JP2017522888A5 - - Google Patents

Download PDF

Info

Publication number
JP2017522888A5
JP2017522888A5 JP2017504773A JP2017504773A JP2017522888A5 JP 2017522888 A5 JP2017522888 A5 JP 2017522888A5 JP 2017504773 A JP2017504773 A JP 2017504773A JP 2017504773 A JP2017504773 A JP 2017504773A JP 2017522888 A5 JP2017522888 A5 JP 2017522888A5
Authority
JP
Japan
Prior art keywords
domain
heavy chain
amino acid
variable
light chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017504773A
Other languages
English (en)
Japanese (ja)
Other versions
JP6744292B2 (ja
JP2017522888A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2015/067369 external-priority patent/WO2016016299A1/en
Publication of JP2017522888A publication Critical patent/JP2017522888A/ja
Publication of JP2017522888A5 publication Critical patent/JP2017522888A5/ja
Application granted granted Critical
Publication of JP6744292B2 publication Critical patent/JP6744292B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017504773A 2014-07-29 2015-07-29 多重特異性抗体 Active JP6744292B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14178908.1 2014-07-29
EP14178908 2014-07-29
PCT/EP2015/067369 WO2016016299A1 (en) 2014-07-29 2015-07-29 Multispecific antibodies

Publications (3)

Publication Number Publication Date
JP2017522888A JP2017522888A (ja) 2017-08-17
JP2017522888A5 true JP2017522888A5 (enExample) 2018-08-30
JP6744292B2 JP6744292B2 (ja) 2020-08-19

Family

ID=51225412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017504773A Active JP6744292B2 (ja) 2014-07-29 2015-07-29 多重特異性抗体

Country Status (5)

