JP2012231801A5 - - Google Patents
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- JP2012231801A5 JP2012231801A5 JP2012188756A JP2012188756A JP2012231801A5 JP 2012231801 A5 JP2012231801 A5 JP 2012231801A5 JP 2012188756 A JP2012188756 A JP 2012188756A JP 2012188756 A JP2012188756 A JP 2012188756A JP 2012231801 A5 JP2012231801 A5 JP 2012231801A5
- Authority
- JP
- Japan
- Prior art keywords
- mir
- gene product
- subject
- level
- ductal adenocarcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091070501 miRNA Proteins 0.000 claims 43
- 238000000034 method Methods 0.000 claims 38
- 108090000623 proteins and genes Proteins 0.000 claims 36
- -1 MIR-130a-P Proteins 0.000 claims 30
- 238000012360 testing method Methods 0.000 claims 16
- 230000014509 gene expression Effects 0.000 claims 14
- 201000008129 pancreatic ductal adenocarcinoma Diseases 0.000 claims 12
- 108091033773 MiR-155 Proteins 0.000 claims 9
- 108091042844 let-7i stem-loop Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 108091028108 MiR-212 Proteins 0.000 claims 7
- 108091028049 Mir-221 microRNA Proteins 0.000 claims 7
- 108091007423 let-7b Proteins 0.000 claims 7
- 108091033753 let-7d stem-loop Proteins 0.000 claims 7
- 108091053935 miR-212 stem-loop Proteins 0.000 claims 7
- 108091028397 miR-212-1 stem-loop Proteins 0.000 claims 7
- 108091028945 miR-212-2 stem-loop Proteins 0.000 claims 7
- 108091074563 miR-301-1 stem-loop Proteins 0.000 claims 7
- 108091034144 miR-301-2 stem-loop Proteins 0.000 claims 7
- 108091028066 Mir-126 Proteins 0.000 claims 6
- 239000012472 biological sample Substances 0.000 claims 6
- 239000013068 control sample Substances 0.000 claims 6
- 108091026375 miR-135b stem-loop Proteins 0.000 claims 6
- 108091086065 miR-135b-2 stem-loop Proteins 0.000 claims 6
- 108091054189 miR-196a stem-loop Proteins 0.000 claims 6
- 108091048308 miR-210 stem-loop Proteins 0.000 claims 6
- 230000001105 regulatory effect Effects 0.000 claims 6
- 108091007772 MIRLET7C Proteins 0.000 claims 5
- 108091028080 MiR-132 Proteins 0.000 claims 5
- 108091062140 Mir-223 Proteins 0.000 claims 5
- 108091092072 miR-100 stem-loop Proteins 0.000 claims 5
- 108091027034 miR-148a stem-loop Proteins 0.000 claims 5
- 108091037426 miR-152 stem-loop Proteins 0.000 claims 5
- 108091061917 miR-221 stem-loop Proteins 0.000 claims 5
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims 5
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims 5
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims 5
- 108091093189 Mir-375 Proteins 0.000 claims 4
- 108091084619 miR-125b-1 stem-loop Proteins 0.000 claims 4
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims 4
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims 4
- 108091031103 miR-181a stem-loop Proteins 0.000 claims 4
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims 4
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims 4
- 108091092367 miR-196a-2 stem-loop Proteins 0.000 claims 4
- 108091025686 miR-199a stem-loop Proteins 0.000 claims 4
- 108091035328 miR-217 stem-loop Proteins 0.000 claims 4
- 108091039135 miR-217-1 stem-loop Proteins 0.000 claims 4
- 108091029206 miR-217-2 stem-loop Proteins 0.000 claims 4
- 108091065218 miR-218-1 stem-loop Proteins 0.000 claims 4
- 108091046551 miR-324 stem-loop Proteins 0.000 claims 4
- 108091088856 miR-345 stem-loop Proteins 0.000 claims 4
- 108091057414 miR-376 stem-loop Proteins 0.000 claims 4
- 210000000496 pancreas Anatomy 0.000 claims 4
- 108091080933 Mir-192/215 microRNA precursor Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 108091029710 let-7f-1 stem-loop Proteins 0.000 claims 3
- 108091077112 miR-128a stem-loop Proteins 0.000 claims 3
- 108091047467 miR-136 stem-loop Proteins 0.000 claims 3
- 108091088730 miR-215 stem-loop Proteins 0.000 claims 3
