JP2011524887A5 - - Google Patents
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- Publication number
- JP2011524887A5 JP2011524887A5 JP2011514119A JP2011514119A JP2011524887A5 JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5 JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011514119 A JP2011514119 A JP 2011514119A JP 2011524887 A5 JP2011524887 A5 JP 2011524887A5
- Authority
- JP
- Japan
- Prior art keywords
- retroviral vector
- formulation
- ultrafiltration
- filter
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7368508P | 2008-06-18 | 2008-06-18 | |
| US61/073,685 | 2008-06-18 | ||
| PCT/GB2009/001527 WO2009153563A1 (en) | 2008-06-18 | 2009-06-18 | Virus purification |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Division JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524887A JP2011524887A (ja) | 2011-09-08 |
| JP2011524887A5 true JP2011524887A5 (https=) | 2012-07-19 |
| JP5615271B2 JP5615271B2 (ja) | 2014-10-29 |
Family
ID=40940324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514119A Active JP5615271B2 (ja) | 2008-06-18 | 2009-06-18 | ウイルス精製法 |
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014142447A Expired - Fee Related JP6002720B2 (ja) | 2008-06-18 | 2014-07-10 | ウイルス精製法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9169491B2 (https=) |
| EP (2) | EP2307551B1 (https=) |
| JP (2) | JP5615271B2 (https=) |
| CN (2) | CN102124115B (https=) |
| DK (2) | DK2307551T3 (https=) |
| ES (2) | ES2762864T3 (https=) |
| PL (2) | PL3192874T3 (https=) |
| WO (1) | WO2009153563A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011094198A1 (en) * | 2010-01-28 | 2011-08-04 | The Children's Hospital Of Philadelphia Research Institute, Abramson Research Center | A scalable manufacturing platform for viral vector purification and viral vectors so purified for use in gene therapy |
| WO2011148194A1 (en) | 2010-05-28 | 2011-12-01 | Oxford Biomedica (Uk) Ltd | Delivery of lentiviral vectors to the brain |
| GB201118636D0 (en) | 2011-10-28 | 2011-12-07 | Oxford Biomedica Ltd | Nucleotide sequence |
| US20140315294A1 (en) | 2011-11-24 | 2014-10-23 | Genethon | Scalable lentiviral vector production system compatible with industrial pharmaceutical applications |
| WO2013090409A1 (en) | 2011-12-12 | 2013-06-20 | The Children's Hospital Of Philadelphia | Large commercial scale lentiviral vector production system and vectors produced thereby |
| EP3246400B1 (en) | 2012-01-09 | 2019-10-23 | Sanofi Pasteur Biologics, LLC | Purification of herpes virus |
| EP2852662B1 (en) | 2012-05-21 | 2020-09-16 | Sanofi Pasteur Limited | Herpesvirus compositions and related methods |
| WO2014127215A1 (en) | 2013-02-15 | 2014-08-21 | Biogen Idec Ma Inc. | Optimized factor viii gene |
| EP2970920B1 (en) * | 2013-03-15 | 2018-04-25 | The Children's Hospital of Philadelphia | Scalable manufacturing process to produce recombinant lentiviral vectors in serum-free suspension cell culture system |
| FR3010720B1 (fr) | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
| FR3014901B1 (fr) * | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
| GB201322798D0 (en) | 2013-12-20 | 2014-02-05 | Oxford Biomedica Ltd | Production system |
| US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
| CN104371982A (zh) * | 2014-10-21 | 2015-02-25 | 武汉维诺赛生物技术有限公司 | 一种慢病毒的纯化方法 |
