KR102242874B1 - Ｉｌ―６에 결합하는 압타머 및 ｉｌ―６ 매개된 질환을 치료하거나 진단하는 데에서 이의 용도 - Google Patents
Ｉｌ―６에 결합하는 압타머 및 ｉｌ―６ 매개된 질환을 치료하거나 진단하는 데에서 이의 용도 Download PDFInfo
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- KR102242874B1 KR102242874B1 KR1020157027953A KR20157027953A KR102242874B1 KR 102242874 B1 KR102242874 B1 KR 102242874B1 KR 1020157027953 A KR1020157027953 A KR 1020157027953A KR 20157027953 A KR20157027953 A KR 20157027953A KR 102242874 B1 KR102242874 B1 KR 102242874B1
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| PCT/US2014/024669 WO2014159669A2 (en) | 2013-03-14 | 2014-03-12 | Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions |
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| KR20150140669A KR20150140669A (ko) | 2015-12-16 |
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| CN104561013A (zh) * | 2015-01-05 | 2015-04-29 | 中国人民解放军南京军区福州总医院 | 基于高通量测序技术进行核酸适配体序列优化的方法 |
| CN105891486A (zh) * | 2015-11-15 | 2016-08-24 | 陈博 | 一种口腔癌特异性检测的试剂盒 |
| CN109312346B (zh) * | 2016-07-01 | 2024-07-30 | 私募蛋白质体操作有限公司 | 包含修饰核苷的寡核苷酸 |
| CN107663220B (zh) * | 2016-07-27 | 2020-10-02 | 上海伯豪医学检验所有限公司 | 修饰碱基、包含修饰碱基的核酸、适配体及其应用 |
| WO2018079864A1 (ko) * | 2016-10-24 | 2018-05-03 | 김성천 | TNF-α 결합 압타머 및 그것의 치료적 용도 |
| CN107238712B (zh) * | 2017-06-05 | 2018-12-28 | 中国人民解放军沈阳军区总医院 | 血浆s100a12在st段抬高型心肌梗死预后中的应用 |
| AU2019352635B2 (en) | 2018-10-02 | 2024-12-19 | WearOptimo Pty Ltd | Actuator system |
| JP7379505B2 (ja) | 2018-10-02 | 2023-11-14 | ウェアオプティモ ピーティーワイ リミテッド | 流体レベルの判定 |
| US11649460B2 (en) | 2020-03-20 | 2023-05-16 | Joao Francisco Peinado Pereira | DNA aptamers, method for inhibiting human galectin-1 and method of treating a mammal in need thereof |
| CN115851742B (zh) * | 2022-10-28 | 2025-10-10 | 合肥工业大学 | 一种IL-6/sIL-6R双特异性环状核酸适配体及试剂盒与应用 |
| KR20250168544A (ko) * | 2023-04-26 | 2025-12-02 | 유러스 세러퓨틱스 가부시키가이샤 | 표적 뉴클레오티드 서열의 개변을 위한 비천연형 폴리뉴클레오티드 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018537A2 (en) | 2003-05-23 | 2005-03-03 | Board Of Regents - The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors |
| WO2005086835A2 (en) | 2004-03-05 | 2005-09-22 | Archemix Corp. | Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics |
| US20100055695A1 (en) * | 2007-01-16 | 2010-03-04 | Somalogic, Inc. | Method For Generating Aptamers with Improved Off-Rates |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| DK1994171T3 (en) | 2006-01-17 | 2015-06-15 | Somalogic Inc | Multiplex Analyses of test samples |
| US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| US8975026B2 (en) * | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| CA2696431C (en) | 2007-07-17 | 2021-01-05 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US20110275794A1 (en) * | 2010-04-12 | 2011-11-10 | Somalogic, Inc. | 5-position modified pyrimidines and their use |
| US8658613B2 (en) | 2010-11-30 | 2014-02-25 | Otc Biotechnologies, Llc | Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health |
| FR2978964B1 (fr) * | 2011-08-09 | 2015-02-20 | Conservatoire Nat Arts | Composition vaccinale anti-il-6 |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005018537A2 (en) | 2003-05-23 | 2005-03-03 | Board Of Regents - The University Of Texas System | Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting ap-1 transcription factors |
| WO2005086835A2 (en) | 2004-03-05 | 2005-09-22 | Archemix Corp. | Aptamers to the human il-12 cytokine family and their use as autoimmune disease therapeutics |
| US20100055695A1 (en) * | 2007-01-16 | 2010-03-04 | Somalogic, Inc. | Method For Generating Aptamers with Improved Off-Rates |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201507335QA (en) | 2015-10-29 |
| CN109439664B (zh) | 2024-03-08 |
| JP6591392B2 (ja) | 2019-10-16 |
| AU2014244534A1 (en) | 2015-09-10 |
| EP2970979A2 (en) | 2016-01-20 |
| HK1217512A1 (en) | 2017-01-13 |
| CN105051193A (zh) | 2015-11-11 |
| CA2902186A1 (en) | 2014-10-02 |
| EP2970979B1 (en) | 2018-11-21 |
| CN109439664A (zh) | 2019-03-08 |
| US9206429B2 (en) | 2015-12-08 |
| WO2014159669A3 (en) | 2014-12-04 |
| KR20150140669A (ko) | 2015-12-16 |
| CN112961860A (zh) | 2021-06-15 |
| US20140315986A1 (en) | 2014-10-23 |
| AU2014244534B2 (en) | 2020-04-30 |
| WO2014159669A2 (en) | 2014-10-02 |
| CA2902186C (en) | 2023-04-11 |
| EP2970979A4 (en) | 2016-11-09 |
| ES2710723T3 (es) | 2019-04-26 |
| JP2016517273A (ja) | 2016-06-16 |
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