- 108091029997 miR-328 stem-loop Proteins 0.000 claims 3
- 108091087125 miR-376a stem-loop Proteins 0.000 claims 3
- 108091073138 miR-376a-3 stem-loop Proteins 0.000 claims 3
- 108091030938 miR-424 stem-loop Proteins 0.000 claims 3
- 238000011269 treatment regimen Methods 0.000 claims 3
- 206010052747 Adenocarcinoma pancreas Diseases 0.000 claims 2
- 108091093082 MiR-146 Proteins 0.000 claims 2
- 108091046841 MiR-150 Proteins 0.000 claims 2
- 108091033433 MiR-191 Proteins 0.000 claims 2
- 108091028141 MiR-203 Proteins 0.000 claims 2
- 108091026807 MiR-214 Proteins 0.000 claims 2
- 108091036422 MiR-296 Proteins 0.000 claims 2
- 108091093085 MiR-338 Proteins 0.000 claims 2
- 108091028076 Mir-127 Proteins 0.000 claims 2
- 108091027766 Mir-143 Proteins 0.000 claims 2
- 108091028684 Mir-145 Proteins 0.000 claims 2
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims 2
- 230000002946 anti-pancreatic effect Effects 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 201000010985 invasive ductal carcinoma Diseases 0.000 claims 2
- 108091024449 let-7e stem-loop Proteins 0.000 claims 2
- 108091044227 let-7e-1 stem-loop Proteins 0.000 claims 2
- 108091071181 let-7e-2 stem-loop Proteins 0.000 claims 2
- 108091063986 let-7f stem-loop Proteins 0.000 claims 2
- 108091007427 let-7g Proteins 0.000 claims 2
- 108091037473 miR-103 stem-loop Proteins 0.000 claims 2
- 108091045790 miR-106b stem-loop Proteins 0.000 claims 2
- 108091050539 miR-107 stem-loop Proteins 0.000 claims 2
- 108091044988 miR-125a stem-loop Proteins 0.000 claims 2
- 108091049513 miR-125a-1 stem-loop Proteins 0.000 claims 2
- 108091040046 miR-125a-2 stem-loop Proteins 0.000 claims 2
- 108091064138 miR-129-2 stem-loop Proteins 0.000 claims 2
- 108091079016 miR-133b Proteins 0.000 claims 2
- 108091043162 miR-133b stem-loop Proteins 0.000 claims 2
- 108091029379 miR-139 stem-loop Proteins 0.000 claims 2
- 108091060382 miR-140 stem-loop Proteins 0.000 claims 2
- 108091043612 miR-146b stem-loop Proteins 0.000 claims 2
- 108091026495 miR-148b stem-loop Proteins 0.000 claims 2
- 108091047577 miR-149 stem-loop Proteins 0.000 claims 2
- 108091035696 miR-149-1 stem-loop Proteins 0.000 claims 2
- 108091031096 miR-149-2 stem-loop Proteins 0.000 claims 2
- 108091029500 miR-183 stem-loop Proteins 0.000 claims 2
- 108091047641 miR-186 stem-loop Proteins 0.000 claims 2
- 108091081505 miR-190 stem-loop Proteins 0.000 claims 2
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims 2
- 108091054642 miR-194 stem-loop Proteins 0.000 claims 2
- 108091092012 miR-199b stem-loop Proteins 0.000 claims 2
- 108091059199 miR-200a stem-loop Proteins 0.000 claims 2
- 108091031479 miR-204 stem-loop Proteins 0.000 claims 2
- 108091032382 miR-204-1 stem-loop Proteins 0.000 claims 2
- 108091085803 miR-204-2 stem-loop Proteins 0.000 claims 2
- 108091089766 miR-204-3 stem-loop Proteins 0.000 claims 2
- 108091073500 miR-204-4 stem-loop Proteins 0.000 claims 2
- 108091053626 miR-204-5 stem-loop Proteins 0.000 claims 2
- 108091040176 miR-218 stem-loop Proteins 0.000 claims 2
- 108091080321 miR-222 stem-loop Proteins 0.000 claims 2
- 108091023968 miR-330 stem-loop Proteins 0.000 claims 2
- 108091090692 miR-337 stem-loop Proteins 0.000 claims 2
- 108091065159 miR-339 stem-loop Proteins 0.000 claims 2
- 108091044951 miR-339-2 stem-loop Proteins 0.000 claims 2
- 108091049667 miR-340 stem-loop Proteins 0.000 claims 2
- 108091057189 miR-340-2 stem-loop Proteins 0.000 claims 2
- 108091055145 miR-342 stem-loop Proteins 0.000 claims 2
- 108091073301 miR-346 stem-loop Proteins 0.000 claims 2
- 108091068963 miR-361 stem-loop Proteins 0.000 claims 2
- 108091062637 miR-367 stem-loop Proteins 0.000 claims 2
- 108091036633 miR-370 stem-loop Proteins 0.000 claims 2
- 108091040651 miR-371 stem-loop Proteins 0.000 claims 2