| JP6718444B2 (ja) | 2014-11-03 | 2020-07-08 | アカデミッシュ ザイケンホイス レイデン （エイチ．オー．ディー．エヌ． エルユーエムシー） | Ｂｏｂ１に対して指向されるＴ細胞レセプターおよびその使用 |
| EP3054007A1 (en) | 2015-02-09 | 2016-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant adeno-associated virus particle purification comprising an immuno-affinity purification step |
| CA2978171A1 (en) | 2015-03-10 | 2016-09-15 | J.H. Frederik Falkenburg | T-cell receptors directed against the preferentially expressed antigen of melanoma and uses thereof |
| FI3380620T3 (fi) | 2015-11-23 | 2024-08-01 | Novartis Ag | Optimoituja lentiviruksen siirtovektoreita ja niiden käyttötapoja |
| CA3012695A1 (en) | 2016-02-01 | 2017-08-10 | Bioverativ Therapeutics Inc. | Optimized factor viii genes |
| CN107043784A (zh) * | 2016-02-05 | 2017-08-15 | 上海吉凯基因化学技术有限公司 | 一种慢病毒载体的制备方法 |
| JP2019519250A (ja) | 2016-05-10 | 2019-07-11 | ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズＵｎｉｔｅｄ Ｓｔａｔｅｓ Ｇｏｖｅｒｎｍｅｎｔ Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｖｅｔｅｒａｎｓ Ａｆｆａｉｒｓ | Ｈｉｖ−１感染と複製に必須な遺伝子を切断するｃｒｉｓｐｒ／ｃａｓの構築物のレンチウィルスによる送達 |
| GB201614050D0 (en) * | 2016-08-17 | 2016-09-28 | Glaxosmithkline Ip Dev Ltd | Method for purifying viral vectors |
| CA3082450A1 (en) | 2017-11-21 | 2019-05-31 | Crispr Therapeutics Ag | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| WO2019123430A1 (en) | 2017-12-21 | 2019-06-27 | Casebia Therapeutics Llp | Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp) |
| EP3696272A1 (en) | 2017-12-22 | 2020-08-19 | Oxford BioMedica (UK) Limited | Retroviral vector |
| CN113056561A (zh) * | 2018-04-05 | 2021-06-29 | 牛津大学科技创新有限公司 | 用于治疗黄斑营养不良的组合物和方法 |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| IL279295B2 (en) | 2018-06-12 | 2026-03-01 | Kentucky Bioprocessing Inc | Purification and cross-linking of virus and antigen |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| BR112021002765A2 (pt) * | 2018-08-16 | 2021-07-20 | Spacecraft Seven, Llc | métodos de produção para vetores virais |
| US20220175962A1 (en) | 2019-03-10 | 2022-06-09 | Sio Gene Therapies Inc. | Gene therapy compositions and methods for treating parkinson's disease |
| WO2020214676A1 (en) * | 2019-04-15 | 2020-10-22 | Children's Hospital Medical Center | Viral vector manufacturing methods |
| WO2021041322A1 (en) | 2019-08-23 | 2021-03-04 | Lonza Walkersville, Inc. | Methods and constructs for production of lentiviral vector |
| KR20220097891A (ko) | 2019-09-30 | 2022-07-08 | 바이오버라티브 테라퓨틱스 인크. | 렌티바이러스 벡터 제형 |
| WO2021094752A1 (en) | 2019-11-12 | 2021-05-20 | Oxford Biomedica (Uk) Limited | Production system |
| EP4103723A1 (en) | 2020-02-13 | 2022-12-21 | Oxford BioMedica (UK) Limited | Production of lentiviral vectors |
| WO2021181108A1 (en) | 2020-03-13 | 2021-09-16 | Oxford Biomedica (Uk) Limited | Lentiviral vectors |
| AU2021264465A1 (en) | 2020-04-27 | 2022-12-15 | University Of Iowa Research Foundation | Compositions and methods for the treatment of cystic fibrosis |
| GB202007199D0 (en) | 2020-05-15 | 2020-07-01 | Oxford Biomedica Ltd | Viral vector production |
| MX2023000156A (es) | 2020-06-24 | 2023-02-16 | Bioverativ Therapeutics Inc | Metodos para la eliminacion de factor viii libre de preparaciones de vectores lentivirales modificados para expresar dicha proteina. |
