JP2011514169A - 幹細胞培養のためのマイクロキャリア - Google Patents

幹細胞培養のためのマイクロキャリア Download PDF

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Publication number
JP2011514169A
JP2011514169A JP2011500744A JP2011500744A JP2011514169A JP 2011514169 A JP2011514169 A JP 2011514169A JP 2011500744 A JP2011500744 A JP 2011500744A JP 2011500744 A JP2011500744 A JP 2011500744A JP 2011514169 A JP2011514169 A JP 2011514169A
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microcarrier
cells
stem cells
microcarriers
passages
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JP2011514169A5 (https=
Inventor
オー，スティーブ
レシナ，マルティ
チュー，アンドレ
ルーヴェニー，ショール
ツヴァイゲルト，ロベルト
チェン，アレン
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Agency for Science Technology and Research Singapore
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Agency for Science Technology and Research Singapore
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Application filed by Agency for Science Technology and Research Singapore filed Critical Agency for Science Technology and Research Singapore
Publication of JP2011514169A publication Critical patent/JP2011514169A/ja
Publication of JP2011514169A5 publication Critical patent/JP2011514169A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C12N5/0075—General culture methods using substrates using microcarriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2011500744A 2008-03-17 2009-03-17 幹細胞培養のためのマイクロキャリア Pending JP2011514169A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6969408P 2008-03-17 2008-03-17
US11025608P 2008-10-31 2008-10-31
US14806409P 2009-01-29 2009-01-29
US15594009P 2009-02-27 2009-02-27
PCT/SG2009/000088 WO2009116951A2 (en) 2008-03-17 2009-03-17 Microcarriers for stem cell culture

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012079873A Division JP2012147793A (ja) 2008-03-17 2012-03-30 幹細胞培養のためのマイクロキャリア

Publications (2)

Publication Number Publication Date
JP2011514169A true JP2011514169A (ja) 2011-05-06
JP2011514169A5 JP2011514169A5 (https=) 2012-02-02

Family

ID=40872517

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2011500744A Pending JP2011514169A (ja) 2008-03-17 2009-03-17 幹細胞培養のためのマイクロキャリア
JP2012079873A Pending JP2012147793A (ja) 2008-03-17 2012-03-30 幹細胞培養のためのマイクロキャリア
JP2015151501A Pending JP2015226543A (ja) 2008-03-17 2015-07-31 幹細胞培養のためのマイクロキャリア
JP2017222498A Pending JP2018068302A (ja) 2008-03-17 2017-11-20 幹細胞培養のためのマイクロキャリア
JP2019211253A Active JP6943937B2 (ja) 2008-03-17 2019-11-22 幹細胞培養のためのマイクロキャリア

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2012079873A Pending JP2012147793A (ja) 2008-03-17 2012-03-30 幹細胞培養のためのマイクロキャリア
JP2015151501A Pending JP2015226543A (ja) 2008-03-17 2015-07-31 幹細胞培養のためのマイクロキャリア
JP2017222498A Pending JP2018068302A (ja) 2008-03-17 2017-11-20 幹細胞培養のためのマイクロキャリア
JP2019211253A Active JP6943937B2 (ja) 2008-03-17 2019-11-22 幹細胞培養のためのマイクロキャリア

Country Status (5)

