UA112529C2 - Пристрій та процес інтегрованого безперервного виробництва біологічних молекул - Google Patents

Пристрій та процес інтегрованого безперервного виробництва біологічних молекул

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Publication number
UA112529C2
UA112529C2 UAA201304498A UAA201304498A UA112529C2 UA 112529 C2 UA112529 C2 UA 112529C2 UA A201304498 A UAA201304498 A UA A201304498A UA A201304498 A UAA201304498 A UA A201304498A UA 112529 C2 UA112529 C2 UA 112529C2
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UA
Ukraine
Prior art keywords
flow rate
specific flow
continuous production
enlightened
interest
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UAA201304498A
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English (en)
Inventor
Єнс Фогель
Роберто Джованніні
Константін Б. Константінов
Хуон Нгуєнь
Пенг У
Original Assignee
Байер Хелскеа Елелсі
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Application filed by Байер Хелскеа Елелсі filed Critical Байер Хелскеа Елелсі
Publication of UA112529C2 publication Critical patent/UA112529C2/uk

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/24—Apparatus for enzymology or microbiology tube or bottle type
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/10—Specific supply elements
    • B01D2313/105—Supply manifolds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2317/00—Membrane module arrangements within a plant or an apparatus
    • B01D2317/04—Elements in parallel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Filtration Of Liquid (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Винахід стосується процесу та пристрою для виділення молекули, що становить інтерес, із гетерогенної просвітленої рідкої суміші та очищення цієї молекули. Процес включає фільтрування гетерогенної просвітленої рідкої суміші шляхом безперервного ультрафільтрування з питомою швидкістю потоку, вибраною нижче граничної точки на залежній від тиску ділянці кривої потік-трансмембранний тиск, побудованої для молекули, що становить інтерес, причому питому швидкість потоку забезпечує пристінкову концентрацію, що менш ніж на 20 % перевищує концентрацію осаду на мембрані, причому згадану питому швидкість потоку підтримують на по суті постійному рівні протягом усього безперервного процесу ультрафільтрування.
UAA201304498A 2004-09-30 2005-09-30 Пристрій та процес інтегрованого безперервного виробництва біологічних молекул UA112529C2 (uk)

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US61499504P 2004-09-30 2004-09-30

Publications (1)

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UA112529C2 true UA112529C2 (uk) 2016-09-26

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Application Number Title Priority Date Filing Date
UAA201202077A UA107937C2 (uk) 2004-09-30 2005-09-30 Спосіб інтегрованого безпервного виробництва біологічних молекул
UAA201304498A UA112529C2 (uk) 2004-09-30 2005-09-30 Пристрій та процес інтегрованого безперервного виробництва біологічних молекул
UAA200704547A UA99249C2 (uk) 2004-09-30 2005-09-30 Пристрій та спосіб для інтегрованого безперервного виробництва біологічних молекул

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Country Status (25)

