JP2012231801A5 - - Google Patents
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- JP2012231801A5 JP2012231801A5 JP2012188756A JP2012188756A JP2012231801A5 JP 2012231801 A5 JP2012231801 A5 JP 2012231801A5 JP 2012188756 A JP2012188756 A JP 2012188756A JP 2012188756 A JP2012188756 A JP 2012188756A JP 2012231801 A5 JP2012231801 A5 JP 2012231801A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- gene product
- subject
- level
- ductal adenocarcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091070501 miRNA Proteins 0.000 claims 43
- 238000000034 method Methods 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 36
- -1 MIR-130a-P Proteins 0.000 claims 30
- 238000012360 testing method Methods 0.000 claims 16
- 230000014509 gene expression Effects 0.000 claims 14
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims 12
- 108091033773 MiR-155 Proteins 0.000 claims 9
- 108091042844 let-7i stem-loop Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 108091028108 MiR-212 Proteins 0.000 claims 7
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 7
- 108091007423 let-7b Proteins 0.000 claims 7
- 108091033753 let-7d stem-loop Proteins 0.000 claims 7
- 108091053935 miR-212 stem-loop Proteins 0.000 claims 7
- 108091028397 miR-212-1 stem-loop Proteins 0.000 claims 7
- 108091028945 miR-212-2 stem-loop Proteins 0.000 claims 7
- 108091074563 miR-301-1 stem-loop Proteins 0.000 claims 7
- 108091034144 miR-301-2 stem-loop Proteins 0.000 claims 7
- 108091028066 Mir-126 Proteins 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 6
- 239000013068 control sample Substances 0.000 claims 6
- 108091026375 miR-135b stem-loop Proteins 0.000 claims 6
- 108091086065 miR-135b-2 stem-loop Proteins 0.000 claims 6
- 108091054189 miR-196a stem-loop Proteins 0.000 claims 6
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 108091007772 MIRLET7C Proteins 0.000 claims 5
- 108091028080 MiR-132 Proteins 0.000 claims 5
- 108091062140 Mir-223 Proteins 0.000 claims 5
- 108091092072 miR-100 stem-loop Proteins 0.000 claims 5
- 108091027034 miR-148a stem-loop Proteins 0.000 claims 5
- 108091037426 miR-152 stem-loop Proteins 0.000 claims 5
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 5
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 5
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 5
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 5
- 108091093189 Mir-375 Proteins 0.000 claims 4
- 108091084619 miR-125b-1 stem-loop Proteins 0.000 claims 4
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims 4
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims 4
- 108091031103 miR-181a stem-loop Proteins 0.000 claims 4
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims 4
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims 4
- 108091092367 miR-196a-2 stem-loop Proteins 0.000 claims 4
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 4
- 108091035328 miR-217 stem-loop Proteins 0.000 claims 4
- 108091039135 miR-217-1 stem-loop Proteins 0.000 claims 4
- 108091029206 miR-217-2 stem-loop Proteins 0.000 claims 4
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims 4
- 108091046551 miR-324 stem-loop Proteins 0.000 claims 4
- 108091088856 miR-345 stem-loop Proteins 0.000 claims 4
- 108091057414 miR-376 stem-loop Proteins 0.000 claims 4
- 210000000496 pancreas Anatomy 0.000 claims 4
- 108091080933 Mir-192/215 microRNA precursor Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108091029710 let-7f-1 stem-loop Proteins 0.000 claims 3
- 108091077112 miR-128a stem-loop Proteins 0.000 claims 3
- 108091047467 miR-136 stem-loop Proteins 0.000 claims 3
- 108091088730 miR-215 stem-loop Proteins 0.000 claims 3
- 108091029997 miR-328 stem-loop Proteins 0.000 claims 3
- 108091087125 miR-376a stem-loop Proteins 0.000 claims 3
- 108091073138 miR-376a-3 stem-loop Proteins 0.000 claims 3
- 108091030938 miR-424 stem-loop Proteins 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 3
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 2
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091046841 MiR-150 Proteins 0.000 claims 2
- 108091033433 MiR-191 Proteins 0.000 claims 2
- 108091028141 MiR-203 Proteins 0.000 claims 2
- 108091026807 MiR-214 Proteins 0.000 claims 2
- 108091036422 MiR-296 Proteins 0.000 claims 2
- 108091093085 MiR-338 Proteins 0.000 claims 2
- 108091028076 Mir-127 Proteins 0.000 claims 2
- 108091027766 Mir-143 Proteins 0.000 claims 2
- 108091028684 Mir-145 Proteins 0.000 claims 2
