JP2015504307A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015504307A5 JP2015504307A5 JP2014542588A JP2014542588A JP2015504307A5 JP 2015504307 A5 JP2015504307 A5 JP 2015504307A5 JP 2014542588 A JP2014542588 A JP 2014542588A JP 2014542588 A JP2014542588 A JP 2014542588A JP 2015504307 A5 JP2015504307 A5 JP 2015504307A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- mir
- micrornas
- item
- combinations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108700011259 MicroRNAs Proteins 0.000 claims description 87
- 238000000034 method Methods 0.000 claims description 69
- 108091079658 miR-142-1 stem-loop Proteins 0.000 claims description 48
- 108091071830 miR-142-2 stem-loop Proteins 0.000 claims description 48
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 46
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 46
- 108091023805 miR-411 stem-loop Proteins 0.000 claims description 46
- 108091091807 let-7a stem-loop Proteins 0.000 claims description 42
- 108091057746 let-7a-4 stem-loop Proteins 0.000 claims description 42
- 108091028376 let-7a-5 stem-loop Proteins 0.000 claims description 42
- 108091024393 let-7a-6 stem-loop Proteins 0.000 claims description 42
- 108091091174 let-7a-7 stem-loop Proteins 0.000 claims description 42
- 108091068952 miR-362 stem-loop Proteins 0.000 claims description 42
- 108091029119 miR-34a stem-loop Proteins 0.000 claims description 40
- 108091031326 miR-15b stem-loop Proteins 0.000 claims description 39
- 108091093142 MiR-144 Proteins 0.000 claims description 38
- 108091062895 miR-144 stem-loop Proteins 0.000 claims description 38
- 108091026495 miR-148b stem-loop Proteins 0.000 claims description 37
- 108091049679 miR-20a stem-loop Proteins 0.000 claims description 37
- 108091047175 miR-374a stem-loop Proteins 0.000 claims description 34
- 108091062762 miR-21 stem-loop Proteins 0.000 claims description 32
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims description 32
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims description 32
- 108091080995 Mir-9/mir-79 microRNA precursor family Proteins 0.000 claims description 31
- 108091091751 miR-17 stem-loop Proteins 0.000 claims description 31
- 108091069239 miR-17-2 stem-loop Proteins 0.000 claims description 31
- 108091039812 miR-28 stem-loop Proteins 0.000 claims description 31
- 108091047084 miR-9 stem-loop Proteins 0.000 claims description 31
- 108091053257 miR-99b stem-loop Proteins 0.000 claims description 31
- 108091070404 miR-27b stem-loop Proteins 0.000 claims description 30
- 108091049667 miR-340 stem-loop Proteins 0.000 claims description 30
- 108091057189 miR-340-2 stem-loop Proteins 0.000 claims description 30
- 108091028049 Mir-221 microRNA Proteins 0.000 claims description 29
- 108091033753 let-7d stem-loop Proteins 0.000 claims description 28
- 108091007427 let-7g Proteins 0.000 claims description 28
- 108091063344 miR-30b stem-loop Proteins 0.000 claims description 27
- 108091046551 miR-324 stem-loop Proteins 0.000 claims description 27
- 108091045790 miR-106b stem-loop Proteins 0.000 claims description 26
- 108091081505 miR-190 stem-loop Proteins 0.000 claims description 26
- 108091086834 miR-190-2 stem-loop Proteins 0.000 claims description 26
- 108091057017 miR-551b stem-loop Proteins 0.000 claims description 26
- 108091023402 miR-26a-2 stem-loop Proteins 0.000 claims description 25
- 108091063986 let-7f stem-loop Proteins 0.000 claims description 24
- 108091026465 miR-1244 stem-loop Proteins 0.000 claims description 24
- 108091024545 miR-1244-1 stem-loop Proteins 0.000 claims description 24
- 108091085131 miR-1244-2 stem-loop Proteins 0.000 claims description 24
- 108091046603 miR-1244-3 stem-loop Proteins 0.000 claims description 24
- 108091047769 miR-1244-4 stem-loop Proteins 0.000 claims description 24
- 108091038502 miR-1244-5 stem-loop Proteins 0.000 claims description 24
- 108091029789 miR-1244-6 stem-loop Proteins 0.000 claims description 24
- 108091027323 miR-1244-7 stem-loop Proteins 0.000 claims description 24
- 108091090907 miR-1244-8 stem-loop Proteins 0.000 claims description 24
- 108091069968 miR-1244-9 stem-loop Proteins 0.000 claims description 24
- 108091025686 miR-199a stem-loop Proteins 0.000 claims description 24
- 108091083769 miR-199a-1 stem-loop Proteins 0.000 claims description 24
- 108091047470 miR-199a-2 stem-loop Proteins 0.000 claims description 24
- 108091048350 miR-199a-3 stem-loop Proteins 0.000 claims description 24
- 108091056793 miR-199a-4 stem-loop Proteins 0.000 claims description 24
- 108091047483 miR-24-2 stem-loop Proteins 0.000 claims description 24
- 108091043187 miR-30a stem-loop Proteins 0.000 claims description 24
- 108091029750 miR-30a-1 stem-loop Proteins 0.000 claims description 24
- 108091030035 miR-30a-2 stem-loop Proteins 0.000 claims description 24
- 108091091696 miR-331 stem-loop Proteins 0.000 claims description 24
- 108091044133 miR-454 stem-loop Proteins 0.000 claims description 24
- 108091025542 miR-668 stem-loop Proteins 0.000 claims description 24
- 108091026807 MiR-214 Proteins 0.000 claims description 23
- 108091024449 let-7e stem-loop Proteins 0.000 claims description 23
- 108091044227 let-7e-1 stem-loop Proteins 0.000 claims description 23
- 108091071181 let-7e-2 stem-loop Proteins 0.000 claims description 23
- 108091061970 miR-26a stem-loop Proteins 0.000 claims description 23
- 108091088477 miR-29a stem-loop Proteins 0.000 claims description 23
- 108091029716 miR-29a-1 stem-loop Proteins 0.000 claims description 23
- 108091092089 miR-29a-2 stem-loop Proteins 0.000 claims description 23
- 108091066559 miR-29a-3 stem-loop Proteins 0.000 claims description 23
- 108091057431 miR-30d stem-loop Proteins 0.000 claims description 23
- 108091031484 miR-335 stem-loop Proteins 0.000 claims description 23
- 108091079015 miR-379 Proteins 0.000 claims description 23
