JP2011125348A5 - - Google Patents
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- JP2011125348A5 JP2011125348A5 JP2011036102A JP2011036102A JP2011125348A5 JP 2011125348 A5 JP2011125348 A5 JP 2011125348A5 JP 2011036102 A JP2011036102 A JP 2011036102A JP 2011036102 A JP2011036102 A JP 2011036102A JP 2011125348 A5 JP2011125348 A5 JP 2011125348A5
- Authority
- JP
- Japan
- Prior art keywords
- perfusion culture
- cells
- present
- animal cells
- cell density
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000010412 perfusion Effects 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims 13
- 210000004102 animal cell Anatomy 0.000 claims 8
- 239000006143 cell culture medium Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 238000004220 aggregation Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04075702.3 | 2004-03-05 | ||
| EP04075703.1 | 2004-03-05 | ||
| EP04075703 | 2004-03-05 | ||
| EP04075702 | 2004-03-05 | ||
| EP04077657.7 | 2004-09-27 | ||
| EP04077656.9 | 2004-09-27 | ||
| EP04077656 | 2004-09-27 | ||
| EP04077657 | 2004-09-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501239A Division JP2007525984A (ja) | 2004-03-05 | 2005-03-04 | 連続的灌流および交互接線流による細胞培養の方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015209828A Division JP2016039817A (ja) | 2004-03-05 | 2015-10-26 | 連続的灌流および交互接線流による細胞培養の方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011125348A JP2011125348A (ja) | 2011-06-30 |
| JP2011125348A5 true JP2011125348A5 (enExample) | 2013-06-27 |
Family
ID=34961830
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501239A Pending JP2007525984A (ja) | 2004-03-05 | 2005-03-04 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011036102A Pending JP2011125348A (ja) | 2004-03-05 | 2011-02-22 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2011259168A Pending JP2012090632A (ja) | 2004-03-05 | 2011-11-28 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2014016778A Expired - Fee Related JP5719947B2 (ja) | 2004-03-05 | 2014-01-31 | 灌流培養方法の、細胞培養物中の細胞の凝集度合いを減少させるための使用 |
| JP2015209828A Pending JP2016039817A (ja) | 2004-03-05 | 2015-10-26 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2017132997A Pending JP2017225443A (ja) | 2004-03-05 | 2017-07-06 | 連続的灌流および交互接線流による細胞培養の方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007501239A Pending JP2007525984A (ja) | 2004-03-05 | 2005-03-04 | 連続的灌流および交互接線流による細胞培養の方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259168A Pending JP2012090632A (ja) | 2004-03-05 | 2011-11-28 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2014016778A Expired - Fee Related JP5719947B2 (ja) | 2004-03-05 | 2014-01-31 | 灌流培養方法の、細胞培養物中の細胞の凝集度合いを減少させるための使用 |
| JP2015209828A Pending JP2016039817A (ja) | 2004-03-05 | 2015-10-26 | 連続的灌流および交互接線流による細胞培養の方法 |
| JP2017132997A Pending JP2017225443A (ja) | 2004-03-05 | 2017-07-06 | 連続的灌流および交互接線流による細胞培養の方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8206981B2 (enExample) |
| EP (3) | EP2308958A3 (enExample) |
| JP (6) | JP2007525984A (enExample) |
