JP2010539952A5 - - Google Patents
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- JP2010539952A5 JP2010539952A5 JP2010527257A JP2010527257A JP2010539952A5 JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5 JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010527257 A JP2010527257 A JP 2010527257A JP 2010539952 A5 JP2010539952 A5 JP 2010539952A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 239000000758 substrate Substances 0.000 claims 16
- 150000001413 amino acids Chemical group 0.000 claims 12
- 101001110310 Lentilactobacillus kefiri NADP-dependent (R)-specific alcohol dehydrogenase Proteins 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 5
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 5
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 5
- 239000004474 valine Substances 0.000 claims 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 4
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 4
- 239000004473 Threonine Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- LVJARDSTTGGMSM-UHFFFAOYSA-N methyl 2-(benzamidomethyl)-3-oxobutanoate Chemical compound COC(=O)C(C(C)=O)CNC(=O)C1=CC=CC=C1 LVJARDSTTGGMSM-UHFFFAOYSA-N 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 235000014304 histidine Nutrition 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- NQUVCRCCRXRJCK-UHFFFAOYSA-N 4-methylbenzoyl chloride Chemical compound CC1=CC=C(C(Cl)=O)C=C1 NQUVCRCCRXRJCK-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
- 150000001342 alkaline earth metals Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- ATBIFOORFZTUKF-UHFFFAOYSA-N methyl 2-(benzamidomethyl)-3-hydroxybutanoate Chemical compound COC(=O)C(C(C)O)CNC(=O)C1=CC=CC=C1 ATBIFOORFZTUKF-UHFFFAOYSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 0 C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O Chemical compound C[C@@](*)[C@]([C@]1N2C(C(O*)=O)=C(*)[C@@]1*)C2=O 0.000 description 8
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O Chemical compound C[C@H]([C@H]([C@@H](C1)N2C(C(O)=O)=C1SCCNC=N)C2=O)O ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 3
- JUZNIMUFDBIJCM-GATUNPTCSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1C(Nc1cc(C(O)=O)ccc1)=O)C2=O)O JUZNIMUFDBIJCM-GATUNPTCSA-N 0.000 description 2
- XFPGUZAJZDKQEC-VFCYFNJJSA-N C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O Chemical compound C[C@H]([C@H](C([C@H]1C)N2C(C(O)=O)=C1SC(C1)CN[C@@H]1NCS(C)(=O)=O)C2=O)O XFPGUZAJZDKQEC-VFCYFNJJSA-N 0.000 description 2
- DMJNNHOOLUXYBV-PQTSNVLCSA-N C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O Chemical compound C[C@H]([C@H]([C@@H]([C@H]1C)N2C(C(O)=O)=C1S[C@@H](C1)CN[C@@H]1C(N(C)C)=O)C2=O)O DMJNNHOOLUXYBV-PQTSNVLCSA-N 0.000 description 2
- HOYUMWJOTCLELZ-OLNVJHKFSA-N C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O Chemical compound C[C@H](C(C)([C@@H](C12CC1)N1C(C(O)=O)=C2SC(C2)CN[C@@H]2NCS(C)(=O)=O)C1=O)O HOYUMWJOTCLELZ-OLNVJHKFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97655507P | 2007-10-01 | 2007-10-01 | |
| US60/976,555 | 2007-10-01 | ||
| PCT/US2008/078513 WO2009046153A1 (en) | 2007-10-01 | 2008-10-01 | Ketoreductase polypeptides for the production of azetidinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539952A JP2010539952A (ja) | 2010-12-24 |
| JP2010539952A5 true JP2010539952A5 (https=) | 2011-11-10 |
| JP5646328B2 JP5646328B2 (ja) | 2014-12-24 |
Family
ID=40262027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527257A Active JP5646328B2 (ja) | 2007-10-01 | 2008-10-01 | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US7883879B2 (https=) |
| EP (1) | EP2205727B1 (https=) |
| JP (1) | JP5646328B2 (https=) |
| KR (1) | KR20100065387A (https=) |
| CN (1) | CN101883846A (https=) |
| ES (1) | ES2547528T3 (https=) |
| HU (1) | HUE027683T2 (https=) |
| IL (2) | IL204379A (https=) |
| SI (1) | SI2205727T1 (https=) |
| WO (1) | WO2009046153A1 (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2625681C (en) | 2005-10-12 | 2016-08-02 | Morphosys Ag | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
| EP2115130B1 (en) | 2007-02-08 | 2011-08-03 | Codexis, Inc. | Ketoreductases and uses thereof |
| JP2010536385A (ja) * | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| EP2198018B1 (en) | 2007-09-13 | 2013-11-20 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
| EP2203557B1 (en) * | 2007-09-28 | 2012-02-29 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| HUE027683T2 (en) | 2007-10-01 | 2016-10-28 | Codexis Inc | Ketoreductase polypeptides for the production of azetidinone |