- 108091062109 miR-372 stem-loop Proteins 0.000 claims 2
- 108091041286 miR-374 stem-loop Proteins 0.000 claims 2
- 108091055954 miR-377 stem-loop Proteins 0.000 claims 2
- 108091079015 miR-379 Proteins 0.000 claims 2
- 108091086215 miR-379 stem-loop Proteins 0.000 claims 2
- 108091048468 miR-383 stem-loop Proteins 0.000 claims 2
- 108091090987 miR-425 stem-loop Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 201000002094 pancreatic adenocarcinoma Diseases 0.000 claims 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims 2
- 101150073075 Chrm1 gene Proteins 0.000 claims 1
- 101710190174 E3 ubiquitin-protein ligase MYLIP Proteins 0.000 claims 1
- 108091007775 MIR1-1 Proteins 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108091044592 miR-1-1 stem-loop Proteins 0.000 claims 1
- 108091091360 miR-125b stem-loop Proteins 0.000 claims 1
- 108091043222 miR-181b stem-loop Proteins 0.000 claims 1
- 108091064825 miR-181c stem-loop Proteins 0.000 claims 1
- 108091044400 miR-181c-1 stem-loop Proteins 0.000 claims 1
- 108091048818 miR-181c-2 stem-loop Proteins 0.000 claims 1
- 108091032779 miR-181c-3 stem-loop Proteins 0.000 claims 1
- 108091086416 miR-192 stem-loop Proteins 0.000 claims 1
- 108091028838 miR-2 stem-loop Proteins 0.000 claims 1
- 108091089775 miR-200b stem-loop Proteins 0.000 claims 1
- 108091059105 miR-216-1 stem-loop Proteins 0.000 claims 1
- 108091045470 miR-216-2 stem-loop Proteins 0.000 claims 1
- 108091053185 miR-302d stem-loop Proteins 0.000 claims 1
- 108091091696 miR-331 stem-loop Proteins 0.000 claims 1
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims 1
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims 1
- 108091029103 miR-38 stem-loop Proteins 0.000 claims 1
- 108091029712 miR-38-1 stem-loop Proteins 0.000 claims 1
- 108091092686 miR-38-2 stem-loop Proteins 0.000 claims 1
- 108091032985 miR-382 Proteins 0.000 claims 1
- 108091050135 miR-382 stem-loop Proteins 0.000 claims 1
- 108091037240 miR-423 stem-loop Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 210000001819 pancreatic juice Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 230000009452 underexpressoin Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77827106P | 2006-03-02 | 2006-03-02 | |
| US60/778,271 | 2006-03-02 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Division JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023199A Division JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012231801A JP2012231801A (ja) | 2012-11-29 |
| JP2012231801A5 true JP2012231801A5 (enExample) | 2013-03-28 |
| JP5841024B2 JP5841024B2 (ja) | 2016-01-06 |
Family
ID=38475730
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Pending JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
| JP2012188756A Expired - Fee Related JP5841024B2 (ja) | 2006-03-02 | 2012-08-29 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
| JP2013023199A Pending JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557519A Pending JP2009528070A (ja) | 2006-03-02 | 2007-03-02 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013023199A Pending JP2013081483A (ja) | 2006-03-02 | 2013-02-08 | 膵臓癌に関連するマイクロｒｎａ発現プロファイル |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20100286232A1 (enExample) |
| EP (6) | EP2522748A1 (enExample) |
| JP (3) | JP2009528070A (enExample) |
| AU (1) | AU2007223311C1 (enExample) |
| CA (1) | CA2638844C (enExample) |
| ES (1) | ES2448491T3 (enExample) |
| WO (1) | WO2007103808A2 (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2471924A1 (en) | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US8592384B2 (en) | 2005-04-04 | 2013-11-26 | The Board Of Regents Of The University Of Texas System | Micro-RNA's that regulate muscle cells |
