CR10380A - Procesos de purificacion para aislar virus purificado de la estomatitis vesicular provenientes de cultivo celular. - Google Patents
Procesos de purificacion para aislar virus purificado de la estomatitis vesicular provenientes de cultivo celular.Info
- Publication number
- CR10380A CR10380A CR10380A CR10380A CR10380A CR 10380 A CR10380 A CR 10380A CR 10380 A CR10380 A CR 10380A CR 10380 A CR10380 A CR 10380A CR 10380 A CR10380 A CR 10380A
- Authority
- CR
- Costa Rica
- Prior art keywords
- cell culture
- vsv
- purification processes
- vesicular stomatitis
- purified viruses
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000004113 cell culture Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 208000003265 stomatitis Diseases 0.000 title abstract 2
- 208000005925 vesicular stomatitis Diseases 0.000 title 1
- 239000012930 cell culture fluid Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000006228 supernatant Substances 0.000 abstract 2
- 238000000464 low-speed centrifugation Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20241—Use of virus, viral particle or viral elements as a vector
- C12N2760/20243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20251—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
- C12N2760/20251—Methods of production or purification of viral material
- C12N2760/20252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Son procesos de purificacion para obtener virus de estomatitis vasicular (VSV) novedosos de pureza mejorada. Mas particularmente, en ciertas modalidades, se describe un proceso para purificar VSV del fluido de cultivo celular de un cultivo celular mamifero infectado con VSV, el proceso comprende: clarificar el fluido de cultivo celular mediante centrifugacion a baja velocidad y recuperar el VSV en el sobrenadante; filtrar el sobrenadante a traves de un filtro de 0.2 a 0.45 pm y recuperar el VSV en la solucion filtrada.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79337606P | 2006-04-20 | 2006-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR10380A true CR10380A (es) | 2008-12-02 |
Family
ID=38625574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR10380A CR10380A (es) | 2006-04-20 | 2008-10-20 | Procesos de purificacion para aislar virus purificado de la estomatitis vesicular provenientes de cultivo celular. |
Country Status (19)
Country | Link |
---|---|
US (1) | US7875446B2 (es) |
EP (1) | EP2007883B1 (es) |
JP (1) | JP5129805B2 (es) |
KR (1) | KR101385927B1 (es) |
CN (1) | CN101426905B (es) |
AT (1) | ATE539149T1 (es) |
AU (1) | AU2007240797B2 (es) |
BR (1) | BRPI0710820A2 (es) |
CA (1) | CA2648792C (es) |
CR (1) | CR10380A (es) |
DK (1) | DK2007883T3 (es) |
ES (1) | ES2377356T3 (es) |
IL (1) | IL194629A (es) |
MX (1) | MX2008013494A (es) |
PL (1) | PL2007883T3 (es) |
PT (1) | PT2007883E (es) |
RU (1) | RU2484135C2 (es) |
SI (1) | SI2007883T1 (es) |
WO (1) | WO2007123961A2 (es) |
Families Citing this family (33)
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CN103555670B (zh) * | 2004-12-23 | 2015-08-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
EP2069480B1 (en) | 2006-09-15 | 2014-03-19 | MedImmune, LLC | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
EP2173861B2 (en) * | 2007-06-15 | 2017-02-22 | Amgen Inc. | Methods of treating cell culture media for use in a bioreactor |
ES2401162T3 (es) * | 2007-10-02 | 2013-04-17 | Ptc Phage Technology Center Gmbh | Procedimiento y sistema para la purificación a escala industrial de bacteriófagos destinados para terapia con bacteriófagos |