| KR (1) | KR101050585B1 (enExample) |
| CN (3) | CN104593277A (enExample) |
| AU (1) | AU2005229359C1 (enExample) |
| CA (1) | CA2557046A1 (enExample) |
| DK (1) | DK1720972T3 (enExample) |
| ES (1) | ES2456015T3 (enExample) |
| IL (2) | IL177724A (enExample) |
| PL (1) | PL1720972T3 (enExample) |
| PT (1) | PT1720972E (enExample) |
| SI (1) | SI1720972T1 (enExample) |
| WO (1) | WO2005095578A1 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101050585B1 (ko) | 2004-03-05 | 2011-07-19 | 디에스엠 아이피 어셋츠 비.브이. | 연속식 살포 및 교호 접선 흐름에 의한 세포 배양 방법 |
| DK1988170T3 (da) | 2006-02-24 | 2019-07-22 | Toray Industries | Fremgangsmåde til fremstilling af et kemisk produkt og indretning til kontinuerlig fermentering |
| EP1870450A1 (en) * | 2006-06-21 | 2007-12-26 | DSMIP Assets B.V. | Process for the culturing of E1-immortalized HER cells |
| AU2011211462C1 (en) * | 2006-07-14 | 2015-01-22 | Dpx Holdings B.V. | Improved process for the culturing of cells |
| PT2634243T (pt) * | 2006-07-14 | 2017-12-18 | Patheon Holdings I B V | Método para melhorar a cultura de células |
| EP2014760A1 (en) | 2007-06-13 | 2009-01-14 | CMC Biopharmaceuticals A/S | A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process |
| DK2235197T3 (en) * | 2007-12-27 | 2017-10-09 | Baxalta GmbH | Methods of cell culture |
| WO2010003759A2 (en) * | 2008-06-17 | 2010-01-14 | Dsm Ip Assets B.V. | Cell culturing method |
| CN105708862B (zh) | 2008-09-02 | 2020-11-06 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| ES2532015T3 (es) * | 2008-11-03 | 2015-03-23 | Crucell Holland B.V. | Método para la producción de vectores adenovíricos |
| EP2454364B1 (en) | 2009-07-16 | 2014-04-23 | Crucell Holland B.V. | Production of polio virus at high titers for vaccine production |
| WO2011045378A1 (en) | 2009-10-15 | 2011-04-21 | Crucell Holland B.V. | Method for the purification of adenovirus particles |
| MX2012004221A (es) | 2009-10-15 | 2012-06-08 | Crucell Holland Bv | Proceso para purificacion de adenovirus de cultivos de alta densidad celular. |
| ES2642629T3 (es) | 2009-11-17 | 2017-11-17 | E. R. Squibb & Sons, L.L.C. | Métodos para la producción mejorada de proteínas |
| ES2578514T3 (es) * | 2010-02-15 | 2016-07-27 | Crucell Holland B.V. | Método para la producción de vectores adenovíricos |
| US20120315696A1 (en) * | 2010-02-15 | 2012-12-13 | Alfred Luitjens | METHOD FOR THE PRODUCTION OF Ad26 ADENOVIRAL VECTORS |
| WO2011144561A1 (en) | 2010-05-18 | 2011-11-24 | Crucell Holland B.V. | Methods for welding ethylene vinyl acetate (eva) tubing, tubing obtained thereby and use of such tubing for sterile transfer of content into a bioreactor |
| EP2625262B1 (en) * | 2010-10-05 | 2015-09-23 | Novo Nordisk Health Care AG | Process for protein production |
| BR112013028006A2 (pt) * | 2011-05-13 | 2016-09-06 | Octapharma Ag | método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii |
| IL315908A (en) * | 2011-07-01 | 2024-11-01 | Amgen Inc | Mammalian cell culture |
| US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
