JP2010538653A5 - - Google Patents
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- JP2010538653A5 JP2010538653A5 JP2010525014A JP2010525014A JP2010538653A5 JP 2010538653 A5 JP2010538653 A5 JP 2010538653A5 JP 2010525014 A JP2010525014 A JP 2010525014A JP 2010525014 A JP2010525014 A JP 2010525014A JP 2010538653 A5 JP2010538653 A5 JP 2010538653A5
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- 108091070501 miRNA Proteins 0.000 claims 106
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 55
- 201000010099 disease Diseases 0.000 claims 49
- 230000001105 regulatory effect Effects 0.000 claims 27
- 238000000034 method Methods 0.000 claims 17
- 108091033773 MiR-155 Proteins 0.000 claims 16
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 13
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 13
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 13
- -1 miR-016 Proteins 0.000 claims 11
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 9
- 101001120822 Homo sapiens Putative microRNA 17 host gene protein Proteins 0.000 claims 8
- 108091028684 Mir-145 Proteins 0.000 claims 8
- 108091062140 Mir-223 Proteins 0.000 claims 8
- 102100026055 Putative microRNA 17 host gene protein Human genes 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 108091050874 miR-19a stem-loop Proteins 0.000 claims 8
- 108091086850 miR-19a-1 stem-loop Proteins 0.000 claims 8
- 108091088468 miR-19a-2 stem-loop Proteins 0.000 claims 8
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 8
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 8
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 8
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 8
- 206010033128 Ovarian cancer Diseases 0.000 claims 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 7
- 108091033433 MiR-191 Proteins 0.000 claims 6
- 108091060585 Mir-31 Proteins 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 6
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 6
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims 6
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims 6
- 108091007774 MIR107 Proteins 0.000 claims 5
- 108091046841 MiR-150 Proteins 0.000 claims 5
- 108091062154 Mir-205 Proteins 0.000 claims 5
- 108091092722 miR-23b stem-loop Proteins 0.000 claims 5
- 108091031298 miR-23b-1 stem-loop Proteins 0.000 claims 5
- 108091082339 miR-23b-2 stem-loop Proteins 0.000 claims 5
- 206010028537 myelofibrosis Diseases 0.000 claims 5
- 108091007773 MIR100 Proteins 0.000 claims 4
- 108091028141 MiR-203 Proteins 0.000 claims 4
- 108091007419 MiR-27 Proteins 0.000 claims 4
- 108091027766 Mir-143 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 108091037473 miR-103 stem-loop Proteins 0.000 claims 4
- 108091079012 miR-133a Proteins 0.000 claims 4
- 108091024038 miR-133a stem-loop Proteins 0.000 claims 4
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 4
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 4
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 4
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims 4
- 108091047758 miR-185 stem-loop Proteins 0.000 claims 4
- 108091039812 miR-28 stem-loop Proteins 0.000 claims 4
- 108091088477 miR-29a stem-loop Proteins 0.000 claims 4
- 108091029716 miR-29a-1 stem-loop Proteins 0.000 claims 4
- 108091092089 miR-29a-2 stem-loop Proteins 0.000 claims 4
- 108091066559 miR-29a-3 stem-loop Proteins 0.000 claims 4
- 108091007432 miR-29b Proteins 0.000 claims 4
- 108091091696 miR-331 stem-loop Proteins 0.000 claims 4
- 108091029119 miR-34a stem-loop Proteins 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 3
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 208000003950 B-cell lymphoma Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 241000711549 Hepacivirus C Species 0.000 claims 3
- 241000725303 Human immunodeficiency virus Species 0.000 claims 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 3
- 206010021143 Hypoxia Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000005485 Thrombocytosis Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 3
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 3
- 230000001146 hypoxic effect Effects 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 108091091751 miR-17 stem-loop Proteins 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000037244 polycythemia vera Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 2
