JP5875597B2 - ヒト万能性幹細胞の成長を阻害する薬剤および方法 - Google Patents

ヒト万能性幹細胞の成長を阻害する薬剤および方法 Download PDF

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JP5875597B2
JP5875597B2 JP2013543140A JP2013543140A JP5875597B2 JP 5875597 B2 JP5875597 B2 JP 5875597B2 JP 2013543140 A JP2013543140 A JP 2013543140A JP 2013543140 A JP2013543140 A JP 2013543140A JP 5875597 B2 JP5875597 B2 JP 5875597B2
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JP2014501518A5 (enExample
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シュルツ，トーマス
ロビンス，アラン
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ヴィアサイト，インコーポレイテッド
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening

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  • General Physics & Mathematics (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2013543140A 2010-12-08 2010-12-08 ヒト万能性幹細胞の成長を阻害する薬剤および方法 Expired - Fee Related JP5875597B2 (ja)

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PCT/US2010/059586 WO2012078153A1 (en) 2010-12-08 2010-12-08 Agents and methods for inhibiting human pluripotent stem cell growth

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JP2014501518A JP2014501518A (ja) 2014-01-23
JP2014501518A5 JP2014501518A5 (enExample) 2014-03-13
JP5875597B2 true JP5875597B2 (ja) 2016-03-02

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US (2) US9365830B2 (enExample)
EP (1) EP2649177B1 (enExample)
JP (1) JP5875597B2 (enExample)
CN (1) CN103354835B (enExample)
AU (1) AU2010365057B2 (enExample)
CA (1) CA2820419A1 (enExample)
ES (1) ES2690663T3 (enExample)
WO (1) WO2012078153A1 (enExample)

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KR102164270B1 (ko) * 2013-03-25 2020-10-12 고에키 자이단 호징 고베 이료 산교 도시 스이신 기코 세포의 선별 방법
EP3006558B1 (en) * 2013-05-30 2020-05-13 Ajinomoto Co., Inc. Medium for culturing stem cells
AU2014309730B2 (en) * 2013-08-23 2020-11-19 Riken Method for producing retinal tissue and retina-related cells
JP6791756B2 (ja) 2014-01-21 2020-11-25 ザ メディカル カレッジ オブ ウィスコンシン インクＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ Ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． 多能性幹細胞の選択的な阻害のための方法
KR20160142340A (ko) * 2014-03-31 2016-12-12 아지노모토 가부시키가이샤 간세포용 배지
JP6780870B2 (ja) * 2015-08-13 2020-11-04 北昊干細胞与再生医学研究院有限公司Ｂｅｉｈａｏ Ｓｔｅｍ Ｃｅｌｌ Ａｎｄ Ｒｅｇｅｎｅｒａｔｉｖｅ Ｍｅｄｉｃｉｎｅ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Ｃｏ．， Ｌｔｄ． 誘導された拡張された多能性幹細胞、作製方法および使用方法
EP3355907B1 (en) 2015-10-02 2021-01-20 Silver Creek Pharmaceuticals, Inc. Bi-specific therapeutic proteins for tissue repair
US20190018000A1 (en) 2016-01-12 2019-01-17 Cedars-Sinai Medical Center A method of non destructive monitoring of biological processes in microfluidic tissue culture systems
US11913022B2 (en) * 2017-01-25 2024-02-27 Cedars-Sinai Medical Center In vitro induction of mammary-like differentiation from human pluripotent stem cells
US11746331B2 (en) 2017-01-27 2023-09-05 Kaneka Corporation Endodermal cell population, and method for producing cell population of any of three germ layers from pluripotent cell
AU2018231210A1 (en) * 2017-03-07 2019-09-19 Platelet Biogenesis, Inc. Recirculating bioreactor
US11767513B2 (en) 2017-03-14 2023-09-26 Cedars-Sinai Medical Center Neuromuscular junction
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
WO2018225705A1 (ja) 2017-06-05 2018-12-13 テルモ株式会社 細胞培養物の製造方法
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
CN108570443A (zh) * 2017-12-05 2018-09-25 皓昇莱生物制药有限公司 一种用于培养尿液来源细胞的培养基
EP3768823B1 (en) 2018-03-23 2025-12-31 Cedars-Sinai Medical Center METHODS FOR USING CELLS FROM PANCREATIC ISLETS
US12291727B2 (en) * 2018-03-28 2025-05-06 Osaka University Method for producing stem cell-derived lacrimal gland tissue
US11981918B2 (en) 2018-04-06 2024-05-14 Cedars-Sinai Medical Center Differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells
US12241085B2 (en) 2018-04-06 2025-03-04 Cedars-Sinai Medical Center Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip
CN110684714B (zh) * 2018-07-05 2023-05-09 广东博溪生物科技有限公司 一种屏障功能弱化模型的构建方法
CA3106613A1 (en) 2018-07-19 2020-01-23 Platelet Biogenesis, Inc. Stacked recirculating bioreactor
US10724052B2 (en) 2018-09-07 2020-07-28 Crispr Therapeutics Ag Universal donor cells
CN112867787B (zh) * 2018-09-19 2024-11-22 千纸鹤治疗公司 胰岛素产生细胞
WO2020067438A1 (ja) 2018-09-27 2020-04-02 国立大学法人大阪大学 多能性幹細胞由来細胞のシート化方法
US20220364065A1 (en) * 2018-12-21 2022-11-17 National University Corporation Hokkaido University Composition for removing pluripotent stem cells and method of removing pluripotent stem cells
CN110373375A (zh) * 2019-03-19 2019-10-25 杭州原生生物科技有限公司 一种制备纤维细胞作为细胞培养基的方法和用途
US11116797B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
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CA3203707A1 (en) 2020-12-31 2022-07-07 Alireza Rezania Universal donor cells
TW202523836A (zh) * 2023-12-12 2025-06-16 佛教慈濟醫療財團法人 選擇性去除未分化多潛能幹細胞的方法

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EP2649177A1 (en) 2013-10-16
US9365830B2 (en) 2016-06-14
US20160281058A1 (en) 2016-09-29
AU2010365057A1 (en) 2013-06-20
WO2012078153A1 (en) 2012-06-14
CA2820419A1 (en) 2012-06-14
JP2014501518A (ja) 2014-01-23
US20130280802A1 (en) 2013-10-24
CN103354835B (zh) 2016-03-02
ES2690663T3 (es) 2018-11-21
AU2010365057B2 (en) 2016-12-22
EP2649177A4 (en) 2014-04-23
CN103354835A (zh) 2013-10-16
EP2649177B1 (en) 2018-09-05

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