AU2012340698A1 - Methods of diagnosing and treating idiopathic pulmonary fibrosis - Google Patents

Methods of diagnosing and treating idiopathic pulmonary fibrosis Download PDF

Info

Publication number
AU2012340698A1
AU2012340698A1 AU2012340698A AU2012340698A AU2012340698A1 AU 2012340698 A1 AU2012340698 A1 AU 2012340698A1 AU 2012340698 A AU2012340698 A AU 2012340698A AU 2012340698 A AU2012340698 A AU 2012340698A AU 2012340698 A1 AU2012340698 A1 AU 2012340698A1
Authority
AU
Australia
Prior art keywords
seq
mir
microrna
combinations
ipf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012340698A
Other languages
English (en)
Inventor
Williamson Ziegler Bradford
Karl Kossen
Sharlene Lim
Xiaoli Qin
Scott D. Seiwert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intermune Inc
Original Assignee
Intermune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermune Inc filed Critical Intermune Inc
Publication of AU2012340698A1 publication Critical patent/AU2012340698A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Nuclear Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2012340698A 2011-11-22 2012-11-21 Methods of diagnosing and treating idiopathic pulmonary fibrosis Abandoned AU2012340698A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161562770P 2011-11-22 2011-11-22
US61/562,770 2011-11-22
US201261648548P 2012-05-17 2012-05-17
US61/648,548 2012-05-17
PCT/US2012/066221 WO2013078283A1 (en) 2011-11-22 2012-11-21 Methods of diagnosing and treating idiopathic pulmonary fibrosis

Publications (1)

Publication Number Publication Date
AU2012340698A1 true AU2012340698A1 (en) 2014-04-24

Family

ID=47258131

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012340698A Abandoned AU2012340698A1 (en) 2011-11-22 2012-11-21 Methods of diagnosing and treating idiopathic pulmonary fibrosis

Country Status (11)

Country Link
US (1) US20130150426A1 (enExample)
EP (1) EP2783016A1 (enExample)
JP (1) JP2015504307A (enExample)
CN (1) CN103987858A (enExample)
AU (1) AU2012340698A1 (enExample)
BR (1) BR112014012288A2 (enExample)
CA (1) CA2853136A1 (enExample)
EA (1) EA201491019A1 (enExample)
HK (2) HK1201299A1 (enExample)
MX (1) MX2014006130A (enExample)
WO (1) WO2013078283A1 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986538B1 (fr) 2012-02-06 2016-03-11 Centre Nat Rech Scient Utilisation du mir-199a-5p de ses cibles et/ou inhibiteurs pour le diagnostic, le pronostic et le traitement des pathologies fibroproliferatives
US10119135B2 (en) 2012-05-22 2018-11-06 Ruprecht-Karls-Universität Heidelberg Therapeutic micro RNA targets in chronic pulmonary diseases
CN104560991B (zh) * 2013-10-10 2021-02-26 复旦大学附属妇产科医院 用于防治人乳头瘤病毒感染和宫颈癌的微小rna
GB201403489D0 (en) * 2014-02-27 2014-04-16 Univ London Queen Mary Biomarkers for endometriosis
US20170226507A1 (en) * 2014-05-05 2017-08-10 The Brigham And Women's Hospital, Inc. Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases
CN105132525B (zh) * 2014-05-29 2018-11-09 中国医学科学院基础医学研究所 miRNA分子在精神分裂症的诊断和预后中的用途
EP2957634A1 (en) * 2014-06-20 2015-12-23 Consejo Superior De Investigaciones Científicas Compounds for prevention and/or treatment of fibrotic diseases
RU2712511C2 (ru) 2014-09-08 2020-01-29 Мираген Терапеутикс, Инк. Миметики mir-29 и пути их применения
WO2016054094A1 (en) * 2014-09-30 2016-04-07 Research Institute At Nationwide Children's Hospital Compositions and methods for treating hepatic fibrosis
CN112063714A (zh) * 2014-10-28 2020-12-11 广州复能基因有限公司 一种与结直肠癌相关的miRNA及其应用
CN104450707B (zh) * 2014-12-25 2017-08-29 厦门大学 一种血清miRNA生物标志物的应用
CN104694542A (zh) * 2015-03-19 2015-06-10 中国人民解放军第四军医大学 一种促进组织工程骨血管化的 microRNA 及其应用
CN105079808B (zh) * 2015-05-22 2018-04-03 重庆医科大学 miR590的用途及其相关药物
WO2016205226A1 (en) * 2015-06-15 2016-12-22 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosing and treating affective disorders
GB201513128D0 (en) * 2015-07-24 2015-09-09 Sense Biodetection Ltd Nucleic acid detection method
CN105106972A (zh) * 2015-08-13 2015-12-02 常州市第一人民医院 miR-338-5p及靶向作用于miR-338-5p核酸制剂的新用途
CN105169393B (zh) * 2015-08-31 2018-07-03 北京泱深生物信息技术有限公司 miRNA-548a-3p抗急性髓系白血病中的应用
US11180810B2 (en) 2015-09-29 2021-11-23 Research Institute At Nationwide Children's Hospital Methods for detecting hepatic fibrosis and responsiveness to therapy
JP2017143810A (ja) * 2016-02-19 2017-08-24 学校法人慶應義塾 抗酸菌症又は抗酸菌感染のバイオマーカー
CN106011303B (zh) * 2016-08-08 2019-05-24 南京市妇幼保健院 一种与儿童肥胖相关的血清或血浆miRNA标志物及其应用
WO2018170622A1 (zh) * 2017-03-18 2018-09-27 深圳市博奥康生物科技有限公司 一种同步下调微小rna-152和微小rna-185表达的方法
WO2018170652A1 (zh) * 2017-03-19 2018-09-27 深圳市博奥康生物科技有限公司 多重敲低三种miRNA的Tud RNA及其应用
CN107236799B (zh) * 2017-06-15 2020-06-09 昆明医科大学第六附属医院 一种肾纤维化miRNA标记物
CN108186564B (zh) * 2018-01-03 2020-06-02 上海市肿瘤研究所 一种肿瘤微环境响应型基因纳米胶束及其制备方法和应用
CN108611414A (zh) * 2018-04-26 2018-10-02 北京工业大学 新的靶向肿瘤微环境与肺癌干细胞相互作用的miRNA的检测及应用
CN109486911A (zh) * 2018-11-28 2019-03-19 上海纳米技术及应用国家工程研究中心有限公司 基于滚环扩增和DNA折纸术检测microRNAs的方法
CN109825575A (zh) * 2019-04-08 2019-05-31 首都医科大学附属北京胸科医院 辅助诊断结核病的miRNA标志物及其应用
CN110055322A (zh) * 2019-05-12 2019-07-26 青岛大学 用于急性心肌梗死诊断的循环miRNA标志物及其应用
HUE070614T2 (hu) * 2019-06-14 2025-06-28 Novo Nordisk As Szívelégtelenség és fibrózis kezelése humán alanyokon
WO2021009317A1 (en) 2019-07-16 2021-01-21 Université de Liège Extracellular vesicles containing mir-142-3p to treat fibrosing diseases
JP7392224B2 (ja) * 2020-02-19 2023-12-06 国立医薬品食品衛生研究所長 びまん性肺胞傷害型薬剤性間質性肺炎のｍｉＲＮＡ診断バイオマーカー