- 108091007780 MiR-122 Proteins 0.000 claims 2
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091026807 MiR-214 Proteins 0.000 claims 2
- 108091028695 MiR-224 Proteins 0.000 claims 2
- 108091028076 Mir-127 Proteins 0.000 claims 2
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims 2
- 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 claims 2
- 108091027559 Mir-96 microRNA Proteins 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 239000000090 biomarker Substances 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 201000010260 leiomyoma Diseases 0.000 claims 2
- 108091050170 miR-103-1 stem-loop Proteins 0.000 claims 2
- 108091079786 miR-105 stem-loop Proteins 0.000 claims 2
- 108091064157 miR-106a stem-loop Proteins 0.000 claims 2
- 108091035155 miR-10a stem-loop Proteins 0.000 claims 2
- 108091051828 miR-122 stem-loop Proteins 0.000 claims 2
- 108091070946 miR-128 stem-loop Proteins 0.000 claims 2
- 108091071817 miR-128b stem-loop Proteins 0.000 claims 2
- 108091079016 miR-133b Proteins 0.000 claims 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims 2
- 108091026375 miR-135b stem-loop Proteins 0.000 claims 2
- 108091086065 miR-135b-2 stem-loop Proteins 0.000 claims 2
- 108091044046 miR-17-1 stem-loop Proteins 0.000 claims 2
- 108091065423 miR-17-3 stem-loop Proteins 0.000 claims 2
- 108091041042 miR-18 stem-loop Proteins 0.000 claims 2
- 108091055042 miR-181 stem-loop Proteins 0.000 claims 2
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 2
- 108091074194 miR-181b-1 stem-loop Proteins 0.000 claims 2
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 2
- 108091062221 miR-18a stem-loop Proteins 0.000 claims 2
- 108091081505 miR-190 stem-loop Proteins 0.000 claims 2
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims 2
- 108091088515 miR-197 stem-loop Proteins 0.000 claims 2
- 108091046261 miR-198 stem-loop Proteins 0.000 claims 2
- 108091047177 miR-199 stem-loop Proteins 0.000 claims 2
- 108091031898 miR-199-5 stem-loop Proteins 0.000 claims 2
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 2
- 108091031479 miR-204 stem-loop Proteins 0.000 claims 2
- 108091032382 miR-204-1 stem-loop Proteins 0.000 claims 2
- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims 2
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims 2
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims 2
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims 2
- 108091049679 miR-20a stem-loop Proteins 0.000 claims 2
- 108091059105 miR-216-1 stem-loop Proteins 0.000 claims 2
- 108091045470 miR-216-2 stem-loop Proteins 0.000 claims 2
- 108091035328 miR-217 stem-loop Proteins 0.000 claims 2
- 108091039135 miR-217-1 stem-loop Proteins 0.000 claims 2
- 108091029206 miR-217-2 stem-loop Proteins 0.000 claims 2
- 108091040176 miR-218 stem-loop Proteins 0.000 claims 2
- 108091053008 miR-23 stem-loop Proteins 0.000 claims 2
- 108091092825 miR-24 stem-loop Proteins 0.000 claims 2
- 108091048857 miR-24-1 stem-loop Proteins 0.000 claims 2
- 108091032978 miR-24-3 stem-loop Proteins 0.000 claims 2
- 108091064025 miR-24-4 stem-loop Proteins 0.000 claims 2
- 108091046553 miR-26 stem-loop Proteins 0.000 claims 2
- 108091023821 miR-26-1 stem-loop Proteins 0.000 claims 2
- 108091045094 miR-26-2 stem-loop Proteins 0.000 claims 2
- 108091083275 miR-26b stem-loop Proteins 0.000 claims 2
- 108091007431 miR-29 Proteins 0.000 claims 2
- 108091047189 miR-29c stem-loop Proteins 0.000 claims 2
- 108091054490 miR-29c-2 stem-loop Proteins 0.000 claims 2
- 108091055059 miR-30c stem-loop Proteins 0.000 claims 2
- 108091046551 miR-324 stem-loop Proteins 0.000 claims 2
- 108091042879 miR-326 stem-loop Proteins 0.000 claims 2
- 108091055145 miR-342 stem-loop Proteins 0.000 claims 2
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 2
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 2
- 108091032985 miR-382 Proteins 0.000 claims 2
- 108091050135 miR-382 stem-loop Proteins 0.000 claims 2
- 108091080700 miR-484 stem-loop Proteins 0.000 claims 2
- 108091047084 miR-9 stem-loop Proteins 0.000 claims 2
- 108091032902 miR-93 stem-loop Proteins 0.000 claims 2
- 108091023525 miR-95 stem-loop Proteins 0.000 claims 2
- 108091086713 miR-96 stem-loop Proteins 0.000 claims 2
- 108091070961 miR-96-3 stem-loop Proteins 0.000 claims 2
