JP2013502931A5 - - Google Patents
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- JP2013502931A5 JP2013502931A5 JP2012527011A JP2012527011A JP2013502931A5 JP 2013502931 A5 JP2013502931 A5 JP 2013502931A5 JP 2012527011 A JP2012527011 A JP 2012527011A JP 2012527011 A JP2012527011 A JP 2012527011A JP 2013502931 A5 JP2013502931 A5 JP 2013502931A5
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- mir
- mirna
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- lung cancer
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- 108091070501 miRNA Proteins 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 43
- 239000002679 microRNA Substances 0.000 claims description 42
- -1 miR-195 Proteins 0.000 claims description 25
- 208000020816 lung neoplasm Diseases 0.000 claims description 16
- 208000019693 Lung disease Diseases 0.000 claims description 14
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 13
- 201000005202 lung cancer Diseases 0.000 claims description 13
- 210000002966 serum Anatomy 0.000 claims description 10
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 8
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 8
- 108091028066 Mir-126 Proteins 0.000 claims description 7
- 108091031326 miR-15b stem-loop Proteins 0.000 claims description 6
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 6
- 108091028080 MiR-132 Proteins 0.000 claims description 5
- 108091073628 miR-181d stem-loop Proteins 0.000 claims description 5
- 108091048308 miR-210 stem-loop Proteins 0.000 claims description 5
- 108091070404 miR-27b stem-loop Proteins 0.000 claims description 5
- 108091046551 miR-324 stem-loop Proteins 0.000 claims description 5
- 108091046841 MiR-150 Proteins 0.000 claims description 4
- 108091033773 MiR-155 Proteins 0.000 claims description 4
- 108091028049 Mir-221 microRNA Proteins 0.000 claims description 4
- 108091060302 Mir-320 Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 238000010240 RT-PCR analysis Methods 0.000 claims description 4
- 206010041067 Small cell lung cancer Diseases 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 230000003902 lesion Effects 0.000 claims description 4
- 108091007423 let-7b Proteins 0.000 claims description 4
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 4
- 108091007427 let-7g Proteins 0.000 claims description 4
- 208000037841 lung tumor Diseases 0.000 claims description 4
- 108091028466 miR-130b stem-loop Proteins 0.000 claims description 4
- 108091079016 miR-133b Proteins 0.000 claims description 4
- 108091043162 miR-133b stem-loop Proteins 0.000 claims description 4
- 108091060382 miR-140 stem-loop Proteins 0.000 claims description 4
- 108091025686 miR-199a stem-loop Proteins 0.000 claims description 4
- 108091045665 miR-202 stem-loop Proteins 0.000 claims description 4
- 108091092825 miR-24 stem-loop Proteins 0.000 claims description 4
- 108091032978 miR-24-3 stem-loop Proteins 0.000 claims description 4
- 108091064025 miR-24-4 stem-loop Proteins 0.000 claims description 4
- 108091074563 miR-301-1 stem-loop Proteins 0.000 claims description 4
- 108091034144 miR-301-2 stem-loop Proteins 0.000 claims description 4
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- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims description 4
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims description 4
- 108091052738 miR-486-1 stem-loop Proteins 0.000 claims description 4
- 108091030654 miR-486-2 stem-loop Proteins 0.000 claims description 4
- 108091063151 miR-660 stem-loop Proteins 0.000 claims description 4
- 108091059456 miR-92-1 stem-loop Proteins 0.000 claims description 4
- 108091084336 miR-92-2 stem-loop Proteins 0.000 claims description 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 208000000587 small cell lung carcinoma Diseases 0.000 claims description 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 4
- 108091062154 Mir-205 Proteins 0.000 claims description 3
- 108091045790 miR-106b stem-loop Proteins 0.000 claims description 3
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- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims description 3
