ES2690663T3 - Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas - Google Patents

Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas Download PDF

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Publication number
ES2690663T3
ES2690663T3 ES10860584.1T ES10860584T ES2690663T3 ES 2690663 T3 ES2690663 T3 ES 2690663T3 ES 10860584 T ES10860584 T ES 10860584T ES 2690663 T3 ES2690663 T3 ES 2690663T3
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Spain
Prior art keywords
cells
cell
inhibitor
pluripotent stem
differentiated
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ES10860584.1T
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English (en)
Spanish (es)
Inventor
Thomas Schulz
Allan Robins
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Viacyte Inc
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Viacyte Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
ES10860584.1T 2010-12-08 2010-12-08 Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas Active ES2690663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/059586 WO2012078153A1 (en) 2010-12-08 2010-12-08 Agents and methods for inhibiting human pluripotent stem cell growth

Publications (1)

Publication Number Publication Date
ES2690663T3 true ES2690663T3 (es) 2018-11-21

Family

ID=46207417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10860584.1T Active ES2690663T3 (es) 2010-12-08 2010-12-08 Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas

Country Status (8)

Country Link
US (2) US9365830B2 (enExample)
EP (1) EP2649177B1 (enExample)
JP (1) JP5875597B2 (enExample)
CN (1) CN103354835B (enExample)
AU (1) AU2010365057B2 (enExample)
CA (1) CA2820419A1 (enExample)
ES (1) ES2690663T3 (enExample)
WO (1) WO2012078153A1 (enExample)

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US8691771B2 (en) 2010-05-21 2014-04-08 Merrimack Pharmaceuticals, Inc. Bi-specific fusion proteins for tissue repair
WO2012175633A1 (en) 2011-06-21 2012-12-27 Novo Nordisk A/S Efficient induction of definitive endoderm from pluripotent stem cells
JP6473686B2 (ja) * 2013-03-25 2019-02-20 公益財団法人神戸医療産業都市推進機構 細胞の選別方法
SG11201509767UA (en) * 2013-05-30 2015-12-30 Ajinomoto Kk Medium for culturing stem cells
CN105683366B (zh) 2013-08-23 2020-11-06 住友化学株式会社 用于制备视网膜组织和视网膜相关细胞的方法
WO2015112581A1 (en) 2014-01-21 2015-07-30 The Medical College Of Wisconsin, Inc. Methods for selective inhibition of pluripotent stem cells
JP6197947B2 (ja) * 2014-03-31 2017-09-20 味の素株式会社 幹細胞用培地
CA2994192C (en) * 2015-08-13 2020-06-16 Peking University Induced extended pluripotent stem cells, methods of making and using
CA3000742A1 (en) 2015-10-02 2017-04-06 Silver Creek Pharmaceuticals, Inc. Bi-specific therapeutic proteins for tissue repair
GB2562406B (en) 2016-01-12 2020-09-02 Cedars Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
US11913022B2 (en) * 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
KR102448428B1 (ko) * 2017-01-27 2022-09-30 가부시키가이샤 가네카 내배엽계 세포 집단, 및 다능성 세포로부터 3배엽 중 어느 하나의 세포 집단을 제조하는 방법
US20200017812A1 (en) * 2017-03-07 2020-01-16 Platelet Biogenesis, Inc. Recirculating Bioreactor
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018225705A1 (ja) 2017-06-05 2018-12-13 テルモ株式会社 細胞培養物の製造方法
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CN108570443A (zh) * 2017-12-05 2018-09-25 皓昇莱生物制药有限公司 一种用于培养尿液来源细胞的培养基
US12161676B2 (en) 2018-03-23 2024-12-10 Cedars-Sinai Medical Center Methods of use of islet cells
WO2019189640A1 (ja) * 2018-03-28 2019-10-03 国立大学法人大阪大学 幹細胞由来涙腺組織の作製方法
WO2019195798A1 (en) 2018-04-06 2019-10-10 Cedars-Sinai Medical Center Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
JP7543143B2 (ja) 2018-04-30 2024-09-02 シーダーズ－サイナイ メディカル センター 早期発症型孤発性パーキンソン病の分子シグネチャの診断及び薬物スクリーニング
CN110684714B (zh) * 2018-07-05 2023-05-09 广东博溪生物科技有限公司 一种屏障功能弱化模型的构建方法
BR112021000996A2 (pt) * 2018-07-19 2021-04-20 Platelet Biogenesis, Inc. biorreator de recirculação empilhado
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
TWI862513B (zh) * 2018-09-19 2024-11-21 日商千紙鶴治療公司 包含胰島素產生細胞之細胞集團、包含該細胞集團之醫藥、其用途及製造方法
JP7781522B2 (ja) 2018-09-27 2025-12-08 国立大学法人大阪大学 多能性幹細胞由来細胞のシート化方法
WO2020130077A1 (ja) * 2018-12-21 2020-06-25 国立大学法人北海道大学 多能性幹細胞を除去するための組成物、及び多能性幹細胞の除去方法
CN110373375A (zh) * 2019-03-19 2019-10-25 杭州原生生物科技有限公司 一种制备纤维细胞作为细胞培养基的方法和用途
US11116798B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
US11104918B2 (en) 2019-09-05 2021-08-31 Crispr Therapeutics Ag Universal donor cells
EP4196611A1 (en) 2020-08-15 2023-06-21 Regeneron Pharmaceuticals, Inc. Treatment of obesity in subjects having variant nucleic acid molecules encoding calcitonin receptor (calcr)
US11566230B2 (en) 2020-12-31 2023-01-31 Crispr Therapeutics Ag Universal donor cells
TW202523836A (zh) * 2023-12-12 2025-06-16 佛教慈濟醫療財團法人 選擇性去除未分化多潛能幹細胞的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
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US5861483A (en) * 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
EP1129176A4 (en) 1998-11-09 2002-10-30 Es Cell Int Pte Ltd EMBRYONIC STEM CELLS
US8597947B2 (en) * 2004-12-29 2013-12-03 Hadasit Medical Research Services & Development Limited Undifferentiated stem cell culture systems
US20080070303A1 (en) * 2005-11-21 2008-03-20 West Michael D Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
US20120295346A1 (en) * 2009-07-22 2012-11-22 Tufts University Methods and compositions for modulating membrane potential to influence cell behavior

Also Published As

Publication number Publication date
EP2649177A1 (en) 2013-10-16
US20130280802A1 (en) 2013-10-24
US20160281058A1 (en) 2016-09-29
CN103354835A (zh) 2013-10-16
CA2820419A1 (en) 2012-06-14
EP2649177A4 (en) 2014-04-23
WO2012078153A1 (en) 2012-06-14
AU2010365057B2 (en) 2016-12-22
AU2010365057A1 (en) 2013-06-20
JP5875597B2 (ja) 2016-03-02
EP2649177B1 (en) 2018-09-05
US9365830B2 (en) 2016-06-14
JP2014501518A (ja) 2014-01-23
CN103354835B (zh) 2016-03-02

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