| CA2664383C (en) * | 2006-09-19 | 2017-08-22 | Asuragen, Inc. | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
| US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| WO2009062169A2 (en) | 2007-11-09 | 2009-05-14 | The Board Of Regents Of The University Of Texas System | Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| WO2009117418A2 (en) | 2008-03-17 | 2009-09-24 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| JP2012507300A (ja) | 2008-10-30 | 2012-03-29 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | Ｒｎａパターンを評価する方法 |
| WO2010054386A2 (en) * | 2008-11-10 | 2010-05-14 | Battelle Memorial Institute | Methods, compositions, and devices utilizing microrna to determine physiological conditions |
| EP2350320A4 (en) | 2008-11-12 | 2012-11-14 | Caris Life Sciences Luxembourg Holdings | METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES |
| US9074206B2 (en) | 2008-11-13 | 2015-07-07 | Fudan University | Compositions and methods for micro-RNA expression profiling of colorectal cancer |
| AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| WO2011150855A1 (en) * | 2010-06-04 | 2011-12-08 | Fudan University | Micro-rna biomarkers and methods for diagnosis of early colorectal carcinoma and high-grade adenoma |
| EP2591106A1 (en) | 2010-07-06 | 2013-05-15 | InteRNA Technologies B.V. | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| CA2812650C (en) * | 2010-09-27 | 2019-11-05 | Sabanci Universitesi | Use of mirnas for the diagnosis, prophylaxis, treatment and follow-up of diseases involving macroautophagy abnormalities |
| EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
| US9644241B2 (en) | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| US9850541B2 (en) | 2011-12-19 | 2017-12-26 | Valley Health System | Methods and kits for detecting subjects at risk of having cancer |
| WO2013101783A2 (en) | 2011-12-30 | 2013-07-04 | Bio-Rad Laboratories, Inc. | Methods and compositions for performing nucleic acid amplification reactions |
| US9334498B2 (en) | 2012-05-10 | 2016-05-10 | Uab Research Foundation | Methods and compositions for modulating MIR-204 activity |
| US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
| US20150344961A1 (en) * | 2012-09-11 | 2015-12-03 | New York University | Sera Based miRNAs as Non-Invasive Biomarkers in Melanoma |
| WO2014093924A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| DK3363902T3 (da) * | 2012-12-06 | 2020-01-02 | Sigma Aldrich Co Llc | Crispr-baseret genommodifikation og -regulering |
| EP3434774A1 (en) | 2013-01-17 | 2019-01-30 | ModernaTX, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| KR101501562B1 (ko) * | 2013-04-05 | 2015-03-11 | 연세대학교 산학협력단 | 췌장암 진단 마커를 검출하는 방법 |
| US20150018230A1 (en) * | 2013-06-11 | 2015-01-15 | Indiana University Research And Technology Corp. | PLASMA miRNA SIGNATURE FOR THE ACCURATE DIAGNOSIS OF PANCREATIC DUCTAL ADENOCARCINOMA |
| JP6611411B2 (ja) * | 2013-12-05 | 2019-11-27 | 東レ株式会社 | 膵臓がんの検出キット及び検出方法 |
| EP3108012A4 (en) | 2014-02-18 | 2017-10-11 | Baylor Research Institute | Mir-320e and colorectal cancer |
| WO2015133477A1 (ja) | 2014-03-04 | 2015-09-11 | 国立大学法人広島大学 | 膵がんの検出を補助する方法 |
| JP6797017B2 (ja) | 2014-05-30 | 2020-12-09 | 東レ株式会社 | 膵臓がんの検出キット又はデバイス及び検出方法 |
| US9623040B2 (en) | 2014-07-14 | 2017-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | Immunomodulation by controlling expression levels of microRNAs in dendritic cells |
| EP3461904A1 (en) | 2014-11-10 | 2019-04-03 | ModernaTX, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
| JP2016123340A (ja) * | 2014-12-26 | 2016-07-11 | 株式会社エバンス | 膵癌治療感受性の診断方法及び膵癌治療感受性の増強剤 |
| EP3405579A1 (en) | 2016-01-22 | 2018-11-28 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| KR102574024B1 (ko) | 2016-03-31 | 2023-09-04 | 국립연구개발법인 고쿠리츠간켄큐센터 | 조기 췌장암 또는 췌장암 전구 병변의 검출 키트 또는 디바이스 및 검출 방법 |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| PL3458083T3 (pl) | 2016-05-18 | 2023-03-13 | Modernatx, Inc. | Polinukleotydy kodujące interleukinę-12 (il12) i ich zastosowania |