- 108091086215 miR-379 stem-loop Proteins 0.000 claims description 23
- 239000002679 microRNA Substances 0.000 claims description 23
- 108091064399 miR-10b stem-loop Proteins 0.000 claims description 22
- 108091044988 miR-125a stem-loop Proteins 0.000 claims description 22
- 108091041042 miR-18 stem-loop Proteins 0.000 claims description 22
- 108091062221 miR-18a stem-loop Proteins 0.000 claims description 22
- 108091064378 miR-196b stem-loop Proteins 0.000 claims description 22
- 108091055059 miR-30c stem-loop Proteins 0.000 claims description 22
- 108091065159 miR-339 stem-loop Proteins 0.000 claims description 22
- 108091023791 miR-339-1 stem-loop Proteins 0.000 claims description 22
- 108091031110 miR-539 stem-loop Proteins 0.000 claims description 22
- 108091007422 miR-98 Proteins 0.000 claims description 22
- 108091007700 MIR543 Proteins 0.000 claims description 21
- 108091037473 miR-103 stem-loop Proteins 0.000 claims description 21
- 108091091207 miR-127 stem-loop Proteins 0.000 claims description 21
- 108091032604 miR-1303 stem-loop Proteins 0.000 claims description 21
- 108091092591 miR-181a-2 stem-loop Proteins 0.000 claims description 21
- 108091088515 miR-197 stem-loop Proteins 0.000 claims description 21
- 108091080321 miR-222 stem-loop Proteins 0.000 claims description 21
- 108091029203 miR-301 stem-loop Proteins 0.000 claims description 21
- 108091026505 miR-301a stem-loop Proteins 0.000 claims description 21
- 108091036633 miR-370 stem-loop Proteins 0.000 claims description 21
- 108091060330 miR-520a stem-loop Proteins 0.000 claims description 21
- 108091076271 miR-543 stem-loop Proteins 0.000 claims description 21
- 108091080668 miR-548j stem-loop Proteins 0.000 claims description 21
- 108091080296 miR-758 stem-loop Proteins 0.000 claims description 21
- 108091007774 MIR107 Proteins 0.000 claims description 20
- 108091069563 miR-1227 stem-loop Proteins 0.000 claims description 20
- 108091027034 miR-148a stem-loop Proteins 0.000 claims description 20
- 108091059964 miR-154 stem-loop Proteins 0.000 claims description 20
- 108091059135 miR-429 stem-loop Proteins 0.000 claims description 20
- 108091028080 MiR-132 Proteins 0.000 claims description 19
- 108091093189 Mir-375 Proteins 0.000 claims description 19
- 108091032320 miR-146 stem-loop Proteins 0.000 claims description 19
- 108091024530 miR-146a stem-loop Proteins 0.000 claims description 19
- 108091028067 miR-19b-1 stem-loop Proteins 0.000 claims description 19
- 108091048101 miR-374b stem-loop Proteins 0.000 claims description 19
- 108091069948 miR-548a-1 stem-loop Proteins 0.000 claims description 19
- 108091073707 miR-548a-2 stem-loop Proteins 0.000 claims description 19
- 108091034066 miR-548a-3 stem-loop Proteins 0.000 claims description 19
- 108091024411 miR-590 stem-loop Proteins 0.000 claims description 19
- 108091072761 miR-598 stem-loop Proteins 0.000 claims description 19
- 108091045794 miR-766 stem-loop Proteins 0.000 claims description 19
- 108091007780 MiR-122 Proteins 0.000 claims description 18
- 108091028684 Mir-145 Proteins 0.000 claims description 18
- 108091074709 miR-1183 stem-loop Proteins 0.000 claims description 18
- 108091051828 miR-122 stem-loop Proteins 0.000 claims description 18
- 108091007432 miR-29b Proteins 0.000 claims description 18
- 108091088856 miR-345 stem-loop Proteins 0.000 claims description 18
- 108091027983 miR-378-1 stem-loop Proteins 0.000 claims description 18
- 108091089716 miR-378-2 stem-loop Proteins 0.000 claims description 18
- 108091055140 miR-574 stem-loop Proteins 0.000 claims description 18
- 108091033741 miR-579 stem-loop Proteins 0.000 claims description 18
- 108091064157 miR-106a stem-loop Proteins 0.000 claims description 17
- 108091058688 miR-141 stem-loop Proteins 0.000 claims description 17
- 108091037426 miR-152 stem-loop Proteins 0.000 claims description 17
- 108091047758 miR-185 stem-loop Proteins 0.000 claims description 17
- 108091039097 miR-193b stem-loop Proteins 0.000 claims description 17
- 108091050874 miR-19a stem-loop Proteins 0.000 claims description 17
- 108091086850 miR-19a-1 stem-loop Proteins 0.000 claims description 17
- 108091088468 miR-19a-2 stem-loop Proteins 0.000 claims description 17
- 108091074450 miR-200c stem-loop Proteins 0.000 claims description 17
- 108091047189 miR-29c stem-loop Proteins 0.000 claims description 17
- 108091054490 miR-29c-2 stem-loop Proteins 0.000 claims description 17
- 108091070038 miR-338 stem-loop Proteins 0.000 claims description 17
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 16
- 108091062170 Mir-22 Proteins 0.000 claims description 16
- 108091031190 miR-495 stem-loop Proteins 0.000 claims description 16
- 230000000694 effects Effects 0.000 claims description 15
- 108091007423 let-7b Proteins 0.000 claims description 15
- 108091060382 miR-140 stem-loop Proteins 0.000 claims description 15
- 108091030617 miR-140-1 stem-loop Proteins 0.000 claims description 15
- 108091023370 miR-140-2 stem-loop Proteins 0.000 claims description 15
- 108091063796 miR-206 stem-loop Proteins 0.000 claims description 15
- 108091091870 miR-30a-3 stem-loop Proteins 0.000 claims description 15
- 108091067477 miR-30a-4 stem-loop Proteins 0.000 claims description 15
- 108091090987 miR-425 stem-loop Proteins 0.000 claims description 15
- 108091046841 MiR-150 Proteins 0.000 claims description 14
- 108091056875 miR-1256 stem-loop Proteins 0.000 claims description 14
- 108091031103 miR-181a stem-loop Proteins 0.000 claims description 14
- 108091046591 miR-181a-4 stem-loop Proteins 0.000 claims description 14
- 108091049627 miR-181a-5 stem-loop Proteins 0.000 claims description 14
- 108091083275 miR-26b stem-loop Proteins 0.000 claims description 14
- 108091068963 miR-361 stem-loop Proteins 0.000 claims description 14