Country Link
US (4) US8716018B2 (https=)
EP (2) EP2479260B1 (https=)
JP (5) JP2011514169A (https=)
SG (1) SG188918A1 (https=)
WO (1) WO2009116951A2 (https=)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526387A (ja) * 2013-06-24 2016-09-05 アントフロゲネシス コーポレーション 細胞培養のための細胞外マトリクス組成物ビーズ
JP2017500013A (ja) * 2013-11-01 2017-01-05 ヤンセン バイオテツク，インコーポレーテツド 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化
WO2018225703A1 (ja) * 2017-06-05 2018-12-13 テルモ株式会社 分化誘導細胞の調製方法
WO2020203753A1 (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
JP2021510527A (ja) * 2018-01-18 2021-04-30 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 懸濁培養におけるヒト多能性幹細胞系の分化のための方法
JPWO2020027163A1 (ja) * 2018-07-31 2021-09-24 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
JP2022523129A (ja) * 2019-01-31 2022-04-21 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
JP2023505988A (ja) * 2019-12-09 2023-02-14 デウン ファーマシューティカル カンパニー リミテッド ヒト多能性幹細胞から間葉系幹細胞の製造方法およびこれによって製造された間葉系幹細胞
JP2023508971A (ja) * 2020-09-15 2023-03-06 エルジー・ケム・リミテッド 細胞培養用マイクロキャリアおよびその製造方法
JP2023537969A (ja) * 2020-08-10 2023-09-06 リネージ セル セラピューティクス インコーポレイテッド 胚性幹細胞増殖のための組成物及び方法
WO2024253069A1 (ja) * 2023-06-06 2024-12-12 東ソー株式会社 温度応答性マイクロキャリア

