ES2690663T3 - Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas - Google Patents

Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas Download PDF

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Publication number
ES2690663T3
ES2690663T3 ES10860584.1T ES10860584T ES2690663T3 ES 2690663 T3 ES2690663 T3 ES 2690663T3 ES 10860584 T ES10860584 T ES 10860584T ES 2690663 T3 ES2690663 T3 ES 2690663T3
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Prior art keywords
cells
cell
inhibitor
pluripotent stem
differentiated
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ES10860584.1T
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English (en)
Spanish (es)
Inventor
Thomas Schulz
Allan Robins
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Viacyte Inc
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Viacyte Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
ES10860584.1T 2010-12-08 2010-12-08 Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas Active ES2690663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/059586 WO2012078153A1 (en) 2010-12-08 2010-12-08 Agents and methods for inhibiting human pluripotent stem cell growth

Publications (1)

Publication Number Publication Date
ES2690663T3 true ES2690663T3 (es) 2018-11-21

Family

ID=46207417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10860584.1T Active ES2690663T3 (es) 2010-12-08 2010-12-08 Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas

Country Status (8)

Country Link
US (2) US9365830B2 (enExample)
EP (1) EP2649177B1 (enExample)
JP (1) JP5875597B2 (enExample)
CN (1) CN103354835B (enExample)
AU (1) AU2010365057B2 (enExample)
CA (1) CA2820419A1 (enExample)
ES (1) ES2690663T3 (enExample)
WO (1) WO2012078153A1 (enExample)

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ES2674567T3 (es) 2010-05-21 2018-07-02 Merrimack Pharmaceuticals, Inc. Proteínas de fusión biespecíficas
JP6312591B2 (ja) 2011-06-21 2018-04-18 ノヴォ ノルディスク アー／エス 多能性幹細胞からの胚体内胚葉の効率的な誘導
US10072242B2 (en) 2013-03-25 2018-09-11 Foundation For Biomedical Research And Innovation At Kobe Cell sorting method
CN105283541B (zh) * 2013-05-30 2019-02-19 味之素株式会社 干细胞培养用培养基
WO2015025967A1 (ja) 2013-08-23 2015-02-26 住友化学株式会社 網膜組織及び網膜関連細胞の製造方法
EP3097186B1 (en) 2014-01-21 2019-05-08 The Medical College of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
CA2944393C (en) 2014-03-31 2019-02-05 Ajinomoto Co., Inc. Medium for stem cell use
US11028369B2 (en) 2015-08-13 2021-06-08 Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. Induced extended pluripotent stem cells, method of making and using
CA3000742A1 (en) 2015-10-02 2017-04-06 Silver Creek Pharmaceuticals, Inc. Bi-specific therapeutic proteins for tissue repair
WO2017123806A1 (en) 2016-01-12 2017-07-20 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
WO2018140647A1 (en) * 2017-01-25 2018-08-02 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
US11746331B2 (en) 2017-01-27 2023-09-05 Kaneka Corporation Endodermal cell population, and method for producing cell population of any of three germ layers from pluripotent cell
EP3592838A4 (en) * 2017-03-07 2021-01-13 Platelet Biogenesis, Inc. RECIRCULATING BIOREACTOR
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN110506109B (zh) 2017-06-05 2024-03-12 泰尔茂株式会社 细胞培养物的制造方法
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CN108570443A (zh) * 2017-12-05 2018-09-25 皓昇莱生物制药有限公司 一种用于培养尿液来源细胞的培养基
US12161676B2 (en) 2018-03-23 2024-12-10 Cedars-Sinai Medical Center Methods of use of islet cells
JP7016185B2 (ja) * 2018-03-28 2022-02-04 国立大学法人大阪大学 幹細胞由来涙腺組織の作製方法
JP7464532B2 (ja) 2018-04-06 2024-04-09 シーダーズ－サイナイ メディカル センター マイクロ流体チップ上のヒト多能性幹細胞由来の神経変性疾患モデル
WO2019195800A1 (en) 2018-04-06 2019-10-10 Cedars-Sinai Medical Center Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
US20210033628A1 (en) 2018-04-30 2021-02-04 Cedars-Sinai Medical Center Diagnostic and drug screening for molecular signatures of early onset sporadic parkinson's disease
CN110684714B (zh) * 2018-07-05 2023-05-09 广东博溪生物科技有限公司 一种屏障功能弱化模型的构建方法
BR112021000996A2 (pt) 2018-07-19 2021-04-20 Platelet Biogenesis, Inc. biorreator de recirculação empilhado
US10724052B2 (en) 2018-09-07 2020-07-28 Crispr Therapeutics Ag Universal donor cells
TWI862513B (zh) * 2018-09-19 2024-11-21 日商千紙鶴治療公司 包含胰島素產生細胞之細胞集團、包含該細胞集團之醫藥、其用途及製造方法
EP3739040B1 (en) 2018-09-27 2023-07-05 Osaka University Sheeting method for pluripotent stem cell-derived cells
EP3901252A4 (en) * 2018-12-21 2022-10-26 National University Corporation Hokkaido University COMPOSITION FOR REMOVAL OF PLURIPOTENTER STEM CELLS AND METHOD OF REMOVAL OF PLURIPOTENTER STEM CELLS
CN110373375A (zh) * 2019-03-19 2019-10-25 杭州原生生物科技有限公司 一种制备纤维细胞作为细胞培养基的方法和用途
AU2020340622A1 (en) 2019-09-05 2022-03-03 Crispr Therapeutics Ag Universal donor cells
US11118195B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
KR20230051519A (ko) 2020-08-15 2023-04-18 리제너론 파마슈티칼스 인코포레이티드 칼시토닌 수용체 (calcr)를 인코딩하는 변이체 핵산 분자를 갖는 대상체에서 비만의 치료
KR20230146007A (ko) 2020-12-31 2023-10-18 크리스퍼 테라퓨틱스 아게 범용 공여자 세포
TW202523836A (zh) * 2023-12-12 2025-06-16 佛教慈濟醫療財團法人 選擇性去除未分化多潛能幹細胞的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
WO2000027995A1 (en) 1998-11-09 2000-05-18 Monash University Embryonic stem cells
US8597947B2 (en) * 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
US20080070303A1 (en) * 2005-11-21 2008-03-20 West Michael D Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
US20120295346A1 (en) * 2009-07-22 2012-11-22 Tufts University Methods and compositions for modulating membrane potential to influence cell behavior

Also Published As

Publication number Publication date
CN103354835A (zh) 2013-10-16
US9365830B2 (en) 2016-06-14
EP2649177B1 (en) 2018-09-05
EP2649177A1 (en) 2013-10-16
US20160281058A1 (en) 2016-09-29
AU2010365057B2 (en) 2016-12-22
US20130280802A1 (en) 2013-10-24
EP2649177A4 (en) 2014-04-23
WO2012078153A1 (en) 2012-06-14
JP2014501518A (ja) 2014-01-23
JP5875597B2 (ja) 2016-03-02
CN103354835B (zh) 2016-03-02
CA2820419A1 (en) 2012-06-14
AU2010365057A1 (en) 2013-06-20

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