- 108091007420 miR‐142 Proteins 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 108091008065 MIR21 Proteins 0.000 claims 1
- 108091028066 Mir-126 Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000012830 cancer therapeutic Substances 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 108091053410 let-7 family Proteins 0.000 claims 1
- 108091023663 let-7 stem-loop Proteins 0.000 claims 1
- 108091063478 let-7-1 stem-loop Proteins 0.000 claims 1
- 108091049777 let-7-2 stem-loop Proteins 0.000 claims 1
- 108091050539 miR-107 stem-loop Proteins 0.000 claims 1
- 108091032320 miR-146 stem-loop Proteins 0.000 claims 1
- 108091024530 miR-146a stem-loop Proteins 0.000 claims 1
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 1
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims 1
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 1
- 108091035591 miR-23a stem-loop Proteins 0.000 claims 1
- 108091061970 miR-26a stem-loop Proteins 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 claims 1
- 201000007954 uterine fibroid Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99380907P | 2007-09-14 | 2007-09-14 | |
| US60/993,809 | 2007-09-14 | ||
| US5517808P | 2008-05-22 | 2008-05-22 | |
| US61/055,178 | 2008-05-22 | ||
| PCT/US2008/076109 WO2009036236A1 (en) | 2007-09-14 | 2008-09-12 | Mirna expression in human peripheral blood microvesicles and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010538653A JP2010538653A (ja) | 2010-12-16 |
| JP2010538653A5 true JP2010538653A5 (enExample) | 2011-10-27 |
| JP5624470B2 JP5624470B2 (ja) | 2014-11-12 |
Family
ID=40452488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525014A Active JP5624470B2 (ja) | 2007-09-14 | 2008-09-12 | ヒト末梢血微小胞におけるｍｉＲＮＡの発現およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8455199B2 (enExample) |
| EP (3) | EP3112464A1 (enExample) |
| JP (1) | JP5624470B2 (enExample) |
| CN (2) | CN104975089A (enExample) |
| AU (1) | AU2008298744B8 (enExample) |
| BR (1) | BRPI0816852A2 (enExample) |
| CA (1) | CA2699646A1 (enExample) |
| ES (2) | ES2575868T3 (enExample) |
| IL (2) | IL204484A (enExample) |
| WO (1) | WO2009036236A1 (enExample) |
Families Citing this family (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2487260B1 (en) | 2006-01-05 | 2015-07-08 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis and treatment of solid cancers |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| BRPI0711011A2 (pt) | 2006-05-18 | 2011-08-23 | Molecular Profiling Inst Inc | método para a determinação da intervenção médica para um estado de doença, método para a identificação de uma terapia de droga com capacidade de interação com um alvo molecular e sistema para a determinação da intervenção médica individualizada para um estado de doença |
| AU2008207735B2 (en) | 2007-01-26 | 2013-10-03 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| US8053186B2 (en) * | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| CA2676113C (en) | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| AU2008283997B2 (en) | 2007-08-03 | 2014-04-10 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP2176665B1 (en) | 2007-08-16 | 2016-03-02 | The Royal Institution for the Advancement of Learning / McGill University | Tumor cell-derived microvesicles |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| US8455199B2 (en) | 2007-09-14 | 2013-06-04 | The Ohio State University Research Foundation | MicroRNA expression in human peripheral blood microvesicles and uses thereof |
| CN101424640B (zh) * | 2007-11-02 | 2012-07-25 | 江苏命码生物科技有限公司 | 血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法 |
| US20110195426A1 (en) * | 2009-07-16 | 2011-08-11 | The General Hospital Corporation | Nucleic acids analysis |
| EP2604704B1 (en) * | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
| WO2010018564A1 (en) * | 2008-08-13 | 2010-02-18 | Rosetta Genomics Ltd. | Compositions and methods for determining the prognosis of bladder urothelial cancer |
| US7888035B2 (en) | 2008-10-30 | 2011-02-15 | Caris Mpi, Inc. | Methods for assessing RNA patterns |
| US20130178383A1 (en) * | 2008-11-12 | 2013-07-11 | David Spetzler | Vesicle isolation methods |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| RU2400203C1 (ru) * | 2009-04-17 | 2010-09-27 | Илья Николаевич Медведев | Способ уменьшения содержания микровезикул в крови при артериальной гипертонии, дислипидемии и абдоминальном ожирении |
