CN102088993A - 炎症的治疗方法 - Google Patents
炎症的治疗方法 Download PDFInfo
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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Applications Claiming Priority (9)
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| US3838108P | 2008-03-20 | 2008-03-20 | |
| US61/038,381 | 2008-03-20 | ||
| US3937108P | 2008-03-25 | 2008-03-25 | |
| US61/039,371 | 2008-03-25 | ||
| US4580708P | 2008-04-17 | 2008-04-17 | |
| US61/045,807 | 2008-04-17 | ||
| US12109508P | 2008-12-09 | 2008-12-09 | |
| US61/121,095 | 2008-12-09 | ||
| PCT/US2009/037887 WO2009117710A2 (en) | 2008-03-20 | 2009-03-20 | Methods of treating inflammation |
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|---|---|
| CN102088993A true CN102088993A (zh) | 2011-06-08 |
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| CN2009801093284A Pending CN102088993A (zh) | 2008-03-20 | 2009-03-20 | 炎症的治疗方法 |
| CN200980109905XA Pending CN102046199A (zh) | 2008-03-20 | 2009-03-20 | 使用抗mif抗体的治疗方法 |
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| EP (2) | EP2254597A4 (enExample) |
| JP (2) | JP2011526244A (enExample) |
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| CN (2) | CN102088993A (enExample) |
| AU (2) | AU2009225385A1 (enExample) |
| BR (1) | BRPI0910259A2 (enExample) |
| CA (2) | CA2717365A1 (enExample) |
| CO (1) | CO6300848A2 (enExample) |
| EA (1) | EA201001529A1 (enExample) |
| IL (1) | IL207752A0 (enExample) |
| MX (1) | MX2010010198A (enExample) |
| NZ (1) | NZ588033A (enExample) |
| WO (2) | WO2009117706A2 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427574A (zh) * | 2015-01-09 | 2017-12-01 | 阿达尔塔私人有限公司 | Cxcr4结合分子 |
| WO2018137701A1 (zh) * | 2017-01-26 | 2018-08-02 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| CN108368485A (zh) * | 2015-09-18 | 2018-08-03 | 综合医院公司以麻省总医院名义经营 | 具有抗趋除特性的修饰的天然杀伤细胞及其用途 |
| CN109069426A (zh) * | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| CN113383235A (zh) * | 2018-12-26 | 2021-09-10 | 高露洁-棕榄公司 | 作为牙龈炎诊断物的中性粒细胞失调的生物标志物 |
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| KR20110014141A (ko) * | 2008-03-20 | 2011-02-10 | 카롤러스 테라퓨틱스, 인코포레이티드 | 염증을 치료하는 방법 |
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| WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
| US9133164B2 (en) * | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| TWI407964B (zh) * | 2011-05-10 | 2013-09-11 | Univ Fu Jen Catholic | 干擾性核糖核酸用於治療或減緩疼痛之用途 |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
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Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69435303D1 (de) * | 1993-05-17 | 2010-09-02 | Cytokine Pharmasciences Inc | Er behandlung von krankheiten bei denen eine cytok |
| US6645493B1 (en) * | 1993-05-17 | 2003-11-11 | The Picower Institute For Medical Research | Composition containing anti-MIF antibody |
| US20070072861A1 (en) * | 2000-03-27 | 2007-03-29 | Barbara Roniker | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
| CN1842346A (zh) * | 2001-01-12 | 2006-10-04 | 塞托凯恩药物科学公司 | 由巨噬细胞迁移抑制因子调节细胞毒性淋巴细胞反应 |
| JP2003226653A (ja) * | 2001-11-30 | 2003-08-12 | Jun Nishihira | 多発性硬化症治療剤 |
| WO2003047622A1 (fr) * | 2001-11-30 | 2003-06-12 | Jun Nishihira | Remedes pour la sclerose en plaques |
| US6656168B2 (en) * | 2001-12-18 | 2003-12-02 | Kimberly-Clark Worldwide, Inc. | Feminine care product with discrete areas of a skin wellness additive |
| WO2003072753A2 (en) * | 2002-02-27 | 2003-09-04 | Emory University | Multimeric binding complexes |
| EP1483294B2 (en) * | 2002-03-01 | 2019-10-30 | Immunomedics, Inc. | Internalizing anti-cd74 antibodies and methods of use |