KR20110004354A (ko) * | 2007-12-21 | 2011-01-13 | 와이어쓰 엘엘씨 | 유전자 변형된 약독화 수포성 구내염 바이러스, 이의 조성물 및 사용 방법 |
US9169491B2 (en) * | 2008-06-18 | 2015-10-27 | Oxford Biomedica (Uk) Limited | Virus purification |
CN103952376A (zh) * | 2008-09-24 | 2014-07-30 | 米迪缪尼有限公司 | 培养细胞、增殖和纯化病毒的方法 |
KR20110074563A (ko) * | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
EP2346891A1 (en) * | 2008-10-17 | 2011-07-27 | Percivia LLC. | Clarification process at higher cell density |
US20100143889A1 (en) * | 2008-12-02 | 2010-06-10 | Mayo Foundation For Medical Education And Research | Rhabdoviridae virus preparations |
JP5843615B2 (ja) * | 2009-02-06 | 2016-01-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 密度勾配超遠心分離によるウイルスまたはウイルス抗原の精製 |
MX2012004711A (es) | 2009-10-20 | 2012-05-23 | Abbott Lab | Aislamiento y purificacion de los anticuerpos anti-il-13 al usar cromatografia de afinidad con proteina a. |
CN102191226A (zh) * | 2010-03-08 | 2011-09-21 | 北京清大天一科技有限公司 | 细胞培养混合物的分离纯化方法 |
CN103052399B (zh) | 2010-08-12 | 2016-06-29 | 依生生物制药控股有限公司 | 用于减少病毒组合物中dna杂质的方法 |
US9044498B2 (en) | 2010-12-02 | 2015-06-02 | Oncolytics Biotech Inc. | Lyophilized viral formulations |
JP6034798B2 (ja) | 2010-12-02 | 2016-11-30 | オンコリティクス バイオテク,インコーポレーテッド | 液体ウイルス製剤 |
JP6027104B2 (ja) * | 2011-07-08 | 2016-11-16 | イー・エム・デイー・ミリポア・コーポレイシヨン | 使い捨てバイオテクノロジー方法のための改良されたデプスフィルター |
US9610346B2 (en) | 2012-03-23 | 2017-04-04 | International Aids Vaccine Initiative | Recombinant viral vectors |
US9005888B2 (en) | 2012-06-14 | 2015-04-14 | System Biosciences, Llc | Methods for microvesicle isolation and selective removal |
CN110172405A (zh) * | 2012-08-20 | 2019-08-27 | 泰尔茂比司特公司 | 浓缩穿过细胞生长腔室循环的流体的组分 |
AU2013306080B2 (en) * | 2012-08-24 | 2019-01-31 | Global Life Sciences Solutions Usa Llc | Virus purification and formulation process |
FR3010720B1 (fr) | 2013-09-16 | 2017-08-11 | Genethon | Procede de production de virus enveloppes |
FR3014901B1 (fr) * | 2013-12-17 | 2017-06-09 | Genethon | Procede de purification de virus ou vecteurs viraux enveloppes |
US10640531B2 (en) * | 2014-05-21 | 2020-05-05 | Unchained Labs | Systems and methods for exchange of buffer solutions |
CN106857498B (zh) * | 2016-12-27 | 2021-05-14 | 科兴(大连)疫苗技术有限公司 | 一种不含二甲基亚砜的细胞冻存保护液及其应用 |
CN107964037A (zh) * | 2017-05-16 | 2018-04-27 | 浙江海隆生物科技有限公司 | 基于cho细胞表达系统的重组猪瘟e2蛋白的纯化方法及应用 |
CN110317832B (zh) | 2018-03-28 | 2022-07-05 | 西比曼生物科技(香港)有限公司 | Gmp级规模化制备重组慢病毒载体的纯化制剂的方法 |
CN110317791A (zh) | 2018-03-29 | 2019-10-11 | 西比曼生物科技(香港)有限公司 | Gmp级无血清悬浮细胞大规模生产慢病毒的方法 |
EP3823677A4 (en) * | 2018-07-19 | 2022-06-01 | Helixmith Co., Ltd. | FREEZE-DRIED PHARMACEUTICAL COMPOSITIONS INTENDED FOR NAKED-DNA GENE THERAPY |
CA3107462A1 (en) * | 2018-07-24 | 2020-01-30 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
TW202043466A (zh) | 2019-01-25 | 2020-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
CN110305850A (zh) * | 2019-05-15 | 2019-10-08 | 苏州奥特铭医药科技有限公司 | 一种利用293细胞生产制备溶瘤病毒的方法 |
BR112022025251A2 (pt) * | 2020-07-10 | 2023-01-17 | Boehringer Ingelheim Int | Processo para produzir rabdovírus purificado a partir de cultura celular |
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US4556556A (en) * | 1984-03-23 | 1985-12-03 | Advanced Genetics Research Institute | Vaccine for the prevention of vesicular stomatitis virus infection |
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US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
FR2737730B1 (fr) | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
US6261823B1 (en) * | 1996-12-13 | 2001-07-17 | Schering Corporation | Methods for purifying viruses |