| EP3468537A1 (en) | 2016-06-14 | 2019-04-17 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| JP2019518063A (ja) * | 2016-06-20 | 2019-06-27 | クラ オンコロジー， インコーポレイテッド | Ｅｒｋ阻害剤を用いた扁平上皮細胞癌の処置 |
| CA3029119A1 (en) | 2016-06-29 | 2018-01-04 | Crispr Therapeutics Ag | Materials and methods for treatment of friedreich ataxia and other related disorders |
| WO2018002762A1 (en) | 2016-06-29 | 2018-01-04 | Crispr Therapeutics Ag | Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders |
| US11427838B2 (en) | 2016-06-29 | 2022-08-30 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders |
| EP4650364A3 (en) | 2016-07-06 | 2026-01-21 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| EP3481857B1 (en) | 2016-07-06 | 2026-02-11 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of pain related disorders |
| CA3042015A1 (en) | 2016-10-26 | 2018-05-03 | Modernatx, Inc. | Messenger ribonucleic acids for enhancing immune responses and methods of use thereof |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| EP3538067A1 (en) | 2016-11-08 | 2019-09-18 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| MX2019009070A (es) | 2017-02-01 | 2019-10-30 | Modernatx Inc | Composiciones de arnm terapeuticas inmunomoduladoras que codifican peptidos de mutacion de oncogenes de activacion. |
| WO2018154462A2 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders |
| AU2018224387B2 (en) | 2017-02-22 | 2024-08-08 | Crispr Therapeutics Ag | Compositions and methods for gene editing |
| WO2018154439A1 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of spinocerebellar ataxia type 1 (sca1) and other spinocerebellar ataxia type 1 protein (atxn1) gene related conditions or disorders |
| EP3585899A1 (en) | 2017-02-22 | 2020-01-01 | CRISPR Therapeutics AG | Materials and methods for treatment of primary hyperoxaluria type 1 (ph1) and other alanine-glyoxylate aminotransferase (agxt) gene related conditions or disorders |
| WO2018154418A1 (en) | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| US20200131498A1 (en) | 2017-06-14 | 2020-04-30 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-coa mutase |
| AU2018301704A1 (en) | 2017-07-14 | 2020-03-05 | Cofactor Genomics, Inc. | Immuno-oncology applications using next generation sequencing |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| EP3714055A1 (en) | 2017-11-21 | 2020-09-30 | CRISPR Therapeutics AG | Materials and methods for treatment of autosomal dominant retinitis pigmentosa |
| EP3725881A1 (en) * | 2017-12-13 | 2020-10-21 | Hiroshima University | Method for aiding detection of pancreatic cancer |
| AU2018393050A1 (en) | 2017-12-21 | 2020-06-18 | Bayer Healthcare Llc | Materials and methods for treatment of Usher Syndrome Type 2A |
| US20190314291A1 (en) | 2018-01-30 | 2019-10-17 | Modernatx, Inc. | Compositions and methods for delivery of agents to immune cells |
| US20210163928A1 (en) | 2018-04-11 | 2021-06-03 | Modernatx, Inc. | Messenger rna comprising functional rna elements |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US20210386788A1 (en) | 2018-10-24 | 2021-12-16 | Obsidian Therapeutics, Inc. | Er tunable protein regulation |
| CN113939282A (zh) | 2019-01-31 | 2022-01-14 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| BR112021017744A2 (pt) | 2019-03-08 | 2021-11-16 | Obsidian Therapeutics Inc | Composições e métodos de cd40l para regulação ajustável |
| WO2020218489A1 (ja) * | 2019-04-26 | 2020-10-29 | 国立大学法人大阪大学 | トンネル電流を使用したマイクロｒｎａ解析 |
| MA56517A (fr) | 2019-06-24 | 2022-04-27 | Modernatx Inc | Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations |
