JP2009527517A5 - - Google Patents
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- Publication number
- JP2009527517A5 JP2009527517A5 JP2008555684A JP2008555684A JP2009527517A5 JP 2009527517 A5 JP2009527517 A5 JP 2009527517A5 JP 2008555684 A JP2008555684 A JP 2008555684A JP 2008555684 A JP2008555684 A JP 2008555684A JP 2009527517 A5 JP2009527517 A5 JP 2009527517A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- adamantaneamine
- acid
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06003477A EP1820792B1 (en) | 2006-02-21 | 2006-02-21 | Process for the preparation of adamantanamines |
| EP06003477.4 | 2006-02-21 | ||
| PCT/EP2007/001440 WO2007096124A1 (en) | 2006-02-21 | 2007-02-20 | Process for the preparation of adamantanamines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009527517A JP2009527517A (ja) | 2009-07-30 |
| JP2009527517A5 true JP2009527517A5 (https=) | 2010-04-08 |
| JP5235683B2 JP5235683B2 (ja) | 2013-07-10 |
Family
ID=36754153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555684A Active JP5235683B2 (ja) | 2006-02-21 | 2007-02-20 | アダマンタンアミン類の調製方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090082596A1 (https=) |
| EP (1) | EP1820792B1 (https=) |
| JP (1) | JP5235683B2 (https=) |
| CN (1) | CN101389594B (https=) |
| AT (1) | ATE541827T1 (https=) |
| AU (1) | AU2007218140B2 (https=) |
| CA (1) | CA2640127C (https=) |
| DK (1) | DK1820792T3 (https=) |
| ES (1) | ES2379181T3 (https=) |
| PL (1) | PL1820792T3 (https=) |
| PT (1) | PT1820792E (https=) |
| SI (1) | SI1820792T1 (https=) |
| WO (1) | WO2007096124A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1908748A1 (en) | 2006-10-05 | 2008-04-09 | Krka | Process for the preparation of memantine and its hydrochloric acid salt form |
| WO2010007351A1 (en) * | 2008-07-14 | 2010-01-21 | Cipla Limited | Process for the preparation of memantine and its salts and intermediate for use therein |
| CN101560157B (zh) * | 2009-06-02 | 2013-09-18 | 王彦明 | 盐酸金刚烷胺生产工艺及其专用设备 |
| CN102070463A (zh) * | 2009-06-11 | 2011-05-25 | 辽宁利锋科技开发有限公司 | 具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用 |
| JP5749260B2 (ja) * | 2009-06-29 | 2015-07-15 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | ネラメキサンの製造方法 |
| HRP20130485T1 (en) * | 2009-06-29 | 2013-06-30 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane |
| HRP20130486T1 (en) * | 2009-06-29 | 2013-06-30 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing neramexane |
| EP2448911A1 (en) * | 2009-06-29 | 2012-05-09 | Merz Pharma GmbH & Co. KGaA | Method of preparing 1-chloroacetamido-1,3,3,5,5-pentamethylcyclohexane |
| CN101993377A (zh) * | 2009-08-07 | 2011-03-30 | 出光兴产株式会社 | 具有金刚烷骨架的胺类和季铵盐的制造方法 |
| CN104936942A (zh) * | 2013-01-23 | 2015-09-23 | 三菱瓦斯化学株式会社 | 美金刚胺的制造工艺 |
| CN103483205B (zh) * | 2013-10-12 | 2015-02-04 | 合肥久诺医药科技有限公司 | 一种高纯度盐酸美金刚的制备方法 |
| CN103524353B (zh) * | 2013-10-12 | 2015-03-25 | 合肥久诺医药科技有限公司 | 一种高纯度盐酸美金刚的制备方法 |
| CN104693039B (zh) * | 2015-01-06 | 2016-11-16 | 中山大学 | 一种金刚烷胺类衍生物及其制备方法和应用 |
| CN105399636A (zh) * | 2015-12-18 | 2016-03-16 | 天津民祥生物医药股份有限公司 | 一种利用盐酸金刚烷胺制备金刚烷胺游离胺的工艺 |