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222846D0 (en) * 2002-10-03 2002-11-06 Choo Yen Cell culture
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
JP2009500297A (ja) 2005-06-08 2009-01-08 セントカー・インコーポレーテツド 眼の変性についての細胞療法
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
DK2185693T3 (da) 2007-07-31 2019-09-23 Lifescan Inc Differentiering af humane embryoniske stamceller
CA2954431C (en) 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
JP5733986B2 (ja) 2008-02-21 2015-06-10 ヤンセン バイオテツク，インコーポレーテツド 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20110143433A1 (en) * 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US9458431B2 (en) 2008-03-17 2016-10-04 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8691569B2 (en) 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
JP2011514169A (ja) 2008-03-17 2011-05-06 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 幹細胞培養のためのマイクロキャリア
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
EP2942392B1 (en) 2008-06-30 2018-10-03 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
AU2009267167A1 (en) * 2008-06-30 2010-01-07 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
US9234178B2 (en) 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
EP2350265B1 (en) 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
KR101774546B1 (ko) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
KR101687344B1 (ko) 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 평면 기재상의 세포 부착 및 배양을 위한 방법 및 조성물
JP2012520672A (ja) 2009-03-20 2012-09-10 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ マイクロキャリアー上の多能性（ｐｌｕｒｉｐｏｔｅｎｔ）および多分化能（ｍｕｌｔｉｐｏｔｅｎｔ）細胞の培養
CN103952372B (zh) 2009-07-20 2016-10-05 詹森生物科技公司 人胚胎干细胞的分化
US8785184B2 (en) 2009-07-20 2014-07-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN102482643B (zh) 2009-07-20 2016-06-29 詹森生物科技公司 人胚胎干细胞的分化
EP2361968B1 (en) * 2010-02-26 2014-11-19 Corning Incorporated Synthetic polysaccharide microcarriers for culturing cells
US9068182B2 (en) 2009-07-28 2015-06-30 Corning Incorporated Synthetic polysaccharide microcarriers for culturing cells
US20120214230A1 (en) * 2009-10-22 2012-08-23 Ge Healthcare Bio-Sciences Ab Cell culture/handling product and method for production and use thereof
SG10201408552YA (en) * 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
CN102712902B (zh) * 2009-12-23 2019-01-08 詹森生物科技公司 人胚胎干细胞的分化
PH12012501686A1 (en) 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
KR101744040B1 (ko) * 2010-03-01 2017-06-07 후지필름 가부시키가이샤 생체 친화성을 갖는 고분자 블록과 세포로 이루어지는 세포 구조체
US8652845B2 (en) * 2010-03-18 2014-02-18 Kyoto University Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium
RU2587634C2 (ru) 2010-05-12 2016-06-20 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
EP2575913B1 (en) 2010-05-25 2018-07-25 Cook Biotech Incorporated Methods, substrates, and systems useful for cell seeding of medical grafts
KR20130112028A (ko) * 2010-06-17 2013-10-11 스템알디, 인크. 무혈청 합성 세포배양 배지
US10240121B2 (en) 2010-08-16 2019-03-26 Kiyatec Inc. Bioreactor system
PL2853589T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Różnicowanie ludzkich zarodkowych komórek macierzystych
CN103154237B (zh) 2010-08-31 2016-03-16 詹森生物科技公司 多能干细胞的分化
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN103153318B (zh) * 2010-09-02 2015-09-02 生命技术公司 用于细胞的生物反应器放大的细胞培养系统
WO2012056997A1 (ja) * 2010-10-28 2012-05-03 国立大学法人熊本大学 多能性幹細胞の分化誘導効率を改善するための方法及び培地
US9534206B2 (en) 2010-12-16 2017-01-03 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
US9926523B2 (en) 2010-12-16 2018-03-27 General Electric Company Cell carriers and methods for culturing cells
US9453196B2 (en) 2010-12-16 2016-09-27 General Electric Company Cell carrier, methods of making and use
US9453197B2 (en) 2010-12-16 2016-09-27 General Electric Company Methods of making cell carrier
US9518249B2 (en) 2010-12-16 2016-12-13 General Electric Company Cell carrier, associated methods for making cell carrier and culturing cells using the same
CN102174497B (zh) * 2010-12-30 2013-05-22 北京民海生物科技有限公司 一种微载体的回收方法
JP5999658B2 (ja) 2011-11-25 2016-09-28 国立大学法人京都大学 多能性幹細胞の培養方法
FI2794857T3 (fi) 2011-12-22 2026-03-25 Janssen Biotech Inc Ihmisen alkion kantasolujen erilaistaminen yksittäisiksi hormonaalisiksi insuliinipositiivisiksi soluiksi
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