- 108091070778 miR-520e stem-loop Proteins 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 108091070946 miR-128 stem-loop Proteins 0.000 claims description 13
- 108091082518 miR-1290 stem-loop Proteins 0.000 claims description 13
- 108091056912 miR-663b stem-loop Proteins 0.000 claims description 13
- 108091066091 miR-767 stem-loop Proteins 0.000 claims description 13
- 108091080557 miR-875 stem-loop Proteins 0.000 claims description 13
- 108091008063 MIR618 Proteins 0.000 claims description 12
- 108091034054 MiR-138 Proteins 0.000 claims description 12
- 108091061943 Mir-218 microRNA precursor family Proteins 0.000 claims description 12
- 108091062140 Mir-223 Proteins 0.000 claims description 12
- 108091087268 miR-1233 stem-loop Proteins 0.000 claims description 12
- 108091029546 miR-1233-2 stem-loop Proteins 0.000 claims description 12
- 108091082430 miR-1233-3 stem-loop Proteins 0.000 claims description 12
- 108091063365 miR-1247 stem-loop Proteins 0.000 claims description 12
- 108091057905 miR-1249 stem-loop Proteins 0.000 claims description 12
- 108091036056 miR-1249-1 stem-loop Proteins 0.000 claims description 12
- 108091092614 miR-1249-2 stem-loop Proteins 0.000 claims description 12
- 108091062947 miR-1270 stem-loop Proteins 0.000 claims description 12
- 108091046573 miR-1275 stem-loop Proteins 0.000 claims description 12
- 108091081029 miR-1298 stem-loop Proteins 0.000 claims description 12
- 108091026375 miR-135b stem-loop Proteins 0.000 claims description 12
- 108091086065 miR-135b-2 stem-loop Proteins 0.000 claims description 12
- 108091030496 miR-138 stem-loop Proteins 0.000 claims description 12
- 108091040176 miR-218 stem-loop Proteins 0.000 claims description 12
- 108091024082 miR-32 stem-loop Proteins 0.000 claims description 12
- 108091073301 miR-346 stem-loop Proteins 0.000 claims description 12
- 108091028100 miR-431 stem-loop Proteins 0.000 claims description 12
- 108091036674 miR-450a stem-loop Proteins 0.000 claims description 12
- 108091056535 miR-455-1 stem-loop Proteins 0.000 claims description 12
- 108091058273 miR-487a stem-loop Proteins 0.000 claims description 12
- 108091053306 miR-493 stem-loop Proteins 0.000 claims description 12
- 108091092564 miR-494 stem-loop Proteins 0.000 claims description 12
- 108091048782 miR-501 stem-loop Proteins 0.000 claims description 12
- 108091024531 miR-518d stem-loop Proteins 0.000 claims description 12
- 108091088210 miR-518d-1 stem-loop Proteins 0.000 claims description 12
- 108091087689 miR-518d-2 stem-loop Proteins 0.000 claims description 12
- 108091062441 miR-518e stem-loop Proteins 0.000 claims description 12
- 108091044445 miR-518f stem-loop Proteins 0.000 claims description 12
- 108091036604 miR-518f-1 stem-loop Proteins 0.000 claims description 12
- 108091080798 miR-518f-2 stem-loop Proteins 0.000 claims description 12
- 108091051536 miR-523 stem-loop Proteins 0.000 claims description 12
- 108091084017 miR-570 stem-loop Proteins 0.000 claims description 12
- 108091086764 miR-571 stem-loop Proteins 0.000 claims description 12
- 108091075061 miR-571-1 stem-loop Proteins 0.000 claims description 12
- 108091051054 miR-571-2 stem-loop Proteins 0.000 claims description 12
- 108091048173 miR-577 stem-loop Proteins 0.000 claims description 12
- 108091054673 miR-618 stem-loop Proteins 0.000 claims description 12
- 108091063151 miR-660 stem-loop Proteins 0.000 claims description 12
- 108091084078 miR-744 stem-loop Proteins 0.000 claims description 12
- 108091053417 miR-885 stem-loop Proteins 0.000 claims description 12
- 108091023525 miR-95 stem-loop Proteins 0.000 claims description 12
- 108091033773 MiR-155 Proteins 0.000 claims description 11
- 108091062154 Mir-205 Proteins 0.000 claims description 11
- 108091060302 Mir-320 Proteins 0.000 claims description 11
- 108091072763 miR-151 stem-loop Proteins 0.000 claims description 11
- 108091063348 miR-193 stem-loop Proteins 0.000 claims description 11
- 108091036762 miR-193a stem-loop Proteins 0.000 claims description 11
- 108091073055 miR-193a-1 stem-loop Proteins 0.000 claims description 11
- 108091040345 miR-193a-2 stem-loop Proteins 0.000 claims description 11
- 108091054642 miR-194 stem-loop Proteins 0.000 claims description 11
- 108091092722 miR-23b stem-loop Proteins 0.000 claims description 11
- 108091031298 miR-23b-1 stem-loop Proteins 0.000 claims description 11
- 108091082339 miR-23b-2 stem-loop Proteins 0.000 claims description 11
- 108091055145 miR-342 stem-loop Proteins 0.000 claims description 11
- 108091027743 miR-450b stem-loop Proteins 0.000 claims description 11
- 108091026346 miR-450b-1 stem-loop Proteins 0.000 claims description 11
- 108091041548 miR-450b-2 stem-loop Proteins 0.000 claims description 11
- 108091053449 miR-511 stem-loop Proteins 0.000 claims description 11
- 108091029118 miR-548c stem-loop Proteins 0.000 claims description 11
- 238000003745 diagnosis Methods 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 108091041587 let-7f-2 stem-loop Proteins 0.000 claims description 10
- 108091077112 miR-128a stem-loop Proteins 0.000 claims description 10
- 108091074057 miR-16-1 stem-loop Proteins 0.000 claims description 10
- 108091089005 miR-329 stem-loop Proteins 0.000 claims description 10
- 108091090692 miR-337 stem-loop Proteins 0.000 claims description 10
- 108091057188 miR-369 stem-loop Proteins 0.000 claims description 10
- 108091087125 miR-376a stem-loop Proteins 0.000 claims description 10
- 108091073138 miR-376a-3 stem-loop Proteins 0.000 claims description 10
- 108091056921 miR-532 stem-loop Proteins 0.000 claims description 10
- 108091023818 miR-7 stem-loop Proteins 0.000 claims description 10
- 108091062872 miR-892b stem-loop Proteins 0.000 claims description 10
- 108091070501 miRNA Proteins 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 108091092012 miR-199b stem-loop Proteins 0.000 claims description 9
- 108091059199 miR-200a stem-loop Proteins 0.000 claims description 9
