JP2010539948A - ケトレダクターゼポリペプチドおよびその使用 - Google Patents

ケトレダクターゼポリペプチドおよびその使用 Download PDF

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JP2010539948A
JP2010539948A JP2010527227A JP2010527227A JP2010539948A JP 2010539948 A JP2010539948 A JP 2010539948A JP 2010527227 A JP2010527227 A JP 2010527227A JP 2010527227 A JP2010527227 A JP 2010527227A JP 2010539948 A JP2010539948 A JP 2010539948A
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residue
residue corresponding
nonpolar
aliphatic
amino acid
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JP2010539948A5 (https=
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ジャック リャン，
バース ボーアップ，
ベスナ ミッチェル，
エミリー マンドルフ，
ジェイムス ラロンド，
ジャルト ヒュイズマン，
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コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2010527227A 2007-09-28 2008-09-28 ケトレダクターゼポリペプチドおよびその使用 Pending JP2010539948A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97634507P 2007-09-28 2007-09-28
PCT/US2008/078046 WO2009042984A1 (en) 2007-09-28 2008-09-28 Ketoreductase polypeptides and uses thereof

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JP2010539948A true JP2010539948A (ja) 2010-12-24
JP2010539948A5 JP2010539948A5 (https=) 2011-11-10

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US (2) US8088610B2 (https=)
EP (1) EP2203557B1 (https=)
JP (1) JP2010539948A (https=)
KR (1) KR20100061571A (https=)
CN (1) CN101889081B (https=)
AT (1) ATE547513T1 (https=)
IL (1) IL204331A (https=)
WO (1) WO2009042984A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2010538657A (ja) * 2007-09-13 2010-12-16 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2022549852A (ja) * 2019-09-26 2022-11-29 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびポリヌクレオチド

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HUE027683T2 (en) 2007-10-01 2016-10-28 Codexis Inc Ketoreductase polypeptides for the production of azetidinone
EP2329013B1 (en) * 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
WO2010034115A1 (en) 2008-09-26 2010-04-01 Kesen Ma Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis
SG177331A1 (en) * 2009-06-22 2012-02-28 Codexis Inc Ketoreductase-mediated stereoselective route to alpha chloroalcohols
ES2575560T3 (es) 2009-08-19 2016-06-29 Codexis, Inc. Polipéptidos cetorreductasa para preparar fenilefrina
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CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN103827309A (zh) * 2011-08-05 2014-05-28 赢创德固赛有限公司 仲醇的氧化和胺化
IN2014CN04470A (https=) 2011-11-18 2015-09-04 Codexis Inc
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
CN102776157B (zh) * 2012-08-21 2013-09-04 尚科生物医药（上海）有限公司 改进的酮还原酶多肽、其编码基因以及表达该多肽的细胞
CN102827851B (zh) * 2012-09-06 2013-11-13 江苏阿尔法药业有限公司 一种酮还原酶基因及其应用
WO2014081616A1 (en) * 2012-11-21 2014-05-30 Merck Sharp & Dohme Corp. Preparation of precursors for leukotriene antagonists
WO2014150633A1 (en) 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
CN103421854A (zh) * 2013-07-30 2013-12-04 苏州汉酶生物技术有限公司 一种(s)-3-(二甲胺基)-1-(噻吩-2-基)-1-丙醇的生物制备方法
RU2016116253A (ru) 2013-09-27 2017-11-01 Кодексис, Инк. Автоматизированный скрининг вариантов фермента
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
CN103710405A (zh) * 2013-12-31 2014-04-09 苏州汉酶生物技术有限公司 一种生物法制备孟鲁斯特中间体的方法
CN104928265B (zh) * 2014-03-17 2018-01-02 江苏阿尔法药业有限公司 一种酮还原酶突变体及其制备和应用
CN121203988A (zh) 2014-04-22 2025-12-26 C-乐克塔股份有限公司 酮还原酶
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN104561052A (zh) * 2014-12-22 2015-04-29 江苏阿尔法药业有限公司 一种重组甲酸脱氢酶及其制备方法和应用
CN104745652A (zh) * 2015-03-25 2015-07-01 苏州汉酶生物技术有限公司 一种孟鲁斯特中间体的制备方法
WO2017066001A1 (en) 2015-10-16 2017-04-20 Zoll Medical Corporaton Dual sensor electrodes for providing enhanced resuscitation feedback
EP3652328A1 (en) 2017-07-14 2020-05-20 c-LEcta GmbH Ketoreductases
CN109182410B (zh) * 2018-09-29 2020-10-02 台州学院 一种(S)-N-Boc-3-羟基哌啶的酶催化制备方法
WO2020084621A1 (en) * 2018-10-26 2020-04-30 Tami Bar Compositions and methods for biodegrading alcohol
CN109371067A (zh) * 2018-11-30 2019-02-22 上海合全药业股份有限公司 生物催化制备(r)-4-癸醇的方法
CN109486866A (zh) * 2018-11-30 2019-03-19 上海合全药业股份有限公司 生物催化制备(s)-4-癸醇的方法
CN111718965A (zh) * 2020-06-17 2020-09-29 宁波酶赛生物工程有限公司 一种(2s,3s)-2,3-丁二醇的制备方法
CN111676201A (zh) * 2020-06-30 2020-09-18 宁波酶赛生物工程有限公司 具有立体选择性的酮还原酶与(s)-3-羟基丁酸乙酯的不对称合成方法
CN119101668B (zh) * 2024-09-05 2025-05-09 华南师范大学 突变酶及其发酵生产方法和在制备荞麦碱中的应用
CN119570755B (zh) * 2025-01-07 2026-03-17 上海泓博尚奕药物技术有限公司 一种酮还原酶突变体及其在合成(r)-1-(2,6-二氯苯基)乙醇中的应用

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Cited By (7)

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JP2010538657A (ja) * 2007-09-13 2010-12-16 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2015091269A (ja) * 2007-09-13 2015-05-14 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
JP2018086028A (ja) * 2007-09-13 2018-06-07 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
US10927351B2 (en) 2007-09-13 2021-02-23 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US11479756B2 (en) 2007-09-13 2022-10-25 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
US12415990B2 (en) 2007-09-13 2025-09-16 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
JP2022549852A (ja) * 2019-09-26 2022-11-29 コデクシス， インコーポレイテッド ケトレダクターゼポリペプチドおよびポリヌクレオチド

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US20090155863A1 (en) 2009-06-18
KR20100061571A (ko) 2010-06-07
US8088610B2 (en) 2012-01-03
WO2009042984A1 (en) 2009-04-02
EP2203557B1 (en) 2012-02-29
CN101889081B (zh) 2014-06-18
ATE547513T1 (de) 2012-03-15
IL204331A (en) 2013-04-30
EP2203557A1 (en) 2010-07-07
US20120184000A1 (en) 2012-07-19
CN101889081A (zh) 2010-11-17
US8617853B2 (en) 2013-12-31

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