JP6339943B2 (ja) * 2012-03-13 2018-06-06 インスティテュート オブ ジェネティックス アンド ディベロップメンタル バイオロジー，チャイニーズ アカデミー オブ サイエンシズ ３次元培養による細胞の再プログラミング
CN102586173B (zh) * 2012-03-20 2014-07-02 广东大华农动物保健品股份有限公司 一种提高微载体重复使用次数的回收处理方法
EP3450544A1 (en) 2012-06-08 2019-03-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endodrine cells
BR112015015714A2 (pt) * 2012-12-31 2017-07-11 Janssen Biotech Inc suspensão e aglomeração de células pluripotentes humanas para diferenciação em célu-las endócrinas pancreáticas
ES2837763T3 (es) 2012-12-31 2021-07-01 Janssen Biotech Inc Cultivo de células madre embrionarias humanas en la interconexión aire-líquido para la diferenciación en células endocrinas pancreáticas
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
DK2938723T3 (da) 2012-12-31 2023-02-20 Janssen Biotech Inc Differentiering af humane embryonale stamceller til pancreatiske endokrine celler under anvendelse af hb9-regulatorer
US9738861B2 (en) 2013-03-06 2017-08-22 Kyoto University Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells
HK1221402A1 (zh) * 2013-04-02 2017-06-02 University Of Florida Research Foundation, Inc. 用於诱导并调节血管生成的组合物和方法以及用於鉴别血管生成调节剂的方法和实验
US20160215072A1 (en) * 2013-05-27 2016-07-28 Agency For Science, Technology And Research Heparan sulphate
US20160145580A1 (en) * 2013-06-18 2016-05-26 Agency For Science, Technology And Research Method of culturing cancer stem cells
WO2015008275A1 (en) * 2013-07-17 2015-01-22 Kadimastem Ltd Methods for large scale generation of stem cells
JP6486354B2 (ja) * 2013-08-01 2019-03-20 エヌエムイー ナトゥルヴィッセンシャフトリヘス ウント メディツィニシェス インスティトゥト アン ダー ウニヴェルジテート テュービンゲン それを必要とするヒト又は動物被験体の虚血心を治療する方法に使用するための、細胞外マトリックスのグリコシル化タンパク質
EP3048169B1 (en) * 2013-09-04 2019-07-10 Otsuka Pharmaceutical Factory, Inc. Method for preparing pluripotent stem cells
WO2015175307A1 (en) 2014-05-16 2015-11-19 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
WO2016020719A1 (en) * 2014-08-04 2016-02-11 Euroresearch S.R.L. Novel collagen microcarriers
US20170335286A1 (en) * 2014-10-30 2017-11-23 Stembiosys, Inc. Methods for maintaining and expanding mesenchymal stem cells on extracellular matrix coated microcarriers
WO2016121737A1 (ja) * 2015-01-29 2016-08-04 株式会社カネカ 細胞凝集塊の作製方法
FR3035107A1 (fr) * 2015-04-15 2016-10-21 Celenys Procede de preparation d'hydrogel a partir d'acide hyaluronique modifie et de collagene de type i
KR101705245B1 (ko) * 2015-05-22 2017-02-09 건국대학교 글로컬산학협력단 마트리겔이 코팅된 신경줄기세포 배양용 플레이트
WO2017124022A2 (en) * 2016-01-13 2017-07-20 Felix Pets, Llc Methods for producing hypo-allergenic cats using gene editing technology
GB201615517D0 (en) 2016-09-13 2016-10-26 Micromatrices Ass L Spheroid tissue miroarray and method of manufacture
US10420803B2 (en) 2016-04-14 2019-09-24 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
CN111051499A (zh) * 2017-05-24 2020-04-21 哈佛学院校长同事会 卫星细胞及其组合物和生产方法
GB201718556D0 (en) * 2017-11-09 2017-12-27 Univ Oxford Innovation Ltd Macrocarrier
WO2019163948A1 (ja) * 2018-02-23 2019-08-29 学校法人創価大学 細胞培養用基材及び培養方法
CN112313329A (zh) * 2018-06-27 2021-02-02 味之素株式会社 干细胞培养用添加物和培养用培养基、以及培养方法
CN110564674B (zh) * 2019-09-29 2021-05-11 广东工业大学 一种干细胞铺底工作液及其应用
FR3106141B1 (fr) * 2020-01-09 2024-12-20 Carroucell Microporteurs pour culture cellulaire et procédé de fabrication de microporteurs
EP4118190A1 (en) 2020-03-10 2023-01-18 Life & Brain GmbH Up-scaled production of microglia-like/-precursor cells and macrophage cells using mesh macrocarriers
CN111467579B (zh) * 2020-04-03 2021-10-26 北京臻溪谷医学研究中心（有限合伙） 基于合金内核的治疗动脉瘤与血管狭窄用干细胞支架及其制法
JPWO2022004822A1 (https=) * 2020-06-30 2022-01-06
KR102864804B1 (ko) * 2020-09-15 2025-09-25 주식회사 엘지화학 세포 배양용 마이크로-캐리어 및 그 제조방법
WO2023163560A1 (ko) * 2022-02-25 2023-08-31 주식회사 강스템바이오텍 마이크로캐리어를 이용한 줄기세포 배양 방법
WO2023208212A1 (zh) * 2022-04-29 2023-11-02 北京华龛生物科技有限公司 基于三维多孔微载体的病毒载体生产方法
WO2024102777A2 (en) * 2022-11-08 2024-05-16 Lineage Cell Therapeutics, Inc. Compositions and method for expansion of embryonic stem cells
WO2025059779A1 (en) * 2023-09-22 2025-03-27 Spiderwort Biotechnologies Inc. Plant-based or fungal-based micro-carrier scaffolds optimized for large-scale cell-culture production and other applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007002086A2 (en) * 2005-06-22 2007-01-04 Geron Corporation Suspension culture of human embryonic stem cells
WO2008004990A2 (en) * 2006-07-06 2008-01-10 Es Cell International Pte Ltd Method for stem cell culture and cells derived therefrom