- 108091039792 miR-20b stem-loop Proteins 0.000 claims description 9
- 108091055878 miR-20b-1 stem-loop Proteins 0.000 claims description 9
- 108091027746 miR-20b-2 stem-loop Proteins 0.000 claims description 9
- 108091023108 miR-30e stem-loop Proteins 0.000 claims description 9
- 108091027549 miR-30e-1 stem-loop Proteins 0.000 claims description 9
- 108091029213 miR-30e-2 stem-loop Proteins 0.000 claims description 9
- 108091042879 miR-326 stem-loop Proteins 0.000 claims description 9
- 108091044721 miR-422a stem-loop Proteins 0.000 claims description 9
- 108091041309 miR-505 stem-loop Proteins 0.000 claims description 9
- 108091073864 miR-520d stem-loop Proteins 0.000 claims description 9
- 108091056126 miR-769 stem-loop Proteins 0.000 claims description 9
- 239000000523 sample Substances 0.000 claims description 9
- 229940124597 therapeutic agent Drugs 0.000 claims description 9
- 108091028108 MiR-212 Proteins 0.000 claims description 8
- 230000007423 decrease Effects 0.000 claims description 8
- 108091056404 miR-1197 stem-loop Proteins 0.000 claims description 8
- 108091053207 miR-1255b stem-loop Proteins 0.000 claims description 8
- 108091028466 miR-130b stem-loop Proteins 0.000 claims description 8
- 108091047641 miR-186 stem-loop Proteins 0.000 claims description 8
- 108091053935 miR-212 stem-loop Proteins 0.000 claims description 8
- 108091028397 miR-212-1 stem-loop Proteins 0.000 claims description 8
- 108091028945 miR-212-2 stem-loop Proteins 0.000 claims description 8
- 108091061917 miR-221 stem-loop Proteins 0.000 claims description 8
- 108091063489 miR-221-1 stem-loop Proteins 0.000 claims description 8
- 108091055391 miR-221-2 stem-loop Proteins 0.000 claims description 8
- 108091031076 miR-221-3 stem-loop Proteins 0.000 claims description 8
- 108091044918 miR-320b stem-loop Proteins 0.000 claims description 8
- 108091026895 miR-320b-1 stem-loop Proteins 0.000 claims description 8
- 108091040992 miR-320b-2 stem-loop Proteins 0.000 claims description 8
- 108091049902 miR-33a stem-loop Proteins 0.000 claims description 8
- 108091041657 miR-381 stem-loop Proteins 0.000 claims description 8
- 108091028761 miR-409 stem-loop Proteins 0.000 claims description 8
- 108091039994 miR-486 stem-loop Proteins 0.000 claims description 8
- 108091058133 miR-502 stem-loop Proteins 0.000 claims description 8
- 108091049934 miR-616 stem-loop Proteins 0.000 claims description 8
- 108091038240 miR-638 stem-loop Proteins 0.000 claims description 8
- 108091050734 miR-652 stem-loop Proteins 0.000 claims description 8
- 108091089548 miR-656 stem-loop Proteins 0.000 claims description 8
- 108091033433 MiR-191 Proteins 0.000 claims description 7
- 108091045665 miR-202 stem-loop Proteins 0.000 claims description 7
- 108091062225 miR-323 stem-loop Proteins 0.000 claims description 7
- 108091037240 miR-423 stem-loop Proteins 0.000 claims description 7
- 108091086222 miR-520c stem-loop Proteins 0.000 claims description 7
- 108091071822 miR-572 stem-loop Proteins 0.000 claims description 7
- 108091091900 miR-636 stem-loop Proteins 0.000 claims description 7
- 108091032902 miR-93 stem-loop Proteins 0.000 claims description 7
- 108091028066 Mir-126 Proteins 0.000 claims description 6
- 108091027766 Mir-143 Proteins 0.000 claims description 6
- 108091047467 miR-136 stem-loop Proteins 0.000 claims description 6
- 108091037787 miR-19b stem-loop Proteins 0.000 claims description 6
- 108091085564 miR-25 stem-loop Proteins 0.000 claims description 6
- 108091080167 miR-25-1 stem-loop Proteins 0.000 claims description 6
- 108091083056 miR-25-2 stem-loop Proteins 0.000 claims description 6
- 108091029997 miR-328 stem-loop Proteins 0.000 claims description 6
- 108091045118 miR-576 stem-loop Proteins 0.000 claims description 6
- 108091064825 miR-181c stem-loop Proteins 0.000 claims description 5
- 108091044400 miR-181c-1 stem-loop Proteins 0.000 claims description 5
- 108091048818 miR-181c-2 stem-loop Proteins 0.000 claims description 5
- 108091032779 miR-181c-3 stem-loop Proteins 0.000 claims description 5
- 108091034117 Oligonucleotide Proteins 0.000 claims description 4
- 230000003510 anti-fibrotic effect Effects 0.000 claims description 4
- 238000002405 diagnostic procedure Methods 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 206010016654 Fibrosis Diseases 0.000 claims description 3
- 210000001808 exosome Anatomy 0.000 claims description 3
- 230000004761 fibrosis Effects 0.000 claims description 3
- 108091048196 miR-5 stem-loop Proteins 0.000 claims description 3
- 108091082444 miR-5-1 stem-loop Proteins 0.000 claims description 3
- 108091078363 miR-5-2 stem-loop Proteins 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 claims description 3
- 108091028606 miR-1 stem-loop Proteins 0.000 claims description 2
- 108091050539 miR-107 stem-loop Proteins 0.000 claims description 2
- 108091049773 miR-14 stem-loop Proteins 0.000 claims description 2
- 108091048549 miR-29b stem-loop Proteins 0.000 claims description 2
- 108091059434 miR-45 stem-loop Proteins 0.000 claims description 2
- 108091029227 miR-45-1 stem-loop Proteins 0.000 claims description 2
- 108091085809 miR-45-2 stem-loop Proteins 0.000 claims description 2
- 108091055584 miR-81c stem-loop Proteins 0.000 claims description 2
- 229960003073 pirfenidone Drugs 0.000 claims description 2
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical group C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 description 12
- 230000008685 targeting Effects 0.000 description 6
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 5
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 5
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 5
- 230000003472 neutralizing effect Effects 0.000 description 5
- 102000001301 EGF receptor Human genes 0.000 description 4
- 108060006698 EGF receptor Proteins 0.000 description 4