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims description 3
- 108091043222 miR-181b stem-loop Proteins 0.000 claims description 3
- 108091062762 miR-21 stem-loop Proteins 0.000 claims description 3
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims description 3
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims description 3
- 108091043187 miR-30a stem-loop Proteins 0.000 claims description 3
- 108091029750 miR-30a-1 stem-loop Proteins 0.000 claims description 3
- 108091030035 miR-30a-2 stem-loop Proteins 0.000 claims description 3
- 108091091870 miR-30a-3 stem-loop Proteins 0.000 claims description 3
- 108091067477 miR-30a-4 stem-loop Proteins 0.000 claims description 3
- 108091085103 miR-496 stem-loop Proteins 0.000 claims description 3
- 108091063340 miR-497 stem-loop Proteins 0.000 claims description 3
- 108091077027 miR-518b stem-loop Proteins 0.000 claims description 3
- 108091065658 miR-518b-1 stem-loop Proteins 0.000 claims description 3
- 108091053758 miR-518b-2 stem-loop Proteins 0.000 claims description 3
- 108091028859 miR-518b-3 stem-loop Proteins 0.000 claims description 3
- 108091083761 miR-518b-4 stem-loop Proteins 0.000 claims description 3
- 108091032902 miR-93 stem-loop Proteins 0.000 claims description 3
- 108091007772 MIRLET7C Proteins 0.000 claims description 2
- 108091033433 MiR-191 Proteins 0.000 claims description 2
- 108091036422 MiR-296 Proteins 0.000 claims description 2
- 108091027766 Mir-143 Proteins 0.000 claims description 2
- 108091093189 Mir-375 Proteins 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 2
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 2
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 2
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 2
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 2
- 108091024449 let-7e stem-loop Proteins 0.000 claims description 2
- 108091044227 let-7e-1 stem-loop Proteins 0.000 claims description 2
- 108091071181 let-7e-2 stem-loop Proteins 0.000 claims description 2
- 108091063986 let-7f stem-loop Proteins 0.000 claims description 2
- 108091042844 let-7i stem-loop Proteins 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 108091064157 miR-106a stem-loop Proteins 0.000 claims description 2
- 108091035155 miR-10a stem-loop Proteins 0.000 claims description 2
- 108091064399 miR-10b stem-loop Proteins 0.000 claims description 2
- 108091044988 miR-125a stem-loop Proteins 0.000 claims description 2
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims description 2
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims description 2
- 108091029379 miR-139 stem-loop Proteins 0.000 claims description 2
- 108091043612 miR-146b stem-loop Proteins 0.000 claims description 2
- 108091026495 miR-148b stem-loop Proteins 0.000 claims description 2
- 108091072763 miR-151 stem-loop Proteins 0.000 claims description 2
- 108091037426 miR-152 stem-loop Proteins 0.000 claims description 2
- 108091047641 miR-186 stem-loop Proteins 0.000 claims description 2
- 108091081505 miR-190 stem-loop Proteins 0.000 claims description 2
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims description 2
- 108091054642 miR-194 stem-loop Proteins 0.000 claims description 2
- 108091064378 miR-196b stem-loop Proteins 0.000 claims description 2
- 108091037787 miR-19b stem-loop Proteins 0.000 claims description 2
- 108091031479 miR-204 stem-loop Proteins 0.000 claims description 2
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- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims description 2
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims description 2
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims description 2
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims description 2
- 108091039792 miR-20b stem-loop Proteins 0.000 claims description 2
- 108091055878 miR-20b-1 stem-loop Proteins 0.000 claims description 2
- 108091027746 miR-20b-2 stem-loop Proteins 0.000 claims description 2