EP1032269B1 (en) * | 1997-10-09 | 2007-08-29 | Wellstat Biologics Corporation | Treatment of neoplasms with interferon-sensitive, clonal viruses |
KR100991683B1 (ko) * | 1998-02-17 | 2010-11-04 | 쉐링 코포레이션 | 바이러스 제제의 농축방법 |
AU2002362761A1 (en) * | 2001-10-09 | 2003-04-22 | University Of Miami | Generation of virus-like particles by vsv |
US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
US20030175688A1 (en) | 2002-03-15 | 2003-09-18 | Rukmini Pennathur-Das | Method for the purification and production of oncolytic adenoviruses |
WO2003093463A1 (en) * | 2002-04-30 | 2003-11-13 | Oncolytics Biotech Inc. | Improved viral purification methods |
US20050196854A1 (en) * | 2002-05-14 | 2005-09-08 | Konz John O.Jr. | Methods of adenovirus purification |
US20050009168A1 (en) | 2003-05-12 | 2005-01-13 | Robbins Joan Marie | Methods and apparatus for Adeno associated virus purification |
DE102004004043B4 (de) | 2004-01-27 | 2013-04-18 | Apanovis Biotechnologie Gmbh | Reinigung von hochmolekularen Verbindungen mittels Affinitätsmembranchromatographie |
CN1922308A (zh) * | 2004-02-23 | 2007-02-28 | 克鲁塞尔荷兰公司 | 病毒纯化方法 |
KR101255016B1 (ko) * | 2004-04-09 | 2013-04-17 | 와이어쓰 엘엘씨 | 소포성 구내염 바이러스의 상승적 감쇠, 그의 벡터 및 그의 면역원성 조성물 |
US20090042274A1 (en) | 2004-07-27 | 2009-02-12 | Genomidea Inc. | Method of Purifying Virus Envelope |
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2007
- 2007-04-19 DK DK07755685.0T patent/DK2007883T3/da active
- 2007-04-19 JP JP2009506566A patent/JP5129805B2/ja active Active
- 2007-04-19 ES ES07755685T patent/ES2377356T3/es active Active
- 2007-04-19 PT PT07755685T patent/PT2007883E/pt unknown
- 2007-04-19 CA CA2648792A patent/CA2648792C/en active Active
- 2007-04-19 KR KR1020087028205A patent/KR101385927B1/ko active IP Right Grant
- 2007-04-19 WO PCT/US2007/009510 patent/WO2007123961A2/en active Application Filing
- 2007-04-19 RU RU2008140137/10A patent/RU2484135C2/ru not_active IP Right Cessation
- 2007-04-19 MX MX2008013494A patent/MX2008013494A/es active IP Right Grant
- 2007-04-19 US US11/788,071 patent/US7875446B2/en active Active
- 2007-04-19 BR BRPI0710820-6A patent/BRPI0710820A2/pt not_active Application Discontinuation
- 2007-04-19 AT AT07755685T patent/ATE539149T1/de active
- 2007-04-19 CN CN2007800140908A patent/CN101426905B/zh active Active
- 2007-04-19 SI SI200730829T patent/SI2007883T1/sl unknown
- 2007-04-19 AU AU2007240797A patent/AU2007240797B2/en active Active
- 2007-04-19 PL PL07755685T patent/PL2007883T3/pl unknown
- 2007-04-19 EP EP07755685A patent/EP2007883B1/en active Active
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2008
- 2008-10-07 IL IL194629A patent/IL194629A/en active IP Right Grant
- 2008-10-20 CR CR10380A patent/CR10380A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK2007883T3 (da) | 2012-02-06 |
RU2008140137A (ru) | 2010-05-27 |
AU2007240797A1 (en) | 2007-11-01 |
RU2484135C2 (ru) | 2013-06-10 |
ATE539149T1 (de) | 2012-01-15 |
MX2008013494A (es) | 2009-01-26 |
CN101426905A (zh) | 2009-05-06 |
CN101426905B (zh) | 2013-03-27 |
SI2007883T1 (sl) | 2012-02-29 |
KR20080111544A (ko) | 2008-12-23 |
ES2377356T3 (es) | 2012-03-26 |
WO2007123961A3 (en) | 2008-03-06 |
JP5129805B2 (ja) | 2013-01-30 |
US20070249019A1 (en) | 2007-10-25 |
KR101385927B1 (ko) | 2014-04-24 |
IL194629A (en) | 2013-11-28 |
PT2007883E (pt) | 2012-02-17 |
IL194629A0 (en) | 2011-08-01 |
EP2007883A2 (en) | 2008-12-31 |
JP2009534030A (ja) | 2009-09-24 |
PL2007883T3 (pl) | 2012-07-31 |
EP2007883B1 (en) | 2011-12-28 |
US7875446B2 (en) | 2011-01-25 |
AU2007240797B2 (en) | 2013-05-23 |
CA2648792A1 (en) | 2007-11-01 |
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