-La Roche Ag Bispecific antibodies against human tweak and human il17 and uses thereof
HK1203517A1 (en) * 2012-05-24 2015-10-30 F. Hoffmann-La Roche Ag Multispecific antibodies
HK1215950A1 (zh) * 2012-09-25 2016-09-30 艾科诺斯科技股份有限公司 异源二聚免疫球蛋白的纯化
UY35148A (es) * 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas

Similar Documents

Publication Publication Date Title
JP2018535196A5 (enExample)
JP2012254092A5 (enExample)
JP2019527047A5 (enExample)
JP2020122013A5 (enExample)
JP2014526898A5 (enExample)
JP2013538057A5 (enExample)
JP2017532290A5 (enExample)
JP2019500007A5 (enExample)
JP2019523221A5 (enExample)
JP2016196468A5 (enExample)
JP2020504101A5 (enExample)
AR095980A1 (es) Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización
JP2014534242A5 (enExample)
RU2018133708A (ru) Антитела, обладающие специфичностью к btla, и их использование
JP2015529641A5 (enExample)
JP2015214563A5 (enExample)
AR105026A1 (es) ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO
RU2018125624A (ru) Антитела к с5 и способы их применения
JP2015504306A5 (enExample)
RU2014136103A (ru) Антагонистические антитела против рецептора IL-7 и способы
EA201290370A1 (ru) Антитела против flt3 и способы их применения
JP2016511277A5 (enExample)
JP2014001217A5 (enExample)
JP2015517309A5 (enExample)
PH12014500167A1 (en) Tnf-alpha antigen-binding proteins with increased fcrn binding