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 description 3
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 3
- 108091008606 PDGF receptors Proteins 0.000 description 3
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 3
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 3
- 108091008605 VEGF receptors Proteins 0.000 description 3
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 3
- -1 bevacizumab Chemical compound 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 230000019491 signal transduction Effects 0.000 description 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 3
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 description 2
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 description 2
- 102000004388 Interleukin-4 Human genes 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 102000010787 Interleukin-4 Receptors Human genes 0.000 description 2
- 108010038486 Interleukin-4 Receptors Proteins 0.000 description 2
- 108091008065 MIR21 Proteins 0.000 description 2
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 2
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 2
- 108091005682 Receptor kinases Proteins 0.000 description 2
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 2
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 2
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 description 2
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 description 2
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 description 2
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 description 2
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 2
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 229960003065 bosentan Drugs 0.000 description 2
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 102000006495 integrins Human genes 0.000 description 2
- 108010044426 integrins Proteins 0.000 description 2
- 108091084679 miR-3 stem-loop Proteins 0.000 description 2
- 108091033354 miR-3-1 stem-loop Proteins 0.000 description 2
- 108091058771 miR-3-2 stem-loop Proteins 0.000 description 2
- 108091049552 miR-889 stem-loop Proteins 0.000 description 2
- 229960004378 nintedanib Drugs 0.000 description 2
- XZXHXSATPCNXJR-ZIADKAODSA-N nintedanib Chemical compound O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 2
- CXVCSRUYMINUSF-UHFFFAOYSA-N tetrathiomolybdate(2-) Chemical compound [S-][Mo]([S-])(=S)=S CXVCSRUYMINUSF-UHFFFAOYSA-N 0.000 description 2
- FDDCAZRCTMQKHP-LBPRGKRZSA-N (2r)-2-acetamido-3-[(1-hydroxy-3-methoxy-7-methyl-5,8-dioxonaphthalen-2-yl)methylsulfanyl]propanoic acid Chemical compound O=C1C=C(C)C(=O)C2=C1C=C(OC)C(CSC[C@H](NC(C)=O)C(O)=O)=C2O FDDCAZRCTMQKHP-LBPRGKRZSA-N 0.000 description 1
- CSGQVNMSRKWUSH-IAGOWNOFSA-N (3r,4r)-4-amino-1-[[4-(3-methoxyanilino)pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol Chemical compound COC1=CC=CC(NC=2C3=C(CN4C[C@@H](O)[C@H](N)CC4)C=CN3N=CN=2)=C1 CSGQVNMSRKWUSH-IAGOWNOFSA-N 0.000 description 1
- SRSHBZRURUNOSM-DEOSSOPVSA-N (4-chlorophenyl) (1s)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate Chemical compound C1=CC(OC)=CC=C1[C@H]1C(NC=2C3=CC(Cl)=CC=2)=C3CCN1C(=O)OC1=CC=C(Cl)C=C1 SRSHBZRURUNOSM-DEOSSOPVSA-N 0.000 description 1
- YPFZMBHKIVDSNR-UHFFFAOYSA-N 5-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-4h-pyrazolo[4,3-d]pyrimidin-7-one Chemical compound C1=C(C=2NC(=O)C3=NN(CCOC)C(CC)=C3N=2)C(OCC)=NC=C1S(=O)(=O)N1CCN(CC)CC1 YPFZMBHKIVDSNR-UHFFFAOYSA-N 0.000 description 1
- TXGZJQLMVSIZEI-UQMAOPSPSA-N Bardoxolone Chemical compound C1=C(C#N)C(=O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5[C@H]4C(=O)C=C3[C@]21C TXGZJQLMVSIZEI-UQMAOPSPSA-N 0.000 description 1
- PNDCCASNKRUOMF-AXUFZUPDSA-N CO[C@H]1[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1CO[C@@H](O[C@@H]2[C@@H](O)[C@H](O)CO[C@H]2N2[C@@H](CC(N)=O)C(=O)\C(=C(/O)\C=C\C=C\C=C\C=C\C=C(/Cl)\C=C\C=C(/Cl)[C@H]3O[C@H](C)C[C@@H]3Cl)C2=O)[C@@H](O)[C@@H]1O Chemical compound CO[C@H]1[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1CO[C@@H](O[C@@H]2[C@@H](O)[C@H](O)CO[C@H]2N2[C@@H](CC(N)=O)C(=O)\C(=C(/O)\C=C\C=C\C=C\C=C\C=C(/Cl)\C=C\C=C(/Cl)[C@H]3O[C@H](C)C[C@@H]3Cl)C2=O)[C@@H](O)[C@@H]1O PNDCCASNKRUOMF-AXUFZUPDSA-N 0.000 description 1
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108091068651 Drosophila melanogaster miR-7 stem-loop Proteins 0.000 description 1
- 102000030168 Endothelin A Receptor Human genes 0.000 description 1
- 108010090549 Endothelin A Receptor Proteins 0.000 description 1
- 102000010180 Endothelin receptor Human genes 0.000 description 1
- 108050001739 Endothelin receptor Proteins 0.000 description 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 1
- FDDCAZRCTMQKHP-UHFFFAOYSA-N Fibrostatin A Natural products O=C1C=C(C)C(=O)C2=C1C=C(OC)C(CSCC(NC(C)=O)C(O)=O)=C2O FDDCAZRCTMQKHP-UHFFFAOYSA-N 0.000 description 1
- 101001092910 Homo sapiens Serum amyloid P-component Proteins 0.000 description 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000004559 Interleukin-13 Receptors Human genes 0.000 description 1
- 108010017511 Interleukin-13 Receptors Proteins 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 description 1
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 108091028076 Mir-127 Proteins 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 101150097381 Mtor gene Proteins 0.000 description 1
- 239000012826 P38 inhibitor Substances 0.000 description 1
- 239000012828 PI3K inhibitor Substances 0.000 description 1
- 108010089484 PRM-151 Proteins 0.000 description 1
- PTKFEDGHUVZLPL-LLUYWJARSA-N Pectenotoxin 2 Chemical compound O[C@@H]1[C@H](C)CCO[C@]1(O)[C@H]1O[C@@H]2/C=C/C(/C)=C/[C@H](C)C[C@](C)(O3)CC[C@@H]3[C@](O3)(O4)CC[C@@]3(C)C[C@@H]4[C@@H](O3)C(=O)C[C@]3(C)[C@@H](O)[C@@H](O3)CC[C@@]3(O3)CCC[C@H]3[C@@H](C)C(=O)O[C@@H]2C1 PTKFEDGHUVZLPL-LLUYWJARSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description 1