- 108091061917 miR-221 stem-loop Proteins 0.000 claims description 2
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims description 2
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims description 2
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims description 2
- 108091080321 miR-222 stem-loop Proteins 0.000 claims description 2
- 108091035591 miR-23a stem-loop Proteins 0.000 claims description 2
- 108091061970 miR-26a stem-loop Proteins 0.000 claims description 2
- 108091083275 miR-26b stem-loop Proteins 0.000 claims description 2
- 108091088477 miR-29a stem-loop Proteins 0.000 claims description 2
- 108091029716 miR-29a-1 stem-loop Proteins 0.000 claims description 2
- 108091092089 miR-29a-2 stem-loop Proteins 0.000 claims description 2
- 108091066559 miR-29a-3 stem-loop Proteins 0.000 claims description 2
- 108091063344 miR-30b stem-loop Proteins 0.000 claims description 2
- 108091055059 miR-30c stem-loop Proteins 0.000 claims description 2
- 108091057431 miR-30d stem-loop Proteins 0.000 claims description 2
- 108091023108 miR-30e stem-loop Proteins 0.000 claims description 2
- 108091027549 miR-30e-1 stem-loop Proteins 0.000 claims description 2
- 108091029213 miR-30e-2 stem-loop Proteins 0.000 claims description 2
- 108091085488 miR-30e-3 stem-loop Proteins 0.000 claims description 2
- 108091042879 miR-326 stem-loop Proteins 0.000 claims description 2
- 108091031484 miR-335 stem-loop Proteins 0.000 claims description 2
- 108091065159 miR-339 stem-loop Proteins 0.000 claims description 2
- 108091044951 miR-339-2 stem-loop Proteins 0.000 claims description 2
- 108091049667 miR-340 stem-loop Proteins 0.000 claims description 2
- 108091057189 miR-340-2 stem-loop Proteins 0.000 claims description 2
- 108091029119 miR-34a stem-loop Proteins 0.000 claims description 2
- 108091030670 miR-365 stem-loop Proteins 0.000 claims description 2
- 108091036688 miR-365-3 stem-loop Proteins 0.000 claims description 2
- 108091090987 miR-425 stem-loop Proteins 0.000 claims description 2
- 108091029445 miR-432 stem-loop Proteins 0.000 claims description 2
- 108091035982 miR-485 stem-loop Proteins 0.000 claims description 2
- 108091041309 miR-505 stem-loop Proteins 0.000 claims description 2
- 108091027598 miR-525 stem-loop Proteins 0.000 claims description 2
- 108091025230 miR-605 stem-loop Proteins 0.000 claims description 2
- 108091038240 miR-638 stem-loop Proteins 0.000 claims description 2
- 108091023818 miR-7 stem-loop Proteins 0.000 claims description 2
- 108091007422 miR-98 Proteins 0.000 claims description 2
- 108091076732 miR-99a stem-loop Proteins 0.000 claims description 2
- 108091064318 miR-99a-1 stem-loop Proteins 0.000 claims description 2
- 108091086202 miR-99a-2 stem-loop Proteins 0.000 claims description 2
- 108091053257 miR-99b stem-loop Proteins 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 108091063348 miR-193 stem-loop Proteins 0.000 claims 1
- 108091036762 miR-193a stem-loop Proteins 0.000 claims 1
- 108091048196 miR-5 stem-loop Proteins 0.000 claims 1
- 108091082444 miR-5-1 stem-loop Proteins 0.000 claims 1
- 108091078363 miR-5-2 stem-loop Proteins 0.000 claims 1
- 108091026807 MiR-214 Proteins 0.000 description 3
- 108091028684 Mir-145 Proteins 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000011976 chest X-ray Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 108091091751 miR-17 stem-loop Proteins 0.000 description 1
- 108091044046 miR-17-1 stem-loop Proteins 0.000 description 1
- 108091065423 miR-17-3 stem-loop Proteins 0.000 description 1
- 108091047758 miR-185 stem-loop Proteins 0.000 description 1
- 108091063796 miR-206 stem-loop Proteins 0.000 description 1
- 108091048549 miR-29b stem-loop Proteins 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23797209P | 2009-08-28 | 2009-08-28 | |
| US61/237,972 | 2009-08-28 | ||
| PCT/US2010/046916 WO2011025919A1 (en) | 2009-08-28 | 2010-08-27 | Mirna biomarkers of lung disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502931A JP2013502931A (ja) | 2013-01-31 |
| JP2013502931A5 true JP2013502931A5 (enExample) | 2013-10-10 |