| EP4196596A4 (en) * | 2020-08-13 | 2025-01-01 | Tmunity Therapeutics Inc. | METHOD FOR PRODUCING A CLINICAL QUALITY LENTIVIRAL VECTOR |
| CN112226418B (zh) * | 2020-09-25 | 2022-07-08 | 阜外华中心血管病医院 | 重组腺相关病毒纯化方法 |
| EP4222250A1 (en) * | 2020-10-02 | 2023-08-09 | Genelux Corporation | Bioreactor production of virus from adherent cells |
| GB202017725D0 (en) | 2020-11-10 | 2020-12-23 | Oxford Biomedica Ltd | Method |
| CN112899242A (zh) * | 2021-02-03 | 2021-06-04 | 苏州博腾生物制药有限公司 | 慢病毒纯化工艺 |
| GB202114529D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| GB202114534D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Novel viral regulatory elements |
| GB202114528D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral vectors |
| GB202114532D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Lentiviral Vectors |
| GB202114530D0 (en) | 2021-10-12 | 2021-11-24 | Oxford Biomedica Ltd | Retroviral vectors |
| KR20240093931A (ko) | 2021-10-29 | 2024-06-24 | 에이지씨 가부시키가이샤 | 세포 첨가용 조성물 |
| WO2023085382A1 (ja) | 2021-11-12 | 2023-05-19 | Ａｇｃ株式会社 | ウイルスの精製方法 |
| GB202117844D0 (en) | 2021-12-09 | 2022-01-26 | Oxford Biomedica Ltd | Purification method |
| GB202211935D0 (en) | 2022-08-16 | 2022-09-28 | Oxford Biomedica Ltd | envelope proteins |
| CN116240241A (zh) * | 2022-12-30 | 2023-06-09 | 上海本导基因技术有限公司 | 重组慢病毒载体的纯化制备方法 |
| CN121002189A (zh) * | 2023-02-01 | 2025-11-21 | 因特尔乌斯生物治疗公司 | 用于过滤或纯化病毒颗粒的方法 |
| WO2024259299A1 (en) | 2023-06-14 | 2024-12-19 | The Broad Institute, Inc. | Compositions and methods for identification of vhh antibodies that bind a target antigen |
| WO2025235738A1 (en) * | 2024-05-08 | 2025-11-13 | Interius Biotherapeutics, Inc. | Methods of detecting residual dna in viral preparations |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78703A (en) | 1985-05-10 | 1993-02-21 | Benzon Alfred | Method of producing extracellular enzymes, the enzymes produced thereby and compositions containing them; a hybrid plasmid and a dna fragment comprising dna encoding the enzymes; a microorganism harbouring the plasmid; and a method for removing nucleic acids from biological materials |
| DE4006630A1 (de) | 1990-03-03 | 1991-09-12 | Behringwerke Ag | Humane monoklonale antikoerper gegen tollwutviren, ihre herstellung und verwendung |
| US5512421A (en) | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| DE69131908T3 (de) | 1991-02-19 | 2008-04-03 | Oxford Biomedica (Uk) Ltd. | Viruspartikel mit veraendertem wirtspektrum |
| EP0738319A4 (en) * | 1994-01-12 | 2000-03-29 | Genetic Therapy Inc | Purification of retroviral vectors |
| DE69515028T2 (de) | 1994-03-22 | 2000-06-29 | The Immune Response Corp., Carlsbad | Die hocheffiziente herstellung und isolierung von viruspartikeln |
| US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| US5723315A (en) | 1996-08-23 | 1998-03-03 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| WO1998005635A1 (en) | 1996-08-07 | 1998-02-12 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| PT904392E (pt) | 1996-10-17 | 2001-06-29 | Oxford Biomedica Ltd | Vectores retrovirais |
| WO1998022588A2 (en) * | 1996-11-20 | 1998-05-28 | Introgen Therapeutics, Inc. | An improved method for the production and purification of adenoviral vectors |
| US6261823B1 (en) | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
| GB9720465D0 (en) | 1997-09-25 | 1997-11-26 | Oxford Biomedica Ltd | Dual-virus vectors |