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims 2
- 230000002946 anti-pancreatic effect Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 2
- 108091024449 let-7e stem-loop Proteins 0.000 claims 2
- 108091044227 let-7e-1 stem-loop Proteins 0.000 claims 2
- 108091071181 let-7e-2 stem-loop Proteins 0.000 claims 2
- 108091063986 let-7f stem-loop Proteins 0.000 claims 2
- 108091007427 let-7g Proteins 0.000 claims 2
- 108091037473 miR-103 stem-loop Proteins 0.000 claims 2
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 2
- 108091050539 miR-107 stem-loop Proteins 0.000 claims 2
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 2
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 2
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 2
- 108091064138 miR-129-2 stem-loop Proteins 0.000 claims 2
- 108091079016 miR-133b Proteins 0.000 claims 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims 2
- 108091029379 miR-139 stem-loop Proteins 0.000 claims 2
- 108091060382 miR-140 stem-loop Proteins 0.000 claims 2
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 2
- 108091026495 miR-148b stem-loop Proteins 0.000 claims 2
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 2
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 2
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 2
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 2
- 108091047641 miR-186 stem-loop Proteins 0.000 claims 2
- 108091081505 miR-190 stem-loop Proteins 0.000 claims 2
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims 2
- 108091054642 miR-194 stem-loop Proteins 0.000 claims 2
- 108091092012 miR-199b stem-loop Proteins 0.000 claims 2
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 2
- 108091031479 miR-204 stem-loop Proteins 0.000 claims 2
- 108091032382 miR-204-1 stem-loop Proteins 0.000 claims 2
- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims 2
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims 2
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims 2
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims 2
- 108091040176 miR-218 stem-loop Proteins 0.000 claims 2
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 2
- 108091023968 miR-330 stem-loop Proteins 0.000 claims 2
- 108091090692 miR-337 stem-loop Proteins 0.000 claims 2
- 108091065159 miR-339 stem-loop Proteins 0.000 claims 2
- 108091044951 miR-339-2 stem-loop Proteins 0.000 claims 2
- 108091049667 miR-340 stem-loop Proteins 0.000 claims 2
- 108091057189 miR-340-2 stem-loop Proteins 0.000 claims 2
- 108091055145 miR-342 stem-loop Proteins 0.000 claims 2
- 108091073301 miR-346 stem-loop Proteins 0.000 claims 2
- 108091068963 miR-361 stem-loop Proteins 0.000 claims 2
- 108091062637 miR-367 stem-loop Proteins 0.000 claims 2
- 108091036633 miR-370 stem-loop Proteins 0.000 claims 2
- 108091040651 miR-371 stem-loop Proteins 0.000 claims 2
- 108091062109 miR-372 stem-loop Proteins 0.000 claims 2
- 108091041286 miR-374 stem-loop Proteins 0.000 claims 2
- 108091055954 miR-377 stem-loop Proteins 0.000 claims 2
- 108091079015 miR-379 Proteins 0.000 claims 2
- 108091086215 miR-379 stem-loop Proteins 0.000 claims 2
- 108091048468 miR-383 stem-loop Proteins 0.000 claims 2
- 108091090987 miR-425 stem-loop Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims 2
- 101150073075 Chrm1 gene Proteins 0.000 claims 1
- 101710190174 E3 ubiquitin-protein ligase MYLIP Proteins 0.000 claims 1
- 108091007775 MIR1-1 Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091044592 miR-1-1 stem-loop Proteins 0.000 claims 1
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 1
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 1
- 108091064825 miR-181c stem-loop Proteins 0.000 claims 1
- 108091044400 miR-181c-1 stem-loop Proteins 0.000 claims 1
- 108091048818 miR-181c-2 stem-loop Proteins 0.000 claims 1
- 108091032779 miR-181c-3 stem-loop Proteins 0.000 claims 1
- 108091086416 miR-192 stem-loop Proteins 0.000 claims 1
- 108091028838 miR-2 stem-loop Proteins 0.000 claims 1
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 1
- 108091059105 miR-216-1 stem-loop Proteins 0.000 claims 1
- 108091045470 miR-216-2 stem-loop Proteins 0.000 claims 1
- 108091053185 miR-302d stem-loop Proteins 0.000 claims 1
- 108091091696 miR-331 stem-loop Proteins 0.000 claims 1
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 1
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 1
- 108091029103 miR-38 stem-loop Proteins 0.000 claims 1
- 108091029712 miR-38-1 stem-loop Proteins 0.000 claims 1