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430136A (en) 1984-10-16 1995-07-04 Chiron Corporation Oligonucleotides having selectably cleavable and/or abasic sites
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5359100A (en) 1987-10-15 1994-10-25 Chiron Corporation Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers
US5310562A (en) 1989-11-22 1994-05-10 Margolin Solomon B Composition and method for reparation and prevention of fibrotic lesions
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5580731A (en) 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5597909A (en) 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6114353A (en) 1995-03-03 2000-09-05 Margolin; Solomon B. Compositions and method for treatment of lymphomas, leukemias, and leiomyomas
US6090822A (en) 1995-03-03 2000-07-18 Margolin; Solomon B. Treatment of cytokine growth factor caused disorders
US5962478A (en) 1995-09-19 1999-10-05 Margolin; Solomon B. Inhibition of tumor necrosis factor α
US7785842B2 (en) 1996-03-26 2010-08-31 Oncomedx, Inc. Comparative analysis of extracellular RNA species
EP1258484B1 (en) 2000-02-18 2009-01-14 Kyowa Hakko Kirin Co., Ltd. Novel isoxazole and thiazole compounds and use thereof as drugs
US6956044B1 (en) 2000-02-21 2005-10-18 Margolin Solomon B Compositions and methods for treatment of epilepsy
ATE447970T1 (de) 2001-02-08 2009-11-15 Ono Pharmaceutical Co Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors
PL218749B1 (pl) 2002-02-14 2015-01-30 Pharmacia Corp Pochodna pirydynonu oraz jej zastosowanie do wytwarzania leku
JP2005027804A (ja) 2003-07-10 2005-02-03 Konica Minolta Medical & Graphic Inc 診察支援システム、データ処理端末及びデータ処理プログラム
WO2005012269A1 (ja) 2003-08-05 2005-02-10 Ajinomoto Co., Inc. 新規アゾール化合物
JP4614884B2 (ja) 2003-11-14 2011-01-19 シャンハイ ゲノミックス インク ピリドンの誘導体とその使用
JP5697297B2 (ja) 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロｎａｓおよびその使用
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
JP2009542608A (ja) * 2006-06-29 2009-12-03 アステックス・セラピューティクス・リミテッド 医薬組合せ剤
US8765812B2 (en) 2006-07-05 2014-07-01 Fibrotech Therapeutics Pty Ltd Therapeutic compounds
KR101767849B1 (ko) 2007-06-20 2017-08-11 오스펙스 파마슈티칼스, 인코포레이티드 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논
WO2009035598A1 (en) 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
US20100323357A1 (en) * 2007-11-30 2010-12-23 The Ohio State University Research Foundation MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer
EP2245002A4 (en) 2008-02-01 2011-08-17 Amira Pharmaceuticals Inc AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN
JP2011512359A (ja) 2008-02-14 2011-04-21 アミラ ファーマシューティカルズ，インク． プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物
EP2096171A1 (en) * 2008-02-27 2009-09-02 Julius-Maximilians-Universität Würzburg MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes
WO2010039502A2 (en) * 2008-09-23 2010-04-08 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Micrornas in idiopathic pulmonary fibrosis
WO2010054386A2 (en) * 2008-11-10 2010-05-14 Battelle Memorial Institute Methods, compositions, and devices utilizing microrna to determine physiological conditions
WO2010068775A2 (en) 2008-12-11 2010-06-17 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
GB2466121B (en) 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
AP2011005824A0 (en) 2009-01-26 2011-08-31 Intermune Inc Methods for treating acute myocardial infarctions and associated disorders.
US20120059020A1 (en) * 2009-05-29 2012-03-08 Shizuoka Coffein Co., Ltd Prophylactic or therapeutic agent for pulmonary fibrosis
GB2470833B (en) 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
WO2011017350A2 (en) 2009-08-04 2011-02-10 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
US7816383B1 (en) * 2009-12-04 2010-10-19 Intermune, Inc. Methods of administering pirfenidone therapy

