JP2016517273A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016517273A5 JP2016517273A5 JP2016501598A JP2016501598A JP2016517273A5 JP 2016517273 A5 JP2016517273 A5 JP 2016517273A5 JP 2016501598 A JP2016501598 A JP 2016501598A JP 2016501598 A JP2016501598 A JP 2016501598A JP 2016517273 A5 JP2016517273 A5 JP 2016517273A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- deoxyuridine
- disease
- independently selected
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 52
- 102000004889 Interleukin-6 Human genes 0.000 claims 19
- 108090001005 Interleukin-6 Proteins 0.000 claims 19
- 150000003230 pyrimidines Chemical class 0.000 claims 15
- 125000005647 linker group Chemical group 0.000 claims 12
- 125000003729 nucleotide group Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims 4
- -1 alkylene glycols Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims 3
- 229940035437 1,3-propanediol Drugs 0.000 claims 3
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 3
- 206010042953 Systemic sclerosis Diseases 0.000 claims 3
- 206010047115 Vasculitis Diseases 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000003211 malignant effect Effects 0.000 claims 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 208000007465 Giant cell arteritis Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 241000598436 Human T-cell lymphotropic virus Species 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 208000001106 Takayasu Arteritis Diseases 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 229920001515 polyalkylene glycol Polymers 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 206010043207 temporal arteritis Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 208000033316 Acquired hemophilia A Diseases 0.000 claims 1
- 208000026326 Adult-onset Still disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000005024 Castleman disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 claims 1
- 101000617830 Homo sapiens Sterol O-acyltransferase 1 Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims 1
- 208000034762 Meningococcal Infections Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000003926 Myelitis Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000000770 Non-ST Elevated Myocardial Infarction Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 206010065159 Polychondritis Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
- 208000008765 Sciatica Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 102000054727 Serum Amyloid A Human genes 0.000 claims 1
- 108700028909 Serum Amyloid A Proteins 0.000 claims 1
- 102100021993 Sterol O-acyltransferase 1 Human genes 0.000 claims 1
- 101000697584 Streptomyces lavendulae Streptothricin acetyltransferase Proteins 0.000 claims 1
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 208000024340 acute graft versus host disease Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000029499 cancer-related condition Diseases 0.000 claims 1
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 1
- 125000005518 carboxamido group Chemical group 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 201000003278 cryoglobulinemia Diseases 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000007373 indentation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 208000031223 plasma cell leukemia Diseases 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- YRVCHYUHISNKSG-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO.OCCCO YRVCHYUHISNKSG-UHFFFAOYSA-N 0.000 claims 1
- 208000009169 relapsing polychondritis Diseases 0.000 claims 1
- 230000000552 rheumatic effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782938P | 2013-03-14 | 2013-03-14 | |
| US61/782,938 | 2013-03-14 | ||
| US201361789244P | 2013-03-15 | 2013-03-15 | |
| US61/789,244 | 2013-03-15 | ||
| PCT/US2014/024669 WO2014159669A2 (en) | 2013-03-14 | 2014-03-12 | Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016517273A JP2016517273A (ja) | 2016-06-16 |
| JP2016517273A5 true JP2016517273A5 (enExample) | 2017-03-16 |
| JP6591392B2 JP6591392B2 (ja) | 2019-10-16 |
Family
ID=51625609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501598A Active JP6591392B2 (ja) | 2013-03-14 | 2014-03-12 | Ｉｌ−６に結合するアプタマー及びｉｌ−６介在性状態の治療または診断におけるそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9206429B2 (enExample) |
| EP (1) | EP2970979B1 (enExample) |
| JP (1) | JP6591392B2 (enExample) |
| KR (1) | KR102242874B1 (enExample) |
| CN (3) | CN112961860A (enExample) |
| AU (1) | AU2014244534B2 (enExample) |
| CA (1) | CA2902186C (enExample) |
| ES (1) | ES2710723T3 (enExample) |
| SG (1) | SG11201507335QA (enExample) |
| WO (1) | WO2014159669A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104561013A (zh) * | 2015-01-05 | 2015-04-29 | 中国人民解放军南京军区福州总医院 | 基于高通量测序技术进行核酸适配体序列优化的方法 |
| CN105911295A (zh) * | 2015-11-15 | 2016-08-31 | 陈博 | 一种口腔癌特异性检测的试剂盒 |
| WO2018005974A1 (en) * | 2016-07-01 | 2018-01-04 | Somalogic, Inc. | Oligonucleotides comprising modified nucleosides |
| CN107663220B (zh) * | 2016-07-27 | 2020-10-02 | 上海伯豪医学检验所有限公司 | 修饰碱基、包含修饰碱基的核酸、适配体及其应用 |
| JP2019535249A (ja) * | 2016-10-24 | 2019-12-12 | バイオイズ カンパニー リミテッド | ＴＮＦ−α結合アプタマー及びその治療的用途 |
| CN107238712B (zh) * | 2017-06-05 | 2018-12-28 | 中国人民解放军沈阳军区总医院 | 血浆s100a12在st段抬高型心肌梗死预后中的应用 |
| WO2020069569A1 (en) | 2018-10-02 | 2020-04-09 | WearOptimo Pty Ltd | Actuator system |
| JP7379505B2 (ja) | 2018-10-02 | 2023-11-14 | ウェアオプティモ ピーティーワイ リミテッド | 流体レベルの判定 |
| US11649460B2 (en) | 2020-03-20 | 2023-05-16 | Joao Francisco Peinado Pereira | DNA aptamers, method for inhibiting human galectin-1 and method of treating a mammal in need thereof |
| CN115851742B (zh) * | 2022-10-28 | 2025-10-10 | 合肥工业大学 | 一种IL-6/sIL-6R双特异性环状核酸适配体及试剂盒与应用 |
| WO2024225425A1 (ja) * | 2023-04-26 | 2024-10-31 | Ｅｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ株式会社 | 標的ヌクレオチド配列の改変のための非天然型ポリヌクレオチド |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070166741A1 (en) * | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| EP1667729A4 (en) * | 2003-05-23 | 2007-10-17 | Univ Texas | STRUCTURAL BASED AND COMBINATORY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOAT AND PHOSPHORODITHIOAT APTAMIC TARGETING AP-1 TRANSCRIPTION FACTORS |
| RU2006135119A (ru) * | 2004-03-05 | 2008-04-10 | Аркемикс Корп. (Us) | Аптамеры к семейству цитокинов il-12 человека и их применение в качестве лекарственных средств для аутоиммунных заболеваний |
| CN101374965B (zh) | 2006-01-17 | 2013-08-14 | 私募蛋白质体公司 | 测试样品的多元化分析 |
| US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) * | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| AU2008275915B2 (en) | 2007-07-17 | 2013-07-11 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
| WO2011130195A1 (en) * | 2010-04-12 | 2011-10-20 | Somalogic, Inc. | APTAMERS TO β-NGF AND THEIR USE IN TREATING β-NGF MEDIATED DISEASES AND DISORDERS |
| US8658613B2 (en) | 2010-11-30 | 2014-02-25 | Otc Biotechnologies, Llc | Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health |
| FR2978964B1 (fr) * | 2011-08-09 | 2015-02-20 | Conservatoire Nat Arts | Composition vaccinale anti-il-6 |
-
2014
- 2014-03-12 CN CN202110252614.9A patent/CN112961860A/zh active Pending
- 2014-03-12 WO PCT/US2014/024669 patent/WO2014159669A2/en not_active Ceased
- 2014-03-12 CA CA2902186A patent/CA2902186C/en active Active
- 2014-03-12 EP EP14775454.3A patent/EP2970979B1/en active Active
- 2014-03-12 ES ES14775454T patent/ES2710723T3/es active Active
- 2014-03-12 KR KR1020157027953A patent/KR102242874B1/ko active Active
- 2014-03-12 CN CN201480014093.1A patent/CN105051193A/zh active Pending
- 2014-03-12 SG SG11201507335QA patent/SG11201507335QA/en unknown
- 2014-03-12 JP JP2016501598A patent/JP6591392B2/ja active Active
- 2014-03-12 CN CN201811220016.8A patent/CN109439664B/zh active Active
- 2014-03-12 AU AU2014244534A patent/AU2014244534B2/en not_active Ceased
- 2014-03-12 US US14/206,814 patent/US9206429B2/en active Active