CN103987858A - 诊断和治疗特发性肺纤维化的方法 - Google Patents

诊断和治疗特发性肺纤维化的方法 Download PDF

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Publication number
CN103987858A
CN103987858A CN201280057373.1A CN201280057373A CN103987858A CN 103987858 A CN103987858 A CN 103987858A CN 201280057373 A CN201280057373 A CN 201280057373A CN 103987858 A CN103987858 A CN 103987858A
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mir
kinds
microrna
micrornas
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K.科森
S.林
秦晓丽
W.Z.布拉德福
S.D.塞维尔特
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Intermune Inc
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nuclear Medicine (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN201280057373.1A 2011-11-22 2012-11-21 诊断和治疗特发性肺纤维化的方法 Pending CN103987858A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161562770P 2011-11-22 2011-11-22
US61/562,770 2011-11-22
US201261648548P 2012-05-17 2012-05-17
US61/648,548 2012-05-17
PCT/US2012/066221 WO2013078283A1 (en) 2011-11-22 2012-11-21 Methods of diagnosing and treating idiopathic pulmonary fibrosis

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CN103987858A true CN103987858A (zh) 2014-08-13

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US (1) US20130150426A1 (enExample)
EP (1) EP2783016A1 (enExample)
JP (1) JP2015504307A (enExample)
CN (1) CN103987858A (enExample)
AU (1) AU2012340698A1 (enExample)
BR (1) BR112014012288A2 (enExample)
CA (1) CA2853136A1 (enExample)
EA (1) EA201491019A1 (enExample)
HK (2) HK1201298A1 (enExample)
MX (1) MX2014006130A (enExample)
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CN104694542A (zh) * 2015-03-19 2015-06-10 中国人民解放军第四军医大学 一种促进组织工程骨血管化的 microRNA 及其应用
CN105079808A (zh) * 2015-05-22 2015-11-25 重庆医科大学 miR590的用途及其相关药物
CN105106972A (zh) * 2015-08-13 2015-12-02 常州市第一人民医院 miR-338-5p及靶向作用于miR-338-5p核酸制剂的新用途
CN105169393A (zh) * 2015-08-31 2015-12-23 北京泱深生物信息技术有限公司 miRNA-548a-3p抗急性髓系白血病中的应用
CN105624271A (zh) * 2014-10-28 2016-06-01 广州复能基因有限公司 一种与结直肠癌相关的miRNA及其应用
CN106011303A (zh) * 2016-08-08 2016-10-12 南京市妇幼保健院 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用
CN107236799A (zh) * 2017-06-15 2017-10-10 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107922485A (zh) * 2015-06-15 2018-04-17 斯坦福大学托管董事会 诊断和治疗情绪障碍的方法
WO2018170652A1 (zh) * 2017-03-19 2018-09-27 深圳市博奥康生物科技有限公司 多重敲低三种miRNA的Tud RNA及其应用
WO2018170622A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 一种同步下调微小rna-152和微小rna-185表达的方法
CN108611414A (zh) * 2018-04-26 2018-10-02 北京工业大学 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用
CN109486911A (zh) * 2018-11-28 2019-03-19 上海纳米技术及应用国家工程研究中心有限公司 基于滚环扩增和DNA折纸术检测microRNAs的方法
CN109825575A (zh) * 2019-04-08 2019-05-31 首都医科大学附属北京胸科医院 辅助诊断结核病的miRNA标志物及其应用
CN110055322A (zh) * 2019-05-12 2019-07-26 青岛大学 用于急性心肌梗死诊断的循环miRNA标志物及其应用
CN114450067A (zh) * 2019-06-14 2022-05-06 卡迪奥尔药物有限公司 人受试者的心力衰竭的治疗

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105624271A (zh) * 2014-10-28 2016-06-01 广州复能基因有限公司 一种与结直肠癌相关的miRNA及其应用
CN104450707B (zh) * 2014-12-25 2017-08-29 厦门大学 一种血清miRNA生物标志物的应用
CN104450707A (zh) * 2014-12-25 2015-03-25 厦门大学 一种血清miRNA生物标志物的应用
CN104694542A (zh) * 2015-03-19 2015-06-10 中国人民解放军第四军医大学 一种促进组织工程骨血管化的 microRNA 及其应用
CN105079808A (zh) * 2015-05-22 2015-11-25 重庆医科大学 miR590的用途及其相关药物
CN105079808B (zh) * 2015-05-22 2018-04-03 重庆医科大学 miR590的用途及其相关药物
CN107922485A (zh) * 2015-06-15 2018-04-17 斯坦福大学托管董事会 诊断和治疗情绪障碍的方法
CN105106972A (zh) * 2015-08-13 2015-12-02 常州市第一人民医院 miR-338-5p及靶向作用于miR-338-5p核酸制剂的新用途
CN105169393B (zh) * 2015-08-31 2018-07-03 北京泱深生物信息技术有限公司 miRNA-548a-3p抗急性髓系白血病中的应用
CN105169393A (zh) * 2015-08-31 2015-12-23 北京泱深生物信息技术有限公司 miRNA-548a-3p抗急性髓系白血病中的应用
CN106011303B (zh) * 2016-08-08 2019-05-24 南京市妇幼保健院 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用
CN106011303A (zh) * 2016-08-08 2016-10-12 南京市妇幼保健院 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用
WO2018170622A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 一种同步下调微小rna-152和微小rna-185表达的方法
WO2018170652A1 (zh) * 2017-03-19 2018-09-27 深圳市博奥康生物科技有限公司 多重敲低三种miRNA的Tud RNA及其应用
CN107236799A (zh) * 2017-06-15 2017-10-10 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN107236799B (zh) * 2017-06-15 2020-06-09 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN108611414A (zh) * 2018-04-26 2018-10-02 北京工业大学 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用
CN109486911A (zh) * 2018-11-28 2019-03-19 上海纳米技术及应用国家工程研究中心有限公司 基于滚环扩增和DNA折纸术检测microRNAs的方法
CN109825575A (zh) * 2019-04-08 2019-05-31 首都医科大学附属北京胸科医院 辅助诊断结核病的miRNA标志物及其应用
CN110055322A (zh) * 2019-05-12 2019-07-26 青岛大学 用于急性心肌梗死诊断的循环miRNA标志物及其应用
CN114450067A (zh) * 2019-06-14 2022-05-06 卡迪奥尔药物有限公司 人受试者的心力衰竭的治疗
CN114450067B (zh) * 2019-06-14 2024-03-15 卡迪奥尔药物有限公司 人受试者的心力衰竭的治疗

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HK1201298A1 (en) 2015-08-28
MX2014006130A (es) 2015-04-13
WO2013078283A1 (en) 2013-05-30
AU2012340698A1 (en) 2014-04-24
CA2853136A1 (en) 2013-05-30
EA201491019A1 (ru) 2014-08-29
EP2783016A1 (en) 2014-10-01
BR112014012288A2 (pt) 2017-05-23
US20130150426A1 (en) 2013-06-13
HK1201299A1 (en) 2015-08-28
JP2015504307A (ja) 2015-02-12

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