| IN2014CN02527A (enExample) | 2011-10-18 | 2015-06-26 | Coherus Biosciences Inc | |
| CN103305417A (zh) * | 2012-03-07 | 2013-09-18 | 无锡药明康德生物技术有限公司 | 进行蛋白生产的高产量反应器及其生产方法和应用 |
| GB201211256D0 (en) * | 2012-06-25 | 2012-08-08 | Glaxosmithkline Biolog Sa | Fermentation process |
| HK1209343A1 (en) | 2012-07-09 | 2016-04-01 | Coherus Biosciences, Inc. | Etanercept formulations exhibiting marked reduction in sub-visible particles |
| CA2882551A1 (en) | 2012-09-11 | 2014-03-20 | Coherus Biosciences, Inc. | Correctly folded etanercept in high purity and excellent yield |
| US9663753B2 (en) | 2012-09-27 | 2017-05-30 | Ge Healthcare Bio-Sciences Ab | Tangential flow perfusion system |
| TWI637057B (zh) | 2012-11-09 | 2018-10-01 | 拜爾沙納有限公司 | 具交替生物反應器用途之不連續進料批次製程 |
| US10188099B2 (en) * | 2013-03-15 | 2019-01-29 | Genzyme Corporation | High density cell banking methods |
| ES2842350T3 (es) | 2013-03-19 | 2021-07-13 | Cmc Biologics As | Un procedimiento para la producción de un producto (por ejemplo, polipéptido) en un proceso de fermentación de cultivo celular continuo |
| AU2014241259B9 (en) | 2013-03-26 | 2018-12-20 | Coherus Biosciences, Inc. | Protein production method |
| US9790465B2 (en) | 2013-04-30 | 2017-10-17 | Corning Incorporated | Spheroid cell culture well article and methods thereof |
| BR122021001466B1 (pt) * | 2013-09-16 | 2021-10-13 | Genzyme Corporation | Sistema de filtração de circuito aberto |
| EP3052613A1 (en) | 2013-09-30 | 2016-08-10 | Crucell Holland B.V. | Method for the clarification of high density crude cell culture harvest |
| CN103525756B (zh) * | 2013-10-23 | 2015-04-08 | 南京农业大学 | 一种原代鸡肝细胞的分离培养方法 |
| JP2017500017A (ja) * | 2013-12-20 | 2017-01-05 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
| CN106170554B (zh) * | 2014-01-29 | 2021-08-17 | 美国安进公司 | 过表达n-糖基化途径调节基因以调节重组蛋白的糖基化 |
| BR112016018797A8 (pt) * | 2014-02-17 | 2020-06-23 | Advantech Bioscience Farm Ltda | aperfeiçoamento de expressão de proteína recombinante com o uso de um sistema de retenção de célula baseado em membrana |
| EA039148B1 (ru) * | 2014-06-04 | 2021-12-10 | Эмджен Инк. | Способ сбора рекомбинантного белка |
| BR112017001177B1 (pt) | 2014-07-24 | 2022-05-24 | Janssen Vaccines & Prevention B.V | Método de purificação e de potenciação da liberação de poliovírus a partir de uma colheita de cultura celular bruta contendo poliovírus e uso de um detergente catiônico |
| JP6530171B2 (ja) * | 2014-09-09 | 2019-06-12 | 旭化成メディカル株式会社 | 培養産生物の回収方法 |
| DK3193594T3 (da) * | 2014-09-18 | 2021-09-27 | Genzyme Corp | Fremgangsmåder til frembringelse af cellebank med ultrahøj densitet |
| JP6930914B2 (ja) | 2014-10-29 | 2021-09-01 | コーニング インコーポレイテッド | 灌流バイオリアクタ・プラットフォーム |
| JP2017532971A (ja) | 2014-10-29 | 2017-11-09 | コーニング インコーポレイテッド | 細胞培養集合体を生成するためのマイクロウェル設計および製造 |
| SG11201703493SA (en) | 2014-10-29 | 2017-05-30 | Corning Inc | Cell culture insert |
| WO2016073858A1 (en) | 2014-11-07 | 2016-05-12 | Genesis Technologies, Llc | Linear reciprocating actuator |