Country Link
US (2) US20170349669A1 (enExample)
EP (1) EP3174897B1 (enExample)
JP (1) JP6744292B2 (enExample)
CN (1) CN106573986A (enExample)
WO (1) WO2016016299A1 (enExample)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
DK2417156T3 (en) 2009-04-07 2015-03-02 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
RU2607038C2 (ru) 2011-02-28 2017-01-10 Ф. Хоффманн-Ля Рош Аг Антигенсвязывающие белки
CN103403025B (zh) 2011-02-28 2016-10-12 弗·哈夫曼-拉罗切有限公司 单价抗原结合蛋白
RU2016115866A (ru) 2013-10-11 2017-11-16 Ф. Хоффманн-Ля Рош Аг Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP6721590B2 (ja) 2014-12-03 2020-07-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 多重特異性抗体
MA41375A (fr) 2015-01-22 2017-11-28 Lilly Co Eli Anticorps igg bispécifiques et leurs procédés de préparation
AR103477A1 (es) * 2015-01-28 2017-05-10 Lilly Co Eli Compuestos de vegfa / ang2
CN108136012B (zh) 2015-08-07 2022-10-04 伊麦吉纳博公司 靶向分子的抗原结合构建体
EP3150636A1 (en) * 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Tetravalent multispecific antibodies
KR102799807B1 (ko) 2015-12-30 2025-04-24 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
EP3433281A1 (en) 2016-03-21 2019-01-30 Elstar Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
TW201829463A (zh) 2016-11-18 2018-08-16 瑞士商赫孚孟拉羅股份公司 抗hla-g抗體及其用途
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
US20200291089A1 (en) 2017-02-16 2020-09-17 Elstar Therapeutics, Inc. Multifunctional molecules comprising a trimeric ligand and uses thereof
CN110402253B (zh) * 2017-03-10 2024-01-05 豪夫迈·罗氏有限公司 用于生产多特异性抗体的方法
RU2019134462A (ru) 2017-04-03 2021-05-05 Ф. Хоффманн-Ля Рош Аг Антитела, связывающиеся с steap-1
KR102294136B1 (ko) 2017-04-05 2021-08-26 에프. 호프만-라 로슈 아게 항-lag3 항체
JP2020522254A (ja) 2017-05-31 2020-07-30 エルスター セラピューティクス, インコーポレイテッド 骨髄増殖性白血病(mpl)タンパク質に結合する多特異性分子およびその使用
CN110799540B (zh) * 2017-06-25 2024-02-13 西雅图免疫公司 多特异性抗体及其制备和使用方法
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
WO2019122052A2 (en) 2017-12-21 2019-06-27 F. Hoffmann-La Roche Ag Antibodies binding to hla-a2/wt1
EP3731865A1 (en) 2017-12-29 2020-11-04 F. Hoffmann-La Roche AG Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
WO2019139987A1 (en) 2018-01-09 2019-07-18 Elstar Therapeutics, Inc. Calreticulin binding constructs and engineered t cells for the treatment of diseases
CN111630063A (zh) 2018-01-31 2020-09-04 豪夫迈·罗氏有限公司 稳定化的免疫球蛋白结构域
EP3746480A1 (en) 2018-01-31 2020-12-09 F. Hoffmann-La Roche AG Bispecific antibodies comprising an antigen-binding site binding to lag3
TWI829667B (zh) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 結合gprc5d之抗體
CN112203679A (zh) 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
WO2019178364A2 (en) 2018-03-14 2019-09-19 Elstar Therapeutics, Inc. Multifunctional molecules and uses thereof
CN111936625B (zh) 2018-03-29 2025-02-07 豪夫迈·罗氏有限公司 调节哺乳动物细胞中的生乳活性
AR114789A1 (es) 2018-04-18 2020-10-14 Hoffmann La Roche Anticuerpos anti-hla-g y uso de los mismos
AR115052A1 (es) 2018-04-18 2020-11-25 Hoffmann La Roche Anticuerpos multiespecíficos y utilización de los mismos
CN112955465A (zh) 2018-07-03 2021-06-11 马伦戈治疗公司 抗tcr抗体分子及其用途
KR20240155361A (ko) 2018-12-21 2024-10-28 에프. 호프만-라 로슈 아게 Cd3에 결합하는 항체
PH12021551470A1 (en) 2018-12-21 2022-04-11 Hoffmann La Roche Antibody that binds to vegf and il-1beta and methods of use
SG11202106525TA (en) * 2018-12-24 2021-07-29 Sanofi Sa Multispecific binding proteins with mutant fab domains
EP3902560A1 (en) 2018-12-28 2021-11-03 F. Hoffmann-La Roche AG A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response
JP7737306B2 (ja) 2019-02-21 2025-09-10 マレンゴ・セラピューティクス,インコーポレーテッド T細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用
CN114127113A (zh) 2019-02-21 2022-03-01 马伦戈治疗公司 与钙网蛋白结合的多功能分子及其用途
CA3130754A1 (en) 2019-02-21 2020-08-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to t cell related cancer cells and uses thereof
AU2020226904B2 (en) 2019-02-21 2025-05-01 Marengo Therapeutics, Inc. Anti-TCR antibody molecules and uses thereof
CN114127111B (zh) 2019-02-21 2024-09-10 马伦戈治疗公司 与nkp30结合的抗体分子及其用途
CN114981286A (zh) 2019-05-03 2022-08-30 豪夫迈·罗氏有限公司 降低从纯化平台获得的组合物中酶水解活性速率的方法
BR112021021673A2 (pt) 2019-05-09 2021-12-21 Genentech Inc Método para melhorar o emparelhamento preferencial de uma cadeia pesada e uma cadeia leve de um anticorpo e anticorpo
CN114702587A (zh) * 2019-05-09 2022-07-05 美勒斯公司 用于使蛋白质多聚化的变体结构域及其分离
MX2021015057A (es) * 2019-06-13 2022-01-18 Allogene Therapeutics Inc Anticuerpos anti-talen y usos de los mismos.
HUE071032T2 (hu) 2019-06-26 2025-07-28 Hoffmann La Roche Emlõs sejtvonalak SIRT-1 gén kiiktatásával
AR119393A1 (es) 2019-07-15 2021-12-15 Hoffmann La Roche Anticuerpos que se unen a nkg2d
MY206610A (en) 2019-07-31 2024-12-26 Hoffmann La Roche Antibodies binding to gprc5d