Country Link
US (3) US9045725B2 (uk)
EP (2) EP1807101B1 (uk)
JP (2) JP5579966B2 (uk)
KR (2) KR101335936B1 (uk)
CN (2) CN101076347B (uk)
AU (1) AU2005292358B2 (uk)
BR (1) BRPI0515849B1 (uk)
CA (1) CA2579845C (uk)
CY (1) CY1117699T1 (uk)
DK (2) DK1807101T3 (uk)
ES (2) ES2634323T3 (uk)
HK (1) HK1110519A1 (uk)
HR (1) HRP20070097B1 (uk)
HU (2) HUE032538T2 (uk)
IL (5) IL181775A (uk)
LT (1) LT2550971T (uk)
NO (2) NO341439B1 (uk)
NZ (2) NZ554307A (uk)
PL (1) PL1807101T3 (uk)
PT (1) PT2550971T (uk)
RU (1) RU2390526C2 (uk)
SI (1) SI2550971T1 (uk)
UA (3) UA107937C2 (uk)
WO (1) WO2006039588A2 (uk)
ZA (1) ZA200702578B (uk)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2634323T3 (es) 2004-09-30 2017-09-27 Bayer Healthcare Llc Dispositivos y procedimientos para la fabricación continua integrada de moléculas biológicas
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
TWI548747B (zh) 2006-09-13 2016-09-11 艾伯維有限公司 細胞培養改良
FR2920429B1 (fr) * 2007-08-30 2012-10-05 Lfb Biotechnologies Procede de purification du facteur viii et du facteur von willebrand
ES2535734T3 (es) 2008-10-20 2015-05-14 Abbvie Inc. Aislamiento y purificación de anticuerpos mediante cromatografía de afinidad con la proteína A
TW201028433A (en) 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
US9527010B2 (en) 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
WO2012051517A2 (en) * 2010-10-15 2012-04-19 Xcellerex, Inc. Large volume disposable ultrafiltration systems and methods
CN102154408B (zh) * 2011-01-13 2013-06-05 天津市工业微生物研究所 小核菌硬葡聚糖在线发酵提取方法及系统
US9388373B2 (en) * 2011-03-08 2016-07-12 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
US10774304B2 (en) * 2011-03-08 2020-09-15 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
US9982227B2 (en) 2011-03-08 2018-05-29 University Of Maryland, Baltimore County System and method for production of on-demand proteins in a portable unit for point of care delivery
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013055942A1 (en) * 2011-10-11 2013-04-18 Guardian F D S, Llc Depressurization system for an electrical transformer
WO2013109520A1 (en) 2012-01-18 2013-07-25 Bayer Healthcare Llc Perfusion bioreactor systems and methods of operating the same
US9997264B2 (en) * 2012-02-14 2018-06-12 Control Components, Inc. Enhanced nuclear sump strainer system
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9505833B2 (en) 2012-04-20 2016-11-29 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
AU2014218715B2 (en) 2013-02-22 2019-12-12 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CA2901950A1 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
TWI671312B (zh) * 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
EP3137484A1 (en) * 2014-05-02 2017-03-08 Novo Nordisk A/S Integrated continuous biomanufacturing process
CA2947887C (en) 2014-05-13 2023-04-04 Amgen Inc. Process control systems and methods for use with filters and filtration processes
JP6671300B2 (ja) * 2014-05-27 2020-03-25 アーティフィシャル セル テクノロジーズ インコーポレイテッド Ｔｆｆによる多層コーティング化コアの自動交互積層構築
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
WO2015195452A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
CN110756051B (zh) 2014-06-25 2022-11-04 Emd 密理博公司 过滤器元件、切向流过滤系统、产生进料筛网的方法
US10195550B2 (en) 2014-08-29 2019-02-05 Emd Millipore Corporation Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
ES2935333T3 (es) 2014-08-29 2023-03-06 Emd Millipore Corp Procesos para filtrar líquidos utilizando sistemas de filtración de flujo tangencial de paso único y sistemas de filtración de flujo tangencial con recirculación de retenido
USD762811S1 (en) 2014-12-18 2016-08-02 Emd Millipore Corporation Diverter plate
USD761381S1 (en) 2014-12-18 2016-07-12 Emd Millipore Corporation Retentate plate
EP3093335A1 (de) 2015-05-13 2016-11-16 Bayer Technology Services GmbH Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten
ITUA20161506A1 (it) * 2016-03-09 2017-09-09 Della Toffola Spa Metodo ed impianto perfezionato di filtrazione tangenziale
JP7082453B2 (ja) * 2016-07-21 2022-06-08 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 高体積分率粒子精密濾過のための外壁集束のための装置及びその製造方法
RU2755065C2 (ru) * 2016-11-11 2021-09-13 Байер Акциенгезельшафт Способ отбора образцов из потока текучей среды для отслеживания загрязняющей примеси в непрерывном режиме