| GB9803351D0 (en) | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| DE69941049D1 (de) | 1998-05-22 | 2009-08-13 | Oxford Biomedica Ltd | Retrovirales verabreichungssystem |
| GB9904905D0 (en) | 1999-03-03 | 1999-04-28 | Oxford Biomedica Ltd | Cells |
| GB0009760D0 (en) | 2000-04-19 | 2000-06-07 | Oxford Biomedica Ltd | Method |
| GB0024550D0 (https=) | 2000-10-06 | 2000-11-22 | Oxford Biomedica Ltd | |
| EP1492890A4 (en) * | 2002-03-29 | 2006-10-18 | Merck & Co Inc | EXPLOSIVE PROCEDURE FOR THE PRODUCTION OF ADENOVIRUS AND ADENOVIRUS STEM MIXTURES |
| ATE360683T1 (de) | 2002-05-14 | 2007-05-15 | Merck & Co Inc | Verfahren zur reinigung von adenovirus |
| EP1534847B1 (en) | 2002-09-03 | 2015-10-28 | Oxford Biomedica (UK) Limited | Retroviral vector and stable packaging cell lines |
| WO2004098531A2 (en) * | 2003-05-05 | 2004-11-18 | Virxsys Corporation | Increased transduction using abc transporter substrates and/or inhibitors |
| SE0302509D0 (sv) | 2003-09-19 | 2003-09-19 | Amersham Biosciences Ab | Matrix for separation of polyethers and method of separation |
| BRPI0415563A (pt) * | 2003-10-20 | 2007-01-02 | Nsgene As | método para o tratamento do mal de parkinson, uso de um vetor viral, vetor de expressão viral, composição farmacêutica, célula hospedeira isolada, linhagem de células de empacotamento, mamìfero não humano quimérico, dispositivo de cultura celular implantável, cápsula biocompatìvel, método para tratamento de uma doença do sistema nervoso, célula de mamìfero, e, método para produzir neurturin ou um seu equivalente funcional |
| US20070207461A1 (en) * | 2004-02-23 | 2007-09-06 | Crucell Holland B.V. | Virus Purification Methods |
| GB0526210D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Vectors |
| GB0526211D0 (en) | 2005-12-22 | 2006-02-01 | Oxford Biomedica Ltd | Viral vectors |
| US7875446B2 (en) | 2006-04-20 | 2011-01-25 | Wyeth Llc | Purification processes for isolating purified vesicular stomatitis virus from cell culture |
| WO2008065430A2 (en) * | 2006-12-01 | 2008-06-05 | Oxford Biomedica (Uk) Limited | Promoter construct |
| JP5332064B2 (ja) | 2007-03-01 | 2013-11-06 | ウェルスタット イムノセラピューティクス， エルエルシー | 炎症により特徴付けられる疾患の治療 |
| CN101855248B (zh) * | 2007-11-13 | 2012-08-22 | 生物技术通用（以色列）有限公司 | 用于粘弹性生物聚合物的稀释过滤灭菌方法 |
-
2009
- 2009-06-18 DK DK09766124.3T patent/DK2307551T3/en active
- 2009-06-18 JP JP2011514119A patent/JP5615271B2/ja active Active
- 2009-06-18 EP EP09766124.3A patent/EP2307551B1/en active Active
- 2009-06-18 US US12/487,215 patent/US9169491B2/en active Active
- 2009-06-18 DK DK16002644.9T patent/DK3192874T3/da active
- 2009-06-18 PL PL16002644T patent/PL3192874T3/pl unknown
- 2009-06-18 ES ES16002644T patent/ES2762864T3/es active Active
- 2009-06-18 CN CN200980132555.9A patent/CN102124115B/zh not_active Expired - Fee Related
- 2009-06-18 EP EP16002644.9A patent/EP3192874B1/en active Active
- 2009-06-18 PL PL09766124T patent/PL2307551T3/pl unknown
- 2009-06-18 WO PCT/GB2009/001527 patent/WO2009153563A1/en not_active Ceased
- 2009-06-18 CN CN201410244813.5A patent/CN103993040B/zh not_active Expired - Fee Related
- 2009-06-18 ES ES09766124.3T patent/ES2618851T3/es active Active
-
2014
- 2014-07-10 JP JP2014142447A patent/JP6002720B2/ja not_active Expired - Fee Related
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