JP2022543551A (ja) 2019-07-31 2022-10-13 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Gprc5dに結合する抗体
BR112022004972A2 (pt) 2019-09-18 2022-06-28 Genentech Inc Anticorpos, ácidos nucleicos isolados, células hospedeiras isoladas, métodos de produção de um anticorpo, de produção de um anticorpo biespecífico e de tratamento de um indivíduo, anticorpos biespecíficos, composição farmacêutica, anticorpo, anticorpo biespecífico ou composição farmacêutica, combinação de um anticorpo, uso do anticorpo, uso de uma combinação do anticorpo e métodos para reduzir a inflamação e para melhorar a descamação e/ou de erupção cutânea e combinação para uso
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
EP4057980A1 (en) 2019-11-15 2022-09-21 F. Hoffmann-La Roche AG Prevention of visible particle formation in aqueous protein solutions
JP7415005B2 (ja) 2019-12-18 2024-01-16 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗ccl2抗体
BR112022011854A2 (pt) 2019-12-18 2022-09-06 Hoffmann La Roche Anticorpos, polinucleotídeo isolado, célula hospedeira, métodos para produzir um anticorpo e para tratar uma doença, composição farmacêutica, usos do anticorpo e invenção
WO2021133723A2 (en) 2019-12-23 2021-07-01 Genentech, Inc. Apolipoprotein l1-specific antibodies and methods of use
EP4084821A4 (en) 2020-01-03 2024-04-24 Marengo Therapeutics, Inc. Multifunctional molecules that bind to cd33 and uses thereof
CN116234829A (zh) 2020-01-03 2023-06-06 马伦戈治疗公司 抗tcr抗体分子及其用途
KR20220129003A (ko) 2020-01-15 2022-09-22 에프. 호프만-라 로슈 아게 재조합 단백질 제조 공정으로부터 불순물을 감소시키기 위한 방법
JP7735291B2 (ja) 2020-02-21 2025-09-08 エーアールエス ファーマシューティカルズ、インコーポレイテッド ネクチン-4抗体コンジュゲートおよびその使用
JP2023518841A (ja) 2020-03-26 2023-05-08 ジェネンテック, インコーポレイテッド 宿主細胞タンパク質が減少した修飾哺乳動物細胞
WO2021198034A1 (en) 2020-03-30 2021-10-07 F. Hoffmann-La Roche Ag Antibody that binds to vegf and pdgf-b and methods of use
AU2021261420A1 (en) 2020-04-24 2022-12-01 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
EP4149421A1 (en) 2020-05-15 2023-03-22 F. Hoffmann-La Roche AG Prevention of visible particle formation in parenteral protein solutions
WO2021233853A1 (en) 2020-05-19 2021-11-25 F. Hoffmann-La Roche Ag The use of chelators for the prevention of visible particle formation in parenteral protein solutions
US20230340081A1 (en) 2020-06-08 2023-10-26 Hoffmann-La Roche Inc. Anti-hbv antibodies and methods of use
MX2022015887A (es) 2020-06-19 2023-01-24 Hoffmann La Roche Anticuerpos que se unen a cd3 y folr1.
US11780920B2 (en) 2020-06-19 2023-10-10 Hoffmann-La Roche Inc. Antibodies binding to CD3 and CD19
WO2021255146A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cea
CA3176579A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3
CA3184747A1 (en) 2020-06-24 2021-12-30 Genentech, Inc. Apoptosis resistant cell lines
KR20230047361A (ko) 2020-07-01 2023-04-07 아르스 파마슈티컬스 인크. 항-asgr1 항체 접합체 및 이의 용도
WO2022008468A1 (en) 2020-07-07 2022-01-13 F. Hoffmann-La Roche Ag Alternative surfactants as stabilizers for therapeutic protein formulations
MX2023000617A (es) 2020-07-17 2023-02-13 Genentech Inc Anticuerpos anti-notch2 y metodos de uso.
WO2022046920A2 (en) 2020-08-26 2022-03-03 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
GB2616128A (en) 2020-08-26 2023-08-30 Marengo Therapeutics Inc Antibody molecules that bind to NKp30 and uses thereof
EP4204458A4 (en) 2020-08-26 2024-10-09 Marengo Therapeutics, Inc. METHODS FOR DETECTION OF TRBC1 OR TRBC2
TW202227625A (zh) 2020-08-28 2022-07-16 美商建南德克公司 宿主細胞蛋白質之CRISPR/Cas9多重剔除
IL300616A (en) 2020-09-04 2023-04-01 Hoffmann La Roche Antibody that binds to VEGF-A and ANG2 and methods of use
MX2023003328A (es) 2020-09-24 2023-03-27 Hoffmann La Roche Lineas de celulas de mamifero con desactivacion genica.
WO2022086957A1 (en) 2020-10-20 2022-04-28 Genentech, Inc. Peg-conjugated anti-mertk antibodies and methods of use
EP4263609A1 (en) 2020-12-17 2023-10-25 F. Hoffmann-La Roche AG Anti-hla-g antibodies and use thereof
WO2022136140A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Oligonucleotides targeting xbp1
WO2022169872A1 (en) 2021-02-03 2022-08-11 Genentech, Inc. Multispecific binding protein degrader platform and methods of use
JP2024512377A (ja) 2021-03-12 2024-03-19 ジェネンテック, インコーポレイテッド 抗klk7抗体、抗klk5抗体、多重特異性抗klk5/klk7抗体、及び使用方法
GB2623199A (en) 2021-04-08 2024-04-10 Marengo Therapeutics Inc Multifunctional molecules binding to TCR and uses thereof
WO2022214565A1 (en) 2021-04-09 2022-10-13 F. Hoffmann-La Roche Ag Process for selecting cell clones expressing a heterologous polypeptide
KR20230173164A (ko) 2021-04-19 2023-12-26 제넨테크, 인크. 변형된 포유류 세포
EP4341385A1 (en) 2021-05-21 2024-03-27 Genentech, Inc. Modified cells for the production of a recombinant product of interest
