JP2011518564A5 - - Google Patents
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- JP2011518564A5 JP2011518564A5 JP2011506460A JP2011506460A JP2011518564A5 JP 2011518564 A5 JP2011518564 A5 JP 2011518564A5 JP 2011506460 A JP2011506460 A JP 2011506460A JP 2011506460 A JP2011506460 A JP 2011506460A JP 2011518564 A5 JP2011518564 A5 JP 2011518564A5
- Authority
- JP
- Japan
- Prior art keywords
- host cell
- polypeptide
- amino acid
- isoprene
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004027 cell Anatomy 0.000 claims 32
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims 10
- 230000037361 pathway Effects 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 9
- KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 8
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 5
- 108010075483 isoprene synthase Proteins 0.000 claims 5
- 102220606412 Contactin-5_L70R_mutation Human genes 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 229960005150 glycerol Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102200081495 rs1341175303 Human genes 0.000 claims 2
- 102200068287 rs281875291 Human genes 0.000 claims 2
- 102220028560 rs370169077 Human genes 0.000 claims 2
- 102200102378 rs387906638 Human genes 0.000 claims 2
- 102220147269 rs529420082 Human genes 0.000 claims 2
- 102200110711 rs587777733 Human genes 0.000 claims 2
- 102220046369 rs587782872 Human genes 0.000 claims 2
- 102220278125 rs746681057 Human genes 0.000 claims 2
- 102220169675 rs750125257 Human genes 0.000 claims 2
- 102220097243 rs876659111 Human genes 0.000 claims 2
- AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 1
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 239000002028 Biomass Substances 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 claims 1
- NUHSROFQTUXZQQ-UHFFFAOYSA-N Isopentenyl diphosphate Natural products CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 1
- 241000157935 Promicromonospora citrea Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241000223259 Trichoderma Species 0.000 claims 1
- 241000499912 Trichoderma reesei Species 0.000 claims 1
- 241000235013 Yarrowia Species 0.000 claims 1
- 241000235015 Yarrowia lipolytica Species 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 102220354962 c.208C>G Human genes 0.000 claims 1
- 229940041514 candida albicans extract Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940120503 dihydroxyacetone Drugs 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229960001031 glucose Drugs 0.000 claims 1
- 235000001727 glucose Nutrition 0.000 claims 1
- 235000013379 molasses Nutrition 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 102200056122 rs11570605 Human genes 0.000 claims 1
- 102220044222 rs587781255 Human genes 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
- 239000012138 yeast extract Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12533608P | 2008-04-23 | 2008-04-23 | |
| US61/125,336 | 2008-04-23 | ||
| PCT/US2009/041581 WO2009132220A2 (en) | 2008-04-23 | 2009-04-23 | Isoprene synthase variants for improved microbial production of isoprene |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085377A Division JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011518564A JP2011518564A (ja) | 2011-06-30 |
| JP2011518564A5 true JP2011518564A5 (https=) | 2013-09-12 |
Family
ID=40810540
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506460A Pending JP2011518564A (ja) | 2008-04-23 | 2009-04-23 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| JP2014085377A Pending JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085377A Pending JP2014158489A (ja) | 2008-04-23 | 2014-04-17 | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8173410B2 (https=) |
| EP (1) | EP2279251A2 (https=) |
| JP (2) | JP2011518564A (https=) |
| KR (1) | KR20110020234A (https=) |
| CN (1) | CN102171335A (https=) |
| AU (1) | AU2009240505B2 (https=) |
| BR (1) | BRPI0911667A2 (https=) |
| CA (1) | CA2722440A1 (https=) |
| MX (1) | MX2010011706A (https=) |
| MY (1) | MY153871A (https=) |
| RU (2) | RU2516343C2 (https=) |
| SG (2) | SG192545A1 (https=) |
| WO (1) | WO2009132220A2 (https=) |
| ZA (2) | ZA201007564B (https=) |
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- 2009-04-23 MX MX2010011706A patent/MX2010011706A/es unknown
- 2009-04-23 MY MYPI2010004990A patent/MY153871A/en unknown
- 2009-04-23 BR BRPI0911667A patent/BRPI0911667A2/pt not_active IP Right Cessation
- 2009-04-23 SG SG2013055827A patent/SG192545A1/en unknown
- 2009-04-23 SG SG201007802A patent/SG165884A1/en unknown
- 2009-04-23 EP EP09735440A patent/EP2279251A2/en not_active Withdrawn
- 2009-04-23 AU AU2009240505A patent/AU2009240505B2/en not_active Ceased
- 2009-04-23 US US12/429,143 patent/US8173410B2/en not_active Expired - Fee Related
- 2009-04-23 CA CA2722440A patent/CA2722440A1/en not_active Abandoned
- 2009-04-23 KR KR1020107026164A patent/KR20110020234A/ko not_active Ceased
- 2009-04-23 JP JP2011506460A patent/JP2011518564A/ja active Pending
- 2009-04-23 ZA ZA201007564A patent/ZA201007564B/xx unknown
- 2009-04-23 RU RU2010147659/10A patent/RU2516343C2/ru not_active IP Right Cessation
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2011
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- 2012-03-30 US US13/436,612 patent/US8916370B2/en not_active Expired - Fee Related
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2014
- 2014-03-06 RU RU2014108776/10A patent/RU2014108776A/ru not_active Application Discontinuation
- 2014-04-17 JP JP2014085377A patent/JP2014158489A/ja active Pending
- 2014-11-17 US US14/543,628 patent/US20150191712A1/en not_active Abandoned
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