JP2014501518A5 - - Google Patents
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- Publication number
- JP2014501518A5 JP2014501518A5 JP2013543140A JP2013543140A JP2014501518A5 JP 2014501518 A5 JP2014501518 A5 JP 2014501518A5 JP 2013543140 A JP2013543140 A JP 2013543140A JP 2013543140 A JP2013543140 A JP 2013543140A JP 2014501518 A5 JP2014501518 A5 JP 2014501518A5
- Authority
- JP
- Japan
- Prior art keywords
- myumyu
- chelerythrine
- ivermectin
- culturing
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LLEJIEBFSOEYIV-UHFFFAOYSA-N chelerythrine Chemical compound C1=C2OCOC2=CC2=CC=C3C4=CC=C(OC)C(OC)=C4C=[N+](C)C3=C21 LLEJIEBFSOEYIV-UHFFFAOYSA-N 0.000 claims 2
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 claims 2
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 claims 1
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims 1
- SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- RATMHCJTVBHJSU-UHFFFAOYSA-N Dihydrochelerythrine Natural products C1=C2OCOC2=CC2=C(N(C)C(O)C=3C4=CC=C(C=3OC)OC)C4=CC=C21 RATMHCJTVBHJSU-UHFFFAOYSA-N 0.000 claims 1
- 229940074360 caffeic acid Drugs 0.000 claims 1
- 235000004883 caffeic acid Nutrition 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002418 ivermectin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2010/059586 WO2012078153A1 (en) | 2010-12-08 | 2010-12-08 | Agents and methods for inhibiting human pluripotent stem cell growth |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501518A JP2014501518A (ja) | 2014-01-23 |
| JP2014501518A5 true JP2014501518A5 (enExample) | 2014-03-13 |
| JP5875597B2 JP5875597B2 (ja) | 2016-03-02 |
Family
ID=46207417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013543140A Expired - Fee Related JP5875597B2 (ja) | 2010-12-08 | 2010-12-08 | ヒト万能性幹細胞の成長を阻害する薬剤および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9365830B2 (enExample) |
| EP (1) | EP2649177B1 (enExample) |
| JP (1) | JP5875597B2 (enExample) |
| CN (1) | CN103354835B (enExample) |
| AU (1) | AU2010365057B2 (enExample) |
| CA (1) | CA2820419A1 (enExample) |
| ES (1) | ES2690663T3 (enExample) |
| WO (1) | WO2012078153A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103124788B (zh) | 2010-05-21 | 2016-01-13 | 梅里麦克制药股份有限公司 | 双特异性融合蛋白 |
| EP2723852B1 (en) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| EP2980207B1 (en) * | 2013-03-25 | 2018-12-05 | Foundation for Biomedical Research and Innovation at Kobe | Cell sorting method |
| EP3006558B1 (en) * | 2013-05-30 | 2020-05-13 | Ajinomoto Co., Inc. | Medium for culturing stem cells |
| CA2922079C (en) | 2013-08-23 | 2022-07-05 | Sumitomo Chemical Company, Limited | Method for producing retinal tissue and retina-related cells |
| EP3097186B1 (en) * | 2014-01-21 | 2019-05-08 | The Medical College of Wisconsin, Inc. | Methods for selective inhibition of pluripotent stem cells |
| WO2015151307A1 (ja) * | 2014-03-31 | 2015-10-08 | 味の素株式会社 | 幹細胞用培地 |
| WO2017025061A1 (en) * | 2015-08-13 | 2017-02-16 | Peking University | Induced extended pluripotent stem cells, methods of making and using |
| CN108367048B (zh) | 2015-10-02 | 2022-08-12 | 银溪制药股份有限公司 | 用于组织修复的双特异性治疗性蛋白质 |
| WO2017123806A1 (en) | 2016-01-12 | 2017-07-20 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11913022B2 (en) * | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| WO2018139600A1 (ja) * | 2017-01-27 | 2018-08-02 | 株式会社カネカ | 内胚葉系細胞集団、及び多能性細胞から三胚葉のいずれかの細胞集団を製造する方法 |
