PL2007883T3 - Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej - Google Patents

Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej

Info

Publication number
PL2007883T3
PL2007883T3 PL07755685T PL07755685T PL2007883T3 PL 2007883 T3 PL2007883 T3 PL 2007883T3 PL 07755685 T PL07755685 T PL 07755685T PL 07755685 T PL07755685 T PL 07755685T PL 2007883 T3 PL2007883 T3 PL 2007883T3
Authority
PL
Poland
Prior art keywords
vsv
cell culture
recovering
vesicular stomatitis
stomatitis virus
Prior art date
Application number
PL07755685T
Other languages
English (en)
Inventor
Yun Kang
Mark William Cutler
Amadou Affrey Ouattara
Kristen Elissa Syvertsen
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of PL2007883T3 publication Critical patent/PL2007883T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20241—Use of virus, viral particle or viral elements as a vector
    • C12N2760/20243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20251—Methods of production or purification of viral material
    • C12N2760/20252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL07755685T 2006-04-20 2007-04-19 Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej PL2007883T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79337606P 2006-04-20 2006-04-20
EP07755685A EP2007883B1 (en) 2006-04-20 2007-04-19 Purification processes for isolating purified vesicular stomatitis virus from cell culture
PCT/US2007/009510 WO2007123961A2 (en) 2006-04-20 2007-04-19 Purification processes for isolating purified vesicular stomatitis virus from cell culture

Publications (1)

Publication Number Publication Date
PL2007883T3 true PL2007883T3 (pl) 2012-07-31

Family

ID=38625574

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07755685T PL2007883T3 (pl) 2006-04-20 2007-04-19 Sposób oczyszczania do izolacji oczyszczonego wirusa pęcherzykowatego zapalenia jamy ustnej z hodowli komórkowej

Country Status (19)