| JP5995721B2 JP5995721B2 (ja) | 2016-09-21 |
Family
ID=43625469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527011A Expired - Fee Related JP5995721B2 (ja) | 2009-08-28 | 2010-08-27 | 肺疾患のｍｉＲＮＡバイオマーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8735074B2 (enExample) |
| EP (2) | EP2470897A4 (enExample) |
| JP (1) | JP5995721B2 (enExample) |
| CN (1) | CN102725632A (enExample) |
| WO (1) | WO2011025919A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1874962A2 (en) | 2005-04-14 | 2008-01-09 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| EP2605018A1 (en) | 2006-03-09 | 2013-06-19 | The Trustees of the Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| CN101990577A (zh) | 2007-09-19 | 2011-03-23 | 波士顿大学理事会 | 鉴定肺病药物开发的新途径 |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US20100240049A1 (en) | 2009-01-16 | 2010-09-23 | Cepheid | Methods of Detecting Cervical Cancer |
| JP6078339B2 (ja) | 2009-05-07 | 2017-02-08 | ベラサイト インコーポレイテッド | 甲状腺状態の診断のための方法および組成物 |
| EP2505663A1 (en) | 2011-03-30 | 2012-10-03 | IFOM Fondazione Istituto Firc di Oncologia Molecolare | A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids |
| WO2012103355A2 (en) | 2011-01-26 | 2012-08-02 | Cepheid | Methods of detecting lung cancer |
| JP6211511B2 (ja) | 2011-04-18 | 2017-10-11 | ディアミール, エルエルシーDiamir, Llc | ｍｉＲＮＡに基づくユニバーサルスクリーニングテスト（ＵＳＴ） |
| EE201100037A (et) | 2011-05-16 | 2012-12-17 | Tartu Ülikool | MikroRNAde kasutamine biomarkeritena ja sihtmrkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks |
| CN102851282B (zh) * | 2011-06-30 | 2014-10-08 | 上海市肿瘤研究所 | 用于区分原发性肺癌与癌旁组织的microRNA标志物 |
| CN102851283B (zh) * | 2011-06-30 | 2014-07-30 | 上海市肿瘤研究所 | 用于区分转移与非转移肺鳞癌的microRNA标志物 |
| EP2739734A1 (en) | 2011-08-03 | 2014-06-11 | The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System | Treatment of fibrosis using microrna-19b |
| WO2013022953A2 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
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| US9745578B2 (en) | 2011-11-30 | 2017-08-29 | Cedars-Sinai Medical Center | Targeting microRNA miR-409-3P to treat prostate cancer |
| US9753043B2 (en) | 2011-12-18 | 2017-09-05 | 20/20 Genesystems, Inc. | Methods and algorithms for aiding in the detection of cancer |
| CN102533983A (zh) * | 2011-12-19 | 2012-07-04 | 苏州福英基因科技有限公司 | 癌症病理演变前期microrna-330水平原位杂交检测试剂盒及检测方法和应用 |
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| CN102743765A (zh) * | 2012-05-24 | 2012-10-24 | 上海大学 | 非小细胞肺癌中miR-10a基因的应用 |
| US10526655B2 (en) | 2013-03-14 | 2020-01-07 | Veracyte, Inc. | Methods for evaluating COPD status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
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| CN103751801A (zh) * | 2013-09-10 | 2014-04-30 | 上海大学 | 非小细胞肺癌中miR-143基因的应用 |
| CN103555724B (zh) * | 2013-10-24 | 2015-08-05 | 浙江理工大学 | 2型糖尿病的血清miRNA生物标志物及其应用 |
| WO2015073972A1 (en) | 2013-11-18 | 2015-05-21 | Diamir, Llc | METHODS OF USING mIRNAs FROM BODILY FLUIDS FOR DETECTION AND MONITORING OF PARKINSON'S DISEASE (PD) |
| CN103667459A (zh) * | 2013-11-26 | 2014-03-26 | 上海中医药大学附属岳阳中西医结合医院 | 微小核苷酸在高血压诊断和制备降血压药物中的应用 |
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| US10781491B2 (en) | 2014-03-16 | 2020-09-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | MicroRNA signature for predicting progression of Barrett's esophagus |
| CN103937826B (zh) * | 2014-04-04 | 2016-04-06 | 东华大学 | 一种中枢神经系统中特异表达miR-505的载体的制备方法 |
| FR3019901B1 (fr) * | 2014-04-09 | 2020-10-30 | Bio Rad Innovations | Marqueur de controle pour la mise en oeuvre de procedes d'analyse sur spots |
| CN106471132B (zh) | 2014-06-18 | 2020-09-22 | 东丽株式会社 | 肺癌的检测试剂盒或装置以及检测方法 |
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| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| WO2018170622A1 (zh) * | 2017-03-18 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | 一种同步下调微小rna-152和微小rna-185表达的方法 |
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- 2010-08-27 WO PCT/US2010/046916 patent/WO2011025919A1/en not_active Ceased
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