JP2010539948A5 - - Google Patents
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- JP2010539948A5 JP2010539948A5 JP2010527227A JP2010527227A JP2010539948A5 JP 2010539948 A5 JP2010539948 A5 JP 2010539948A5 JP 2010527227 A JP2010527227 A JP 2010527227A JP 2010527227 A JP2010527227 A JP 2010527227A JP 2010539948 A5 JP2010539948 A5 JP 2010539948A5
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- residue corresponding
- substrate
- product
- formula
- phenyl
- Prior art date
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- 239000000758 substrate Substances 0.000 claims 36
- 229920001184 polypeptide Polymers 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 150000001413 amino acids Chemical group 0.000 claims 11
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 10
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 10
- 238000006243 chemical reaction Methods 0.000 claims 10
- 235000014393 valine Nutrition 0.000 claims 10
- 229960004295 valine Drugs 0.000 claims 10
- 239000004474 valine Substances 0.000 claims 10
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 9
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 9
- 235000005772 leucine Nutrition 0.000 claims 9
- 229960003136 leucine Drugs 0.000 claims 9
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 9
- -1 7-chloro-2-quinolinyl Chemical group 0.000 claims 8
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 claims 6
- 239000004475 Arginine Substances 0.000 claims 5
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 5
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 5
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 5
- 229920002554 vinyl polymer Polymers 0.000 claims 5
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 4
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 4
- 229960002898 threonine Drugs 0.000 claims 4
- 235000008521 threonine Nutrition 0.000 claims 4
- RHXXYWBMAWLSOS-UHFFFAOYSA-N 1-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propan-1-one Chemical compound CC(C)(O)C1=CC=CC=C1CCC(=O)C1=CC=CC(C=CC=2N=C3C=C(Cl)C=CC3=CC=2)=C1 RHXXYWBMAWLSOS-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N 2-propanol Substances CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 235000014705 isoleucine Nutrition 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 230000002194 synthesizing effect Effects 0.000 claims 3
- 229930194542 Keto Natural products 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- 229960002433 cysteine Drugs 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000000468 ketone group Chemical group 0.000 claims 2
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- INXATVZSQVIIHJ-UHFFFAOYSA-N methyl 2-[3-[3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-oxopropyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1CCC(=O)C1=CC=CC(C=CC=2N=C3C=C(Cl)C=CC3=CC=2)=C1 INXATVZSQVIIHJ-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- ZSHIDKYITZZTLA-FCPABOFRSA-N (1s)-1-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propan-1-ol Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](O)C1=CC=CC(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)=C1 ZSHIDKYITZZTLA-FCPABOFRSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- KPCSDMZEMDMWKQ-SPNSGGJLSA-N methyl 2-[(3s)-3-[3-[(e)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-hydroxypropyl]benzoate Chemical compound COC(=O)C1=CC=CC=C1CC[C@H](O)C1=CC=CC(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)=C1 KPCSDMZEMDMWKQ-SPNSGGJLSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- 150000003461 sulfonyl halides Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 0 CC(C)(c1c(CC[C@](*)C(C=CC2)=C[C@]2C=Cc(cc2)nc3c2ccc(Cl)c3)cccc1)O Chemical compound CC(C)(c1c(CC[C@](*)C(C=CC2)=C[C@]2C=Cc(cc2)nc3c2ccc(Cl)c3)cccc1)O 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97634507P | 2007-09-28 | 2007-09-28 | |
| PCT/US2008/078046 WO2009042984A1 (en) | 2007-09-28 | 2008-09-28 | Ketoreductase polypeptides and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010539948A JP2010539948A (ja) | 2010-12-24 |
| JP2010539948A5 true JP2010539948A5 (https=) | 2011-11-10 |
Family
ID=40042831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527227A Pending JP2010539948A (ja) | 2007-09-28 | 2008-09-28 | ケトレダクターゼポリペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8088610B2 (https=) |
| EP (1) | EP2203557B1 (https=) |
| JP (1) | JP2010539948A (https=) |
| KR (1) | KR20100061571A (https=) |
| CN (1) | CN101889081B (https=) |