Also Published As

Publication number Publication date
EA201491019A1 (ru) 2014-08-29
EP2783016A1 (en) 2014-10-01
CN103987858A (zh) 2014-08-13
US20130150426A1 (en) 2013-06-13
MX2014006130A (es) 2015-04-13
HK1201298A1 (en) 2015-08-28
BR112014012288A2 (pt) 2017-05-23
JP2015504307A (ja) 2015-02-12
CA2853136A1 (en) 2013-05-30
WO2013078283A1 (en) 2013-05-30
HK1201299A1 (en) 2015-08-28

Similar Documents

Publication Publication Date Title
US20130150426A1 (en) Methods of diagnosing and treating idiopathic pulmonary fibrosis
AU2012265177B2 (en) Methods and devices for prognosis of cancer relapse
EP2190992B1 (en) Mirna expression in human peripheral blood microvesicles and uses thereof
Abu-Halima et al. Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments
US20100202973A1 (en) Microrna molecules associated with inflammatory skin disorders
Lu et al. MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
US20190276892A1 (en) Micrornas in neurodegenerative disorders
US20110107440A1 (en) Skin cancer associated micrornas
JP2020162610A (ja) 骨折および骨障害の診断および治療のための組成物および方法
US20140171484A1 (en) Tissue-specific micrornas and compositions and uses thereof
US20160251720A1 (en) MicroRNA PROFILES IN HEART FAILURE: METHODS AND SYSTEMS FOR DETECTION AND USE
US20120302626A1 (en) Microrna and use thereof in identification of b cell malignancies
AU2012265177A1 (en) Methods and devices for prognosis of cancer relapse
CN102892897A (zh) 用于肺癌的微rna表达谱分析的组合物和方法
JP2011516033A5 (ja) 急性骨髄性白血病（ａｍｌ）における細胞遺伝学および予後と関連するマイクロｒｎａシグネチャーおよびその使用
US20160138106A1 (en) Circulating Non-coding RNA Profiles for Detection of Cardiac Transplant Rejection
WO2011068546A2 (en) Prognosis, diagnosis and identification of multiple myeloma based on global gene expression profiling
US20150152499A1 (en) Diagnostic portfolio and its uses
Chi et al. Interferon‑γ alters the microRNA profile of umbilical cord‑derived mesenchymal stem cells
Arvind et al. ANALYSIS OF MICRORNA EXPRESSION PROFILE IN ASIAN INDIANS WITH CORONARY ARTERY DISEASE
Kim Expression Profiling and Functional Validation of MicroRNAs Involved in Schizophrenia and Bipolar Disorder
Tinaglia INTEGRATED GENOMICS ANALYSIS OF GENE AND MICRORNA EXPRESSION PROFILES IN CLEAR CELL RENAL CARCINOMA CELL LINES
AU2014271293A1 (en) MiRNA expression in human peripheral blood microvesicles and uses thereof

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period