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 1
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 description 1
- 102100036202 Serum amyloid P-component Human genes 0.000 description 1
- 102000014172 Transforming Growth Factor-beta Type I Receptor Human genes 0.000 description 1
- 102000004060 Transforming Growth Factor-beta Type II Receptor Human genes 0.000 description 1
- 108010082684 Transforming Growth Factor-beta Type II Receptor Proteins 0.000 description 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 description 1
- 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229960004308 acetylcysteine Drugs 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229960002414 ambrisentan Drugs 0.000 description 1
- OUJTZYPIHDYQMC-LJQANCHMSA-N ambrisentan Chemical compound O([C@@H](C(OC)(C=1C=CC=CC=1)C=1C=CC=CC=1)C(O)=O)C1=NC(C)=CC(C)=N1 OUJTZYPIHDYQMC-LJQANCHMSA-N 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229960003005 axitinib Drugs 0.000 description 1
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 229950002483 bardoxolone Drugs 0.000 description 1
- 229960000397 bevacizumab Drugs 0.000 description 1
- ACWZRVQXLIRSDF-UHFFFAOYSA-N binimetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1F ACWZRVQXLIRSDF-UHFFFAOYSA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229950007733 clazosentan Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000002308 endothelin receptor antagonist Substances 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 229960001433 erlotinib Drugs 0.000 description 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 1
- 229940126864 fibroblast growth factor Drugs 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 229960002584 gefitinib Drugs 0.000 description 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
- 229950006359 icrucumab Drugs 0.000 description 1
- 229960003685 imatinib mesylate Drugs 0.000 description 1
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 108091043994 let-7g stem-loop Proteins 0.000 description 1
- 108091053972 let-7g-1 stem-loop Proteins 0.000 description 1
- 108091024867 let-7g-2 stem-loop Proteins 0.000 description 1
- 229960001039 macitentan Drugs 0.000 description 1
- JGCMEBMXRHSZKX-UHFFFAOYSA-N macitentan Chemical compound C=1C=C(Br)C=CC=1C=1C(NS(=O)(=O)NCCC)=NC=NC=1OCCOC1=NC=C(Br)C=N1 JGCMEBMXRHSZKX-UHFFFAOYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229950005555 metelimumab Drugs 0.000 description 1
- 108091031158 miR-18a-2 stem-loop Proteins 0.000 description 1
- 108091028838 miR-2 stem-loop Proteins 0.000 description 1
- 108091087148 miR-20 stem-loop Proteins 0.000 description 1
- 108091066984 miR-20-1 stem-loop Proteins 0.000 description 1
- 108091076199 miR-20-2 stem-loop Proteins 0.000 description 1
- 108091062446 miR-2b stem-loop Proteins 0.000 description 1
- 108091062587 miR-32-1 stem-loop Proteins 0.000 description 1
- 108091091173 miR-54 stem-loop Proteins 0.000 description 1
- 108091049326 miR-5b-1 stem-loop Proteins 0.000 description 1
- 108091057902 miR-5b-2 stem-loop Proteins 0.000 description 1
- MIJFNYMSCFYZNY-UHFFFAOYSA-N mirodenafil Chemical compound C1=C(C=2NC=3C(CCC)=CN(CC)C=3C(=O)N=2)C(OCCC)=CC=C1S(=O)(=O)N1CCN(CCO)CC1 MIJFNYMSCFYZNY-UHFFFAOYSA-N 0.000 description 1
- 229950002245 mirodenafil Drugs 0.000 description 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 description 1
- IAYNHDZSSDUYHY-UHFFFAOYSA-N n-(2-acetyl-4,6-dimethylphenyl)-3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide Chemical compound CC(=O)C1=CC(C)=CC(C)=C1NC(=O)C1=C(S(=O)(=O)NC2=C(C(C)=NO2)C)C=CS1 IAYNHDZSSDUYHY-UHFFFAOYSA-N 0.000 description 1
- LFWCJABOXHSRGC-UHFFFAOYSA-N n-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2h-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide Chemical compound COC1=CC=CC=C1OC(C(=NC(=N1)C=2C=C(N=CC=2)C2=NNN=N2)OCCO)=C1NS(=O)(=O)C1=CC=C(C)C=N1 LFWCJABOXHSRGC-UHFFFAOYSA-N 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 229960005095 pioglitazone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
- 108091006073 receptor regulators Proteins 0.000 description 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 description 1
- 229960002586 roflumilast Drugs 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229960002639 sildenafil citrate Drugs 0.000 description 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
- 229960002930 sirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
- 229950011348 sitaxentan sodium Drugs 0.000 description 1
- MDTNUYUCUYPIHE-UHFFFAOYSA-N sodium;(4-chloro-3-methyl-1,2-oxazol-5-yl)-[2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophen-3-yl]sulfonylazanide Chemical compound [Na+].CC1=NOC([N-]S(=O)(=O)C2=C(SC=C2)C(=O)CC=2C(=CC=3OCOC=3C=2)C)=C1Cl MDTNUYUCUYPIHE-UHFFFAOYSA-N 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960000835 tadalafil Drugs 0.000 description 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 description 1
- 229960000235 temsirolimus Drugs 0.000 description 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 1
- 108010093516 tigapotide Proteins 0.000 description 1
- ZRXXHPDJLAQCPC-SFJRRRFZSA-N tigapotide Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](O)C)C(O)=O)NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@@H](NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSCNC(C)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCC(O)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=C(O)C=C1 ZRXXHPDJLAQCPC-SFJRRRFZSA-N 0.000 description 1
- 229950004301 tigapotide Drugs 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 229940100411 torisel Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229960000438 udenafil Drugs 0.000 description 1
- IYFNEFQTYQPVOC-UHFFFAOYSA-N udenafil Chemical compound C1=C(C=2NC=3C(CCC)=NN(C)C=3C(=O)N=2)C(OCCC)=CC=C1S(=O)(=O)NCCC1CCCN1C IYFNEFQTYQPVOC-UHFFFAOYSA-N 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 description 1