| CA2971861C (en) | 2014-12-22 | 2024-02-13 | Genzyme Corporation | Methods of culturing a mammalian cell |
| JP6936937B2 (ja) * | 2015-02-09 | 2021-09-22 | ユニバーセルズ テクノロジーズ エス.エー.Univercells Technologies S.A. | 細胞および/または細胞生成物の製造システム、製造装置および製造方法 |
| WO2017180724A1 (en) * | 2016-04-12 | 2017-10-19 | Artemis Biosystems, Inc. | Perfusion filtration systems |
| KR102535013B1 (ko) * | 2016-04-14 | 2023-05-22 | 트리젤 엘티디. | 정유량 펌프/튜빙 시스템이 있는 고정층 바이오 리액터 |
| KR102718795B1 (ko) | 2016-04-14 | 2024-10-16 | 트리젤 엘티디. | 정유량 펌프/튜빙 시스템이 있는 고정층 바이오 리액터 |
| EP3443064A1 (en) * | 2016-04-15 | 2019-02-20 | Boehringer Ingelheim International GmbH | Cell retention device and method |
| CN109415679A (zh) | 2016-06-30 | 2019-03-01 | 富士胶片株式会社 | 细胞悬液的膜分离方法以及细胞培养装置 |
| IL291373B2 (en) * | 2016-07-11 | 2023-10-01 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Methods and systems for growing cells in culture |
| PL3652291T3 (pl) | 2017-07-14 | 2022-03-28 | Corning Incorporated | Naczynie do hodowli komórkowej |
| US11857970B2 (en) | 2017-07-14 | 2024-01-02 | Corning Incorporated | Cell culture vessel |
| CN111094536B (zh) | 2017-07-14 | 2024-03-29 | 康宁股份有限公司 | 用于3d培养的细胞培养容器及培养3d细胞的方法 |
| EP3652290B1 (en) | 2017-07-14 | 2022-05-04 | Corning Incorporated | 3d cell culture vessels for manual or automatic media exchange |
| WO2019049843A1 (ja) | 2017-09-06 | 2019-03-14 | 富士フイルム株式会社 | 産生物の製造方法 |
| US20200255785A1 (en) * | 2017-09-15 | 2020-08-13 | Bristol-Myers Squibb Company | Online biomass capacitance monitoring during large scale production of polypeptides of interest |
| EP3692358A1 (en) | 2017-10-06 | 2020-08-12 | Lonza Ltd | Automated control of cell culture using raman spectroscopy |
| TWI889045B (zh) | 2017-10-16 | 2025-07-01 | 美商再生元醫藥公司 | 灌注生物反應器及相關使用方法 |
| WO2019118426A1 (en) * | 2017-12-11 | 2019-06-20 | Amgen Inc. | Continuous manufacturing process for bispecific antibody products |
| WO2019173752A1 (en) * | 2018-03-08 | 2019-09-12 | Repligen Corporation | Tangential flow depth filtration systems and methods of filtration using same |
| CN110241012B (zh) * | 2018-03-09 | 2022-11-01 | 嘉和生物药业有限公司 | 一种生物大分子上游分阶段截留的生产方法、生产模块及在生产中的应用 |
| JP6869423B2 (ja) * | 2018-03-19 | 2021-05-12 | 富士フイルム株式会社 | 生産物の製造方法 |
| KR102819571B1 (ko) | 2018-05-25 | 2025-06-12 | 리플리겐 코포레이션 | 접선 유동 여과 시스템 및 방법 |
| CN108504562A (zh) * | 2018-06-21 | 2018-09-07 | 江苏澳创生物科技有限公司 | 一种发酵生产l-苏氨酸的系统及其应用 |
| JP7171696B2 (ja) | 2018-07-13 | 2022-11-15 | コーニング インコーポレイテッド | 相互接続されたウェルを有するマイクロプレートを備えた流体デバイス |
| WO2020013845A1 (en) | 2018-07-13 | 2020-01-16 | Corning Incorporated | Cell culture vessels with stabilizer devices |
| US11912968B2 (en) | 2018-07-13 | 2024-02-27 | Corning Incorporated | Microcavity dishes with sidewall including liquid medium delivery surface |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| WO2020165873A1 (en) * | 2019-02-15 | 2020-08-20 | Oncosimis Biotech Private Limited | Method and system for enhanced continuous production, secretion and separation of recombinant polypeptides from bacteria |
