UA99249C2 - Устройство и способ для интегрированного непрерывного производства биологических молекул - Google Patents

Устройство и способ для интегрированного непрерывного производства биологических молекул

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Publication number
UA99249C2
UA99249C2 UAA200704547A UAA200704547A UA99249C2 UA 99249 C2 UA99249 C2 UA 99249C2 UA A200704547 A UAA200704547 A UA A200704547A UA A200704547 A UAA200704547 A UA A200704547A UA 99249 C2 UA99249 C2 UA 99249C2
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UA
Ukraine
Prior art keywords
continuous
methods
devices
flow rate
biological molecules
Prior art date
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UAA200704547A
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English (en)
Ukrainian (uk)
Inventor
Енс Фогель
Роберто Джованнини
Константин Б. Константинов
Хуон Нгуень
Пол ВУ
Original Assignee
БАЙЕР ХЕЛСКЕА ЭлЭлСи
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Application filed by БАЙЕР ХЕЛСКЕА ЭлЭлСи filed Critical БАЙЕР ХЕЛСКЕА ЭлЭлСи
Publication of UA99249C2 publication Critical patent/UA99249C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B01D2313/105—Supply manifolds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel

Abstract

Изобретение относится к процессу очистки интересующего белка от гетерогенной осветленной жидкой смеси, а также к аппарату, который обеспечивает указанный процесс, который включает непрерывное удаление высокодисперсных загрязнителей, беспрерывное удаление частиц и периодическое выделение мелких загрязнителей на мембране конвективного адсорбера/десорбера.
UAA200704547A 2004-09-30 2005-09-30 Устройство и способ для интегрированного непрерывного производства биологических молекул UA99249C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61499504P 2004-09-30 2004-09-30

Publications (1)

Publication Number Publication Date
UA99249C2 true UA99249C2 (ru) 2012-08-10

Family

ID=36143124

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA200704547A UA99249C2 (ru) 2004-09-30 2005-09-30 Устройство и способ для интегрированного непрерывного производства биологических молекул
UAA201304498A UA112529C2 (uk) 2004-09-30 2005-09-30 Пристрій та процес інтегрованого безперервного виробництва біологічних молекул
UAA201202077A UA107937C2 (en) 2004-09-30 2005-09-30 Way to integrate the continuous production of biological molecules

Family Applications After (2)

Application Number Title Priority Date Filing Date
UAA201304498A UA112529C2 (uk) 2004-09-30 2005-09-30 Пристрій та процес інтегрованого безперервного виробництва біологічних молекул
UAA201202077A UA107937C2 (en) 2004-09-30 2005-09-30 Way to integrate the continuous production of biological molecules

Country Status (25)

Country Link
US (3) US9045725B2 (ru)
EP (2) EP1807101B1 (ru)
JP (2) JP5579966B2 (ru)
KR (2) KR101335936B1 (ru)
CN (2) CN101076347B (ru)
AU (1) AU2005292358B2 (ru)
BR (1) BRPI0515849B1 (ru)
CA (1) CA2579845C (ru)
CY (1) CY1117699T1 (ru)
DK (2) DK2550971T3 (ru)
ES (2) ES2570006T3 (ru)
HK (1) HK1110519A1 (ru)
HR (1) HRP20070097B1 (ru)
HU (2) HUE027136T2 (ru)
IL (5) IL181775A (ru)
LT (1) LT2550971T (ru)
NO (2) NO341439B1 (ru)
NZ (2) NZ588616A (ru)
PL (1) PL1807101T3 (ru)
PT (1) PT2550971T (ru)
RU (1) RU2390526C2 (ru)
SI (1) SI2550971T1 (ru)
UA (3) UA99249C2 (ru)
WO (1) WO2006039588A2 (ru)
ZA (1) ZA200702578B (ru)

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JP5579966B2 (ja) 2014-08-27
EP2550971A1 (en) 2013-01-30
NZ588616A (en) 2012-05-25
JP5762360B2 (ja) 2015-08-12
DK2550971T3 (en) 2017-10-30
BRPI0515849B1 (pt) 2019-07-30
NZ554307A (en) 2011-06-30
ZA200702578B (en) 2008-03-26
EP1807101A4 (en) 2010-03-24
CY1117699T1 (el) 2017-05-17
CN101076347B (zh) 2012-09-26
KR20070092949A (ko) 2007-09-14
WO2006039588A3 (en) 2007-05-18
IL217157A0 (en) 2012-01-31
CN102794109A (zh) 2012-11-28
IL217158A0 (en) 2012-01-31
HUE032538T2 (en) 2017-10-30
KR20130003025A (ko) 2013-01-08
ES2570006T3 (es) 2016-05-13
EP2550971B1 (en) 2016-11-09
IL181775A (en) 2012-02-29
EP1807101A2 (en) 2007-07-18
RU2007115901A (ru) 2008-11-10
SI2550971T1 (sl) 2017-08-31
IL217159A (en) 2015-04-30
US20130345402A1 (en) 2013-12-26
US20080269468A1 (en) 2008-10-30
IL217158A (en) 2016-06-30
NO20072174L (no) 2007-06-27
KR101335936B1 (ko) 2013-12-03
IL217159A0 (en) 2012-01-31
IL217157A (en) 2015-04-30
LT2550971T (lt) 2018-10-25
NO341885B1 (no) 2018-02-12
CN101076347A (zh) 2007-11-21
ES2634323T3 (es) 2017-09-27
CN102794109B (zh) 2015-10-07
PT2550971T (pt) 2017-10-02
IL181775A0 (en) 2007-07-04
PL1807101T3 (pl) 2016-11-30
IL205228A (en) 2015-09-24
EP1807101B1 (en) 2016-04-13
HUE027136T2 (en) 2016-08-29
CA2579845A1 (en) 2006-04-13
WO2006039588A2 (en) 2006-04-13
US20130344585A1 (en) 2013-12-26
UA107937C2 (en) 2015-03-10
BRPI0515849A (pt) 2008-08-12
US9045725B2 (en) 2015-06-02
IL205228A0 (en) 2011-07-31
US9133433B2 (en) 2015-09-15
AU2005292358B2 (en) 2011-06-16
RU2390526C2 (ru) 2010-05-27
JP2012213772A (ja) 2012-11-08
NO20171138A1 (no) 2007-06-27
AU2005292358A1 (en) 2006-04-13
JP2008514237A (ja) 2008-05-08
HRP20070097B1 (hr) 2018-03-23
DK1807101T3 (en) 2016-05-23
KR101238798B1 (ko) 2013-03-04
UA112529C2 (uk) 2016-09-26
CA2579845C (en) 2014-11-18
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HRP20070097A2 (en) 2008-11-30
HK1110519A1 (en) 2008-07-18

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