- 229950005371 zaprinast Drugs 0.000 description 1
- MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
- 229960005332 zileuton Drugs 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562770P | 2011-11-22 | 2011-11-22 | |
| US61/562,770 | 2011-11-22 | ||
| US201261648548P | 2012-05-17 | 2012-05-17 | |
| US61/648,548 | 2012-05-17 | ||
| PCT/US2012/066221 WO2013078283A1 (en) | 2011-11-22 | 2012-11-21 | Methods of diagnosing and treating idiopathic pulmonary fibrosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015504307A JP2015504307A (ja) | 2015-02-12 |
| JP2015504307A5 true JP2015504307A5 (enExample) | 2016-01-21 |
Family
ID=47258131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542588A Pending JP2015504307A (ja) | 2011-11-22 | 2012-11-21 | 特発性肺線維症を診断および治療する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130150426A1 (enExample) |
| EP (1) | EP2783016A1 (enExample) |
| JP (1) | JP2015504307A (enExample) |
| CN (1) | CN103987858A (enExample) |
| AU (1) | AU2012340698A1 (enExample) |
| BR (1) | BR112014012288A2 (enExample) |
| CA (1) | CA2853136A1 (enExample) |
| EA (1) | EA201491019A1 (enExample) |
| HK (2) | HK1201299A1 (enExample) |
| MX (1) | MX2014006130A (enExample) |
| WO (1) | WO2013078283A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2986538B1 (fr) * | 2012-02-06 | 2016-03-11 | Centre Nat Rech Scient | Utilisation du mir-199a-5p de ses cibles et/ou inhibiteurs pour le diagnostic, le pronostic et le traitement des pathologies fibroproliferatives |
| WO2013174692A1 (en) * | 2012-05-22 | 2013-11-28 | Ruprecht-Karls-Universität Heidelberg | Therapeutic micro rna targets in chronic pulmonary diseases |
| CN104560991B (zh) * | 2013-10-10 | 2021-02-26 | 复旦大学附属妇产科医院 | 用于防治人乳头瘤病毒感染和宫颈癌的微小rna |
| GB201403489D0 (en) * | 2014-02-27 | 2014-04-16 | Univ London Queen Mary | Biomarkers for endometriosis |
| US20170226507A1 (en) * | 2014-05-05 | 2017-08-10 | The Brigham And Women's Hospital, Inc. | Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases |
| CN105132525B (zh) * | 2014-05-29 | 2018-11-09 | 中国医学科学院基础医学研究所 | miRNA分子在精神分裂症的诊断和预后中的用途 |
| EP2957634A1 (en) * | 2014-06-20 | 2015-12-23 | Consejo Superior De Investigaciones Científicas | Compounds for prevention and/or treatment of fibrotic diseases |
| CN107108685B (zh) | 2014-09-08 | 2020-10-20 | 米拉根医疗股份有限公司 | miR-29模拟物及其用途 |
| WO2016054094A1 (en) | 2014-09-30 | 2016-04-07 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating hepatic fibrosis |
| CN112063714A (zh) * | 2014-10-28 | 2020-12-11 | 广州复能基因有限公司 | 一种与结直肠癌相关的miRNA及其应用 |
| CN104450707B (zh) * | 2014-12-25 | 2017-08-29 | 厦门大学 | 一种血清miRNA生物标志物的应用 |
| CN104694542A (zh) * | 2015-03-19 | 2015-06-10 | 中国人民解放军第四军医大学 | 一种促进组织工程骨血管化的 microRNA 及其应用 |
| CN105079808B (zh) * | 2015-05-22 | 2018-04-03 | 重庆医科大学 | miR590的用途及其相关药物 |
| CN107922485A (zh) * | 2015-06-15 | 2018-04-17 | 斯坦福大学托管董事会 | 诊断和治疗情绪障碍的方法 |
| GB201513128D0 (en) * | 2015-07-24 | 2015-09-09 | Sense Biodetection Ltd | Nucleic acid detection method |
| CN105106972A (zh) * | 2015-08-13 | 2015-12-02 | 常州市第一人民医院 | miR-338-5p及靶向作用于miR-338-5p核酸制剂的新用途 |
| CN105169393B (zh) * | 2015-08-31 | 2018-07-03 | 北京泱深生物信息技术有限公司 | miRNA-548a-3p抗急性髓系白血病中的应用 |
| CN109477144B (zh) | 2015-09-29 | 2022-12-09 | 国家儿童医院研究所 | 用于检测肝脏纤维化和对疗法的响应性的方法 |
| JP2017143810A (ja) * | 2016-02-19 | 2017-08-24 | 学校法人慶應義塾 | 抗酸菌症又は抗酸菌感染のバイオマーカー |
| CN106011303B (zh) * | 2016-08-08 | 2019-05-24 | 南京市妇幼保健院 | 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用 |
| WO2018170622A1 (zh) * | 2017-03-18 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | 一种同步下调微小rna-152和微小rna-185表达的方法 |
| WO2018170652A1 (zh) * | 2017-03-19 | 2018-09-27 | 深圳市博奥康生物科技有限公司 | 多重敲低三种miRNA的Tud RNA及其应用 |
| CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
| CN108186564B (zh) * | 2018-01-03 | 2020-06-02 | 上海市肿瘤研究所 | 一种肿瘤微环境响应型基因纳米胶束及其制备方法和应用 |
| CN108611414A (zh) * | 2018-04-26 | 2018-10-02 | 北京工业大学 | 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用 |
| CN109486911A (zh) * | 2018-11-28 | 2019-03-19 | 上海纳米技术及应用国家工程研究中心有限公司 | 基于滚环扩增和DNA折纸术检测microRNAs的方法 |
| CN109825575B (zh) * | 2019-04-08 | 2026-01-30 | 首都医科大学附属北京胸科医院 | 辅助诊断结核病的miRNA标志物及其应用 |
| CN110055322A (zh) * | 2019-05-12 | 2019-07-26 | 青岛大学 | 用于急性心肌梗死诊断的循环miRNA标志物及其应用 |
| MX2021015552A (es) * | 2019-06-14 | 2022-10-13 | Cardior Pharmaceuticals Gmbh | Tratamiento de la insuficiencia cardiaca en individuos humanos. |
| CA3146436A1 (en) | 2019-07-16 | 2021-01-21 | Universite De Liege | Extracellular vesicles containing mir-142-3p to treat fibrosing diseases |
| JP7392224B2 (ja) * | 2020-02-19 | 2023-12-06 | 国立医薬品食品衛生研究所長 | びまん性肺胞傷害型薬剤性間質性肺炎のｍｉＲＮＡ診断バイオマーカー |
| CN116042623A (zh) * | 2023-02-01 | 2023-05-02 | 浙江大学医学院附属第一医院 | 一种作为生物标志物的微小rna及在皮肤光老化中的应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5430136A (en) | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| US5681697A (en) | 1993-12-08 | 1997-10-28 | Chiron Corporation | Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor |
| US5597909A (en) | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
| US5580731A (en) | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| US6114353A (en) | 1995-03-03 | 2000-09-05 | Margolin; Solomon B. | Compositions and method for treatment of lymphomas, leukemias, and leiomyomas |
| US6090822A (en) | 1995-03-03 | 2000-07-18 | Margolin; Solomon B. | Treatment of cytokine growth factor caused disorders |
| US5962478A (en) | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| US7785842B2 (en) | 1996-03-26 | 2010-08-31 | Oncomedx, Inc. | Comparative analysis of extracellular RNA species |
| ATE420878T1 (de) | 2000-02-18 | 2009-01-15 | Kyowa Hakko Kirin Co Ltd | Isoxazol- und thiazolverbindungen und ihre verwendung als medikamente |