| US20220243225A1 (en) * | 2019-04-29 | 2022-08-04 | Voyager Therapeutics, Inc. | SYSTEMS AND METHODS FOR PRODUCING BACULOVIRAL INFECTED INSECT CELLS (BIICs) IN BIOREACTORS |
| CA3137494A1 (en) * | 2019-06-13 | 2020-12-17 | Amgen Inc. | Automated biomass-based perfusion control in the manufacturing of biologics |
| CN114127260A (zh) * | 2019-07-16 | 2022-03-01 | 信达生物制药(苏州)有限公司 | 高密度连续接种的细胞培养方法及其应用 |
| EP4058547A1 (en) * | 2019-11-15 | 2022-09-21 | Lonza Ltd. | Process and system for producing an inoculum |
| CN116601279A (zh) | 2020-07-28 | 2023-08-15 | 思进股份有限公司 | 用于生产多肽的方法和系统 |
| CA3215302A1 (en) * | 2021-04-14 | 2022-10-20 | Shawn L. BARRETT | Methods of perfusion culturing a mammalian cell |
| EP4584299A2 (en) | 2022-09-07 | 2025-07-16 | Quantitative Biosciences, Inc. | Fentanyl-specific single variable-domain antibodies and use in a continuous agglutination assay |
| CN116179464A (zh) * | 2022-12-06 | 2023-05-30 | 无锡药明生物技术股份有限公司 | 提高培养液细胞密度和高密度细胞培养的方法 |
| WO2024192116A1 (en) * | 2023-03-14 | 2024-09-19 | Repligen Corporation | High viable cell density transfection |
| AU2024235963A1 (en) * | 2023-03-14 | 2025-08-07 | Sonnet BioTherapeutics, Inc. | Methods of making recombinant il-12 albumin binding domain fusion proteins |
| WO2024226439A1 (en) | 2023-04-24 | 2024-10-31 | Quantitative Biosciences, Inc. | Engineered biosensor strains of e. coli for continuous aerobic detection of analytes |
| WO2024248119A1 (ja) * | 2023-05-31 | 2024-12-05 | 富士フイルム株式会社 | 生産物の生産方法 |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US54544A (en) * | 1866-05-08 | Improvement in low-water detecters | ||
| JPS61199788A (ja) | 1985-02-28 | 1986-09-04 | Mitsubishi Rayon Co Ltd | 醗酵生成物の分離濃縮方法及び連続醗酵方法 |
| US5286646A (en) | 1985-11-25 | 1994-02-15 | Boehringer Mannheim Gmbh | Method for mammalian cell culture |
| GB8617646D0 (en) | 1986-07-18 | 1986-08-28 | Manchester Inst Science Tech | Recovery of biological material |
| US4806484A (en) | 1987-08-07 | 1989-02-21 | Igb Products, Ltd. | Perfusion airlift bioreactor |
| JPH0797982B2 (ja) | 1987-09-24 | 1995-10-25 | 東洋紡績株式会社 | 細胞培養装置 |
| US4921792A (en) | 1987-11-27 | 1990-05-01 | Miles Inc. | Continuous cell dispersion, cultivation and substance recovery process |
| JPH01243985A (ja) | 1988-03-25 | 1989-09-28 | P C C Technol:Kk | 植物器官の培養法及びその培養槽 |
| US5595909A (en) | 1988-05-23 | 1997-01-21 | Regents Of The University Of Minnesota | Filter device |
| DE68917642T2 (de) | 1988-05-25 | 1995-02-09 | Teijin Ltd | Verfahren zur kontinuierlichen Züchtung von haftenden tierischen Zellen. |
| JPH02113896A (ja) * | 1988-10-24 | 1990-04-26 | Snow Brand Milk Prod Co Ltd | ヒト抗リシンモノクローナル抗体およびそれを分泌するハイブリドーマ |
| US5019512A (en) | 1989-03-17 | 1991-05-28 | Baxter International Inc. | Spin filter for removing substantially cell-free culture medium from suspension cell culture system |
| JPH0541984A (ja) * | 1990-09-07 | 1993-02-23 | Dow Chem Co:The | 攪拌容器における中空繊維においての細胞の増殖 |
| US5256294A (en) | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
| GB9118664D0 (en) | 1991-08-30 | 1991-10-16 | Celltech Ltd | Cell culture |