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675187A (en) 1983-05-16 1987-06-23 Bristol-Myers Company BBM-1675, a new antibiotic complex
GB2197915B (en) 1986-11-19 1990-11-14 Rolls Royce Plc Improvements in or relating to fluid bearings
US4975377A (en) 1987-05-14 1990-12-04 Key Marc E Cell growth chambers and method of use thereof
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
DE4117305C2 (de) 1991-05-27 1994-07-21 Weidmueller Interface Zange zum Ergreifen und/oder Verpressen von Bearbeitungsgegenständen
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5661034A (en) 1991-07-18 1997-08-26 Fuji Yakuhin Kogyo Kabushiki Kaisha Serum-free medium for tissue culture containing tissue inhibitor of metalloproteinases and method for growing cells using the medium
US5654183A (en) 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
WO1994007913A1 (en) 1992-09-25 1994-04-14 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
EP0600832A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren
EP0600831A1 (de) 1992-11-27 1994-06-08 Ciba-Geigy Ag Phthalazinonderivate
US5766948A (en) 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5631159A (en) 1993-09-22 1997-05-20 Creative Biomolecules, Inc. Lipid-modified serum free media
US5795790A (en) * 1994-07-20 1998-08-18 Cytotherapeutics, Inc. Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5919449A (en) 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US6015554A (en) 1995-06-07 2000-01-18 Systemix, Inc. Method of reconstituting human lymphoid and dendritic cells
ATE439849T1 (de) 1996-04-19 2009-09-15 Osiris Therapeutics Inc Die wiederherstellung und verstärkung von knochen mittels mesenchymalen stammzellen
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6361996B1 (en) 1997-05-07 2002-03-26 University Of Utah Research Foundation Neuroepithelial stem cells and glial-restricted intermediate precursors
DE69837491T2 (de) 1997-07-03 2008-01-17 Osiris Therapeutics, Inc. Menschliche mesenchymale stammzellen aus peripherem blut
JP4371179B2 (ja) 1997-07-04 2009-11-25 ユニバーシティー オブ ユタ リサーチ ファンデーション 系列限定ニューロン前駆体
US6387369B1 (en) * 1997-07-14 2002-05-14 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
CA2307807C (en) 1997-10-23 2008-09-02 Andrea G. Bodnar Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US6886568B2 (en) 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US6637437B1 (en) 1998-04-08 2003-10-28 Johns Hopkins University Cell-culture and polymer constructs
EP0953633A1 (en) 1998-04-28 1999-11-03 Livercell L.L.C. Cell culturing method and medium for producing proliferated, normal, differentiated human liver cells
KR100979664B1 (ko) 1999-03-10 2010-09-02 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
WO2002002816A2 (en) 2000-06-29 2002-01-10 Mitokor Methods for identifying mitochondrial divalent cation transporters
US7588641B2 (en) 2001-08-30 2009-09-15 Hamamatsu Photonics K.K. Method of forming liquid-drops of mixed liquid, and device for forming liquid-drops of mixed liquid
JP2005506839A (ja) 2001-10-02 2005-03-10 ベクトン・ディキンソン・アンド・カンパニー 細胞外マトリックスおよび他の分子を使用する幹細胞の増殖および分化
WO2003083044A2 (en) 2002-03-25 2003-10-09 Condros, Inc. Tissue analogs for in vitro testing and method of use therefor
US20050129776A1 (en) 2002-05-03 2005-06-16 Inserm Microparticles supporting cells and active substances
CA2532754A1 (en) 2003-07-17 2005-02-03 Global Cell Solutions, Llc Automated cell culture system and process
WO2005007799A2 (en) 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
AU2003289475A1 (en) 2003-10-20 2005-05-05 Jms Co., Ltd. Cell handling device, human tissue regeneration composition, and human tissue regeneration method
WO2005065354A2 (en) * 2003-12-31 2005-07-21 The Burnham Institute Defined media for pluripotent stem cell culture