| EP3987027A1 (en) | 2019-06-24 | 2022-04-27 | ModernaTX, Inc. | Endonuclease-resistant messenger rna and uses thereof |
| WO2021046451A1 (en) | 2019-09-06 | 2021-03-11 | Obsidian Therapeutics, Inc. | Compositions and methods for dhfr tunable protein regulation |
| US20230285297A1 (en) | 2020-01-31 | 2023-09-14 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| US11965162B2 (en) * | 2020-04-16 | 2024-04-23 | The Johns Hopkins University | MicroRNA and inhibitors thereof and methods of treatment |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| US12630881B2 (en) | 2020-07-16 | 2026-05-19 | Kurume University | Use of microRNA as pancreatic cancer biomarker |
| JP2023535225A (ja) | 2020-07-24 | 2023-08-16 | ストランド セラピューティクス インコーポレイテッド | 改変ヌクレオチドを含む脂質ナノ粒子 |
| TW202220637A (zh) | 2020-08-06 | 2022-06-01 | 美商現代公司 | 製備脂質奈米顆粒之方法 |
| KR20230129479A (ko) | 2021-01-08 | 2023-09-08 | 스트랜드 세러퓨틱스 인코포레이티드 | 발현 구성체 및 이의 용도 |
| CA3171589A1 (en) | 2021-05-03 | 2022-11-03 | Moritz THRAN | Improved nucleic acid sequence for cell type specific expression |
| WO2023166425A1 (en) | 2022-03-01 | 2023-09-07 | Crispr Therapeutics Ag | Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions |
| AU2023262576A1 (en) | 2022-04-26 | 2024-10-10 | Strand Therapeutics Inc. | Lipid nanoparticles comprising venezuelan equine encephalitis (vee) replicon and uses thereof |
| WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
| WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
| US20250375391A1 (en) | 2022-07-29 | 2025-12-11 | Modernatx, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and relates uses |
| CN121079317A (zh) | 2023-04-28 | 2025-12-05 | 深圳深信生物科技有限公司 | 经修饰的递送载体及其应用 |
| WO2024259373A1 (en) | 2023-06-14 | 2024-12-19 | Modernatx, Inc. | Compounds and compositions for delivery of therapeutic agents |
| WO2025160381A1 (en) | 2024-01-26 | 2025-07-31 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2025166202A1 (en) | 2024-01-31 | 2025-08-07 | Modernatx, Inc. | Lipid nanoparticle compositions comprising sialic acid derivatives and the uses thereof |
| CN122180503A (zh) | 2024-04-30 | 2026-06-09 | 深圳深信生物科技有限公司 | 脂质纳米颗粒及其应用 |
| ES3048857A1 (es) * | 2024-06-10 | 2025-12-11 | Fundacion Para La Investig E Innovacion Biosanitaria Del Principado De Asturias Finba | FIRMA DE miRNA UTILES EN LA DISCRIMINACION DE TUMORES |
| CN119391860B (zh) * | 2024-12-25 | 2025-03-21 | 慧算基因科技(上海)有限公司 | 一种用于胰腺癌术后mrd检测及动态监测的引物探针组合物、试剂盒及应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1990A (en) | 1841-02-20 | Head-block of sawmills for sawing without stub-shot and gaging the | ||
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DE68921918T2 (de) | 1988-05-09 | 1995-09-07 | Univ Temple | Verfahren zur Voraussage der Wirksamkeit einer antineoplastichen Behandlung bei einzelnen Patienten. |
| AU647741B2 (en) | 1989-12-01 | 1994-03-31 | Regents Of The University Of California, The | Methods and compositions for chromosome-specific staining |
| US5252479A (en) | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
| US5587308A (en) | 1992-06-02 | 1996-12-24 | The United States Of America As Represented By The Department Of Health & Human Services | Modified adeno-associated virus vector capable of expression from a novel promoter |
| US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| US6232068B1 (en) | 1999-01-22 | 2001-05-15 | Rosetta Inpharmatics, Inc. | Monitoring of gene expression by detecting hybridization to nucleic acid arrays using anti-heteronucleic acid antibodies |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| US20020173478A1 (en) | 2000-11-14 | 2002-11-21 | The Trustees Of The University Of Pennsylvania | Post-transcriptional gene silencing by RNAi in mammalian cells |