| US8288131B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| EP2329013B1 (en) * | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| ES2575560T3 (es) | 2009-08-19 | 2016-06-29 | Codexis, Inc. | Polipéptidos cetorreductasa para preparar fenilefrina |
| CN102884178B (zh) | 2009-12-08 | 2014-12-03 | 科德克希思公司 | 拉唑化合物的合成 |
| WO2011100265A2 (en) * | 2010-02-10 | 2011-08-18 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| EP2649187B1 (en) | 2010-12-08 | 2017-11-22 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| IN2014CN04470A (https=) * | 2011-11-18 | 2015-09-04 | Codexis Inc | |
| HUE036947T2 (hu) | 2012-05-11 | 2018-08-28 | Codexis Inc | Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
| CN103045504B (zh) * | 2012-12-05 | 2014-06-04 | 浙江工业大学 | 微生物催化制备(2s, 3r)-2-苯甲酰氨甲基-3-羟基丁酸酯及菌株 |
| WO2014150633A1 (en) | 2013-03-15 | 2014-09-25 | Merck Sharp & Dohme Corp. | Immobilized ketoreductases and process for making and using immobilized ketoreductase |
| CN103373934A (zh) * | 2013-06-14 | 2013-10-30 | 苏州汇和药业有限公司 | 碳青霉烯和青霉烯类药物的手性中间体的催化合成方法 |
| ES2734209T3 (es) | 2013-08-06 | 2019-12-04 | Imago Biosciences Inc | Inhibidores de KDM1A para el tratamiento de enfermedades |
| CN104342412B (zh) * | 2013-08-09 | 2018-12-21 | 南京朗恩生物科技有限公司 | 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体 |
| RU2016116253A (ru) | 2013-09-27 | 2017-11-01 | Кодексис, Инк. | Автоматизированный скрининг вариантов фермента |
| CN106232619B (zh) | 2013-11-13 | 2022-09-09 | 科德克希思公司 | 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| CN121203988A (zh) | 2014-04-22 | 2025-12-26 | C-乐克塔股份有限公司 | 酮还原酶 |
| US10370648B2 (en) | 2014-11-25 | 2019-08-06 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN104531627B (zh) * | 2014-12-23 | 2017-07-21 | 浙江大学 | 羰基还原酶、工程菌及其应用 |
| WO2016130412A1 (en) * | 2015-02-10 | 2016-08-18 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CA2976350C (en) | 2015-02-12 | 2023-09-19 | Hugh Young Rienhoff, Jr. | Kdm1a inhibitors for the treatment of disease |
| CN104846025B (zh) * | 2015-03-31 | 2018-06-01 | 浙江大学 | 一种制备(2s，3r)-2-苯甲酰氨甲基-3-羟基丁酸甲酯的方法 |
| WO2017001907A1 (en) | 2015-06-29 | 2017-01-05 | Teva Pharmaceuticals International Gmbh | Biocatalytic processes for the preparation of vilanterol |
| CN115057796A (zh) * | 2015-12-01 | 2022-09-16 | 焦作健康元生物制品有限公司 | 光学活性的β-羟基酯类化合物的中间体 |
| CN107354179B (zh) * | 2016-05-09 | 2021-02-19 | 上海医药工业研究院 | 一种制备含有羟基的手性化合物的方法 |
| CN111194306B (zh) | 2016-08-16 | 2023-05-16 | 伊美格生物科学公司 | 用于制备kdm1a抑制剂的方法和过程 |
| WO2018035249A1 (en) * | 2016-08-16 | 2018-02-22 | Imago Biosciences, Inc. | Compositions and methods for producing stereoisomerically pure aminocyclopropanes |
| CN110831618B (zh) * | 2017-04-27 | 2023-08-25 | 科德克希思公司 | 酮还原酶多肽及多核苷酸 |
| EP3652328A1 (en) | 2017-07-14 | 2020-05-20 | c-LEcta GmbH | Ketoreductases |
| EP3790867B1 (en) | 2018-05-11 | 2024-03-27 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
| CN109295019B (zh) * | 2018-10-29 | 2021-01-12 | 浙江大学 | 一种醇脱氢酶突变体及其应用 |
| JP7687956B2 (ja) | 2019-03-15 | 2025-06-03 | モルフォシス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 自己抗体介在性自己免疫疾患の処置のための、抗ｃｄ３８抗体及びその医薬組成物 |
| CN111378704A (zh) * | 2020-03-23 | 2020-07-07 | 焦作健康元生物制品有限公司 | 一种酮还原酶生产4-aa中间体的方法 |
| CN111363730A (zh) * | 2020-03-23 | 2020-07-03 | 焦作健康元生物制品有限公司 | 一种用于生产4-aa的酮还原酶制备方法 |
| WO2022036662A1 (zh) * | 2020-08-21 | 2022-02-24 | 浙江华睿生物技术有限公司 | 酶法合成3-羟基丁酸酯的方法 |
| CN114634957B (zh) * | 2020-12-15 | 2024-08-16 | 苏州引航生物科技有限公司 | 一种生物催化合成4aa中间体的方法 |
| CN112941043B (zh) * | 2021-05-17 | 2021-09-10 | 中国科学院天津工业生物技术研究所 | 羰基还原酶突变体及在制备手性β’-羟基-β-氨基酸酯中的应用 |
| CN115478057B (zh) * | 2021-05-31 | 2025-04-04 | 尚科生物医药（上海）有限公司 | 一种用于制备(s)-3,4-二羟基-2’-氯苯乙醇的酮还原酶突变体 |
| CN120981566A (zh) * | 2023-01-12 | 2025-11-18 | 诺华股份有限公司 | 工程化酮还原酶多肽 |
| CN119842647B (zh) * | 2024-12-29 | 2025-07-22 | 苏州诺恩斯生物科技有限公司 | 一种用于合成度洛西汀中间体的脱氢酶突变体及其应用 |
| CN119570755B (zh) * | 2025-01-07 | 2026-03-17 | 上海泓博尚奕药物技术有限公司 | 一种酮还原酶突变体及其在合成(r)-1-(2,6-二氯苯基)乙醇中的应用 |
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| EP0290385B1 (de) | 1987-05-04 | 1992-10-21 | Ciba-Geigy Ag | Neues Verfahren zur Herstellung von 4-Acyloxy-3-hydroxyethyl-azetidinonen |
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- 2008-10-01 KR KR1020107008910A patent/KR20100065387A/ko not_active Withdrawn
- 2008-10-01 SI SI200831472T patent/SI2205727T1/sl unknown
- 2008-10-01 CN CN2008801185718A patent/CN101883846A/zh active Pending
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