Country Link
US (1) US7875446B2 (pl)
EP (1) EP2007883B1 (pl)
JP (1) JP5129805B2 (pl)
KR (1) KR101385927B1 (pl)
CN (1) CN101426905B (pl)
AT (1) ATE539149T1 (pl)
AU (1) AU2007240797B2 (pl)
BR (1) BRPI0710820A2 (pl)
CA (1) CA2648792C (pl)
CR (1) CR10380A (pl)
DK (1) DK2007883T3 (pl)
ES (1) ES2377356T3 (pl)
IL (1) IL194629A (pl)
MX (1) MX2008013494A (pl)
PL (1) PL2007883T3 (pl)
PT (1) PT2007883E (pl)
RU (1) RU2484135C2 (pl)
SI (1) SI2007883T1 (pl)
WO (1) WO2007123961A2 (pl)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2368975B1 (en) * 2004-12-23 2014-09-17 MedImmune, LLC Non-tumorigenic MDCK cell line for propagating viruses
CN101627113B (zh) 2006-09-15 2013-04-24 米迪缪尼有限公司 支持病毒生长到高效价的mdck细胞系和采用该细胞系的生物反应器方法
AU2008266131C1 (en) * 2007-06-15 2025-06-05 Amgen Inc. Methods of treating cell culture media for use in a bioreactor
PL2195418T3 (pl) * 2007-10-02 2013-05-31 Ptc Phage Tech Center Gmbh Sposób i układ do oczyszczania na skalę przemysłową bakteriofagów z przeznaczeniem do terapii bakteriofagowej
AU2008340319A1 (en) * 2007-12-21 2009-07-02 Wyeth Llc Genetically modified attenuated vesicular stomatitis virus, compositions and methods of use thereof
EP3192874B1 (en) * 2008-06-18 2019-10-16 Oxford BioMedica (UK) Limited Virus purification
BRPI0919252A2 (pt) * 2008-09-24 2015-08-11 Medimmune Llc Métodos para cultivar células, propagação e purificação de vírus
CN102215865B (zh) * 2008-09-24 2013-10-30 米迪缪尼有限公司 病毒纯化方法
KR20110085980A (ko) * 2008-10-17 2011-07-27 퍼시비아 엘엘씨 높은 세포 밀도에서의 정화 방법
US20100143889A1 (en) * 2008-12-02 2010-06-10 Mayo Foundation For Medical Education And Research Rhabdoviridae virus preparations
US20110293660A1 (en) * 2009-02-06 2011-12-01 Bruno Rene Andre Novel method
NZ599100A (en) 2009-10-20 2014-07-25 Abbvie Inc Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography
CN102191226A (zh) * 2010-03-08 2011-09-21 北京清大天一科技有限公司 细胞培养混合物的分离纯化方法
WO2012019354A1 (en) 2010-08-12 2012-02-16 Yisheng Biopharma Holdings Ltd. Method for reducing dna impurities in viral compositions
KR101875245B1 (ko) 2010-12-02 2018-08-02 온콜리틱스 바이오테크 인코포레이티드 액체 바이러스 제형
ES2630012T3 (es) 2010-12-02 2017-08-17 Oncolytics Biotech Inc. Formulaciones virales liofilizadas
US20130012689A1 (en) * 2011-07-08 2013-01-10 Emd Millipore Corporation Depth Filters For Disposable Biotechnological Processes
US9610346B2 (en) 2012-03-23 2017-04-04 International Aids Vaccine Initiative Recombinant viral vectors
US9005888B2 (en) 2012-06-14 2015-04-14 System Biosciences, Llc Methods for microvesicle isolation and selective removal
JP2015526094A (ja) * 2012-08-20 2015-09-10 テルモ ビーシーティー、インコーポレーテッド 細胞成長チャンバーを循環する流体の成分を濃縮する方法
AU2013306080B2 (en) * 2012-08-24 2019-01-31 Global Life Sciences Solutions Usa Llc Virus purification and formulation process
FR3010720B1 (fr) 2013-09-16 2017-08-11 Genethon Procede de production de virus enveloppes
FR3014901B1 (fr) * 2013-12-17 2017-06-09 Genethon Procede de purification de virus ou vecteurs viraux enveloppes
CN114797474A (zh) * 2014-05-21 2022-07-29 非链实验室 用于缓冲溶液交换的系统和方法
CN106857498B (zh) * 2016-12-27 2021-05-14 科兴（大连）疫苗技术有限公司 一种不含二甲基亚砜的细胞冻存保护液及其应用
CN107964037A (zh) * 2017-05-16 2018-04-27 浙江海隆生物科技有限公司 基于cho细胞表达系统的重组猪瘟e2蛋白的纯化方法及应用
CN110317832B (zh) * 2018-03-28 2022-07-05 西比曼生物科技（香港）有限公司 Gmp级规模化制备重组慢病毒载体的纯化制剂的方法
CN110317791A (zh) 2018-03-29 2019-10-11 西比曼生物科技（香港）有限公司 Gmp级无血清悬浮细胞大规模生产慢病毒的方法
US11554179B2 (en) * 2018-07-19 2023-01-17 Helixmith Co., Ltd Lyophilized pharmaceutical compositions for naked DNA gene therapy
CA3107462A1 (en) * 2018-07-24 2020-01-30 Voyager Therapeutics, Inc. Systems and methods for producing gene therapy formulations
TWI894135B (zh) 2019-01-25 2025-08-21 德商百靈佳殷格翰國際股份有限公司 編碼ccl21之重組棒狀病毒
WO2020214676A1 (en) * 2019-04-15 2020-10-22 Children's Hospital Medical Center Viral vector manufacturing methods
CN110305850A (zh) * 2019-05-15 2019-10-08 苏州奥特铭医药科技有限公司 一种利用293细胞生产制备溶瘤病毒的方法
JP7612827B2 (ja) * 2020-07-10 2025-01-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 細胞培養物から精製されたラブドウイルスを製造するための方法
WO2025052417A1 (en) * 2023-09-05 2025-03-13 Auro Vaccines Private Limited Thermostable composition comprising vesiculo virus

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556556A (en) * 1984-03-23 1985-12-03 Advanced Genetics Research Institute Vaccine for the prevention of vesicular stomatitis virus infection
ATE257175T1 (de) 1994-07-18 2004-01-15 Conzelmann Karl Klaus Prof Dr Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus
US7153510B1 (en) * 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
FR2737730B1 (fr) 1995-08-10 1997-09-05 Pasteur Merieux Serums Vacc Procede de purification de virus par chromatographie
US6261823B1 (en) * 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
IL135507A0 (en) * 1997-10-09 2001-05-20 Pro Virus Inc Treatment of neoplasms with viruses
DE69936948T2 (de) * 1998-02-17 2008-05-15 Schering Corporation Virusenthaltende Zusammensetzungen und Methoden zur Konzentration von Viruspräparaten
AU2002362761A1 (en) * 2001-10-09 2003-04-22 University Of Miami Generation of virus-like particles by vsv
US20030175688A1 (en) 2002-03-15 2003-09-18 Rukmini Pennathur-Das Method for the purification and production of oncolytic adenoviruses
US20030180936A1 (en) 2002-03-15 2003-09-25 Memarzadeh Bahram Eric Method for the purification, production and formulation of oncolytic adenoviruses
MXPA04010603A (es) 2002-04-30 2004-12-13 Oncolytics Biotech Inc Metodos mejorados de purificacion viral.
AU2003229060A1 (en) * 2002-05-14 2003-12-02 Merck And Co., Inc. Methods of adenovirus purification
US20050009168A1 (en) 2003-05-12 2005-01-13 Robbins Joan Marie Methods and apparatus for Adeno associated virus purification
DE102004004043B4 (de) 2004-01-27 2013-04-18 Apanovis Biotechnologie Gmbh Reinigung von hochmolekularen Verbindungen mittels Affinitätsmembranchromatographie
AU2005214090B2 (en) * 2004-02-23 2008-09-11 Crucell Holland B.V. Virus purification methods
ES2535310T3 (es) 2004-04-09 2015-05-07 Wyeth Llc Atenuación sinérgica del virus de la estomatitis vesicular, vectores del mismo y composiciones inmunogénicas del mismo
WO2006011580A1 (ja) 2004-07-27 2006-02-02 Genomidea, Inc. ウイルスエンベロープの精製方法