| JPH05153973A (ja) | 1991-12-03 | 1993-06-22 | Hitachi Ltd | 細胞培養方法及び装置 |
| US6204000B1 (en) | 1995-04-28 | 2001-03-20 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1 |
| JP2752918B2 (ja) * | 1995-05-16 | 1998-05-18 | ユーエイチティー株式会社 | 動物細胞のマイクロキャリア培養法 |
| US6001585A (en) | 1997-11-14 | 1999-12-14 | Cellex Biosciences, Inc. | Micro hollow fiber bioreactor |
| JP2997771B2 (ja) * | 1998-06-29 | 2000-01-11 | 金沢大学長 | 細胞の懸濁培養方法 |
| US8026096B1 (en) * | 1998-10-08 | 2011-09-27 | Protein Sciences Corporation | In vivo active erythropoietin produced in insect cells |
| US6103526A (en) | 1998-10-08 | 2000-08-15 | Protein Sciences Corporation | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| CA2252972C (en) | 1998-11-26 | 2012-09-18 | National Research Council Of Canada | Serum-free production of recombinant proteins and adenoviral vectors |
| PT1147180E (pt) | 1999-01-26 | 2009-03-10 | Schering Plough Ltd | Propagação de coronavírus bovino em células de ovário de hamster chinês |
| CA2370477C (en) * | 1999-04-15 | 2010-06-29 | Crucell Holland B.V. | Recombinant protein production in a human cell using sequences encoding adenovirus e1 protein |
| US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
| EP1103610A1 (en) | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| JP2001149099A (ja) | 1999-11-26 | 2001-06-05 | Olympus Optical Co Ltd | 染色体異常解析のための有核細胞の標本作製方法 |
| US6544424B1 (en) * | 1999-12-03 | 2003-04-08 | Refined Technology Company | Fluid filtration system |
| US6168941B1 (en) | 2000-04-07 | 2001-01-02 | Genvec, Inc. | Method of producing adenoviral vector stocks |
| JP4138209B2 (ja) | 2000-06-29 | 2008-08-27 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | プラバスタチン含有組成物 |
| JP2002113896A (ja) | 2000-10-05 | 2002-04-16 | Seiko Epson Corp | 画像形成装置 |
| US7157273B2 (en) | 2001-04-17 | 2007-01-02 | Seiren Kabushiki Kaisha | Medium additives and media for culturing animal cells |
| DE10120835C2 (de) | 2001-04-27 | 2003-04-10 | Sifin Inst Fuer Immunpraeparat | Verfahren zur Herstellung von monoklonalen Antikörpern |
| CA2351156A1 (en) | 2001-07-04 | 2003-01-04 | Peter W. Zandstra | A bioprocess for the generation of pluripotent cell derived cells and tissues |
| AU2002333739B2 (en) * | 2001-08-31 | 2007-08-02 | Bayer Intellectual Property Gmbh | A unit and a process for carrying out high cell density fermentation |
| EP1362593B1 (en) | 2001-09-05 | 2005-12-07 | Yamasa Corporation | Cytidine-phosphocholine for the treatment of diabetic neuropathy |
| WO2003025158A1 (en) | 2001-09-14 | 2003-03-27 | Medcell Biologics, Inc. | Oxygen enriched bioreactor and method of culturing cells |
| JP2003219873A (ja) | 2002-01-24 | 2003-08-05 | Japan Science & Technology Corp | サケ科キングサーモン由来の不死化細胞 |
| US20030186335A1 (en) | 2002-03-28 | 2003-10-02 | National Institute Of Advanced Industrial Science And Technology | Monoclonal antibodies, hybridomas, cell isolation method, isolated cells and immunological diagnostic method |
