JP2014501518A5 - - Google Patents
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- Publication number
- JP2014501518A5 JP2014501518A5 JP2013543140A JP2013543140A JP2014501518A5 JP 2014501518 A5 JP2014501518 A5 JP 2014501518A5 JP 2013543140 A JP2013543140 A JP 2013543140A JP 2013543140 A JP2013543140 A JP 2013543140A JP 2014501518 A5 JP2014501518 A5 JP 2014501518A5
- Authority
- JP
- Japan
- Prior art keywords
- myumyu
- chelerythrine
- ivermectin
- culturing
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LLEJIEBFSOEYIV-UHFFFAOYSA-N chelerythrine Chemical compound C1=C2OCOC2=CC2=CC=C3C4=CC=C(OC)C(OC)=C4C=[N+](C)C3=C21 LLEJIEBFSOEYIV-UHFFFAOYSA-N 0.000 claims 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- RATMHCJTVBHJSU-UHFFFAOYSA-N Dihydrochelerythrine Natural products C1=C2OCOC2=CC2=C(N(C)C(O)C=3C4=CC=C(C=3OC)OC)C4=CC=C21 RATMHCJTVBHJSU-UHFFFAOYSA-N 0.000 claims 1
- 229940074360 caffeic acid Drugs 0.000 claims 1
- 235000004883 caffeic acid Nutrition 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002418 ivermectin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/059586 WO2012078153A1 (en) | 2010-12-08 | 2010-12-08 | Agents and methods for inhibiting human pluripotent stem cell growth |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501518A JP2014501518A (ja) | 2014-01-23 |
| JP2014501518A5 true JP2014501518A5 (enExample) | 2014-03-13 |
| JP5875597B2 JP5875597B2 (ja) | 2016-03-02 |
Family
ID=46207417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543140A Expired - Fee Related JP5875597B2 (ja) | 2010-12-08 | 2010-12-08 | ヒト万能性幹細胞の成長を阻害する薬剤および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9365830B2 (enExample) |
| EP (1) | EP2649177B1 (enExample) |
| JP (1) | JP5875597B2 (enExample) |
| CN (1) | CN103354835B (enExample) |
| AU (1) | AU2010365057B2 (enExample) |
| CA (1) | CA2820419A1 (enExample) |
| ES (1) | ES2690663T3 (enExample) |
| WO (1) | WO2012078153A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2800173C (en) | 2010-05-21 | 2019-05-14 | Ulrik Nielsen | Bi-specific fusion proteins |
| CN103890167A (zh) | 2011-06-21 | 2014-06-25 | 诺沃—诺迪斯克有限公司 | 自多潜能干细胞有效诱导定形内胚层 |
| US10072242B2 (en) | 2013-03-25 | 2018-09-11 | Foundation For Biomedical Research And Innovation At Kobe | Cell sorting method |
| CA2913990C (en) * | 2013-05-30 | 2021-10-12 | Ajinomoto Co., Inc. | Medium for culturing stem cells |
| US10501724B2 (en) * | 2013-08-23 | 2019-12-10 | Sumitomo Chemical Company, Limited | Method for producing retinal tissue and retina-related cells |
| JP6791756B2 (ja) * | 2014-01-21 | 2020-11-25 | ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 多能性幹細胞の選択的な阻害のための方法 |
| CA2944393C (en) | 2014-03-31 | 2019-02-05 | Ajinomoto Co., Inc. | Medium for stem cell use |
| US11028369B2 (en) | 2015-08-13 | 2021-06-08 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Induced extended pluripotent stem cells, method of making and using |
| CN115960249A (zh) | 2015-10-02 | 2023-04-14 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| WO2018140647A1 (en) * | 2017-01-25 | 2018-08-02 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| EP3587560A4 (en) * | 2017-01-27 | 2020-12-16 | Kaneka Corporation | Endodermal cell mass, and method for producing any one of three primary germ layer cell mass from pluripotent cells |
| WO2018165308A1 (en) * | 2017-03-07 | 2018-09-13 | Platelet Biogenesis, Inc. | Recirculating bioreactor |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| EP3569693A4 (en) | 2017-06-05 | 2020-11-18 | Terumo Kabushiki Kaisha | CELL CULTURE MANUFACTURING PROCESS |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| CN108570443A (zh) * | 2017-12-05 | 2018-09-25 | 皓昇莱生物制药有限公司 | 一种用于培养尿液来源细胞的培养基 |
| US12161676B2 (en) | 2018-03-23 | 2024-12-10 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| EP3778871A4 (en) * | 2018-03-28 | 2021-07-14 | Osaka University | METHOD FOR PRODUCING TEAR TISSUE FROM STEM CELLS |
| US12241085B2 (en) | 2018-04-06 | 2025-03-04 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
| WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| CN110684714B (zh) * | 2018-07-05 | 2023-05-09 | 广东博溪生物科技有限公司 | 一种屏障功能弱化模型的构建方法 |
| US12157872B2 (en) | 2018-07-19 | 2024-12-03 | Stellular Bio, Inc. | Stacked recirculating bioreactor |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| CN112867787B (zh) * | 2018-09-19 | 2024-11-22 | 千纸鹤治疗公司 | 胰岛素产生细胞 |
| EP3739040B1 (en) | 2018-09-27 | 2023-07-05 | Osaka University | Sheeting method for pluripotent stem cell-derived cells |
| US20220364065A1 (en) * | 2018-12-21 | 2022-11-17 | National University Corporation Hokkaido University | Composition for removing pluripotent stem cells and method of removing pluripotent stem cells |
| CN110373375A (zh) * | 2019-03-19 | 2019-10-25 | 杭州原生生物科技有限公司 | 一种制备纤维细胞作为细胞培养基的方法和用途 |
| BR112022004026A2 (pt) | 2019-09-05 | 2022-08-16 | Crispr Therapeutics Ag | Células doadoras universais |
| US11116798B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| AU2021328501A1 (en) | 2020-08-15 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (CALCR) |
| US11566230B2 (en) | 2020-12-31 | 2023-01-31 | Crispr Therapeutics Ag | Universal donor cells |
| TW202523836A (zh) * | 2023-12-12 | 2025-06-16 | 佛教慈濟醫療財團法人 | 選擇性去除未分化多潛能幹細胞的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| IL142748A0 (en) | 1998-11-09 | 2002-03-10 | Univ Monash | Embryonic stem cells |
| US8597947B2 (en) * | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| US20080070303A1 (en) * | 2005-11-21 | 2008-03-20 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| WO2011011632A1 (en) * | 2009-07-22 | 2011-01-27 | Tufts University | Methods and compositions for modulating membrane potential to influence cell behavior |
-
2010
- 2010-12-08 EP EP10860584.1A patent/EP2649177B1/en not_active Not-in-force
- 2010-12-08 US US13/992,931 patent/US9365830B2/en not_active Expired - Fee Related
- 2010-12-08 AU AU2010365057A patent/AU2010365057B2/en not_active Ceased
- 2010-12-08 CN CN201080071181.7A patent/CN103354835B/zh not_active Expired - Fee Related
- 2010-12-08 CA CA2820419A patent/CA2820419A1/en not_active Abandoned
- 2010-12-08 ES ES10860584.1T patent/ES2690663T3/es active Active
- 2010-12-08 WO PCT/US2010/059586 patent/WO2012078153A1/en not_active Ceased
- 2010-12-08 JP JP2013543140A patent/JP5875597B2/ja not_active Expired - Fee Related
-
2016
- 2016-06-10 US US15/178,852 patent/US20160281058A1/en not_active Abandoned
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