| EP1468110A4 (en) * | 2001-06-10 | 2008-01-30 | Irm Llc | MOLECULAR SIGNATURES NORMALLY TO THE DEATH LEADING CARCINOME |
| EP2428570B1 (en) * | 2001-09-28 | 2018-05-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Microrna molecules |
| JP2005536195A (ja) | 2002-05-31 | 2005-12-02 | ザ リージェント オブ ザ ユニバーシティ オブ カリフォルニア | 哺乳動物細胞における効率的なｒｎａ干渉のための方法 |
| US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
| ATE334794T1 (de) | 2002-08-21 | 2006-08-15 | Mihaly Rigo | Vorrichtung zum herstellen von rohrverbindungen und rohrverbindung |
| US20050260639A1 (en) * | 2002-09-30 | 2005-11-24 | Oncotherapy Science, Inc. | Method for diagnosing pancreatic cancer |
| ATE546528T1 (de) * | 2002-11-13 | 2012-03-15 | Univ Jefferson | Zusammensetzungen und verfahren zur diagnose und behandlung von krebs |
| US7906326B2 (en) * | 2003-05-07 | 2011-03-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides associated with alzheimer's disease and uses thereof |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
| US20050142581A1 (en) * | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| EP1713938A2 (en) * | 2004-02-09 | 2006-10-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| US20050182005A1 (en) * | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| US7365058B2 (en) * | 2004-04-13 | 2008-04-29 | The Rockefeller University | MicroRNA and methods for inhibiting same |
| US20050277139A1 (en) | 2004-04-26 | 2005-12-15 | Itzhak Bentwich | Methods and apparatus for the detection and validation of microRNAs |
| EP2471924A1 (en) * | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Methods and compositions involving microRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| WO2006034387A1 (en) | 2004-09-21 | 2006-03-30 | Applera Corporation | TWO-COLOR REAL-TIME/END-POINT QUANTITATION OF MICRORNAS (miRNAs) |
| WO2007081680A2 (en) * | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| GB2480980A (en) * | 2009-03-02 | 2011-12-07 | Trackfive Diagnostics Inc | Methods for predicting cancer response to EGFR inhibitors |
| WO2012083969A2 (en) * | 2010-12-22 | 2012-06-28 | Herlev Hospital | Microrna for diagnosis of pancreatic cancer |
| US9644241B2 (en) * | 2011-09-13 | 2017-05-09 | Interpace Diagnostics, Llc | Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease |
| US20140100124A1 (en) * | 2012-10-04 | 2014-04-10 | Asuragen, Inc. | Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions |
-
2007
- 2007-03-02 EP EP12168654A patent/EP2522748A1/en not_active Withdrawn
- 2007-03-02 EP EP12168656A patent/EP2522750A1/en not_active Withdrawn
- 2007-03-02 CA CA2638844A patent/CA2638844C/en not_active Expired - Fee Related
- 2007-03-02 JP JP2008557519A patent/JP2009528070A/ja active Pending
- 2007-03-02 AU AU2007223311A patent/AU2007223311C1/en not_active Ceased
- 2007-03-02 WO PCT/US2007/063208 patent/WO2007103808A2/en not_active Ceased
- 2007-03-02 EP EP07757822.7A patent/EP1991706B1/en not_active Not-in-force
- 2007-03-02 US US12/281,194 patent/US20100286232A1/en not_active Abandoned
- 2007-03-02 EP EP12168655A patent/EP2522749A1/en not_active Withdrawn
- 2007-03-02 EP EP12168652A patent/EP2522747A1/en not_active Withdrawn
- 2007-03-02 ES ES07757822.7T patent/ES2448491T3/es active Active
- 2007-03-02 EP EP12168648.9A patent/EP2522746B1/en not_active Ceased
-
2010
- 2010-12-07 US US12/962,065 patent/US20110171646A1/en not_active Abandoned
-
2012
- 2012-08-29 JP JP2012188756A patent/JP5841024B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-08 JP JP2013023199A patent/JP2013081483A/ja active Pending
-
2014
- 2014-04-03 US US14/244,201 patent/US20140357702A1/en not_active Abandoned
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2017
- 2017-09-05 US US15/695,477 patent/US20180105865A1/en not_active Abandoned
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