| AU2018231210A1 (en) * | 2017-03-07 | 2019-09-19 | Platelet Biogenesis, Inc. | Recirculating bioreactor |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| JP7298844B2 (ja) | 2017-06-05 | 2023-06-27 | テルモ株式会社 | 細胞培養物の製造方法 |
| US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
| CN108570443A (zh) * | 2017-12-05 | 2018-09-25 | 皓昇莱生物制药有限公司 | 一种用于培养尿液来源细胞的培养基 |
| EP3768823B1 (en) | 2018-03-23 | 2025-12-31 | Cedars-Sinai Medical Center | METHODS FOR USING CELLS FROM PANCREATIC ISLETS |
| EP3778871A4 (en) * | 2018-03-28 | 2021-07-14 | Osaka University | METHOD FOR PRODUCING TEAR TISSUE FROM STEM CELLS |
| JP7464532B2 (ja) | 2018-04-06 | 2024-04-09 | シーダーズ－サイナイ メディカル センター | マイクロ流体チップ上のヒト多能性幹細胞由来の神経変性疾患モデル |
| US11981918B2 (en) | 2018-04-06 | 2024-05-14 | Cedars-Sinai Medical Center | Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| CN110684714B (zh) * | 2018-07-05 | 2023-05-09 | 广东博溪生物科技有限公司 | 一种屏障功能弱化模型的构建方法 |
| BR112021000996A2 (pt) | 2018-07-19 | 2021-04-20 | Platelet Biogenesis, Inc. | biorreator de recirculação empilhado |
| US10724052B2 (en) | 2018-09-07 | 2020-07-28 | Crispr Therapeutics Ag | Universal donor cells |
| AU2019343003B2 (en) * | 2018-09-19 | 2025-07-17 | Orizuru Therapeutics, Inc. | Insulin-producing cells |
| JP7781522B2 (ja) | 2018-09-27 | 2025-12-08 | 国立大学法人大阪大学 | 多能性幹細胞由来細胞のシート化方法 |
| WO2020130077A1 (ja) * | 2018-12-21 | 2020-06-25 | 国立大学法人北海道大学 | 多能性幹細胞を除去するための組成物、及び多能性幹細胞の除去方法 |
| CN110373375A (zh) * | 2019-03-19 | 2019-10-25 | 杭州原生生物科技有限公司 | 一种制备纤维细胞作为细胞培养基的方法和用途 |
| MX2022002783A (es) | 2019-09-05 | 2022-04-06 | Crispr Therapeutics Ag | Celulas donantes universales. |
| PH12022550542A1 (en) | 2019-09-05 | 2023-03-20 | Crispr Therapeutics Ag | Universal donor cells |
| MX2023001914A (es) | 2020-08-15 | 2023-03-13 | Regeneron Pharma | Tratamiento de la obesidad en sujetos que tienen variantes de moleculas de acido nucleico que codifican el receptor de calcitonina (calcr). |
| US11578309B2 (en) | 2020-12-31 | 2023-02-14 | Crispr Therapeutics Ag | Universal donor cells |
| TW202523836A (zh) * | 2023-12-12 | 2025-06-16 | 佛教慈濟醫療財團法人 | 選擇性去除未分化多潛能幹細胞的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5861483A (en) * | 1996-04-03 | 1999-01-19 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| IL142748A0 (en) | 1998-11-09 | 2002-03-10 | Univ Monash | Embryonic stem cells |
| US8597947B2 (en) * | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| US20080070303A1 (en) * | 2005-11-21 | 2008-03-20 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| US20120295346A1 (en) * | 2009-07-22 | 2012-11-22 | Tufts University | Methods and compositions for modulating membrane potential to influence cell behavior |
-
2010
- 2010-12-08 JP JP2013543140A patent/JP5875597B2/ja not_active Expired - Fee Related
- 2010-12-08 WO PCT/US2010/059586 patent/WO2012078153A1/en not_active Ceased
- 2010-12-08 ES ES10860584.1T patent/ES2690663T3/es active Active
- 2010-12-08 CA CA2820419A patent/CA2820419A1/en not_active Abandoned
- 2010-12-08 AU AU2010365057A patent/AU2010365057B2/en not_active Ceased
- 2010-12-08 CN CN201080071181.7A patent/CN103354835B/zh not_active Expired - Fee Related
- 2010-12-08 US US13/992,931 patent/US9365830B2/en not_active Expired - Fee Related
- 2010-12-08 EP EP10860584.1A patent/EP2649177B1/en not_active Not-in-force
-
2016
- 2016-06-10 US US15/178,852 patent/US20160281058A1/en not_active Abandoned
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