| AT (1) | ATE547513T1 (https=) |
| IL (1) | IL204331A (https=) |
| WO (1) | WO2009042984A1 (https=) |
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|---|---|---|---|---|
| EP2115130B1 (en) | 2007-02-08 | 2011-08-03 | Codexis, Inc. | Ketoreductases and uses thereof |
| JP2010536385A (ja) * | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| EP2198018B1 (en) | 2007-09-13 | 2013-11-20 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
| HUE027683T2 (en) | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| EP2329013B1 (en) * | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8288131B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| WO2010034115A1 (en) | 2008-09-26 | 2010-04-01 | Kesen Ma | Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis |
| SG177331A1 (en) * | 2009-06-22 | 2012-02-28 | Codexis Inc | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| ES2575560T3 (es) | 2009-08-19 | 2016-06-29 | Codexis, Inc. | Polipéptidos cetorreductasa para preparar fenilefrina |
| CN101638381B (zh) * | 2009-09-02 | 2012-08-29 | 鲁南制药集团股份有限公司 | 孟鲁司特钠中间体的合成方法 |
| CN102884178B (zh) | 2009-12-08 | 2014-12-03 | 科德克希思公司 | 拉唑化合物的合成 |
| WO2011100265A2 (en) | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
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| CN103827309A (zh) * | 2011-08-05 | 2014-05-28 | 赢创德固赛有限公司 | 仲醇的氧化和胺化 |
| IN2014CN04470A (https=) | 2011-11-18 | 2015-09-04 | Codexis Inc | |
| HUE036947T2 (hu) | 2012-05-11 | 2018-08-28 | Codexis Inc | Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
| CN102776157B (zh) * | 2012-08-21 | 2013-09-04 | 尚科生物医药（上海）有限公司 | 改进的酮还原酶多肽、其编码基因以及表达该多肽的细胞 |
| CN102827851B (zh) * | 2012-09-06 | 2013-11-13 | 江苏阿尔法药业有限公司 | 一种酮还原酶基因及其应用 |
| WO2014081616A1 (en) * | 2012-11-21 | 2014-05-30 | Merck Sharp & Dohme Corp. | Preparation of precursors for leukotriene antagonists |
| WO2014150633A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| CN103421854A (zh) * | 2013-07-30 | 2013-12-04 | 苏州汉酶生物技术有限公司 | 一种(s)-3-(二甲胺基)-1-(噻吩-2-基)-1-丙醇的生物制备方法 |
| RU2016116253A (ru) | 2013-09-27 | 2017-11-01 | Кодексис, Инк. | Автоматизированный скрининг вариантов фермента |
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| CN104928265B (zh) * | 2014-03-17 | 2018-01-02 | 江苏阿尔法药业有限公司 | 一种酮还原酶突变体及其制备和应用 |
| CN121203988A (zh) | 2014-04-22 | 2025-12-26 | C-乐克塔股份有限公司 | 酮还原酶 |
| US10370648B2 (en) | 2014-11-25 | 2019-08-06 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN104561052A (zh) * | 2014-12-22 | 2015-04-29 | 江苏阿尔法药业有限公司 | 一种重组甲酸脱氢酶及其制备方法和应用 |
| CN104745652A (zh) * | 2015-03-25 | 2015-07-01 | 苏州汉酶生物技术有限公司 | 一种孟鲁斯特中间体的制备方法 |
| WO2017066001A1 (en) | 2015-10-16 | 2017-04-20 | Zoll Medical Corporaton | Dual sensor electrodes for providing enhanced resuscitation feedback |
| EP3652328A1 (en) | 2017-07-14 | 2020-05-20 | c-LEcta GmbH | Ketoreductases |
| CN109182410B (zh) * | 2018-09-29 | 2020-10-02 | 台州学院 | 一种(S)-N-Boc-3-羟基哌啶的酶催化制备方法 |
| WO2020084621A1 (en) * | 2018-10-26 | 2020-04-30 | Tami Bar | Compositions and methods for biodegrading alcohol |
| CN109371067A (zh) * | 2018-11-30 | 2019-02-22 | 上海合全药业股份有限公司 | 生物催化制备(r)-4-癸醇的方法 |
| CN109486866A (zh) * | 2018-11-30 | 2019-03-19 | 上海合全药业股份有限公司 | 生物催化制备(s)-4-癸醇的方法 |
| MX2022003684A (es) * | 2019-09-26 | 2022-04-25 | Codexis Inc | Polipeptidos y polinucleotidos de ceto-reductasa. |
| CN111718965A (zh) * | 2020-06-17 | 2020-09-29 | 宁波酶赛生物工程有限公司 | 一种(2s,3s)-2,3-丁二醇的制备方法 |
| CN111676201A (zh) * | 2020-06-30 | 2020-09-18 | 宁波酶赛生物工程有限公司 | 具有立体选择性的酮还原酶与(s)-3-羟基丁酸乙酯的不对称合成方法 |
| CN119101668B (zh) * | 2024-09-05 | 2025-05-09 | 华南师范大学 | 突变酶及其发酵生产方法和在制备荞麦碱中的应用 |
| CN119570755B (zh) * | 2025-01-07 | 2026-03-17 | 上海泓博尚奕药物技术有限公司 | 一种酮还原酶突变体及其在合成(r)-1-(2,6-二氯苯基)乙醇中的应用 |
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-
2008
- 2008-09-28 EP EP08833139A patent/EP2203557B1/en active Active
- 2008-09-28 WO PCT/US2008/078046 patent/WO2009042984A1/en not_active Ceased
- 2008-09-28 AT AT08833139T patent/ATE547513T1/de active
- 2008-09-28 KR KR1020107009238A patent/KR20100061571A/ko not_active Withdrawn
- 2008-09-28 CN CN200880118039.6A patent/CN101889081B/zh active Active
- 2008-09-28 JP JP2010527227A patent/JP2010539948A/ja active Pending
- 2008-09-29 US US12/240,986 patent/US8088610B2/en active Active
-
2010
- 2010-03-07 IL IL204331A patent/IL204331A/en active IP Right Grant
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2011
- 2011-12-19 US US13/329,986 patent/US8617853B2/en active Active
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