JP4147306B2 (ja) * 2004-02-03 2008-09-10 国立大学法人 熊本大学 唾液腺由来の内胚葉系細胞および外胚葉系細胞の双方に分化可能な未分化な多分化能を有する新規細胞およびその細胞の調製方法
WO2005085422A1 (en) 2004-02-27 2005-09-15 Michigan State University Adult stem cells and uses thereof
JP2007536936A (ja) 2004-05-14 2007-12-20 ベクトン・ディキンソン・アンド・カンパニー 幹細胞集団および使用方法
DE102004043256B4 (de) 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
AU2005282414C1 (en) 2004-09-08 2011-04-07 Wisconsin Alumni Research Foundation Culturing human embryonic stem cells
AU2005286097A1 (en) 2004-09-21 2006-03-30 Nvr Labs. Ltd. Compositions and methods for stem cell expansion and differentiation
WO2006091921A2 (en) 2005-02-25 2006-08-31 Drexel University Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications
JP2006230316A (ja) * 2005-02-25 2006-09-07 Japan Health Science Foundation 瘢痕のない創傷治癒能を有する細胞およびその調製方法
JP2006288244A (ja) * 2005-04-07 2006-10-26 Espec Corp 培養装置並びに細胞の製造方法
JP2009500297A (ja) * 2005-06-08 2009-01-08 セントカー・インコーポレーテツド 眼の変性についての細胞療法
GB2443370A (en) 2005-07-29 2008-04-30 Australian Stem Cell Ct Ltd Compositions and methods for growth of pluripotent cells
US20070077649A1 (en) 2005-09-06 2007-04-05 Sammak Paul J Transplantable cell growth niche and related compositions and methods
GB2444686B (en) 2005-09-12 2010-08-25 Es Cell Int Pte Ltd Differentiation of pluripotent stem cells using p38 MAPK inhibitors or prostaglandins
US20070082328A1 (en) 2005-09-27 2007-04-12 Donnie Rudd Rotatable time varying electromagnetic force bioreactor and method of using the same
JP5122973B2 (ja) * 2005-11-15 2013-01-16 独立行政法人科学技術振興機構 Ｅｓ細胞からすい臓を生産する方法
AU2006326853B2 (en) 2005-12-22 2012-02-16 Es Cell International Pte Ltd Direct differentiation of cardiomyocytes from human embryonic stem cells
PT2471904T (pt) 2005-12-29 2019-02-25 Celularity Inc População de células estaminais placentárias
WO2007149926A1 (en) * 2006-06-20 2007-12-27 Wisconsin Alumni Research Foundation Method for culturing stem cells
CA2657013A1 (en) 2006-07-06 2008-01-10 Organogenesis Inc. Temperature-responsive microcarrier
DK3441459T3 (da) 2006-08-02 2021-06-07 Technion Res & Dev Foundation Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur
US20080138415A1 (en) 2006-09-26 2008-06-12 Mehboob Hussain Composition and method for producing composition for constructing tissue, and tissue construct
PL2089511T3 (pl) 2006-11-13 2015-02-27 Depuy Synthes Products Llc Rozrost in vitro komórek pochodzących z tkanki pępowinowej wykorzystujących mikronośniki
WO2009002456A2 (en) 2007-06-21 2008-12-31 Massachusetts Institute Of Technology Methods and compositions relating to progenitor cells
WO2009006422A1 (en) 2007-06-29 2009-01-08 Stem Cell Products, Inc. Automated method and apparatus for embryonic stem cell culture
JP2011514169A (ja) * 2008-03-17 2011-05-06 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 幹細胞培養のためのマイクロキャリア
US8691569B2 (en) * 2008-03-17 2014-04-08 Agency For Science, Technology And Research Microcarriers for stem cell culture
US8828720B2 (en) * 2008-03-17 2014-09-09 Agency For Science, Technology And Research Microcarriers for stem cell culture
US20110143433A1 (en) * 2008-03-17 2011-06-16 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
US20120028352A1 (en) * 2008-03-17 2012-02-02 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
WO2009139703A1 (en) 2008-05-15 2009-11-19 Ge Healthcare Bio-Sciences Ab Method for cell expansion
KR101774546B1 (ko) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
EP2459701A1 (en) 2009-07-28 2012-06-06 Corning Inc. Synthetic microcarriers for culturing cells
WO2012059775A2 (en) 2010-11-05 2012-05-10 Intesis D.O.O. System for reproducing a 3d color image using narrowband modulation of monochromatic components of the image