| RU2400209C1 (ru) * | 2009-04-17 | 2010-09-27 | Илья Николаевич Медведев | Способ коррекции уровня микровезикул в крови при артериальной гипертонии, дислипидемии и сахарном диабете ii типа |
| CA2758928A1 (en) * | 2009-04-29 | 2010-11-04 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for counteracting, preventing and/or determining heart failure, or a risk of heart failure |
| EP2336353A1 (en) * | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
| EP3461912B1 (en) | 2009-09-09 | 2022-07-13 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| EP2475989A4 (en) | 2009-09-09 | 2013-02-27 | Gen Hospital Corp | USE OF MICROVESICLES IN THE ANALYSIS OF KRAS MUTATIONS |
| JP6143041B2 (ja) * | 2009-09-30 | 2017-06-07 | 公益財団法人ヒューマンサイエンス振興財団 | 大腸がん検査キット |
| WO2011039757A2 (en) * | 2009-10-04 | 2011-04-07 | Rosetta Genomics Ltd. | Compositions and methods for prognosis of renal cancer |
| EP3118334A1 (en) * | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| JP5960060B2 (ja) | 2009-11-23 | 2016-08-02 | ジ・オハイオ・ステート・ユニバーシティ | 腫瘍細胞の増殖、遊走および浸潤に影響を与えるために有用な物質および方法 |
| EP2327783A1 (en) * | 2009-11-27 | 2011-06-01 | Universitätsklinikum Freiburg | Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth |
| CN102080086B (zh) * | 2009-12-01 | 2012-12-26 | 中国科学院上海药物研究所 | 人miR-133a反义核酸及其应用 |
| CN102080083B (zh) * | 2009-12-01 | 2013-02-27 | 中国科学院上海药物研究所 | 人miR-149反义核酸及其应用 |
| WO2011069100A2 (en) * | 2009-12-04 | 2011-06-09 | Duke University | Microrna and use thereof in identification of b cell malignancies |
| CN102770560B (zh) * | 2009-12-24 | 2015-11-25 | 复旦大学 | 用于早期检测结直肠癌的基于血浆的微rna生物标记及方法 |
| CN102892897B (zh) * | 2009-12-24 | 2016-08-03 | 复旦大学 | 用于肺癌的微rna表达谱分析的组合物和方法 |
| WO2011076147A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Plasma-based micro-rna biomarkers and methods for early detection of colorectal cancer |
| WO2011076141A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Diagnostic kits comprising microrna biomarkers and methods for diagnosis of hepatocellular cancer |
| CN102892898B (zh) * | 2009-12-24 | 2016-03-09 | 复旦大学 | 用于肝细胞癌诊断的含微rna生物标记的诊断试剂盒和方法 |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| EP2354246A1 (en) | 2010-02-05 | 2011-08-10 | febit holding GmbH | miRNA in the diagnosis of ovarian cancer |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| EP2363136A1 (en) * | 2010-03-02 | 2011-09-07 | Fresenius Medical Care Deutschland GmbH | Microvesicles (MVs) derived from adult stem cells for use in the therapeutic treatment of a tumor disease |
| JP2011211955A (ja) * | 2010-03-31 | 2011-10-27 | Toray Ind Inc | 肝ガン患者予後予測用組成物及び方法 |
| CA2795776A1 (en) * | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| US9821009B2 (en) | 2010-04-13 | 2017-11-21 | Jiangsu Mingma Biotech Co., Ltd. | Method for modulating microRNA content in living beings and the use thereof |
| EP2796563A1 (en) * | 2010-05-04 | 2014-10-29 | MedImmune, LLC | Optimized degenerative muscle disease diagnostics and treatments |
| US8716258B2 (en) | 2010-06-04 | 2014-05-06 | The Board Of Regents, The University Of Texas System | Regulation of metabolism by miR-378 |
| CN102985563A (zh) * | 2010-06-23 | 2013-03-20 | 香港中文大学 | 结肠直肠癌的微rna标志物 |
| CA2802738A1 (en) * | 2010-06-24 | 2011-12-29 | The Ohio State University | Chronic lymphocytic leukemia modeled in mouse by targeted mir-29 expression |
| US20140045915A1 (en) | 2010-08-31 | 2014-02-13 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| JP2013542192A (ja) * | 2010-09-27 | 2013-11-21 | サバンチ ユニバーシテシ | マクロオートファジーの異常を伴う疾患の診断、予防、治療及びフォローアップのための、ｍｉＲＮＡの使用 |
| EP2638057B1 (en) | 2010-11-10 | 2019-03-06 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| US8889649B2 (en) * | 2010-11-12 | 2014-11-18 | National University Corporation Ehime University | Composition containing antisense oligonucleotide to micro RNA |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| US8642751B2 (en) | 2010-12-15 | 2014-02-04 | Miragen Therapeutics | MicroRNA inhibitors comprising locked nucleotides |
| CN102140465B (zh) * | 2010-12-30 | 2013-06-12 | 苏州吉玛基因股份有限公司 | 人miR-1249反义核酸及其应用 |
| CN102146412B (zh) * | 2011-01-11 | 2012-10-03 | 中山大学 | 一种小分子非编码RNA 基因hsa-miR-29b 及其应用 |
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