| CN117843492A (zh) * | 2023-12-04 | 2024-04-09 | 四川众邦新材料股份有限公司 | 金刚烷胺生产中的产物分离提取方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3391142A (en) | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| ES413944A1 (es) * | 1972-04-20 | 1976-06-01 | Merz & Co | Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5. |
| DE2318461A1 (de) | 1973-04-12 | 1974-10-31 | Merz & Co | Verfahren zur herstellung von 1,3,5trisubstituierten adamanta-verbindungen |
| SU805609A1 (ru) * | 1979-10-12 | 1981-09-30 | Предприятие П/Я В-2343 | S-(1-адамантилкарбпмоилметил) изотиуроний хлорид,обладающий антивирусной активностью |
| ES2059602T3 (es) | 1989-04-14 | 1994-11-16 | Merz & Co Gmbh & Co | Uso de derivados de adamantano para la prevencion y tratamiento de isquemia cerebral. |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| CZ288445B6 (en) | 1996-06-20 | 2001-06-13 | Lachema Np | Process for preparing hydrochloride of 5-amino-1,3-dimethyltricyclo(3,3,1,1 3,7 )decane |
| GB0001093D0 (en) | 2000-01-19 | 2000-03-08 | F2 Chemicals Ltd | Selective nitrogen functionalisation of organic compounds |
| GB0018272D0 (en) * | 2000-07-25 | 2000-09-13 | Vernalis Research Limited | Chemical compounds IV |
| JP4118555B2 (ja) * | 2001-12-13 | 2008-07-16 | 株式会社トクヤマ | Ｎ−（アダマンチル）アミド化合物の製造方法 |
| RU2246482C2 (ru) | 2002-12-25 | 2005-02-20 | ООО "Циклан" | Способ получения гидрохлорида 1-амино-3,5-диметиладамантана |
| CN1240668C (zh) | 2003-09-10 | 2006-02-08 | 上海医药工业研究院 | 一种新的盐酸美金刚制备方法 |
| WO2005062724A2 (en) * | 2003-12-31 | 2005-07-14 | Sun Pharmaceutical Industries Limited | Novel process for the preparation of aminoadamantane derivatives |
| EP1708707A1 (en) * | 2004-01-22 | 2006-10-11 | Neurosearch A/S | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an n-methyl-d-aspartate (nmda) receptors antagonist |
| US7456224B2 (en) * | 2004-04-05 | 2008-11-25 | Forest Laboratories Holdings, Ltd. | Method for treating autism |
| EP1879849A1 (en) * | 2005-05-11 | 2008-01-23 | Dr. Reddy's Laboratories, Inc. | Process for preparing memantine |
-
2006
- 2006-02-21 AT AT06003477T patent/ATE541827T1/de active
- 2006-02-21 ES ES06003477T patent/ES2379181T3/es not_active Expired - Lifetime
- 2006-02-21 EP EP06003477A patent/EP1820792B1/en not_active Expired - Lifetime
- 2006-02-21 DK DK06003477.4T patent/DK1820792T3/da active
- 2006-02-21 SI SI200631279T patent/SI1820792T1/sl unknown
- 2006-02-21 PT PT06003477T patent/PT1820792E/pt unknown
- 2006-02-21 PL PL06003477T patent/PL1820792T3/pl unknown
-
2007
- 2007-02-20 CA CA2640127A patent/CA2640127C/en not_active Expired - Fee Related
- 2007-02-20 CN CN2007800060848A patent/CN101389594B/zh not_active Expired - Fee Related
- 2007-02-20 AU AU2007218140A patent/AU2007218140B2/en not_active Ceased
- 2007-02-20 WO PCT/EP2007/001440 patent/WO2007096124A1/en not_active Ceased
- 2007-02-20 JP JP2008555684A patent/JP5235683B2/ja active Active
- 2007-02-20 US US12/224,147 patent/US20090082596A1/en not_active Abandoned
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