- 108091092686 miR-38-2 stem-loop Proteins 0.000 claims 1
- 108091032985 miR-382 Proteins 0.000 claims 1
- 108091050135 miR-382 stem-loop Proteins 0.000 claims 1
- 108091037240 miR-423 stem-loop Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 210000001819 pancreatic juice Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000009452 underexpressoin Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77827106P | 2006-03-02 | 2006-03-02 | |
| US60/778,271 | 2006-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Division JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023199A Division JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012231801A JP2012231801A (ja) | 2012-11-29 |
| JP2012231801A5 true JP2012231801A5 (enExample) | 2013-03-28 |
| JP5841024B2 JP5841024B2 (ja) | 2016-01-06 |
Family
ID=38475730
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Pending JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
| JP2012188756A Expired - Fee Related JP5841024B2 (ja) | 2006-03-02 | 2012-08-29 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
| JP2013023199A Pending JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Pending JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023199A Pending JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20100286232A1 (enExample) |
| EP (6) | EP2522747A1 (enExample) |
| JP (3) | JP2009528070A (enExample) |
| AU (1) | AU2007223311C1 (enExample) |
| CA (1) | CA2638844C (enExample) |
| ES (1) | ES2448491T3 (enExample) |
| WO (1) | WO2007103808A2 (enExample) |
Families Citing this family (94)
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| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
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| WO2006107826A2 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| AU2007299828C1 (en) * | 2006-09-19 | 2014-07-17 | Interpace Diagnostics, Llc | MicroRNAs differentially expressed in pancreatic diseases and uses thereof |
| JP5592251B2 (ja) * | 2007-04-30 | 2014-09-17 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵臓癌を正常な膵臓機能および／または慢性膵炎と識別する方法 |
| WO2009036332A1 (en) | 2007-09-14 | 2009-03-19 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| CA2705325C (en) * | 2007-11-09 | 2016-11-01 | The Board Of Regents Of The University Of Texas System | Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| CA2718520C (en) | 2008-03-17 | 2020-01-07 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
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| US20150344961A1 (en) * | 2012-09-11 | 2015-12-03 | New York University | Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma |
| WO2014093924A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
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| PT3363902T (pt) * | 2012-12-06 | 2019-12-19 | Sigma Aldrich Co Llc | Modificação e regulação de genoma baseadas em crispr |
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2007
- 2007-03-02 EP EP12168652A patent/EP2522747A1/en not_active Withdrawn
- 2007-03-02 JP JP2008557519A patent/JP2009528070A/ja active Pending
- 2007-03-02 EP EP12168648.9A patent/EP2522746B1/en not_active Ceased
- 2007-03-02 WO PCT/US2007/063208 patent/WO2007103808A2/en not_active Ceased
- 2007-03-02 ES ES07757822.7T patent/ES2448491T3/es active Active
- 2007-03-02 EP EP12168656A patent/EP2522750A1/en not_active Withdrawn
- 2007-03-02 AU AU2007223311A patent/AU2007223311C1/en not_active Ceased
- 2007-03-02 EP EP12168654A patent/EP2522748A1/en not_active Withdrawn
- 2007-03-02 CA CA2638844A patent/CA2638844C/en not_active Expired - Fee Related
- 2007-03-02 EP EP07757822.7A patent/EP1991706B1/en not_active Not-in-force
- 2007-03-02 US US12/281,194 patent/US20100286232A1/en not_active Abandoned
- 2007-03-02 EP EP12168655A patent/EP2522749A1/en not_active Withdrawn
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2010
- 2010-12-07 US US12/962,065 patent/US20110171646A1/en not_active Abandoned
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2012
- 2012-08-29 JP JP2012188756A patent/JP5841024B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-08 JP JP2013023199A patent/JP2013081483A/ja active Pending
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2014
- 2014-04-03 US US14/244,201 patent/US20140357702A1/en not_active Abandoned
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2017
- 2017-09-05 US US15/695,477 patent/US20180105865A1/en not_active Abandoned
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