| DE10237082B4 (de) | 2002-08-09 | 2014-12-31 | Sartorius Stedim Biotech Gmbh | Verfahren und Vorrichtung zur biotechnologischen Herstellung von Wertstoffen |
| DK1623023T3 (da) | 2003-05-09 | 2009-03-02 | Crucell Holland Bv | Kulturer af E1-immortaliserede celler og fremgangsmåder til dyrkning deraf til forögelse af produktudbytter derfra |
| JP2005041984A (ja) | 2003-07-22 | 2005-02-17 | Shin Kobe Electric Mach Co Ltd | 水架橋ポリオレフィン製シートの製造法 |
| KR101050585B1 (ko) | 2004-03-05 | 2011-07-19 | 디에스엠 아이피 어셋츠 비.브이. | 연속식 살포 및 교호 접선 흐름에 의한 세포 배양 방법 |
| PT2634243T (pt) | 2006-07-14 | 2017-12-18 | Patheon Holdings I B V | Método para melhorar a cultura de células |
| JP2008308560A (ja) | 2007-06-13 | 2008-12-25 | Tohcello Co Ltd | 表面防汚性複合フィルムの製造方法 |
-
2005
- 2005-03-04 KR KR1020067018075A patent/KR101050585B1/ko not_active Ceased
- 2005-03-04 ES ES05715787.7T patent/ES2456015T3/es not_active Expired - Lifetime
- 2005-03-04 PL PL05715787T patent/PL1720972T3/pl unknown
- 2005-03-04 AU AU2005229359A patent/AU2005229359C1/en not_active Ceased
- 2005-03-04 US US10/591,118 patent/US8206981B2/en active Active
- 2005-03-04 EP EP10183651A patent/EP2308958A3/en not_active Withdrawn
- 2005-03-04 DK DK05715787.7T patent/DK1720972T3/da active
- 2005-03-04 CN CN201410471955.5A patent/CN104593277A/zh active Pending
- 2005-03-04 SI SI200531842T patent/SI1720972T1/sl unknown
- 2005-03-04 WO PCT/EP2005/002374 patent/WO2005095578A1/en not_active Ceased
- 2005-03-04 CA CA002557046A patent/CA2557046A1/en not_active Withdrawn
- 2005-03-04 EP EP05715787.7A patent/EP1720972B1/en not_active Revoked
- 2005-03-04 CN CN201410601800.9A patent/CN104388324A/zh active Pending
- 2005-03-04 JP JP2007501239A patent/JP2007525984A/ja active Pending
- 2005-03-04 PT PT57157877T patent/PT1720972E/pt unknown
- 2005-03-04 CN CNA2005800071754A patent/CN1930281A/zh active Pending
- 2005-03-04 EP EP12186351A patent/EP2540815A1/en not_active Ceased
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2006
- 2006-08-28 IL IL177724A patent/IL177724A/en unknown
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2010
- 2010-05-06 IL IL205606A patent/IL205606A/en unknown
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2011
- 2011-02-22 JP JP2011036102A patent/JP2011125348A/ja active Pending
- 2011-11-28 JP JP2011259168A patent/JP2012090632A/ja active Pending
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2012
- 2012-05-23 US US13/478,307 patent/US20130266985A1/en not_active Abandoned
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2013
- 2013-10-14 US US14/052,878 patent/US9260695B2/en not_active Expired - Lifetime
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2014
- 2014-01-31 JP JP2014016778A patent/JP5719947B2/ja not_active Expired - Fee Related
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2015
- 2015-10-26 JP JP2015209828A patent/JP2016039817A/ja active Pending
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2017
- 2017-07-06 JP JP2017132997A patent/JP2017225443A/ja active Pending
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