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007002086A2 (en) * 2005-06-22 2007-01-04 Geron Corporation Suspension culture of human embryonic stem cells
WO2008004990A2 (en) * 2006-07-06 2008-01-10 Es Cell International Pte Ltd Method for stem cell culture and cells derived therefrom

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN5011001607; ＴＡＫＡＨＡＳＨＩ，　Ｋ．，　ｅｔ　ａｌ．: ＣＥＬＬ １３１（５）, 20071130, ｐｐ．８６１-８７２, ＣＥＬＬ　ＰＲＥＳＳ *
JPN6013054309; Ｂｉｏｍａｔｅｒｉａｌｓ，　２００７，　Ｖｏｌ．２８，　ｐｐ．３１１０-３１２０ *
JPN6014037687; ＫＩＮＧ，　Ｊ．Ａ．，　ｅｔ　ａｌ．: Ｃｕｒｒｅｎｔ　Ｏｐｉｎｉｏｎ　ｉｎ　Ｃｈｅｍｉｃａｌ　Ｂｉｏｌｏｇｙ １１, 2007, ｐｐ．３９４-３９８ *
JPN6014037689; ＣＡＭＥＲＯＮ，　Ｃ．Ｍ．，　ｅｔ　ａｌ．: Ｂｉｏｔｅｃｈｎｏｌｏｇｙ　ａｎｄ　Ｂｉｏｅｎｇｉｎｅｅｒｉｎｇ ９４（５）, 2006, ｐｐ．９３８-９４８ *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016526387A (ja) * 2013-06-24 2016-09-05 アントフロゲネシス コーポレーション 細胞培養のための細胞外マトリクス組成物ビーズ
JP2017500013A (ja) * 2013-11-01 2017-01-05 ヤンセン バイオテツク，インコーポレーテツド 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化
WO2018225703A1 (ja) * 2017-06-05 2018-12-13 テルモ株式会社 分化誘導細胞の調製方法
JPWO2018225703A1 (ja) * 2017-06-05 2020-04-02 テルモ株式会社 分化誘導細胞の調製方法
JP7100853B2 (ja) 2017-06-05 2022-07-14 テルモ株式会社 分化誘導細胞の調製方法
JP2021510527A (ja) * 2018-01-18 2021-04-30 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 懸濁培養におけるヒト多能性幹細胞系の分化のための方法
US12104173B2 (en) 2018-01-18 2024-10-01 Agency For Science, Technology And Research Method for differentiation of human pluripotent stem cell lines in suspension culture
JP2024103800A (ja) * 2018-07-31 2024-08-01 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
JP7563976B2 (ja) 2018-07-31 2024-10-08 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
JPWO2020027163A1 (ja) * 2018-07-31 2021-09-24 Ｊｃｒファーマ株式会社 歯髄由来細胞の製造方法
JP7588591B2 (ja) 2019-01-31 2024-11-22 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
JP2022523129A (ja) * 2019-01-31 2022-04-21 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
US12338461B2 (en) 2019-01-31 2025-06-24 Beijing Cytoniche Biotechnology Co., Ltd. Three-dimensional culture method for large-scale preparation of stem cells
JP2025024072A (ja) * 2019-01-31 2025-02-19 北京華龕生物科技有限公司 幹細胞の大規模調製のための三次元培養方法
JP2020162551A (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
WO2020203753A1 (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
JP7284985B2 (ja) 2019-03-29 2023-06-01 国立大学法人 長崎大学 肝前駆細胞を含む細胞集団を製造する方法
US12478645B2 (en) 2019-03-29 2025-11-25 Nagasaki University Method for manufacturing cell population including liver precursor cells
JP2023505988A (ja) * 2019-12-09 2023-02-14 デウン ファーマシューティカル カンパニー リミテッド ヒト多能性幹細胞から間葉系幹細胞の製造方法およびこれによって製造された間葉系幹細胞
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JP2023537969A (ja) * 2020-08-10 2023-09-06 リネージ セル セラピューティクス インコーポレイテッド 胚性幹細胞増殖のための組成物及び方法
JP7515952B2 (ja) 2020-09-15 2024-07-16 エルジー・ケム・リミテッド 細胞培養用マイクロキャリアおよびその製造方法
JP2023508971A (ja) * 2020-09-15 2023-03-06 エルジー・ケム・リミテッド 細胞培養用マイクロキャリアおよびその製造方法
WO2024253069A1 (ja) * 2023-06-06 2024-12-12 東ソー株式会社 温度応答性マイクロキャリア

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