| WO2004049095A2 (en) * | 2002-11-25 | 2004-06-10 | Jallal Messadek | Betaine and salicylic acid compositions |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| US20050202010A1 (en) * | 2003-08-29 | 2005-09-15 | Giroir Brett P. | Method of treatment and bioassay involving macrophage migration inhibitory factor (MIF) as cardiac-derived myocardial depressant factor |
| WO2005065328A2 (en) * | 2003-12-30 | 2005-07-21 | The United States Of America, As Represented By The Department Of Veterans Affairs | Macrophage migration inhibitory factor (mif) as marker for urological inflammatory disease |
| US20060257466A1 (en) * | 2005-04-06 | 2006-11-16 | Kim Perry M | Administration of macrophage targeted formulations of compounds which modulate cholesterol-metabolizing enzymes for treatment of atherosclerosis |
| US7612181B2 (en) * | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JPWO2007138961A1 (ja) * | 2006-05-29 | 2009-10-08 | レドックス・バイオサイエンス株式会社 | マクロファージ遊走阻止因子阻害剤 |
| KR20110014141A (ko) * | 2008-03-20 | 2011-02-10 | 카롤러스 테라퓨틱스, 인코포레이티드 | 염증을 치료하는 방법 |
| US20110070184A1 (en) * | 2008-03-24 | 2011-03-24 | Carolus Therpeutics, Inc. | Methods and compositions for treating atherosclerosis and related condidtions |
| WO2010056910A2 (en) * | 2008-11-12 | 2010-05-20 | Carolus Therapeutics, Inc. | Methods of treating cardiovascular disorders |
| US20110256130A1 (en) * | 2008-12-01 | 2011-10-20 | Joshua Robert Schultz | Methods of treating inflammatory disorders |
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2009
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- 2009-03-20 MX MX2010010198A patent/MX2010010198A/es active IP Right Grant
- 2009-03-20 EP EP09722541A patent/EP2254597A4/en not_active Withdrawn
- 2009-03-20 AU AU2009225385A patent/AU2009225385A1/en not_active Abandoned
- 2009-03-20 CA CA2717365A patent/CA2717365A1/en not_active Abandoned
- 2009-03-20 US US12/918,964 patent/US20110262386A1/en not_active Abandoned
- 2009-03-20 CN CN2009801093284A patent/CN102088993A/zh active Pending
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- 2009-03-20 AU AU2009225389A patent/AU2009225389A1/en not_active Abandoned
- 2009-03-20 US US12/918,968 patent/US20110044988A1/en not_active Abandoned
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107427574A (zh) * | 2015-01-09 | 2017-12-01 | 阿达尔塔私人有限公司 | Cxcr4结合分子 |
| CN114478773A (zh) * | 2015-01-09 | 2022-05-13 | 阿达尔塔有限公司 | Cxcr4结合分子 |
| CN108368485A (zh) * | 2015-09-18 | 2018-08-03 | 综合医院公司以麻省总医院名义经营 | 具有抗趋除特性的修饰的天然杀伤细胞及其用途 |
| CN109069426A (zh) * | 2015-12-14 | 2018-12-21 | X4 制药有限公司 | 治疗癌症的方法 |
| CN109069426B (zh) * | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| WO2018137701A1 (zh) * | 2017-01-26 | 2018-08-02 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| CN110225768A (zh) * | 2017-01-26 | 2019-09-10 | 中国医学科学院阜外医院 | 靶向cxcr7的药物组合物和方法 |
| CN113383235A (zh) * | 2018-12-26 | 2021-09-10 | 高露洁-棕榄公司 | 作为牙龈炎诊断物的中性粒细胞失调的生物标志物 |
| CN113383235B (zh) * | 2018-12-26 | 2024-07-26 | 高露洁-棕榄公司 | 作为牙龈炎诊断物的中性粒细胞失调的生物标志物 |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0910259A2 (pt) | 2015-12-01 |
| KR20110014141A (ko) | 2011-02-10 |
| MX2010010198A (es) | 2010-12-21 |
| EP2254597A2 (en) | 2010-12-01 |
| WO2009117710A2 (en) | 2009-09-24 |
| NZ588033A (en) | 2012-11-30 |
| US20110044988A1 (en) | 2011-02-24 |
| CA2717365A1 (en) | 2009-09-24 |
| IL207752A0 (en) | 2010-12-30 |
| WO2009117710A3 (en) | 2010-01-21 |
| CO6300848A2 (es) | 2011-07-21 |
| WO2009117706A2 (en) | 2009-09-24 |
| JP2011515416A (ja) | 2011-05-19 |
| US20110262386A1 (en) | 2011-10-27 |
| AU2009225389A1 (en) | 2009-09-24 |
| AU2009225385A1 (en) | 2009-09-24 |
| EP2252318A4 (en) | 2012-04-18 |
| EA201001529A1 (ru) | 2011-06-30 |
| EP2252318A2 (en) | 2010-11-24 |
| WO2009117706A3 (en) | 2010-01-21 |
| CA2717071A1 (en) | 2009-09-24 |
| EP2254597A4 (en) | 2012-04-18 |
| CN102046199A (zh) | 2011-05-04 |
| JP2011526244A (ja) | 2011-10-06 |
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Application publication date: 20110608 |