EP3141594A3 (en) * 2016-11-11 2017-06-14 Bayer Pharma Aktiengesellschaft Method for sampling fluid streams for monitoring contaminants in a continuous flow
US11034721B2 (en) 2016-12-09 2021-06-15 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
EP3354330A1 (en) * 2017-01-25 2018-08-01 Sartorius Stedim Biotech GmbH Automated modular filtration system
CA2994643A1 (en) * 2017-02-14 2018-08-14 Bart Lipkens Bioreactor using acoustic standing waves
CN110268043A (zh) 2017-03-03 2019-09-20 富士胶片株式会社 细胞培养装置及细胞培养方法
JP2018153168A (ja) * 2017-03-21 2018-10-04 国立大学法人九州大学 微生物収集装置
DE102017110482A1 (de) * 2017-05-15 2018-11-15 Sartorius Stedim Biotech Gmbh Filtrationsmodul bzw. Reinigungsmodul für modulares Filtrationssystem
DE102017111133A1 (de) * 2017-05-22 2018-11-22 Sartorius Stedim Biotech Gmbh Vorkonfigurierte Einweg-Filtrationsvorrichtung
CN111093812B (zh) * 2017-06-20 2022-08-23 旭化成株式会社 中空纤维膜组件及过滤方法
TW202003832A (zh) * 2018-05-04 2020-01-16 美商健臻公司 具有過濾系統的灌注式生物反應器
GB201810772D0 (en) * 2018-06-29 2018-08-15 Ge Healthcare Bio Sciences Ab Method in bioprocess purification system
EP3843869A1 (en) 2018-08-31 2021-07-07 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
AU2020223376A1 (en) * 2019-02-15 2021-07-22 Just - Evotec Biologics, Inc. Automated biomanufacturing systems, facilities, and processes
CN111018968B (zh) * 2019-12-16 2021-07-27 兴盟生物医药(苏州)有限公司 一种通过超滤浓缩制备高浓度抗体制剂的方法
GB202109015D0 (en) * 2021-06-23 2021-08-04 Puridify Ltd A method for purifying a feed in a chromatography system
WO2023191008A1 (ja) * 2022-03-30 2023-10-05 富士フイルム株式会社 バイオ医薬品の原薬の製造方法、バイオ医薬品の原薬の製造システム、およびバイオ医薬品の原薬
WO2024072963A1 (en) * 2022-09-28 2024-04-04 Genzyme Corporation Systems and devices for producing biological products and methods of using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157113A (en) * 1987-08-10 1992-10-20 Miles Inc. Removal of nucleic acids from monoclonal antibody preparations
US5256294A (en) 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5463029A (en) 1992-11-23 1995-10-31 Immunex Corporation Purification of fusion proteins comprising GM-CSF and IL-3
DE69535018T2 (de) * 1994-05-16 2007-02-15 Merck & Co., Inc. Papillomavirus vakzine
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
JP3566461B2 (ja) 1996-06-28 2004-09-15 ユニ・チャーム株式会社 使い捨ての体液吸収性物品
US7122344B2 (en) 1997-05-28 2006-10-17 Claragen, Inc. Methods for the production of purified recombinant human uteroglobin for the treatment of inflammatory and fibrotic conditions
DE19837391A1 (de) * 1997-08-22 1999-02-25 Hoffmann La Roche Immunologische Materialien und Verfahren zum Nachweis von Dihydropyrimidindehydrogenase
US6022477A (en) * 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
US7820796B2 (en) 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6444223B1 (en) * 1999-05-28 2002-09-03 Alkermes Controlled Therapeutics, Inc. Method of producing submicron particles of a labile agent and use thereof
US6544424B1 (en) * 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
US6350382B1 (en) * 2000-06-23 2002-02-26 Scilog, Inc. Enhancing filtration yields in tangential flow filtration
WO2003004690A2 (en) * 2001-07-06 2003-01-16 454$m(3) CORPORATION Method for isolation of independent, parallel chemical micro-reactions using a porous filter
IL160445A0 (en) * 2001-08-31 2004-07-25 Bayer Healthcare Ag A unit and a process for carrying out high cell density fermentation
US6875459B2 (en) * 2001-09-10 2005-04-05 Henry B. Kopf Method and apparatus for separation of milk, colostrum, and whey
US7078507B2 (en) * 2001-11-09 2006-07-18 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Synthetic genes for malarial proteins and methods of use
WO2004072292A1 (fr) * 2003-02-11 2004-08-26 Centre National En Electrochimie Et En Technologies Environnementales Inc. Procede et dispositif pour la production de biomolecules en continu
CN1759189A (zh) * 2003-02-24 2006-04-12 Gtc生物治疗学公司 切向流过滤方法及其装置
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
ES2634323T3 (es) 2004-09-30 2017-09-27 Bayer Healthcare Llc Dispositivos y procedimientos para la fabricación continua integrada de moléculas biológicas

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