Also Published As

Publication number Publication date
ES2377356T3 (es) 2012-03-26
MX2008013494A (es) 2009-01-26
DK2007883T3 (da) 2012-02-06
CA2648792A1 (en) 2007-11-01
CA2648792C (en) 2016-06-21
AU2007240797B2 (en) 2013-05-23
EP2007883A2 (en) 2008-12-31
EP2007883B1 (en) 2011-12-28
CN101426905A (zh) 2009-05-06
IL194629A0 (en) 2011-08-01
JP2009534030A (ja) 2009-09-24
CN101426905B (zh) 2013-03-27
BRPI0710820A2 (pt) 2011-08-23
ATE539149T1 (de) 2012-01-15
KR20080111544A (ko) 2008-12-23
WO2007123961A2 (en) 2007-11-01
WO2007123961A3 (en) 2008-03-06
PT2007883E (pt) 2012-02-17
AU2007240797A1 (en) 2007-11-01
US20070249019A1 (en) 2007-10-25
SI2007883T1 (sl) 2012-02-29
RU2008140137A (ru) 2010-05-27
KR101385927B1 (ko) 2014-04-24
US7875446B2 (en) 2011-01-25
CR10380A (es) 2008-12-02
RU2484135C2 (ru) 2013-06-10
JP5129805B2 (ja) 2013-01-30
IL194629A (en) 2013-11-28

Similar Documents

Publication Publication Date Title
IL194629A0 (en) Purification processes for isolating purified vesicular stomatitis virus from cell culture
JP3746223B2 (ja) 蛋白質溶液から蛋白質凝集体及びウイルスを除去する方法
UA99249C2 (ru) Устройство и способ для интегрированного непрерывного производства биологических молекул
CN104291483A (zh) 一种离子型稀土矿山废水膜分离技术处理方法及装置
EP1457460A3 (en) Water purification system and method, and module for the system
CN103933860A (zh) 一种车用尿素的制备系统
CN102040531A (zh) 一种提取l-异亮氨酸的方法
CN103012470A (zh) 利用菜籽粕制备液体植酸的方法
MY126838A (en) Purification of protein inclusion bodies by crossflow microfiltration.
DE60220184D1 (de) Membranfilter, system diesen enthaltend, und verfahren zu dessen verwendung
CN204162529U (zh) 一种离子型稀土矿山废水膜分离技术处理装置
ATE408010T1 (de) Reinigung von plasmid-dna durch filtration
CN202080964U (zh) 多用途水处理装置
CN101716469A (zh) 一种用于净化水的仿生光催化膜分离组件
CN111003755A (zh) 一种双膜再利用的滤水净化系统及净水器
CN106396214A (zh) 一种可拆卸冲洗式多级过滤净水系统
CN205099484U (zh) 一种模块化生活饮用水膜法净化设备
Higuchi et al. Rejection of single stranded and double stranded DNA by porous hollow fiber membranes
CN212881404U (zh) 一种基于卷式超滤和纳滤技术的核苷酸溶液纯化浓缩系统
CN211445252U (zh) 一种超滤膜净化水处理设备
CN214829439U (zh) 一种复合滤芯的结构
CN210656213U (zh) 净水系统及净水设备
CN2751017Y (zh) 一种复合净水滤芯
CN210481040U (zh) 一种污水处理膜
CN106146609A (zh) 一种利用膜分离技术从谷胱甘肽亚铜盐中分离提纯谷胱甘肽的方法