| US6956044B1 (en) | 2000-02-21 | 2005-10-18 | Margolin Solomon B | Compositions and methods for treatment of epilepsy |
| EP1364659B1 (en) | 2001-02-08 | 2009-11-11 | Ono Pharmaceutical Co., Ltd. | Remedies for urinary diseases comprising lpa receptor controlling agents |
| AP1822A (en) | 2002-02-14 | 2008-01-30 | Pharmacia Corp | Substituted pyridinones as modulators of P38 MAP kinase. |
| JP2005027804A (ja) | 2003-07-10 | 2005-02-03 | Konica Minolta Medical & Graphic Inc | 診察支援システム、データ処理端末及びデータ処理プログラム |
| JP4692281B2 (ja) | 2003-08-05 | 2011-06-01 | 味の素株式会社 | 新規アゾール化合物 |
| US7825133B2 (en) | 2003-11-14 | 2010-11-02 | Shanghai Genomics, Inc. | Derivatives of pyridone and the use of them |
| CA2566519C (en) | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
| US20060292616A1 (en) | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
| JP2009542608A (ja) * | 2006-06-29 | 2009-12-03 | アステックス・セラピューティクス・リミテッド | 医薬組合せ剤 |
| NZ574028A (en) | 2006-07-05 | 2010-10-29 | Fibrotech Therapeutics Pty Ltd | Tranilast analogues (substituted cinnamoyl anthranilate compounds) for treatment of conditions associated with firbrosis |
| AU2008265595B2 (en) | 2007-06-20 | 2014-12-04 | PureTech LYT 100 Inc. | Substituted N-Aryl pyridinones as fibrotic inhibitors |
| US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| EP2225396A4 (en) * | 2007-11-30 | 2011-03-02 | Univ Ohio State Res Found | PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER |
| EP2245002A4 (en) | 2008-02-01 | 2011-08-17 | Amira Pharmaceuticals Inc | AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN |
| EP2257536A4 (en) | 2008-02-14 | 2011-03-23 | Amira Pharmaceuticals Inc | CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS |
| EP2096171A1 (en) * | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| WO2010039502A2 (en) * | 2008-09-23 | 2010-04-08 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Micrornas in idiopathic pulmonary fibrosis |
| WO2010054386A2 (en) * | 2008-11-10 | 2010-05-14 | Battelle Memorial Institute | Methods, compositions, and devices utilizing microrna to determine physiological conditions |
| US8455499B2 (en) | 2008-12-11 | 2013-06-04 | Amira Pharmaceuticals, Inc. | Alkyne antagonists of lysophosphatidic acid receptors |
| GB2466121B (en) | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
| EP2389227A4 (en) | 2009-01-26 | 2012-08-08 | Intermune Inc | METHOD FOR THE TREATMENT OF ACUTE MYOCARDINE CARDS AND ASSOCIATED ILLNESSES THEREOF |
| US20120059020A1 (en) * | 2009-05-29 | 2012-03-08 | Shizuoka Coffein Co., Ltd | Prophylactic or therapeutic agent for pulmonary fibrosis |
| GB2470833B (en) | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
| JP2013501064A (ja) | 2009-08-04 | 2013-01-10 | アミラ ファーマシューティカルス，インコーポレーテッド | リゾホスファチジン酸受容体アンタゴニストとしての化合物 |
| GB2474748B (en) | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
| GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
| US7816383B1 (en) * | 2009-12-04 | 2010-10-19 | Intermune, Inc. | Methods of administering pirfenidone therapy |
-
2012
- 2012-11-21 BR BR112014012288A patent/BR112014012288A2/pt not_active IP Right Cessation
- 2012-11-21 HK HK15101658.4A patent/HK1201299A1/xx unknown
- 2012-11-21 AU AU2012340698A patent/AU2012340698A1/en not_active Abandoned
- 2012-11-21 CA CA2853136A patent/CA2853136A1/en not_active Abandoned
- 2012-11-21 CN CN201280057373.1A patent/CN103987858A/zh active Pending
- 2012-11-21 MX MX2014006130A patent/MX2014006130A/es not_active Application Discontinuation
- 2012-11-21 WO PCT/US2012/066221 patent/WO2013078283A1/en not_active Ceased
- 2012-11-21 EA EA201491019A patent/EA201491019A1/ru unknown
- 2012-11-21 HK HK15101592.3A patent/HK1201298A1/xx unknown
- 2012-11-21 JP JP2014542588A patent/JP2015504307A/ja active Pending
- 2012-11-21 EP EP12791944.7A patent/EP2783016A1/en not_active Withdrawn
- 2012-11-21 US US13/683,099 patent/US20130150426A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20160319364A1 (en) | Reagents and Methods for miRNA Expression Analysis and Identification of Cancer Biomarkers | |
| Sadri Nahand et al. | microRNAs: Key players in virus‐associated hepatocellular carcinoma | |
| Zhang et al. | Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real‐time PCR analysis | |
| Wang et al. | Potential uses of microRNA in lung cancer diagnosis, prognosis, and therapy | |
| JP2015509366A5 (enExample) | ||
| US9821009B2 (en) | Method for modulating microRNA content in living beings and the use thereof | |
| ES2536422T3 (es) | Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático | |
| ES2553442T3 (es) | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón | |
| JP2013502931A5 (enExample) | ||
| JP2010538653A5 (enExample) | ||
| US20100298407A1 (en) | Compositions and methods featuring micronas for treating neoplasia | |
| EP2775300A3 (en) | miRNA Biomarkers of Lung Disease | |
| JP2012231801A5 (enExample) | ||
| RU2012105021A (ru) | Способ выбора пищевого рациона, обеспечивающего получение молока, обладающего иммунорегуляторным действием | |
| JP2008519606A5 (enExample) | ||
| JP2015504307A (ja) | 特発性肺線維症を診断および治療する方法 | |
| CN108463561A (zh) | 用于诊断、预后和治疗监测基于神经性、神经退行性和炎症的疾病的包含基于微rna的小神经胶质细胞微泡的方法 | |
| JP2014513528A5 (enExample) | ||
| Wei et al. | Differential expression and functions of microRNAs in liver transplantation and potential use as non-invasive biomarkers | |
| Nakashima et al. | The role of miR-210, E2F3 and ephrin A3 in angiosarcoma cell proliferation | |
| Song et al. | Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis | |
| Kontomanolis et al. | The impact of microRNAs in breast cancer angiogenesis and progression | |
| Li et al. | The expression and functions of microRNAs in pancreatic adenocarcinoma and hepatocellular carcinoma | |
| Sole et al. | Aberrant expression of MicroRNAs in B-cell lymphomas | |
| Jiang et al. | Induction of MiR‐17‐3p and MiR‐160a by TNFα and LPS |