CN117500829A (zh) 2021-06-18 2024-02-02 豪夫迈·罗氏有限公司 双特异性抗ccl2抗体
US20230197278A1 (en) 2021-07-13 2023-06-22 Genentech, Inc. Multi-variate model for predicting cytokine release syndrome
EP4373859A1 (en) 2021-07-22 2024-05-29 F. Hoffmann-La Roche AG Heterodimeric fc domain antibodies
JP2024528217A (ja) 2021-08-03 2024-07-26 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 二重特異性抗体および使用方法
AR127887A1 (es) 2021-12-10 2024-03-06 Hoffmann La Roche Anticuerpos que se unen a cd3 y plap
EP4416301B1 (en) 2021-12-21 2025-06-11 F. Hoffmann-La Roche AG Method for the determination of hydrolytic activity
TW202340251A (zh) 2022-01-19 2023-10-16 美商建南德克公司 抗notch2抗體及結合物及其使用方法
CN119421890A (zh) 2022-04-19 2025-02-11 豪夫迈·罗氏有限公司 改进的生产细胞
AR129268A1 (es) 2022-05-11 2024-08-07 Hoffmann La Roche Anticuerpo que se une a vegf-a e il6 y métodos de uso
JP2025517572A (ja) 2022-06-03 2025-06-05 エフ. ホフマン-ラ ロシュ アーゲー 改良された産生細胞
CR20250056A (es) 2022-07-22 2025-03-19 Genentech Inc Moléculas de unión al antígeno anti-steap1 y sus usos.
TW202430211A (zh) 2022-10-10 2024-08-01 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及imid之組合療法
TW202423970A (zh) 2022-10-10 2024-06-16 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及cd38抗體之組合療法
TW202423969A (zh) 2022-10-10 2024-06-16 瑞士商赫孚孟拉羅股份公司 Gprc5d tcb及蛋白酶體抑制劑之組合療法
EP4602371A1 (en) 2022-10-12 2025-08-20 F. Hoffmann-La Roche AG Method for classifying cells
IL320073A (en) 2022-11-23 2025-06-01 Hoffmann La Roche Method for increasing recombinant protein expression
CN119546630A (zh) 2022-12-08 2025-02-28 南京诺唯赞生物科技股份有限公司 特异性结合rsv的抗体
WO2024129594A1 (en) 2022-12-12 2024-06-20 Genentech, Inc. Optimizing polypeptide sialic acid content
CN120569410A (zh) 2023-01-25 2025-08-29 豪夫迈·罗氏有限公司 与csf1r和cd3结合的抗体
EP4676519A1 (en) 2023-03-06 2026-01-14 F. Hoffmann-La Roche AG Combination therapy of an anti-egfrviii/anti-cd3 antibody and an tumor-targeted 4-1bb agonist
EP4676951A1 (en) 2023-03-10 2026-01-14 Genentech Inc. Fusions with proteases and uses thereof
CN120936626A (zh) 2023-03-31 2025-11-11 基因泰克公司 抗αvβ8整合素抗体及使用方法
CN121127493A (zh) 2023-05-08 2025-12-12 豪夫迈·罗氏有限公司 靶向干扰素 α 融合蛋白及使用方法
AU2024311704A1 (en) 2023-06-22 2026-01-08 Genentech, Inc. Antibodies and uses thereof
WO2025021838A1 (en) 2023-07-26 2025-01-30 F. Hoffmann-La Roche Ag Antibodies binding to cd3
AU2024323186A1 (en) 2023-08-09 2026-01-15 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
WO2025032071A1 (en) 2023-08-09 2025-02-13 F. Hoffmann-La Roche Ag Mono and multispecific anti-trem2 antibodies, methods and uses thereof
WO2025040567A1 (en) 2023-08-18 2025-02-27 F. Hoffmann-La Roche Ag Protease activatable fc domain binding molecules
AR133909A1 (es) 2023-09-25 2025-11-12 Hoffmann La Roche ANTICUERPO QUE SE UNE A C3bBb
WO2025125386A1 (en) 2023-12-14 2025-06-19 F. Hoffmann-La Roche Ag Antibodies that bind to folr1 and methods of use
WO2025137086A1 (en) 2023-12-20 2025-06-26 Genentech, Inc. Reducing alpha-gal
WO2025132503A1 (en) 2023-12-20 2025-06-26 F. Hoffmann-La Roche Ag Antibodies binding to ceacam5
WO2025133042A2 (en) 2023-12-22 2025-06-26 F. Hoffmann-La Roche Ag Activatable fusion proteins and methods of use
WO2025181189A1 (en) 2024-03-01 2025-09-04 F. Hoffmann-La Roche Ag Antibodies binding to cd3
WO2025215060A1 (en) 2024-04-11 2025-10-16 F. Hoffmann-La Roche Ag Antibodies that specifically bind modified oligonucleotides
WO2025240670A2 (en) 2024-05-15 2025-11-20 Abalytics Oncology, Inc. Anti-pd-1 antibodies and related binding molecules and methods and uses thereof
WO2026006162A2 (en) 2024-06-24 2026-01-02 Genentech, Inc. B vitamin modulation
WO2026011013A1 (en) 2024-07-02 2026-01-08 Epibiologics, Inc. Binding agents and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266967B2 (en) * 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
PL2235064T3 (pl) * 2008-01-07 2016-06-30 Amgen Inc Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
CN102149825B (zh) * 2008-07-08 2015-07-22 Abbvie公司 前列腺素e2双重可变结构域免疫球蛋白及其用途
US8268314B2 (en) * 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
US8703132B2 (en) * 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
SG188605A1 (en) * 2010-10-05 2013-04-30 Hoffmann La Roche Antibodies against human tweak and uses thereof
PL2647707T3 (pl) * 2010-11-30 2019-02-28 Chugai Seiyaku Kabushiki Kaisha Środek terapeutyczny wywołujący cytotoksyczność
CA2868404A1 (en) * 2012-04-05 2013-10-10 F. Hoffmann-La Roche Ag Bispecific antibodies against human tweak and human il17 and uses thereof
WO2013174873A1 (en) * 2012-05-24 2013-11-28 F. Hoffmann-La Roche Ag Multispecific antibodies
EP2900696A1 (en) * 2012-09-25 2015-08-05 Glenmark Pharmaceuticals S.A. Purification of hetero-dimeric immunoglobulins
UY35148A (es) * 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas

Similar Documents

Publication Publication Date Title
JP2017522888A5 (enExample)
JP2018535196A5 (enExample)
JP2012254092A5 (enExample)
JP2019527047A5 (enExample)
JP2020122013A5 (enExample)
JP2014526898A5 (enExample)
JP2013538057A5 (enExample)
JP2017532290A5 (enExample)
JP2019500007A5 (enExample)
JP2019523221A5 (enExample)
JP2016196468A5 (enExample)
JP2018521638A5 (enExample)
AR095980A1 (es) Anticuerpos biespecíficos específicos para fap (proteína de activación fibroblástica) y dr5 (receptor de muerte 5), anticuerpos específicos para dr5 y métodos de utilización
JP2020504101A5 (enExample)
RU2012118636A (ru) Молекула, специфически связывающаяся с rsv
JP2014534242A5 (enExample)
JP2015529641A5 (enExample)
AR080291A1 (es) Anticuerpos antagonistas anti receptor de il-7 y procedimientos
RU2018133708A (ru) Антитела, обладающие специфичностью к btla, и их использование
AR105026A1 (es) ANTICUERPOS MADURADOS POR AFINIDAD Y HUMANIZADOS PARA FcRH5 Y MÉTODOS PARA SU USO
JP2015214563A5 (enExample)
JP2015504306A5 (enExample)
RU2018125624A (ru) Антитела к с5 и способы их применения
EA201290370A1 (ru) Антитела против flt3 и способы их применения
RU2016145906A (ru) Модифицированные антигенсвязывающие полипептидные конструкции и их применение