ATE488252T1 - Erhöhte transduktion mit abc- transportersubstratenhemmern - Google Patents
Erhöhte transduktion mit abc- transportersubstratenhemmernInfo
- Publication number
- ATE488252T1 ATE488252T1 AT04760720T AT04760720T ATE488252T1 AT E488252 T1 ATE488252 T1 AT E488252T1 AT 04760720 T AT04760720 T AT 04760720T AT 04760720 T AT04760720 T AT 04760720T AT E488252 T1 ATE488252 T1 AT E488252T1
- Authority
- AT
- Austria
- Prior art keywords
- increased transduction
- abc transporter
- transporter substrate
- substrate inhibitors
- substrate
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000000758 substrate Substances 0.000 title abstract 3
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 title abstract 2
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 title abstract 2
- 230000026683 transduction Effects 0.000 title abstract 2
- 238000010361 transduction Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pretreatment Of Seeds And Plants (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46820703P | 2003-05-05 | 2003-05-05 | |
| PCT/US2004/013968 WO2004098531A2 (en) | 2003-05-05 | 2004-05-04 | Increased transduction using abc transporter substrates and/or inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488252T1 true ATE488252T1 (de) | 2010-12-15 |
Family
ID=33435167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04760720T ATE488252T1 (de) | 2003-05-05 | 2004-05-04 | Erhöhte transduktion mit abc- transportersubstratenhemmern |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20050123514A1 (de) |
| EP (1) | EP1624899B1 (de) |
| AT (1) | ATE488252T1 (de) |
| DE (1) | DE602004030105D1 (de) |
| WO (1) | WO2004098531A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004104022A2 (en) * | 2003-05-16 | 2004-12-02 | The General Hospital Corporation | Compositions comprising pathogen elicited epithelial chemoattractant (eicosanoid hepoxilin a3), inhibitors thereof and methods of use thereof |
| WO2009142767A1 (en) * | 2008-05-22 | 2009-11-26 | Lentigen Corporation | Lentivector-based protein production |
| WO2009153563A1 (en) * | 2008-06-18 | 2009-12-23 | Oxford Biomedica (Uk) Limited | Virus purification |
| CA2850484C (en) * | 2011-09-30 | 2021-01-26 | Bluebird Bio, Inc. | Compounds for improved viral transduction |
| WO2014109728A1 (en) * | 2013-01-11 | 2014-07-17 | The Scripps Research Institute | Methods and compositions for enchancing transduction efficiency of retroviral vectors |
| WO2015027142A2 (en) * | 2013-08-23 | 2015-02-26 | The Scripps Research Institute | Enhancing efficiency of retroviral transduction of host cells |
| GB201407322D0 (en) * | 2014-04-25 | 2014-06-11 | Ospedale San Raffaele | Gene therapy |
| US10982189B2 (en) | 2014-07-11 | 2021-04-20 | Celgene Corporation | Methods of improving vector transduction efficiency into T lymphocytes |
| KR20250134722A (ko) | 2016-02-12 | 2025-09-11 | 블루버드 바이오, 인코포레이티드. | Vcn 인핸서 조성물 및 이의 사용 방법 |
| CN108883136A (zh) | 2016-02-12 | 2018-11-23 | 蓝鸟生物公司 | Vcn增强子组合物及其使用方法 |
| GB201706394D0 (en) | 2017-04-21 | 2017-06-07 | Ospedale San Raffaele Srl | Gene Therapy |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
| AU2021202658A1 (en) | 2021-04-28 | 2022-11-17 | Fondazione Telethon | Gene therapy |
| GB202206346D0 (en) | 2022-04-29 | 2022-06-15 | Ospedale San Raffaele Srl | Gene therapy |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512421A (en) * | 1991-02-19 | 1996-04-30 | The Regents Of The University Of California | Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors |
| AU3635695A (en) * | 1994-09-19 | 1996-04-09 | Board Of Trustees Of The Leland Stanford Junior University | Methods for genetically modifying hematopoietic stem cells |
| US6818439B1 (en) * | 1994-12-30 | 2004-11-16 | Chiron Corporation | Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders |
| US5885806A (en) | 1995-11-28 | 1999-03-23 | The Johns Hopkins University School Of Medicine | Methods to prepare conditionally replicating viral vectors |
| US5739018A (en) | 1996-08-07 | 1998-04-14 | The Regents Of The University Of California | Packaging cell lines for pseudotyped retroviral vectors |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6251629B1 (en) * | 1997-10-07 | 2001-06-26 | Smithkline Beecham Corporation | ABC transporter |
| US6218181B1 (en) * | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| WO1999061589A2 (en) * | 1998-05-28 | 1999-12-02 | St. Jude Children's Research Hospital | Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof |
| US6943245B2 (en) * | 2000-08-10 | 2005-09-13 | Board Of Regents, The University Of Texas System | Tumor suppressor CAR-1 |
| CA2462628C (en) * | 2001-10-02 | 2019-08-20 | Institut Clayton De La Recherche | Restricted expression lentiviral vectors |
| EP1461087A1 (de) * | 2001-12-06 | 2004-09-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verwendung von cd34+ hematopoetischen vorläuferzellen zur behandlung von zns krankheiten |
-
2004
- 2004-05-04 DE DE602004030105T patent/DE602004030105D1/de not_active Expired - Lifetime
- 2004-05-04 WO PCT/US2004/013968 patent/WO2004098531A2/en not_active Ceased
- 2004-05-04 AT AT04760720T patent/ATE488252T1/de not_active IP Right Cessation
- 2004-05-04 US US10/839,118 patent/US20050123514A1/en not_active Abandoned
- 2004-05-04 EP EP04760720A patent/EP1624899B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004098531A2 (en) | 2004-11-18 |
| EP1624899B1 (de) | 2010-11-17 |
| WO2004098531A3 (en) | 2005-04-28 |
| EP1624899A2 (de) | 2006-02-15 |
| DE602004030105D1 (de) | 2010-12-30 |
| US20050123514A1 (en) | 2005-06-09 |
| EP1624899A4 (de) | 2006-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |